標(biāo)題: Titlebook: Cholecystokinin Antagonists in Gastroenterology; Basic and Clinical S Guido Adler,Christoph Beglinger Book 1991 Springer-Verlag Berlin Heid [打印本頁] 作者: 法令 時(shí)間: 2025-3-21 17:04
書目名稱Cholecystokinin Antagonists in Gastroenterology影響因子(影響力)
書目名稱Cholecystokinin Antagonists in Gastroenterology影響因子(影響力)學(xué)科排名
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書目名稱Cholecystokinin Antagonists in Gastroenterology網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Cholecystokinin Antagonists in Gastroenterology被引頻次
書目名稱Cholecystokinin Antagonists in Gastroenterology被引頻次學(xué)科排名
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書目名稱Cholecystokinin Antagonists in Gastroenterology年度引用學(xué)科排名
書目名稱Cholecystokinin Antagonists in Gastroenterology讀者反饋
書目名稱Cholecystokinin Antagonists in Gastroenterology讀者反饋學(xué)科排名
作者: Acclaim 時(shí)間: 2025-3-21 22:52
,Flexible und aufgabenad?quate Rechenwege,During the 1960s at Rotta Research Laboratorium, Rovati [1] developed a gastrin receptor antagonist named proglumide, i.e., .-4-benzamido-., .dipropyl-glutaramic acid. Proglumide has been used for several years for the treatment of peptic ulcer.作者: 保守 時(shí)間: 2025-3-22 01:32 作者: 慢跑鞋 時(shí)間: 2025-3-22 04:46
Heterogeneity of CCK Receptors: Classification and CharacterizationReceptors which recognize cholecystokinin (CCK) peptides are particularly interesting and notable, both for their similarities and for their differences. There appear to be a family of such receptors which will likely be homologous, yet possess exquisite differences in their structural specficities.作者: 施魔法 時(shí)間: 2025-3-22 10:53
Pentanoic Acid DerivativesDuring the 1960s at Rotta Research Laboratorium, Rovati [1] developed a gastrin receptor antagonist named proglumide, i.e., .-4-benzamido-., .dipropyl-glutaramic acid. Proglumide has been used for several years for the treatment of peptic ulcer.作者: 使人入神 時(shí)間: 2025-3-22 12:53 作者: 使人入神 時(shí)間: 2025-3-22 19:16
http://image.papertrans.cn/c/image/226142.jpg作者: 預(yù)示 時(shí)間: 2025-3-22 22:12 作者: 拱形面包 時(shí)間: 2025-3-23 03:51
978-3-642-76364-9Springer-Verlag Berlin Heidelberg 1991作者: Emasculate 時(shí)間: 2025-3-23 06:51
Pyloric Cholecystokinin Receptorsch these actions may be mediated have been identified in multiple brain regions and at various sites in the gastrointestinal tract. This chapter focuses on the anatomy, pharmacological characterization, and functional significance of a population of CCK receptors localized to the circular muscle layer of the pyloric sphincter.作者: 生意行為 時(shí)間: 2025-3-23 10:52 作者: Confound 時(shí)間: 2025-3-23 14:14
Rechentraining für Finanzdienstleister major hindrance to the investigation of CCK localization has been the fact that its C-terminal pentapeptide is identical to that of another major gut peptide, gastrin. These amino acids are responsible for the biological activity of the peptides, with differential specificity of action being confer作者: 首創(chuàng)精神 時(shí)間: 2025-3-23 21:56 作者: 休閑 時(shí)間: 2025-3-24 01:55
Rechentraining für Finanzierungsvermittler presence of gastrin-like immunoreactivity in mammalian brain, and subsequent studies indicate that the majority of this immunoreactivity could be attributed to CCK. Although a large peptide containing 58 amino acid (CCK58) is the major circulating form of CCK in humans and dogs [21,23], the predomi作者: 燒瓶 時(shí)間: 2025-3-24 03:06 作者: homeostasis 時(shí)間: 2025-3-24 09:38 作者: Aqueous-Humor 時(shí)間: 2025-3-24 13:17
Sicherheitsgerechter EDV-Betrieb,CCK molecule, more particularly the C-terminal phenylalanine residue, was of crucial importance for the complete biological activity of CCK analogues, both in the peripheral system and in the CNS. Suppression of the C-terminal phenylalanine residue, e.g., Z-CCK-27–32-NH. [Z-Tyr(SO.H)-Met-Gly-Trp-Met作者: progestogen 時(shí)間: 2025-3-24 14:53
Rechenübungen zur angewandten Elektronikgonist, five different classes of CCK receptor antagonists have been described in various in vitro studies (Tables 1, 2) [30,31]. Members of at least two of these classes [i.e., amino acid derivatives such as lorglumide (CR 1409) or loxiglumide (CR 1505) and substituted benzodiazepine analogues such作者: 晚來的提名 時(shí)間: 2025-3-24 20:57 作者: 裝勇敢地做 時(shí)間: 2025-3-24 23:28
,Spulen, Schwingkreise und übertrager,olecystokinin (CCK) is generally regarded as an important stimulant of the postprandial pancreatic enzyme output based on studies where the enzyme response to physiological doses of exogenous CCK have been compared to the food stimulated response [1,2]. Most of these studies have concluded that post作者: 衰老 時(shí)間: 2025-3-25 05:18 作者: Fracture 時(shí)間: 2025-3-25 10:00
Inhalte festhalten und verwaltencids into the duodenum. Together with monoglycerides and phospholipids, bile acids form mixed micelles to facilitate fat absorption. Eventually, 95% of them are reabsorbed by the terminal ileum to finish the enterohepatic cycle [4]. Since bile acids presumably get in contact with intestinal CCK cell作者: Parallel 時(shí)間: 2025-3-25 14:52
Beispiel: Recherche in der Praxisch these actions may be mediated have been identified in multiple brain regions and at various sites in the gastrointestinal tract. This chapter focuses on the anatomy, pharmacological characterization, and functional significance of a population of CCK receptors localized to the circular muscle lay作者: fodlder 時(shí)間: 2025-3-25 18:05 作者: Trochlea 時(shí)間: 2025-3-25 22:04
Book 1991p-to-date information in cholecystokinin (CCK) research, especially focusing on the development and characterization of CCK antagonists. The book contains chapters on the synthesis, biochemical and pharmacological characterization of potent and selective CCK antagonists as well as physiological appl作者: 多余 時(shí)間: 2025-3-26 04:12 作者: 大笑 時(shí)間: 2025-3-26 06:15
Biological Actions of CCK in the Central Nervous Systemnant molecular form of CCK in the brain is CCK. (CCK., the eight amino acids at the C terminus of CCK), which contains a sulfated tyrosine residue [14,54]. However, the unsulfated form (CCK.) has been detected, in addition to CCK. [54]. Overall, CCK. is only present in the brain in small (2%-5% of CCK immunoreactivity) amounts [54].作者: aesthetic 時(shí)間: 2025-3-26 08:46
Boc-Tyr(SO3H)-Nle-Gly-Trp-Nle-Asp-2-Phenylethyl Ester — JMV180: A Unique CCK Analogue with Different-Asp-NH.], led to CCK antagonists both in the peripheral system [1] and in the CNS [2,3]. We report here on the modulations in activity which resulted from suppression of the C-terminal primary amide function of CCK, and on its pharmacological consequences.作者: 悅耳 時(shí)間: 2025-3-26 15:52 作者: Benign 時(shí)間: 2025-3-26 20:46 作者: 送秋波 時(shí)間: 2025-3-26 23:14
the most up-to-date information in cholecystokinin (CCK) research, especially focusing on the development and characterization of CCK antagonists. The book contains chapters on the synthesis, biochemical and pharmacological characterization of potent and selective CCK antagonists as well as physiolo作者: anniversary 時(shí)間: 2025-3-27 02:04 作者: 老人病學(xué) 時(shí)間: 2025-3-27 06:05 作者: 痛得哭了 時(shí)間: 2025-3-27 09:27
Book 1991ains chapters on the synthesis, biochemical and pharmacological characterization of potent and selective CCK antagonists as well as physiological applications of these compounds. The last section of the book is devoted to the involvement of CCK in pathological states and potential clinical applications of CCK antagonists.作者: 匍匐前進(jìn) 時(shí)間: 2025-3-27 17:02
Rechentraining für Finanzdienstleisterred by the adjacent residues. This common sequence led to much controversy concerning the activities and localizations of CCK and gastrin but the development of antibodies specific for defined regions of each peptide has helped to resolve many of the complications.作者: Cryptic 時(shí)間: 2025-3-27 18:20
Rechentraining für Finanzierungsvermittlernant molecular form of CCK in the brain is CCK. (CCK., the eight amino acids at the C terminus of CCK), which contains a sulfated tyrosine residue [14,54]. However, the unsulfated form (CCK.) has been detected, in addition to CCK. [54]. Overall, CCK. is only present in the brain in small (2%-5% of CCK immunoreactivity) amounts [54].作者: 清真寺 時(shí)間: 2025-3-28 01:25 作者: 一致性 時(shí)間: 2025-3-28 05:15 作者: parallelism 時(shí)間: 2025-3-28 08:25
Der Rechner zum Buch und zum Seminarthe potential effects of CCK and continue to do so today, but they do not define which of these many responses of the gastrointestinal tract to exogenous stimulation are in fact regulated by endogenous CCK. Table 1 summarizes many of the reported actions of exogenous CCK.作者: Hyperalgesia 時(shí)間: 2025-3-28 12:51 作者: 鋼筆記下懲罰 時(shí)間: 2025-3-28 15:04
Rechenübungen zur angewandten Elektronikuish CCK receptor subtypes or have higher potency, will be developed, probably from one of the five different classes currently described. In this chapter the results of in vitro studies with each of the different classes of CCK receptor antagonists are reviewed.作者: 結(jié)合 時(shí)間: 2025-3-28 19:58
Biological Actions of CCK in the Gastrointestinal Tractthe potential effects of CCK and continue to do so today, but they do not define which of these many responses of the gastrointestinal tract to exogenous stimulation are in fact regulated by endogenous CCK. Table 1 summarizes many of the reported actions of exogenous CCK.作者: 廚師 時(shí)間: 2025-3-28 23:10 作者: pancreas 時(shí)間: 2025-3-29 06:39 作者: Servile 時(shí)間: 2025-3-29 09:02
Biochemistry of CCKle advances in our understanding of the biochemistry of this substance that have taken place over the last 20 years. It also marked the culmination of what can now been seen as the pioneering phase in the development of our ideas of the hormonal regulation of digestion in the small intestine. Mutt a作者: SNEER 時(shí)間: 2025-3-29 15:11
The Morphological Localization of Cholecystokinin and Its Binding Sites in the Diffuse Neuroendocrin major hindrance to the investigation of CCK localization has been the fact that its C-terminal pentapeptide is identical to that of another major gut peptide, gastrin. These amino acids are responsible for the biological activity of the peptides, with differential specificity of action being confer作者: CARE 時(shí)間: 2025-3-29 16:21
Biological Actions of CCK in the Gastrointestinal Tractve years later, it was shown that CCK was chemically identical with pancreozymin [2], another putative hormone thought to cause pancreatic enzyme secretion in response to fat and protein in the intestine [3]. In the years since the discoveries of these two major actions, CCK has been found to have m作者: 易達(dá)到 時(shí)間: 2025-3-29 21:37
Biological Actions of CCK in the Central Nervous System presence of gastrin-like immunoreactivity in mammalian brain, and subsequent studies indicate that the majority of this immunoreactivity could be attributed to CCK. Although a large peptide containing 58 amino acid (CCK58) is the major circulating form of CCK in humans and dogs [21,23], the predomi作者: Polydipsia 時(shí)間: 2025-3-30 00:23 作者: 沙漠 時(shí)間: 2025-3-30 04:24
Characterization of MK-329tion product from Aspergillus alliaceus [1], asperlicin. Its lack of oral activity and the need for greater potency stimulated the design of improved antagonists. On the basis of structural relationships between asperlicin and the molecules diazepam and D-tryptophan, an indolylmethyl benzodiazepine 作者: Water-Brash 時(shí)間: 2025-3-30 11:10
Boc-Tyr(SO3H)-Nle-Gly-Trp-Nle-Asp-2-Phenylethyl Ester — JMV180: A Unique CCK Analogue with DifferentCCK molecule, more particularly the C-terminal phenylalanine residue, was of crucial importance for the complete biological activity of CCK analogues, both in the peripheral system and in the CNS. Suppression of the C-terminal phenylalanine residue, e.g., Z-CCK-27–32-NH. [Z-Tyr(SO.H)-Met-Gly-Trp-Met作者: 癡呆 時(shí)間: 2025-3-30 13:53
Cholecystokinin Receptor Antagonists In Vitrogonist, five different classes of CCK receptor antagonists have been described in various in vitro studies (Tables 1, 2) [30,31]. Members of at least two of these classes [i.e., amino acid derivatives such as lorglumide (CR 1409) or loxiglumide (CR 1505) and substituted benzodiazepine analogues such作者: Ventricle 時(shí)間: 2025-3-30 19:57
Effects of Cholecystokinin Receptor Antagonists in Animal Modelsgonists of CCK’s action on exocrine pancreatic secretion of protein and enzymes in vivo. The antagonists display the same rank order of potency in antagonizing CCK’s action on the pancreas in vivo as that which they show in antagonizing CCK’s action and binding in vitro [4–6,17,46] (Fig. 1). However作者: 媒介 時(shí)間: 2025-3-30 21:06
Effect of MK-329 on Pancreatic Secretion in Manolecystokinin (CCK) is generally regarded as an important stimulant of the postprandial pancreatic enzyme output based on studies where the enzyme response to physiological doses of exogenous CCK have been compared to the food stimulated response [1,2]. Most of these studies have concluded that post作者: 勉強(qiáng) 時(shí)間: 2025-3-31 04:03
Regulation of Gallbladder Contraction and Gastric Emptying by the CCK Receptor Antagonist MK-329er contraction and pancreatic protein secretion as well as regulation of gastric emptying, stimulation of intestinal motility, stimulation of insulin secretion, and induction of satiety [23]. However, it has been difficult to establish whether these are pharmacologic or true physiologic actions of C作者: FACET 時(shí)間: 2025-3-31 07:08
Regulation of CCK Release by Bile Acidscids into the duodenum. Together with monoglycerides and phospholipids, bile acids form mixed micelles to facilitate fat absorption. Eventually, 95% of them are reabsorbed by the terminal ileum to finish the enterohepatic cycle [4]. Since bile acids presumably get in contact with intestinal CCK cell作者: 佛刊 時(shí)間: 2025-3-31 10:25 作者: GLUE 時(shí)間: 2025-3-31 15:35
