標(biāo)題: Titlebook: Chemotherapy; Frederick F. Becker Book 1977 Plenum Press, New York 1977 brain tumors.breast cancer.cancer.cell.chemotherapy.classification [打印本頁(yè)] 作者: 召集會(huì)議 時(shí)間: 2025-3-21 18:24
書(shū)目名稱Chemotherapy影響因子(影響力)
作者: AVOID 時(shí)間: 2025-3-21 23:59 作者: Oligarchy 時(shí)間: 2025-3-22 01:18 作者: CRUE 時(shí)間: 2025-3-22 06:41
Antibiotics: Nucleic Acids As Targets in Chemotherapyucleic acids. For instance, agents such as actinomycin or the anthracyclines, adriamycin and daunomycin, bind DNA ., but this binding is not associated with DNA-strand breakage, at least under the conditions that have been used; the incubation of these agents with intact cells, however, is associate作者: anus928 時(shí)間: 2025-3-22 11:12 作者: OVERT 時(shí)間: 2025-3-22 14:49 作者: OVERT 時(shí)間: 2025-3-22 19:30
f differences bet\een normal and malignant cells have been described, rarely are these differences observed in a vital metabolic pathway or a crucial macromolecu- lar structure. Essentially, the basic metabolic pathways and nutritional require- ments for :lOrmal and malignant cells are the same, resulting in 978-1-4615-6630-4978-1-4615-6628-1作者: 失敗主義者 時(shí)間: 2025-3-23 00:46 作者: 費(fèi)解 時(shí)間: 2025-3-23 05:21 作者: 裁決 時(shí)間: 2025-3-23 07:50
Quantitative Thin-Layer Chromatography27) described many other examples, including ., the elder tree ., the mandrake, and surprisingly, the rose. Among its many other reputed uses, ginseng has been employed to treat cancer in Chinese herbal medicine (Leake, 1975). During the 17th and 18th centuries, the doctrine of signatures, which str作者: Somber 時(shí)間: 2025-3-23 12:34
Diffuse Reflectance from TLC Layers,ucleic acids. For instance, agents such as actinomycin or the anthracyclines, adriamycin and daunomycin, bind DNA ., but this binding is not associated with DNA-strand breakage, at least under the conditions that have been used; the incubation of these agents with intact cells, however, is associate作者: 深陷 時(shí)間: 2025-3-23 14:24
https://doi.org/10.1007/978-3-642-10883-9tly their accessibility to substrates. This very macromolecular nature enables enzymes to demonstrate a high degree of substrate specificity that can be very useful in restricting their cytotoxicity toward specific tissues, e.g., asparaginase therapy of asparagine-dependent leukemia cells.作者: cocoon 時(shí)間: 2025-3-23 21:40
Factors That Influence the Therapeutic Responsecal trial of a chemotherapeutic agent took place in 1942, when nitrogen mustard was given to a patient with advanced lymphosarcoma (Goodman .., 1946). A dramatic but unfortunately brief tumor response was achieved in this patient. Later in that same decade, Sidney Farber observed what he termed an “作者: Muscularis 時(shí)間: 2025-3-24 00:58
Applications of Cell Kinetic Techniques to Human Malignanciesiew data that are available for specific human neoplasms. The chapter includes information that influences the planning of treatment as well as information that reflects the response to therapy. A variety of techniques, both . and ., that have been developed in animal tumor systems are now being app作者: 輕率的你 時(shí)間: 2025-3-24 06:07 作者: gentle 時(shí)間: 2025-3-24 07:12 作者: MAPLE 時(shí)間: 2025-3-24 12:26
Adjunctive Chemotherapyic agents. Many of the drugs have been used effectively in hematologic neoplasms, and with their use, complete remission and survival rates in childhood leukemia and in Hodgkin’s disease and other lymphomas have increased very significantly. Several of the solid tumors such as sarcomas, breast carci作者: Fluctuate 時(shí)間: 2025-3-24 17:23
Principles of Combination Chemotherapyme children with acute leukemia. Remarkable as these early remissions were, it soon became apparent that with the exception of methotrexate-induced cure of choriocarcinoma (Li ..,1956) (and later cyclophosphamide-induced cure of Burkitt’s lymphoma) (Nkrumah and Perkins, 1976; Ziegler .., 1973), sing作者: 天空 時(shí)間: 2025-3-24 19:01
Intraarterial Chemotherapyudicious use of surgery and irradiation (external beam and isotope implantation) has traditionally occupied an important place in the systematic management of patients with advanced malignancy. Systemic chemotherapy can also be used to treat predominantly regional disease, and the intraarterial deli作者: 易達(dá)到 時(shí)間: 2025-3-25 02:57
Treatment of Malignant Disease in Closed Spacess in management. Its occurrence, while a manifestation of systemic disease, does not bear a relationship to prognosis, except perhaps in malignant lymphoma. While removal may be necessary for symptomatic relief, repeated thoracentesis may have significant complications. For this reason, ideal treatm作者: 友好 時(shí)間: 2025-3-25 07:21
Supportive Care in the Cancer Patientis the minimization or prevention of the common complications of cancer and its therapy. Although not unique to those with malignancy, the art and science of caring for their social, psychological, and somatic distress have become more highly developed than for perhaps any other single patient group作者: persistence 時(shí)間: 2025-3-25 10:56 作者: Metastasis 時(shí)間: 2025-3-25 11:44 作者: acquisition 時(shí)間: 2025-3-25 18:08
Pyrimidine Antagonistsits unwelcome visitor. While this approach has been eminently successful in the case of bacterial, fungal, and, to some extent, parasitic infections, less impressive results, unfortunately, have been obtained with neoplastic disease. The reasons for this dichotomy become obvious when metabolic and s作者: antipsychotic 時(shí)間: 2025-3-25 20:42 作者: 打谷工具 時(shí)間: 2025-3-26 03:56
Plant Alkaloidstion of garlic was recommended for skin disorders that may have included cancer. The same document described the use of the seeds of the autumn crocus, ., for joint pain, but a role for this plant or the less toxic . in treating cancer was not established until the time of Dioscorides in the 1st cen作者: 竊喜 時(shí)間: 2025-3-26 06:10
Antibiotics: Nucleic Acids As Targets in ChemotherapyAntibiotic inhibitors of protein biosynthesis are considerably less useful because they lack the required selectivity for neoplastic cells (see Goldberg ..,1975). All the agents discussed in this chapter alter DNA function (replication or transcription or both), but it has not been established in al作者: 報(bào)復(fù) 時(shí)間: 2025-3-26 10:05
Enzyme Therapyantagonists, or by modifying the structures of existing cellular components, e.g., alkylating and intercalating agents. Enzymes have been used in experimental therapeutic trials following these same mechanistic principles. Asparaginase, glutaminase, arginase, methioninase, .-tyrosinease, phenylalani作者: 懸掛 時(shí)間: 2025-3-26 16:06
Hydrazines and Triazenests, are relatively unstable, and provide biologically active groups on their decomposition and metabolism. The basic moieties of hydrazine, H.N-NH., and triazene, NH. N=NH, are substituted with aromatic and aliphatic groups on both ends of their nitrogen bridges; these substituents probably also pro作者: 漫步 時(shí)間: 2025-3-26 20:04 作者: 致敬 時(shí)間: 2025-3-26 23:17 作者: geometrician 時(shí)間: 2025-3-27 02:51 作者: 陪審團(tuán)每個(gè)人 時(shí)間: 2025-3-27 08:08
Alkylating Agents and the Nitrosoureashile interest in the distribution of alkylating agents has led to investigations of drug transport. Besides these and other contributions in the area of cancer chemotherapy, studies of alkylating agents have also increased our understanding of mutagenesis and chemical carcinogenesis.作者: ARK 時(shí)間: 2025-3-27 10:40 作者: 嘲笑 時(shí)間: 2025-3-27 17:27
Bj?rn Rasch,Wilhelm Hofmann,Ewald Naumannrious toxicities of the chemotherapeutic drugs so that these agents can be used as effectively as possible. Each drug has unique antitumor properties and, as would be expected, unique toxicities. Some toxicity is acute, some delayed, but it is always present. This chapter is a review of these toxicities.作者: 玷污 時(shí)間: 2025-3-27 19:30 作者: 廚房里面 時(shí)間: 2025-3-28 01:21
Quality of Service in Heterogeneous Networksesponsible for toxicity to malignant tissue, i.e., inhibition of dihydrofolate reductase. Significant injury to the liver, brain, and kidneys has also been seen as a consequence of antifolate therapy. These latter toxicities, which are not clearly related to reductase inhibition, will be considered later in this chapter.作者: 不透氣 時(shí)間: 2025-3-28 04:58 作者: 摻和 時(shí)間: 2025-3-28 08:45
Book 1977 disease, and, therefore, its failures were felt all the more. Despite the serendipitous discoveries and inspired insights which tantalized us with striking remissions, or the rare tumors which proved to be fully susceptible to a given agent, in the main, there has been either total failure or a pai作者: 解開(kāi) 時(shí)間: 2025-3-28 12:57
Factors That Influence the Therapeutic Responseacceleration phenomenon” in a retrospective analysis of children with acute leukemia treated with folate conjugates. This experience led him to a trial of folate antagonists, and in 1948, he reported dramatic responses in 10 of 16 children treated with the folate antagonist aminopterin (Farbet .., 1948).作者: 針葉類的樹(shù) 時(shí)間: 2025-3-28 18:20 作者: PACK 時(shí)間: 2025-3-28 21:49 作者: 從容 時(shí)間: 2025-3-28 23:33
Folate Antagonistsesponsible for toxicity to malignant tissue, i.e., inhibition of dihydrofolate reductase. Significant injury to the liver, brain, and kidneys has also been seen as a consequence of antifolate therapy. These latter toxicities, which are not clearly related to reductase inhibition, will be considered later in this chapter.作者: 蜿蜒而流 時(shí)間: 2025-3-29 03:38
Hydrazines and Triazenesvide a limited stability to the respective molecules. While a large number of derivatives in both groups have been synthesized and evaluated for biological activity, the representatives reported in this chapter are few, and are the most interesting ones from both the therapeutic and the theoretical points of view.作者: Affable 時(shí)間: 2025-3-29 10:32
Semiclassical Roles for Classical Orbits,cause of the absorption or inactivation, or both, of the drug on passage through the arterial bed. Although the procedure is technically more difficult, effluent drug-containing blood has been diverted from the systemic circulation or prevented from reaching sensitive normal tissues during the drug infusion.作者: 苦惱 時(shí)間: 2025-3-29 12:43 作者: Seizure 時(shí)間: 2025-3-29 18:24
bacterial disease, and, therefore, its failures were felt all the more. Despite the serendipitous discoveries and inspired insights which tantalized us with striking remissions, or the rare tumors which proved to be fully susceptible to a given agent, in the main, there has been either total failur作者: 議程 時(shí)間: 2025-3-29 20:13 作者: Postulate 時(shí)間: 2025-3-30 00:07 作者: 嘲笑 時(shí)間: 2025-3-30 07:31 作者: helper-T-cells 時(shí)間: 2025-3-30 08:20
Supportive Care in the Cancer Patientence of caring for their social, psychological, and somatic distress have become more highly developed than for perhaps any other single patient group. There have been a number of recent reviews of all or parts of this field (Holland and Frei, 1973; Goepp and Hammond, 1975).作者: CRAMP 時(shí)間: 2025-3-30 15:02 作者: enchant 時(shí)間: 2025-3-30 19:49
978-1-4615-6630-4Plenum Press, New York 1977作者: 雜役 時(shí)間: 2025-3-30 21:13
Treatment of Malignant Disease in Closed Spacess in management. Its occurrence, while a manifestation of systemic disease, does not bear a relationship to prognosis, except perhaps in malignant lymphoma. While removal may be necessary for symptomatic relief, repeated thoracentesis may have significant complications. For this reason, ideal treatment should prevent fluid accumulation.作者: LIMN 時(shí)間: 2025-3-31 02:52
Purine Antagonists logical to use purine antagonists as potentially active agents for cancer therapy. Mammalian cells have, to varying extents, the capacity to either use preformed purines or make them .. It is therefore expedient in this discussion to include agents capable of inhibiting either process.作者: Neuropeptides 時(shí)間: 2025-3-31 07:07 作者: Hirsutism 時(shí)間: 2025-3-31 10:02
Marc A. Wilde,Dirk Grundler,Detlef Heitmanns in management. Its occurrence, while a manifestation of systemic disease, does not bear a relationship to prognosis, except perhaps in malignant lymphoma. While removal may be necessary for symptomatic relief, repeated thoracentesis may have significant complications. For this reason, ideal treatment should prevent fluid accumulation.作者: 基因組 時(shí)間: 2025-3-31 17:24
Quality of Service in Heterogeneous Networks logical to use purine antagonists as potentially active agents for cancer therapy. Mammalian cells have, to varying extents, the capacity to either use preformed purines or make them .. It is therefore expedient in this discussion to include agents capable of inhibiting either process.作者: Motilin 時(shí)間: 2025-3-31 21:18 作者: 惡心 時(shí)間: 2025-3-31 22:29 作者: 清澈 時(shí)間: 2025-4-1 03:09 作者: Musket 時(shí)間: 2025-4-1 10:00
