標(biāo)題: Titlebook: Chronic Lymphocytic Leukemia; Book 2005 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, [打印本頁] 作者: 機會 時間: 2025-3-21 16:48
書目名稱Chronic Lymphocytic Leukemia影響因子(影響力)
作者: 博愛家 時間: 2025-3-21 21:52
David Kitchin,Adrian Quark,Jayadev Misrahe cell derivation of B-CLL and provided novel hypotheses concerning its pathogenesis. Here we summarize recent work relevant to these issues and conclude that B-CLLmay be derived from a cell that can be referred to as a marginal zone B cell. Moreover, we propose that the lack of chromosomal translo作者: catagen 時間: 2025-3-22 02:46
,The University of Chicago—1966–1972, epitopes. It is currently unclearwhether this putative antigen-driven process could occur prior to leukaemic transformation and/or that the precursors were transformed into leukaemic cells at distinct maturational stages. Themutational profile of Ig genes has been shown to be associated with diseas作者: profligate 時間: 2025-3-22 05:51
The Temporality of European Governance times. V-gene usage, VDJ structure, and gene expression differences in the two subgroups allowinsights into differential pathogenic mechanisms and provide further prognostic information (V3-21 usage, ZAP-70 expression). Most importantly, the . mutation status and genomic abnormalities have been sho作者: commodity 時間: 2025-3-22 11:34 作者: grieve 時間: 2025-3-22 14:06
New Insights into the Phenotype and Cell Derivation of B Cell Chronic Lymphocytic Leukemia,he cell derivation of B-CLL and provided novel hypotheses concerning its pathogenesis. Here we summarize recent work relevant to these issues and conclude that B-CLLmay be derived from a cell that can be referred to as a marginal zone B cell. Moreover, we propose that the lack of chromosomal translo作者: grieve 時間: 2025-3-22 20:05 作者: 蜈蚣 時間: 2025-3-23 00:15
Genotypic Prognostic Markers, times. V-gene usage, VDJ structure, and gene expression differences in the two subgroups allowinsights into differential pathogenic mechanisms and provide further prognostic information (V3-21 usage, ZAP-70 expression). Most importantly, the . mutation status and genomic abnormalities have been sho作者: grudging 時間: 2025-3-23 02:28
0070-217X g CLL as a very interesting target of many projects which aim at translating the new and exciting developments of basic science into effective new approaches to the patient. .978-3-642-06450-0978-3-540-29933-2Series ISSN 0070-217X Series E-ISSN 2196-9965 作者: 畏縮 時間: 2025-3-23 06:32 作者: 簡潔 時間: 2025-3-23 09:54
Chronic Lymphocytic Leukaemia: Clinical Translations of Biological Features,s and the functioning of the immune response have been scattered, but not quite put together. In addition, clinicians have been given a new tool for determining prognosis, though the tool is too clumsy for day-to-day use and surrogates are being sought. Treatment strategies based on the new biology are in development.作者: 前兆 時間: 2025-3-23 17:48 作者: 嘲弄 時間: 2025-3-23 18:29
Jens Bennedsen,Michael E. Caspersenasma cells—highlighting some of the cellular stages and the molecular mechanisms that can generate and select transformed states of cells. The scenarios for pre-B lymphoma (lymphocytic leukaemia) development are discussed in more detail.作者: 不理會 時間: 2025-3-24 00:46 作者: 擔(dān)心 時間: 2025-3-24 04:39
,‘It Feels Real!’: Excess and Intensity in ,eatures to the cellular and genetic characteristics recently defined for these leukemic cells. The discussion is limited to parameters that define phenotypes or subgroups that may relate to disease activity and clinical outcome.作者: reptile 時間: 2025-3-24 08:19 作者: 北極人 時間: 2025-3-24 11:00
American Meteorological Society, of these genes, ., located at the chromosome 13q14 are also deleted in human CLL samples. In this review we summarize and discuss these new developments. These recently emerged insights into the molecular mechanisms of CLL will allow for the development of new approaches to treat this disease.作者: Credence 時間: 2025-3-24 15:54
https://doi.org/10.1007/978-3-031-64459-7f CD23, MUM1/IRF-4 and cyclin D1, tyrosine phosphorylation and detection of the ZAP-70 kinase. Whenever possible, an attempt is made to interpret the immunohistochemical findings from a functional point of view.作者: 推測 時間: 2025-3-24 21:32 作者: 聰明 時間: 2025-3-24 23:41
Chronic Lymphocytic Leukemia: Molecular Genetics and Animal Models, of these genes, ., located at the chromosome 13q14 are also deleted in human CLL samples. In this review we summarize and discuss these new developments. These recently emerged insights into the molecular mechanisms of CLL will allow for the development of new approaches to treat this disease.作者: Herpetologist 時間: 2025-3-25 04:29 作者: 表皮 時間: 2025-3-25 09:50
Differential Effects on CLL Cell Survival Exerted by Different Microenvironmental Elements,s are involved in sustaining the survival of leukemic B cells, but indicate that their support is different in terms of time of onset and duration. T cells have a short-term support activity while stromal cells provide long-term support.作者: 喃喃訴苦 時間: 2025-3-25 14:15 作者: 條約 時間: 2025-3-25 16:56 作者: GRUEL 時間: 2025-3-25 22:26
Includes supplementary material: 作者: assail 時間: 2025-3-26 03:41 作者: 假裝是我 時間: 2025-3-26 06:46
Chronic Lymphocytic Leukemia978-3-540-29933-2Series ISSN 0070-217X Series E-ISSN 2196-9965 作者: EXTOL 時間: 2025-3-26 11:38 作者: 人造 時間: 2025-3-26 16:23 作者: 嬰兒 時間: 2025-3-26 18:26
David Kitchin,Adrian Quark,Jayadev Misrawork of the available B cell differentiation scheme: First, the histology as well as the immunophenotype did not quite resemble that of any normal lymphocyte; second, in contrast to almost all other B cell tumor subtypes, the immunoglobulin variable region (IgV) genes of B-CLL cases could be either 作者: 群居男女 時間: 2025-3-26 23:51
American Meteorological Society,mic abnormalities in CLL have been identified, mutational and functional analysis of corresponding genes so far have not proved their involvement in CLL. Our latest studies demonstrated functional involvement of Tcl1 oncoprotein and microRNA genes in the pathogenesis of CLL. Deregulated expressionof作者: 兇兆 時間: 2025-3-27 05:00
,The University of Chicago—1966–1972, However, recent studies have shown that 50%–70% of CLL harbour somaticmutations of VH genes, as if they had matured in a lymphoid follicle. Interestingly, the presence or absence of somatic hypermutation (SHM) process is associated with the use of particular VH genes. Particular alleles of the V.1–作者: 使堅硬 時間: 2025-3-27 06:14 作者: VOC 時間: 2025-3-27 09:38 作者: BILK 時間: 2025-3-27 16:16 作者: 輕而薄 時間: 2025-3-27 20:45 作者: 宣誓書 時間: 2025-3-28 01:34
The Temporality of European Governanceimmunoglobulin genes who were mainly men, had aggressive disease and were destined to die from their disease, on average at about 8 years from diagnosis, and those with mutated immunoglobulin genes who were equally distributed between the sexes, had indolent disease and usually died of something els作者: Ligneous 時間: 2025-3-28 02:13
https://doi.org/10.1007/3-540-29933-5Chemokine; cell; gene; gene expression; genetics; hematology; immunogloblulin; immunology; leukemia; lymphade作者: defenses 時間: 2025-3-28 06:59
978-3-642-06450-0The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE作者: deficiency 時間: 2025-3-28 13:25
B Cell Development and Its Deregulation to Transformed States at the Pre-B Cell Receptor-Expressingof the generation of the repertoires of antigen-receptor (immunoglobulin)-expressing cells, to the response of mature B cells to develop memory and plasma cells—highlighting some of the cellular stages and the molecular mechanisms that can generate and select transformed states of cells. The scenari作者: Popcorn 時間: 2025-3-28 16:39
Gene Expression Patterns in Human and Mouse B Cell Development,lobulin genes. Recent studies have combined RNA amplification by in vitro transcription with high-density oligonucleotide array technology to generate gene expression profiles of ex vivo isolated B cell precursor stages from humans and mice. Cellular differentiation through five subsequent stages of作者: aphasia 時間: 2025-3-28 21:07 作者: IST 時間: 2025-3-29 00:02 作者: BATE 時間: 2025-3-29 05:42
What Do Somatic Hypermutation and Class Switch Recombination Teach Us About Chronic Lymphocytic Leu However, recent studies have shown that 50%–70% of CLL harbour somaticmutations of VH genes, as if they had matured in a lymphoid follicle. Interestingly, the presence or absence of somatic hypermutation (SHM) process is associated with the use of particular VH genes. Particular alleles of the V.1–作者: 滔滔不絕地說 時間: 2025-3-29 10:27
Chronic Lymphocytic Leukaemia: A Review of the Immuno-architecture,blood, bone marrow or biopsied tissue. Immunohistochemical analysis on routine sections is less commonly performed; however, this approach allows the pathologist and the researcher to appreciate the immuno-architecture of the involved tissues and to gain insight into some of the events that influenc作者: transdermal 時間: 2025-3-29 13:10
Clinical and Laboratory Parameters That Define Clinically Relevant B-CLL Subgroups,tients experience and by the marked variation in laboratory findings between patients. In this chapter, we will review the various clinical and laboratory parameters that divide B-CLL patients into “subgroups,” and correlate the parameters that define them.When feasible, we will also link clinical f作者: 調(diào)味品 時間: 2025-3-29 15:32
Differential Effects on CLL Cell Survival Exerted by Different Microenvironmental Elements,ort provided by the different cellular components of the microenvironment where CLL cells accumulate. To this end we cultured purified CLL cells in vitro in the presence or absence of different accessory cells (stromal cells, autologous T lymphocytes) and/or soluble molecules (IL-4, sCD40L) and asse作者: Locale 時間: 2025-3-29 22:07
