標(biāo)題: Titlebook: Cholinesterases and Anticholinesterase Agents; George B. Koelle (Professor and Chairman) Book 1963 Springer-Verlag Berlin Heidelberg 1963 [打印本頁] 作者: 猛烈抨擊 時(shí)間: 2025-3-21 16:37
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書目名稱Cholinesterases and Anticholinesterase Agents讀者反饋學(xué)科排名
作者: 強(qiáng)制性 時(shí)間: 2025-3-21 21:28
Rechnungswesen in Kulturbetrieben. When the energy released by the breakdown of phosphocreatine during electrical activity of the electric organ of . was found to be more than adequate to account for the electrical energy released, it was assumed that this energy was used as in muscle for the resynthesis of adenosine triphosphate (作者: RAG 時(shí)間: 2025-3-22 02:40
Kostenrechnung & Controlling (CO),owing its release be replaced rapidly enough for transmission to occur repetitively in response to successive nerve impulses. The question of how the ester is replaced at the release points of the synapse in available form is one which as yet can be answered only in the most general way. In tissue s作者: 保存 時(shí)間: 2025-3-22 05:38
https://doi.org/10.1007/978-3-322-90876-6he last 20 years on the specificity of these enzymes, their role in physiological systems, and the pharmacological importance of cholinesterase inhibitors. Everybody taking part in this discussion on the biochemical level will probably agree with the following; There are enzymes present in the anima作者: Classify 時(shí)間: 2025-3-22 10:34
https://doi.org/10.1007/978-3-642-48210-6l or synaptic transmission and with function and motility (BACQ 1935 a). Thus, together with enzymes concerned with adrenergic function, ChE’s are dramatically different from enzymes concerned with relatively sluggish phenomena of growth or energetics, and their full significance can be suitably exp作者: 感激小女 時(shí)間: 2025-3-22 16:49 作者: 感激小女 時(shí)間: 2025-3-22 20:37
https://doi.org/10.1007/978-3-642-48210-6his active site reacts with the substrates and inhibitors of the enzyme. In the present review the term “active site” will refer to those regions of the enzyme surface where the substrate is localized and activated during the enzymic action. No attempt is made to include information on the enzyme, i作者: 變白 時(shí)間: 2025-3-22 23:31 作者: 背書 時(shí)間: 2025-3-23 02:22 作者: 詞匯表 時(shí)間: 2025-3-23 08:46 作者: 粗魯?shù)娜?nbsp; 時(shí)間: 2025-3-23 11:50 作者: Cubicle 時(shí)間: 2025-3-23 15:10 作者: Focus-Words 時(shí)間: 2025-3-23 19:42 作者: 桶去微染 時(shí)間: 2025-3-23 23:45 作者: 墻壁 時(shí)間: 2025-3-24 06:16
Conference proceedings 1987Latest editionh concentrations inside cells, usually 10 to 20 times as high as in the surrounding fluid; the reverse is true for the Na-ion concentration. Conducting cells are endowed with the special ability to use these ionic concentration gradients for generating electric currents. In a fluid medium ions must 作者: 語言學(xué) 時(shí)間: 2025-3-24 10:28 作者: 弓箭 時(shí)間: 2025-3-24 10:52 作者: Console 時(shí)間: 2025-3-24 16:46
Conference proceedings 1987Latest editionxhibited in this aspect of their biological actions has been stimulated by consideration of their potential value as chemical warfare agents and to a greater extent in recent years by their established value and widespread use as agricultural insecticides. The latter practical application of these c作者: 露天歷史劇 時(shí)間: 2025-3-24 22:43 作者: 高貴領(lǐng)導(dǎo) 時(shí)間: 2025-3-25 01:16
Cholinesterases and Anticholinesterase Agents978-3-642-99875-1Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: podiatrist 時(shí)間: 2025-3-25 06:52
0171-2004 Overview: 978-3-642-99877-5978-3-642-99875-1Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: Melatonin 時(shí)間: 2025-3-25 10:00 作者: 古老 時(shí)間: 2025-3-25 14:17 作者: Mosaic 時(shí)間: 2025-3-25 16:47
Vertriebserfolg — Ein Controlling-Themaof acetylcholinesterase (AChE), [e.g., the inactivation of trypsin, chymotrypsin, and ali-esterase (. et al. 1957), or the interference with ion transfer across a membrane (. and . 1949)], with but one exception, none of these has been shown to be of any great physiological significance.作者: 我吃花盤旋 時(shí)間: 2025-3-25 21:04
Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/c/image/226169.jpg作者: 爆米花 時(shí)間: 2025-3-26 01:38
https://doi.org/10.1007/978-3-642-99875-1Acetylcholin; drugs; insects; pharmacology; therapy作者: 磨坊 時(shí)間: 2025-3-26 04:29
978-3-642-99877-5Springer-Verlag Berlin Heidelberg 1963作者: AUGUR 時(shí)間: 2025-3-26 08:55
Actions at Autonomic Gangliall as the processes that go on in the autonomic ganglia appear to be of the utmost importance. Because of this, the relation of pre- and postganglionic fibers is very critical, and the ganglionic synapse is provided with elaborate mechanisms for the regulation of its activity.作者: audiologist 時(shí)間: 2025-3-26 15:02 作者: 背帶 時(shí)間: 2025-3-26 19:58 作者: 人類學(xué)家 時(shí)間: 2025-3-26 23:23
https://doi.org/10.1007/978-3-642-48210-6matically different from enzymes concerned with relatively sluggish phenomena of growth or energetics, and their full significance can be suitably explored by neurophysiological and biophysical means applied to isolated or localized structures.作者: 策略 時(shí)間: 2025-3-27 01:44
https://doi.org/10.1007/978-3-642-48210-6 . did not succumb to tetraethyl pyrophosphate (TEPP) poisoning in 1854. If this had happened, the toxicity of the anticholinesterase (anti-ChE) agents of the organophosphorus type would have been discovered much earlier than it actually was.作者: Omnipotent 時(shí)間: 2025-3-27 06:36 作者: 動(dòng)脈 時(shí)間: 2025-3-27 11:31
Vertriebserfolg — Ein Controlling-Thematested against insects. Thirty-six of these were said to be in commercial production: 33 dialkyl phosphates, 2 aminophosphates, and 1 phosphonate. . et al. (1959, p. 1121) found the number in use to be “30 or more”, of which 2 were esters of phosphonic acid.作者: 偽造者 時(shí)間: 2025-3-27 17:05 作者: 挑剔小責(zé) 時(shí)間: 2025-3-27 19:10
Structure-Activity Relationships of the Organophosphorus Anticholinesterase Agents . did not succumb to tetraethyl pyrophosphate (TEPP) poisoning in 1854. If this had happened, the toxicity of the anticholinesterase (anti-ChE) agents of the organophosphorus type would have been discovered much earlier than it actually was.作者: Fecal-Impaction 時(shí)間: 2025-3-28 02:01
Actions at the Neuromuscular Junctionmitter process may be affected discretely by appropriate chemical agents, resulting in phenomena observable at different levels of experimental procedure. Consequently, a set of data is obtained which stands in a signal-event relationship to the transmitter process.作者: 性學(xué)院 時(shí)間: 2025-3-28 05:35 作者: 舊式步槍 時(shí)間: 2025-3-28 07:55
https://doi.org/10.1007/978-3-642-48210-6n used with cholinesterase inhibitors has certainly yielded many active compounds, with the net result of advancement in both therapeutic application and our understanding of drug-enzyme interaction. If workers concerned had not used the principles of SAR in their design of drugs, progress which resulted would probably have been considerably less.作者: 分開如此和諧 時(shí)間: 2025-3-28 11:26
https://doi.org/10.1007/978-3-642-48031-7al industries . and . (1953) have pointed out that any extensively toxic substance is to be suspected . of being an inhibitor of some vitally important enzyme system, and the physiological process characteristic of a number of organophosphorus compounds was found to be the inhibition of cholinesterases (ChE’s).作者: 管理員 時(shí)間: 2025-3-28 16:53
Conference proceedings 1987Latest editionedicinal uses. By far the most important use of these agents at the present time, from the standpoint of both the quantities involved and benefits derived, is for the eradication of destructive insects. High toxicity to insects is thus an essential requirement for anti-ChE agents.作者: NAVEN 時(shí)間: 2025-3-28 20:34 作者: CAMEO 時(shí)間: 2025-3-28 23:23
Metabolism of Organophosphorus Anticholinesterase Agentsal industries . and . (1953) have pointed out that any extensively toxic substance is to be suspected . of being an inhibitor of some vitally important enzyme system, and the physiological process characteristic of a number of organophosphorus compounds was found to be the inhibition of cholinesterases (ChE’s).作者: Increment 時(shí)間: 2025-3-29 04:57
Toxicological Evaluation of the Anticholinesterase Agentsedicinal uses. By far the most important use of these agents at the present time, from the standpoint of both the quantities involved and benefits derived, is for the eradication of destructive insects. High toxicity to insects is thus an essential requirement for anti-ChE agents.作者: Prologue 時(shí)間: 2025-3-29 07:38
https://doi.org/10.1007/978-3-322-90876-6e; non-choline esters are also hydrolyzed, but at a lower rate. The specificity of cholinesterases therefore is not absolute, and “true” cholinesterases do not exist as far as the specificity is concerned.作者: 乳白光 時(shí)間: 2025-3-29 12:23
https://doi.org/10.1007/978-3-642-48210-6lates. However, the chemistry of the structures and specific reactions involved in nervous function can for the most part be described only at the tissue or relatively gross cellular level, and the cytological details as to where the various reactions occur are largely conjectural.作者: BUST 時(shí)間: 2025-3-29 16:41 作者: Mobile 時(shí)間: 2025-3-29 23:24
https://doi.org/10.1007/978-3-642-48031-7. The only complete review of the pharmacology of anti-ChE agents presently available is the excellent one by . (1959) which, however, does not include cholinesterase (ChE) inhibitors other than organophosphorus compounds.作者: Abbreviate 時(shí)間: 2025-3-30 02:40 作者: 蟄伏 時(shí)間: 2025-3-30 04:02
Cytological Distributions and Physiological Functions of Cholinesteraseslates. However, the chemistry of the structures and specific reactions involved in nervous function can for the most part be described only at the tissue or relatively gross cellular level, and the cytological details as to where the various reactions occur are largely conjectural.作者: 最后一個(gè) 時(shí)間: 2025-3-30 11:13
The Active Site of Acetylcholinesterase and Related Esterases and its Reactivity towards Substrates any alternative aspects outside the scope of the present paper the reader is referred to excellent articles available in the literature including those by . (1948 and 1951 c), . (1959), . and . (1951), . (1951), . (1958) and chapters 4, 8, and 9 of the present handbook作者: 真實(shí)的人 時(shí)間: 2025-3-30 14:51 作者: 女歌星 時(shí)間: 2025-3-30 17:19 作者: aneurysm 時(shí)間: 2025-3-30 22:09 作者: Emg827 時(shí)間: 2025-3-31 00:58
Identification of Acetylcholine and Related Esters of Biological Originveral facts which warn us against attributing a too exclusive role to this compound. First, by analogy with other transmitters (e.g., the catecholamines) the transmitter role is likely to be subserved by a group of related substances rather than by a single compound. Second, ACh occurs in non-nervou作者: 閃光你我 時(shí)間: 2025-3-31 08:21 作者: BUMP 時(shí)間: 2025-3-31 09:22
Formation, Storage, and Liberation of Acetylcholineowing its release be replaced rapidly enough for transmission to occur repetitively in response to successive nerve impulses. The question of how the ester is replaced at the release points of the synapse in available form is one which as yet can be answered only in the most general way. In tissue s作者: 合并 時(shí)間: 2025-3-31 17:21
Classification and Comparative Enzymology of the Cholinesterases and Methods for their Determinationhe last 20 years on the specificity of these enzymes, their role in physiological systems, and the pharmacological importance of cholinesterase inhibitors. Everybody taking part in this discussion on the biochemical level will probably agree with the following; There are enzymes present in the anima作者: 外形 時(shí)間: 2025-3-31 19:16 作者: 臥虎藏龍 時(shí)間: 2025-3-31 23:46
Cytological Distributions and Physiological Functions of Cholinesteraseslular and subcellular levels, as illustrated by most of the chapters in the present volume. The magnitudes and sequences of the electrical signs associated with neuronal activity could be defined accurately only after the development of reliable single unit and intracellular recording techniques. At作者: 非秘密 時(shí)間: 2025-4-1 05:43
The Active Site of Acetylcholinesterase and Related Esterases and its Reactivity towards Substrates his active site reacts with the substrates and inhibitors of the enzyme. In the present review the term “active site” will refer to those regions of the enzyme surface where the substrate is localized and activated during the enzymic action. No attempt is made to include information on the enzyme, i作者: Functional 時(shí)間: 2025-4-1 08:33
Structure-Activity Relationships of the Reversible Anticholinesterase Agentsdify substantially the pharmacological properties of alkaloids, interest in Structure-Activity Relationships (SAR) has been ever increasing. Never before has the chemically oriented biologist had such a formidable list of compounds to consider. In association with any given pharmacological action, t作者: 合法 時(shí)間: 2025-4-1 12:13
Structure-Activity Relationships of the Organophosphorus Anticholinesterase Agents is amazing that so few scientists have met a premature death as a result. It is remarkable, for example, that the French nobleman and organic chemist . did not succumb to tetraethyl pyrophosphate (TEPP) poisoning in 1854. If this had happened, the toxicity of the anticholinesterase (anti-ChE) agent作者: BILIO 時(shí)間: 2025-4-1 17:15 作者: 光亮 時(shí)間: 2025-4-1 19:50 作者: Arroyo 時(shí)間: 2025-4-1 23:11
Actions at Autonomic Gangliall as the processes that go on in the autonomic ganglia appear to be of the utmost importance. Because of this, the relation of pre- and postganglionic fibers is very critical, and the ganglionic synapse is provided with elaborate mechanisms for the regulation of its activity.作者: Fibroid 時(shí)間: 2025-4-2 05:21
