作者: 生來 時間: 2025-3-21 20:27 作者: amphibian 時間: 2025-3-22 04:07
William N. Valentine,Donald E. Paglialy known. Operationally, chromosome aberrations are believed to be the result of DNA lesions induced by physical and chemical mutagens which, whether “misrepaired” or “misreplicated”, give rise to chromosomal damage (Evans 1968; Kihlman 1971; Bender et al. 1974; Natarajan et al. 1986).作者: 補(bǔ)助 時間: 2025-3-22 08:30
https://doi.org/10.1007/978-3-642-67059-6 To date, several methods have been proposed for the chromosome-based dose assessment (IAEA 1986). However, in spite of the growing importance in the risk assessment, the dose-yield kinetics of chromosome aberrations and their implications for dose assessment are not well established in exposures to low-level radiation.作者: 言外之意 時間: 2025-3-22 09:59
http://image.papertrans.cn/c/image/226329.jpg作者: 裹住 時間: 2025-3-22 15:56 作者: 裹住 時間: 2025-3-22 18:56
https://doi.org/10.1007/978-1-4684-5985-2nknown (for review see Althaus and Richter 1987). In 1985 Ueda and Hayaishi stated that “… a major difficulty in obtaining direct and definitive evidence for the role(s) of poly-ADP-ribosylation has stemmed from the complexity of systems used. A major breakthrough would therefore be expected by reco作者: 向宇宙 時間: 2025-3-22 23:07 作者: Hemodialysis 時間: 2025-3-23 03:41 作者: Oration 時間: 2025-3-23 07:47 作者: Pander 時間: 2025-3-23 12:31
https://doi.org/10.1007/978-1-4684-5985-2bonds. In an irradiated cell, therefore, damage can occur at any point in the structure of DNA. As a result of this high energy per ionizing event, radiation is able to induce a variety of lesions in the DNA of cells which can be grouped into those involving damage to the base moeity without breakag作者: leniency 時間: 2025-3-23 13:51
https://doi.org/10.1007/978-1-349-20304-8cleave DNA to generate either blunt-end or cohesive-end double-strand breaks. The role of DNA double-strand breaks in chromosome damage has long been a matter of some controversy (see Bryant 1988). By introducing restriction endonucleases into cells and examining their cytogenetic effects, investiga作者: 谷物 時間: 2025-3-23 19:53 作者: 懶惰民族 時間: 2025-3-23 22:38 作者: 容易懂得 時間: 2025-3-24 05:11
https://doi.org/10.1007/978-3-662-05181-8 breakage syndromes such as ataxia telangiectasia and xeroderma pigmentosum or constitutional chromosomal abnormalities are found to be at high risk for the development of malignancy (Lejeune et al. 1959; Ray and German 1981). Similarly, individuals who have increased exposure to clastogenic agents 作者: 無瑕疵 時間: 2025-3-24 08:37
René Motais,Hélène Guizouarn,Franck Borgesee, among others, ataxia telangiectasia, Bloom’s syndrome, familial polyposis, Fanconi’s anemia, Gardner’s syndrome, and xeroderma pigmentosum (Setlow 1978). We have shown that skin fibroblasts from affected individuals or individuals with a family history of cancer, compared to cells from clinically作者: 鎮(zhèn)痛劑 時間: 2025-3-24 13:59
George J. Brewer (Conference Chairman)ubsequently, the emphasis was shifted to mutation as a cellular process in which the primary lesion was extensively modified by enzymatic DNA-repair systems constitutively present in the cell (Auerbach 1976). Finally, over the past 15 years, considerable interest has been focused on inducible cellul作者: Vasodilation 時間: 2025-3-24 17:13
Red Cell Metabolism and Functionuce a series of responses that are often related to the repair of the initial damage (see Boothman et al. 1989). One type of induced repair, which was first found in ., has been called the adaptive reponse (Samson and Cairns 1977). In these experiments with bacteria, and in later experiments with ma作者: 只有 時間: 2025-3-24 19:29
Red Cell Metabolism and Functione response was first reported by Samson and Cairns (1977) in . as an inducibile form of DNA repair acting on alkylation damage, in which the bacterial cells that had been exposed to low levels of alkylating agents became less susceptible to the subsequent high doses of the same and other compounds. 作者: Ambulatory 時間: 2025-3-25 00:36
https://doi.org/10.1007/978-3-642-67059-6 To date, several methods have been proposed for the chromosome-based dose assessment (IAEA 1986). However, in spite of the growing importance in the risk assessment, the dose-yield kinetics of chromosome aberrations and their implications for dose assessment are not well established in exposures to作者: 樸素 時間: 2025-3-25 06:32
https://doi.org/10.1007/978-3-642-75682-5Chromosomen; DNA; DNA repair; Vivo; cell; chromosome; influence; lymphocytes; mutagen; mutagenicity; mutation; 作者: 上流社會 時間: 2025-3-25 08:15
978-3-642-75684-9Springer-Verlag Berlin Heidelberg 1990作者: affluent 時間: 2025-3-25 13:05
Is It Misrepair or Lack of Repair Which Kills Cells Irradiated in G2?,the presence of chromosome aberrations has been found to correlate with the loss of clonogenic ability (Dewey et al. 1971; Grote et al. 1981). These studies have been carried out using cells synchronized in G., or log-phase cells, i.e., a population made up mainly of cells in G.-or S-phase.作者: 符合規(guī)定 時間: 2025-3-25 16:59 作者: 疲勞 時間: 2025-3-25 20:43
Biological Dosimetry of Absorbed Radiation Dose: Considerations of Low-Level Radiations, To date, several methods have been proposed for the chromosome-based dose assessment (IAEA 1986). However, in spite of the growing importance in the risk assessment, the dose-yield kinetics of chromosome aberrations and their implications for dose assessment are not well established in exposures to low-level radiation.作者: 輕推 時間: 2025-3-26 01:08 作者: 出來 時間: 2025-3-26 07:20 作者: 違抗 時間: 2025-3-26 09:21 作者: 失望昨天 時間: 2025-3-26 16:24
https://doi.org/10.1007/978-3-642-67059-6In the course of chromosome study of atomic bomb survivors in Hiroshima and Nagasaki, we have obtained evidence relevant to the biological dose assessment in persons exposed to ionizing radiation (Awa 1974, 1975, 1983, 1984; Awa et al. 1971, 1978). The findings are summarized as follows:作者: 考古學(xué) 時間: 2025-3-26 19:47 作者: VOK 時間: 2025-3-26 22:53 作者: 全等 時間: 2025-3-27 01:46 作者: 冰雹 時間: 2025-3-27 08:36 作者: enchant 時間: 2025-3-27 12:01 作者: 能量守恒 時間: 2025-3-27 17:25
Patterns of Chromosome Variation in Neoplasia,day the basic question in cancer cytogenetics. It is now established beyond doubt that most neoplasms, benign and malignant, in both experimental animals and man, have karyotypic changes detectable with existing cytogenetic techniques. The unresolved question is: Are these abnormalities the cause or the consequence of the malignant state?作者: intrude 時間: 2025-3-27 19:19 作者: PHAG 時間: 2025-3-28 01:31 作者: CHASM 時間: 2025-3-28 03:22
William N. Valentine,Donald E. PagliaBs, induce chromosomal aberrations in a pattern similar to that induced by ionizing radiations, i.e., chromosome type of aberrations in G1 and chromatid type of aberrations following G2 treatment (Natarajan and Obe 1984, Obe and Winkel 1985).作者: 清楚 時間: 2025-3-28 09:13 作者: HAIL 時間: 2025-3-28 11:29 作者: 耕種 時間: 2025-3-28 16:41
The Use of Restriction Endonucleases to Study the Mechanisms of Chromosome Damage,ethods for introducing restriction enzymes into cells, and the effects of restriction enzymes on the induction of DNA double-strand breaks, chromosome aberrations, and sister chromatid exchange (SCE).作者: patriarch 時間: 2025-3-28 21:29
Heterogeneity of DNA Repair in Relation to Chromatin Structure, Also, in a number of other cases the removal of pyrimidine dimers from the genome overall turned out to be an invalid parameter to predict UV-induced cytotoxicity. Cockayne’s syndrome (CS) is a human disorder characterized at the cellular level by an increased sensitivity to the killing effects of 作者: Offstage 時間: 2025-3-29 01:23
The Poly-ADP-Ribosylation System of Higher Eukaryotes: How Can It Do What?, us a clue to the biological role of this posttranslational protein modification in chromatin. However, the phenotype of a genetically engineered cell under- or overexpressing components of the poly-ADP-ribosylation system may be difficult to interpret, since these cells, if viable at all, may exhib作者: 鞭打 時間: 2025-3-29 05:17 作者: Angioplasty 時間: 2025-3-29 09:16
Induction of Chromosomal Aberrations by the Restriction Endonuclease AluI in Chinese Hamster Ovary ). Analyses of Bryant and Christie (1989) have shown that the uptake of REs using the “pellet technique” is dependent on the shipping buffer in which the REs are suspended. The authors assume that “this may result from a combination of hypertonic shock and the detergent present in the shipping buffe作者: 腐爛 時間: 2025-3-29 13:09 作者: negligence 時間: 2025-3-29 16:56
Possible Causes of Variability of the Adaptive Response in Human Lymphocytes,nted by a mutagenic agent one of the most interesting responses is the adaptive response (AR; Samson and Cairns 1977). The mechanisms underlying the AR are reasonably well known in prokaryotes in which they were discovered (Sekiguchi and Nakabeppu 1987; Rebeck et al. 1988). In plant (Rieger et al. 1作者: 槍支 時間: 2025-3-29 21:13 作者: 車床 時間: 2025-3-30 02:38
Radio-Adaptive Response: A Novel Chromosomal Response in Chinese Hamster Cells in Vitro, et al. 1982). Interestingly, the adaptive response has been recently found to occur in human lymphocytes exposed to low doses of ionizing radiation (Olivieri et al. 1984; Shadley and Wolff, 1987; Sankaranarayanan et al. 1989). A pretreatment with “conditioning” or “adapting” low doses of either tri作者: 神刊 時間: 2025-3-30 07:43 作者: 消毒 時間: 2025-3-30 08:23
https://doi.org/10.1007/978-1-4684-5985-2 us a clue to the biological role of this posttranslational protein modification in chromatin. However, the phenotype of a genetically engineered cell under- or overexpressing components of the poly-ADP-ribosylation system may be difficult to interpret, since these cells, if viable at all, may exhib作者: AIL 時間: 2025-3-30 15:57
https://doi.org/10.1007/978-1-4684-5985-2chemical agents (e.g. bleomycin) that they induce chromosome aberrations at first mitosis following exposure of a cell in the G1 phase of the cell cycle, whereas agents such as UV that induce almost entirely single-stranded lesions (principally thymine dimers, which are converted to single-strand br作者: Infelicity 時間: 2025-3-30 17:43
The Politics of Life and Death,). Analyses of Bryant and Christie (1989) have shown that the uptake of REs using the “pellet technique” is dependent on the shipping buffer in which the REs are suspended. The authors assume that “this may result from a combination of hypertonic shock and the detergent present in the shipping buffe作者: Dictation 時間: 2025-3-30 22:36 作者: Chivalrous 時間: 2025-3-31 03:44 作者: FANG 時間: 2025-3-31 06:15 作者: 虛弱的神經(jīng) 時間: 2025-3-31 10:32 作者: G-spot 時間: 2025-3-31 14:53
Heterogeneity of DNA Repair in Relation to Chromatin Structure,e repair of ultraviolet light-induced photoproducts has been intensively studied in a variety of mammalian cells and in most cases UV-induced cytotoxicity can be correlated to the extent of unscheduled DNA synthesis or removal of pyrimidine dimers from the nuclear DNA. For example variation in UV-in作者: Feigned 時間: 2025-3-31 21:31
The Poly-ADP-Ribosylation System of Higher Eukaryotes: How Can It Do What?,nknown (for review see Althaus and Richter 1987). In 1985 Ueda and Hayaishi stated that “… a major difficulty in obtaining direct and definitive evidence for the role(s) of poly-ADP-ribosylation has stemmed from the complexity of systems used. A major breakthrough would therefore be expected by reco作者: chalice 時間: 2025-3-31 23:00 作者: habile 時間: 2025-4-1 02:34 作者: hematuria 時間: 2025-4-1 09:48 作者: Ringworm 時間: 2025-4-1 13:34
Restriction Endonuclease- and Radiation-Induced DNA Double-Strand Breaks and Chromosomal Aberrationbonds. In an irradiated cell, therefore, damage can occur at any point in the structure of DNA. As a result of this high energy per ionizing event, radiation is able to induce a variety of lesions in the DNA of cells which can be grouped into those involving damage to the base moeity without breakag作者: JOT 時間: 2025-4-1 15:01 作者: Outspoken 時間: 2025-4-1 20:46
Induction of Chromosomal Aberrations by the Restriction Endonuclease AluI in Chinese Hamster Ovary berrations is a DNA double-strand break (Obe et al. 1987; Bryant, this Vol.; Morgan et al., this Vol.). It is still not clear how living cells can uptake REs. Different methods have been used to treat cells with REs (for discussion see Bryant 1988; Morgan et al., this Vol.) and all of them are more 作者: 其他 時間: 2025-4-2 01:50 作者: KEGEL 時間: 2025-4-2 04:48
Tumorigenesis and Tumor Response: View from the (Prematurely Condensed) Chromosome, breakage syndromes such as ataxia telangiectasia and xeroderma pigmentosum or constitutional chromosomal abnormalities are found to be at high risk for the development of malignancy (Lejeune et al. 1959; Ray and German 1981). Similarly, individuals who have increased exposure to clastogenic agents 作者: 臭名昭著 時間: 2025-4-2 10:34
Detection of Cancer-Prone Individuals Using Cytogenetic Response to X-Rays,e, among others, ataxia telangiectasia, Bloom’s syndrome, familial polyposis, Fanconi’s anemia, Gardner’s syndrome, and xeroderma pigmentosum (Setlow 1978). We have shown that skin fibroblasts from affected individuals or individuals with a family history of cancer, compared to cells from clinically作者: 去才蔑視 時間: 2025-4-2 15:05
Possible Causes of Variability of the Adaptive Response in Human Lymphocytes,ubsequently, the emphasis was shifted to mutation as a cellular process in which the primary lesion was extensively modified by enzymatic DNA-repair systems constitutively present in the cell (Auerbach 1976). Finally, over the past 15 years, considerable interest has been focused on inducible cellul
