作者: 手勢(shì) 時(shí)間: 2025-3-21 23:08 作者: Factual 時(shí)間: 2025-3-22 04:04 作者: 悠然 時(shí)間: 2025-3-22 06:56
Synergism and Adaptive Response in the Interaction of Low Dose Irradiation with Subsequent Mutagenio a subsequent higher dose. The initial dose may protect by inducing or priming a repair mechanism. This so called “adaptive response” has been demonstrated by numerous authors using different materials and different end points (for reviews, see Kelsey et al. 1991; Liu et al. 1992; Luckey 1991; Ofte作者: 世俗 時(shí)間: 2025-3-22 11:17
Implementing a Full Apache Deployment,r by reaction with water which also leads to the release of a proton. For instance the water radical cations convert into OH radicals and protons. The OH radicals diffuse to the DNA and react mainly with the bases and to a smaller extent with the sugar (Scholes et al. 1960). The organic radicals can作者: 玉米棒子 時(shí)間: 2025-3-22 13:26 作者: 玉米棒子 時(shí)間: 2025-3-22 18:13
Red Sanders: Silviculture and Conservationmbination, chromatid segregation and transcription (for a review see Wang 1985; D’Arpa and Liu 1989). These enzymes catalyse the interconversions between topological isomers of DNA. DNA topoisomerase I (Topo I) breaks and rejoins one strand of the DNA double helix, whereas DNA topoisomerase II (Topo作者: subordinate 時(shí)間: 2025-3-23 00:02 作者: Facilities 時(shí)間: 2025-3-23 02:09
Chromatin Structure, Hyperthermia and Repair of UV-Induced DNA Photolesions in Mammalian Cells,atin along nucleoskeleton associated repair enzymes. Perhaps nucleoskeleton-centred repair may be confined only to biological important domains comprising active genes. Results of experiments aimed to discover nucleoskeleton-centred repair point to the existence of such a mechanism for transcriptionally active DNA.作者: 謊言 時(shí)間: 2025-3-23 06:09 作者: hegemony 時(shí)間: 2025-3-23 12:56 作者: 哄騙 時(shí)間: 2025-3-23 14:07 作者: MEEK 時(shí)間: 2025-3-23 21:31
ered. .Further, topics such as automation of aberration scoring, problems associated with using chromosomal aberrations and micronuclei in population monitoring and the importance of chromosomal aberration assays in mutagenicity testing of chemicals are included.978-3-642-78889-5978-3-642-78887-1作者: babble 時(shí)間: 2025-3-24 01:23 作者: 痛苦一下 時(shí)間: 2025-3-24 04:50
https://doi.org/10.1057/9781137507037hile the origin of classical chromosome aberrations e.g. inversions or translocations is mostly well described by the “breakage and fusion” theory (Muller 1938), no such general theory applies to HSRs. We have to choose among several hypotheses (see Windle and Wahl 1992).作者: 暖昧關(guān)系 時(shí)間: 2025-3-24 07:58 作者: chronicle 時(shí)間: 2025-3-24 13:44 作者: 代理人 時(shí)間: 2025-3-24 15:38
https://doi.org/10.1007/978-3-658-35757-3lly assumed that cells would sustain the same amount of initial damage per unit amount of DNA at all times during the cell cycle, but the efficiency with which dsb are repaired would affect the formation of chromosomal aberrations (deletions or exchanges) and determine relative radiosensitivity (Bender et al. 1974).作者: 束縛 時(shí)間: 2025-3-24 22:07 作者: Obsessed 時(shí)間: 2025-3-25 02:38 作者: Exclude 時(shí)間: 2025-3-25 07:03 作者: 考博 時(shí)間: 2025-3-25 10:04
Red Meat Science and Productionhfully or undergo misrepair, resulting in a chromosome exchange (breakage and reunion). An alternative hypothesis was proposed by Revell 1959, whereby all chromosome aberrations are the result of exchanges.作者: 寬宏大量 時(shí)間: 2025-3-25 12:35
https://doi.org/10.1007/978-3-322-90896-4 ultimate lesion for the production of chromosomal alterations is a DNA double-strand break (Obe et al. 1992; Bryant 1990; Morgan et al. 1990). RE induce CA independent of the S-phase of the cell cycle (Obe and Winkel 1985; Obe et al. 1987).作者: 易于 時(shí)間: 2025-3-25 16:24 作者: Coma704 時(shí)間: 2025-3-25 23:40
Quantitative Localization of Chromatid Breaks Induced by , I in the Long Arms of Chromosomes Number ultimate lesion for the production of chromosomal alterations is a DNA double-strand break (Obe et al. 1992; Bryant 1990; Morgan et al. 1990). RE induce CA independent of the S-phase of the cell cycle (Obe and Winkel 1985; Obe et al. 1987).作者: 失敗主義者 時(shí)間: 2025-3-26 01:36 作者: Living-Will 時(shí)間: 2025-3-26 06:48 作者: milligram 時(shí)間: 2025-3-26 12:04 作者: Lipoma 時(shí)間: 2025-3-26 13:54
Warum redaktionelle Bots die Zukunft sind focus on two compounds, dimethyl sulfoxide (DMSO), a highly effective selective scavenger of OH radicals, and WR-1065 [N--(2-mercaptoethyl)-1-3-diaminopropane] an aminothiol structurally similar to cysteamine.作者: 掃興 時(shí)間: 2025-3-26 16:49
Praxis des Redaktionsmanagements,o get information about the “l(fā)ife time” of AluI inside the vesicles we stabilized the vesicles by posttreatment with glycerol and found that there is a decrease of aberration frequencies with the duration of posttreatment. Our experiments indicate that the “l(fā)ife time” of Alul inside of cytoplasmic vesicles can be about 3h.作者: BROW 時(shí)間: 2025-3-27 00:28
UV-Induced Pyrimidine Monoadducts and their , Photofootprints,deaminate to uracil photohydrate and both of these eventually dehydrate to their parent bases (Patrick and Rahn 1976; Boorstein et al. 1990). In double stranded DNA, the half-lives of cytosine hydrate and uracil hydrate are 25 h and 6 h respectively at 37°C (Boorstein et al. 1990).作者: 編輯才信任 時(shí)間: 2025-3-27 01:34 作者: 思考才皺眉 時(shí)間: 2025-3-27 05:55 作者: 戲法 時(shí)間: 2025-3-27 13:11
,“Life time” of AluI inside Glycerol-Induced Vesicles in CHO Cells,o get information about the “l(fā)ife time” of AluI inside the vesicles we stabilized the vesicles by posttreatment with glycerol and found that there is a decrease of aberration frequencies with the duration of posttreatment. Our experiments indicate that the “l(fā)ife time” of Alul inside of cytoplasmic vesicles can be about 3h.作者: Processes 時(shí)間: 2025-3-27 16:12
Radiation-Induced Formation of DNA Double-Strand Breaks in Plasmids and ,,he fact that the chemical changes are the result of ionizations which produce radical cations and electrons from each other. Electronic excitations contribute negligibly to chemical changes in DNA (Redpath et al. 1981; Morgan et al. 1982). The solvated electrons have a small probability of causing s作者: Lumbar-Stenosis 時(shí)間: 2025-3-27 19:15
UV-Induced Pyrimidine Monoadducts and their , Photofootprints,s ≥ pyrimidine monoadducts. The monoadducts include cytosine, uridine, and thymine photohydrates as water additions, and thymine glycol (Patrick and Rahn 1976). The most common UV-induced pyrimidine monoadduct is cytosine photohydrate formed by addition of H.O to the 5,6 double bond of cytosine (Fis作者: placebo 時(shí)間: 2025-3-28 01:23 作者: machination 時(shí)間: 2025-3-28 04:00
An Inherited Homogeneously Staining Region Derived from a Long-Range Repeat Family in the House Mouore or less homogeneously with G-banding techniques (Biedler and Spengler 1976). They are rather well known from somatic cells. In cell cultures, they can be selected for with drugs like methotrexate (Schimke et al. 1980), and they are found in tumors like neuroblastomas (Alitalo and Schwab 1986). W作者: Anticlimax 時(shí)間: 2025-3-28 08:33 作者: 碳水化合物 時(shí)間: 2025-3-28 13:30 作者: callous 時(shí)間: 2025-3-28 17:49 作者: 幸福愉悅感 時(shí)間: 2025-3-28 21:30 作者: Grasping 時(shí)間: 2025-3-29 01:48
Investigations of Aberration Origins Using BrdUrd,tion of the newly synthesised strands is reflected at the chromosome level. Thus, after one S-phase all replicated chromatin has Br in one strand of the DNA (unifilar substitution, TB) but after two S-phases, sister-chromatids differ, one containing unifilar, TB chromatin, the other bifilar substitu作者: 災(zāi)禍 時(shí)間: 2025-3-29 05:16
Use of Antitopoisomerase Drugs to Study the Mechanisms of Induction of Chromosomal Damage,ents which induce specific damage to DNA that can be followed in its evolution to produce chromosomal aberrations. Another approach consists of using agents that affect different cellular functions (i.e. DNA synthesis and repair) which are required to overcome the damage induced at the DNA level. Th作者: 燈泡 時(shí)間: 2025-3-29 10:09
Search for Perturbations induced by X-irradiation in the G2 Phase of Human Lymphocytes,delay induced by low doses of X-irradiation has lead to extensive investigations during the last decade (e.g. Bender 1989; Doida and Okada 1969; Hsu et al. 1962; Mindek 1986; Natarajan and Obe 1978; Obe at al. 1982; Revell 1959; Rowley 1992; Savage and Papworth 1973; Schneidermann et al. 1977; Scott作者: arabesque 時(shí)間: 2025-3-29 12:17
A Comparison of Radiation-Induced Aberrations in Human Cells Involving Early and Late Replicating Xg . chromosome arms. He found these frequencies appreciably higher in the proximal compared to the distal one-third of the arms, and concluded that “...chromosome break or exchange points do not occur at random in the chromosome” (Sax 1938). At the same time he also noted that “....the greatest freq作者: 赦免 時(shí)間: 2025-3-29 16:11 作者: 誘騙 時(shí)間: 2025-3-29 23:24 作者: 把手 時(shí)間: 2025-3-30 00:57
Synergism and Adaptive Response in the Interaction of Low Dose Irradiation with Subsequent Mutagenis and dose rates, however, still remain ambiguous (Pohl-Rüling 1990; Sagan 1987). The study of interaction of low dose irradiation with subsequent mutagenic treatment could be a way of evaluating the effects of low doses of irradiation. This type of research has linked to a general biological phenom作者: BUMP 時(shí)間: 2025-3-30 06:07 作者: SPALL 時(shí)間: 2025-3-30 08:25 作者: BARK 時(shí)間: 2025-3-30 16:10
,“Life time” of AluI inside Glycerol-Induced Vesicles in CHO Cells, hypertonic solutions of glycerol. The uptake of AluI is mediated by the formation of vesicles which upon addition of isotonic medium break and liberate AluI in the cytoplasm (Johannes et al. 1992). The induction of chromosomal aberrations by AluI is more effective in the presence of 2.2 M than of 1作者: HAIRY 時(shí)間: 2025-3-30 17:53
https://doi.org/10.1007/978-3-642-78887-1Chromosom; Chromosomal Aberrations; Chromosomen; Chromosomenaberrationen; DNA; Zytogenetik; chromosome; cyt作者: MIME 時(shí)間: 2025-3-31 00:27 作者: Valves 時(shí)間: 2025-3-31 03:00 作者: 慷慨不好 時(shí)間: 2025-3-31 07:41
Elucidation of Some Factors Involved in the Formation of Chromosomal Aberrations by Inhibiting the Aphidicolin (APC), an inhibitor of polymerases alpha and delta, has a variety of effects when added to cultured cells, either human peripheral blood leukocytes, or the permanent cell line JU56.作者: Synapse 時(shí)間: 2025-3-31 10:27 作者: 污點(diǎn) 時(shí)間: 2025-3-31 15:00
https://doi.org/10.1007/978-981-13-7856-0ome specific DNA libraries, one can . whole chromosomes, or using specific probes it is possible to hybridize with specific regions of the chromosome, such as telomeres, centromeres etc. This technique has been used extensively in our laboratory to study several cytogenetical end points in genetic toxicology.作者: 細(xì)微差別 時(shí)間: 2025-3-31 20:52
Ergebnisse der Journalismusforschung,hromosome aberrations (Bryant 1984; Natarajan and Obe 1984) cell killing (Bryant, 1985), mutation (Singh and Bryant 1990) and oncogenic transformation (Bryant and Riches 1989) indicates the important role played by DNA double-strand breaks (dsb) in the biological effects of radiation and in particular the induction of chromosomal aberrations.作者: 織物 時(shí)間: 2025-3-31 21:40 作者: Pigeon 時(shí)間: 2025-4-1 05:15 作者: Mawkish 時(shí)間: 2025-4-1 06:35
