作者: Aspirin 時間: 2025-3-21 22:08 作者: 字的誤用 時間: 2025-3-22 01:44 作者: concise 時間: 2025-3-22 05:18
Barbara Friebertsh?user Dr. phil.ility and safety issues have not been fully elucidated at present, especially for new-generation TKIs. Recent evidence has emerged that these new agents may sometimes impinge on vital organs such as the heart and lung in an irreversible fashion especially when comorbidities are present; thus, decisi作者: senile-dementia 時間: 2025-3-22 10:29
Reflexive Ethnographic Practice survival of these patients. In recent population-based studies, CML patients have an overall survival that is comparable to that shown in large clinical trials, though relative survival in patients >70 years is still decreased. The importance of socioeconomic factors and health-care setting for out作者: judiciousness 時間: 2025-3-22 14:46 作者: judiciousness 時間: 2025-3-22 18:23 作者: 粗魯性質(zhì) 時間: 2025-3-22 22:38
Anwendungen des RGTM-Forschungsstils,es with imatinib therapy. However, the undesirable side effects of IFNα can make this therapy difficult to deliver, and the optimal therapeutic window for using IFNα in combination therapy is unknown. Further studies are needed to clarify the best niche for IFNα use in CML.作者: 生銹 時間: 2025-3-23 02:41 作者: apiary 時間: 2025-3-23 08:13
Book 20161st editions of survival. Furthermore, updates are provided on the increasing prevalence of CML and its implications and on the changing cost of care for CML, taking into account the forthcoming impact of availability of generic imatinib.?.作者: 漂浮 時間: 2025-3-23 12:13
The Biology and Pathogenesis of Chronic Myeloid Leukemia,The answer behind advanced disease may be intertwined with the other unsolved issue in CML, that being characterisation of primitive CML cells. This chapter introduces the clinical and cell biology of CML and describes examples of genes with important roles for CML stem cell abnormalities and blast 作者: mortgage 時間: 2025-3-23 16:42 作者: Spongy-Bone 時間: 2025-3-23 19:27 作者: 異端邪說下 時間: 2025-3-24 01:31 作者: fatuity 時間: 2025-3-24 05:47 作者: GLADE 時間: 2025-3-24 09:43 作者: 察覺 時間: 2025-3-24 12:25
Managing Pregnancy in Chronic Myeloid Leukemia, fetus of continuing therapy versus the risk to the patient of treatment interruption and potential disease progression. All couples should be counselled as to the risks associated with pregnancy whilst receiving TKI. This is an essential aspect in patient care and frequently not emphasised enough b作者: 進(jìn)入 時間: 2025-3-24 17:35 作者: Lacerate 時間: 2025-3-24 22:52 作者: Incommensurate 時間: 2025-3-25 01:53 作者: Alveoli 時間: 2025-3-25 07:04 作者: 影響深遠(yuǎn) 時間: 2025-3-25 10:43 作者: 一起 時間: 2025-3-25 12:16 作者: Original 時間: 2025-3-25 16:43
https://doi.org/10.1007/978-3-030-34898-4n has focused on the need to define and validate levels of deeper molecular response (MR) within the context of the IS. While there has been substantial progress, . measurement is technically challenging and standardization is an ongoing process.作者: 方舟 時間: 2025-3-25 22:12
Franz Breuer,Petra Muckel,Barbara Dierisbe recommended for patients with a well matched donor and low risk transplant profile as early as possible. It is discouraged for patients with failed response to multiple TKIs and no matched donor. Close interaction between CML physicians and transplant centers facilitates such a targeted risk adapted approach.作者: 發(fā)酵劑 時間: 2025-3-26 01:20
,Gütekriterien und ethische Fragen,ost importance even for drug companies. It should be considered the future criterion to evaluate the success of clinical trials, especially if we want to take into account quality of life of patients and also the economic aspect..The question of cure in CML is now one of the major concerns and has to be considered in the management of the disease.作者: 分期付款 時間: 2025-3-26 04:29
Standardization of Molecular Monitoring for Chronic Myeloid Leukemia,n has focused on the need to define and validate levels of deeper molecular response (MR) within the context of the IS. While there has been substantial progress, . measurement is technically challenging and standardization is an ongoing process.作者: 發(fā)出眩目光芒 時間: 2025-3-26 09:34 作者: Connotation 時間: 2025-3-26 15:38 作者: 決定性 時間: 2025-3-26 18:54
Response-Related Predictors of Survival in CML,h of treatment can be considered if unfavorable outcome has to be expected due to early response failure. Numerous studies have demonstrated the association of long-term outcome with early response for first-line treatment with imatinib, with second-generation TKI, and for second-line TKI treatment as well.作者: 按時間順序 時間: 2025-3-26 23:57
CML Blast Crisis: Implications and Management,vention, and early predictors of progression. Also, open questions concerning the cause of clonal evolution, improvement of prevention, identification of patients at risk for progression, and a better pathophysiologic understanding of BC are addressed. Current treatment options are combined in a concluding algorithm for the management of BC.作者: 以煙熏消毒 時間: 2025-3-27 02:55 作者: 歌曲 時間: 2025-3-27 06:14
Die Struktur reflexiver Erkenntnis, 9;22 translocations as well as cytogenetically cryptic . rearrangements are described. Furthermore, the relevance of additional cytogenetic aberrations in the Ph-positive clone at diagnosis and during the course of the disease is emphasized. Moreover, the impact of the occurrence of Ph-negative clones during follow up is discussed.作者: tympanometry 時間: 2025-3-27 13:02 作者: 使痛苦 時間: 2025-3-27 13:42
Die Struktur reflexiver Erkenntnis,nalysis and its role in the diagnostic work-up of CML in relation to fluorescence in situ hybridization and RT-PCR-based methods. Standard and variant 9;22 translocations as well as cytogenetically cryptic . rearrangements are described. Furthermore, the relevance of additional cytogenetic aberratio作者: projectile 時間: 2025-3-27 20:04
Reflexive Erziehungswissenschaftthe discovery of the Philadelphia chromosome. This genomic abnormality is the result of a t(9;22) translocation, which gives origin to a BCR-ABL1 fusion gene. The research focus thereafter shifted to characterising the functional consequence of BCR-ABL1. It was demonstrated that this fusion protein 作者: Vasodilation 時間: 2025-3-28 01:56 作者: floaters 時間: 2025-3-28 06:05 作者: 手段 時間: 2025-3-28 06:27
Barbara Friebertsh?user Dr. phil.m survival without transformation to blast phase CML has become a reality. However, the majority of patients need to be treated during their entire lifespan; thus, the outcome does not solely depend on treatment efficacy but also on how well therapy is tolerated. TKIs have shown an overall favorable作者: 機(jī)密 時間: 2025-3-28 13:21 作者: 我不怕犧牲 時間: 2025-3-28 17:04 作者: Gastric 時間: 2025-3-28 20:26 作者: insolence 時間: 2025-3-29 02:34 作者: vanquish 時間: 2025-3-29 04:17 作者: Angioplasty 時間: 2025-3-29 07:54 作者: HAUNT 時間: 2025-3-29 11:24
Franz Breuer,Petra Muckel,Barbara Dierishe era of tyrosine kinase inhibitors (TKI). HSCT can induce a BCR/ABL negative state with observation periods now exceeding more than 25 years in substantial numbers of patients. No other treatment so far has achieved this goal. Risk factors for outcome after HSCT are known and selection criteria ca作者: Agnosia 時間: 2025-3-29 16:43
,Gütekriterien und ethische Fragen,f CML patients who respond to TKI is now considered very close to that of the healthy population control. Several clinical trials have demonstrated that some patients with CML in chronic phase who achieve sustained deep molecular responses on TKI therapy can safely suspend therapy and attempt a new 作者: 北京人起源 時間: 2025-3-29 20:41
Anwendungen des RGTM-Forschungsstils,cludes immune activation and specific targeting of CML stem cells. Early studies of IFNα in CML demonstrated that it could induce extremely stable remissions, which correlated with long-term survival. Some patients even sustained their remission after discontinuing therapy, but the mechanism underly作者: 變白 時間: 2025-3-30 02:09 作者: 施加 時間: 2025-3-30 06:14 作者: 儀式 時間: 2025-3-30 09:37
Rüdiger HehlmannPresents state-of-the-art reviews of key issues relating to chronic myeloid leukemia.Covers a wide range of management topics.Discusses prognostic aspects and early response prediction.Examines the ch作者: Observe 時間: 2025-3-30 15:15 作者: intrude 時間: 2025-3-30 17:00
https://doi.org/10.1007/978-3-319-33198-0Chronic myeloid leukaemia; BCR-ABL; Tyrosine kinase inhibitors; Philadelphia chromosome; Fertility; Hemat作者: Musket 時間: 2025-3-30 23:11
978-3-319-81451-3Springer International Publishing Switzerland 2016作者: Sad570 時間: 2025-3-31 02:15
Cytogenetics of Chronic Myeloid Leukemia (CML),nalysis and its role in the diagnostic work-up of CML in relation to fluorescence in situ hybridization and RT-PCR-based methods. Standard and variant 9;22 translocations as well as cytogenetically cryptic . rearrangements are described. Furthermore, the relevance of additional cytogenetic aberratio作者: Chemotherapy 時間: 2025-3-31 06:19
