標(biāo)題: Titlebook: Chemistry and Biology of Pteridines and Folates; June E. Ayling,M. Gopal Nair,Charles M. Baugh Book 1993 The Editor(s) (if applicable) and [打印本頁] 作者: HEIR 時間: 2025-3-21 16:28
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書目名稱Chemistry and Biology of Pteridines and Folates讀者反饋學(xué)科排名
作者: Torrid 時間: 2025-3-21 22:55
https://doi.org/10.1007/978-1-4613-2159-0all yields remained unsatisfactory; ...., . and . were produced in less than a 1% yield by the condensation of biopterin . respectively with D-glucose and D-ribose in DMF in the presence of TsOH at 60 °C for 2 days.. A slighdy improved preparation of the D-Ribofuranoside . was achieved through the sequences shown below (. → .→ . → .)..作者: palliate 時間: 2025-3-22 01:32 作者: 充足 時間: 2025-3-22 08:09 作者: 精密 時間: 2025-3-22 08:50
Principles and Practices of Quality Controlion of the phenylalanine hydroxylating system,. plays a unique role as the essential coenzyme for certain hydroxylases such as the enzymes that catalyze the hydroxylation of the aromatic amino acids, phenylalanine, tyrosine and tryptophan..作者: 傳授知識 時間: 2025-3-22 14:15
,-(,,,-Dimethylaminomethylene)-,,-(2-,-Nitrophenyl. Ethyl)-Biopterin: A Versatile Intermediate for all yields remained unsatisfactory; ...., . and . were produced in less than a 1% yield by the condensation of biopterin . respectively with D-glucose and D-ribose in DMF in the presence of TsOH at 60 °C for 2 days.. A slighdy improved preparation of the D-Ribofuranoside . was achieved through the sequences shown below (. → .→ . → .)..作者: 傳授知識 時間: 2025-3-22 18:05 作者: 返老還童 時間: 2025-3-22 23:59
Histidines 138 and 143 are Copper Binding Ligands in , Phenylalanine Hydroxylasehe active site. and more recently by X-ray absorption spectroscopy of the copper containing enzyme.. We have used a combination of site directed mutagenesis and pulsed EPR spectroscopy to probe the copper binding site of CV PAH and identify the Cu(II) ligands.作者: ADORN 時間: 2025-3-23 01:57
The Isolation and Characterization of Clones of 4a-Hydroxytetrahydrobiopterin Dehydrataseion of the phenylalanine hydroxylating system,. plays a unique role as the essential coenzyme for certain hydroxylases such as the enzymes that catalyze the hydroxylation of the aromatic amino acids, phenylalanine, tyrosine and tryptophan..作者: 無節(jié)奏 時間: 2025-3-23 06:18
Estimating Particle Number and Sizein nature xanthopterin (.) and leucopterin (.). In 1933 a third component, isoxanthopterin (.)., was isolated, but his constitution remained also unknown until Robert Purrmann was able to elucidate the structures of all three pigments., which turned out to be derivatives of the pyrazine [2,3-d]pyrimidine (.) ringsystem termed by Wieland...作者: amnesia 時間: 2025-3-23 12:18 作者: Insufficient 時間: 2025-3-23 17:02 作者: delegate 時間: 2025-3-23 21:50 作者: 悲痛 時間: 2025-3-24 00:19
The Synthesis of Fluorine-Containing Pterinshylene group. To approach this study we have examined the reactions of 2,4,5-triaminopteridin-6(lH)-one (.) with a number of readily available di-and trifluoromethyl carbonyl compounds. We have also examined the electrostatic potentials of the molecules associated with the introduction of fluorine into the pyrazine ring and its substituents.作者: 極肥胖 時間: 2025-3-24 03:16
Characterization of the Iron Environment in Recombinant Human Tyrosine Hydroxylase, Using M?ssbauer e(III) during the reaction.. It has been shown that the tetrahydropterin cofactor can reduce this Fe(III) back to Fe(II), in addition to its function as an electron donor during the catalytic turnover..作者: 橫截,橫斷 時間: 2025-3-24 07:35
Image Understanding and the Cell World Models on some new compounds, reactions, and ring systems, which were investigated during the preparation of a pteridine with a functionalised side chain at position 3. This pteridine was successfully attached to the 5’-OH of a synthetic oligonucleotide.作者: Entrancing 時間: 2025-3-24 12:03
Rudolf Avenhaus,Reiner K. Huberverall process. This converts the oxidized form of cofactor, a quinoid dihydropterin., back to the starting tetrahydrobiopterin at the expense of NADH allowing cofactor to be used catalytically. The clinical symptoms of patients with a deficiency of DHPR have shown that cofactor regeneration is essential..作者: 山頂可休息 時間: 2025-3-24 15:38
Blood Bank Standards and Procedure Manualsfunction of the central nervous system has resulted in a great deal of interest in the enzyme over the years, very little is known about the actual mechanism of catalysis. This report describes recent studies towards elucidating the mechanism of this important monooxygenase.作者: champaign 時間: 2025-3-24 20:36
P. Zoller,E. Matthias,S. J. Smithe cofactor activity. 6R-BH4 molecule, however, is unstable at physiological pH under oxidative conditions. Previous studies on the stereochemistry of this molecule were generally performed at acidic pH. or with the dihydrochloride crystal of it.. In these studies, the atoms of N5 or Nl and N5 of the pterin ring were protonated.作者: 暫時中止 時間: 2025-3-25 02:09
Mindo/3 Molecular-Orbital Calculations on the 6R-BH4 Molecule and Its Metabolic Precursors : Conforme cofactor activity. 6R-BH4 molecule, however, is unstable at physiological pH under oxidative conditions. Previous studies on the stereochemistry of this molecule were generally performed at acidic pH. or with the dihydrochloride crystal of it.. In these studies, the atoms of N5 or Nl and N5 of the pterin ring were protonated.作者: CLOWN 時間: 2025-3-25 05:52 作者: laparoscopy 時間: 2025-3-25 10:59
The Mechanism of Cofactor Regeneration During Phenylalanine Hydroxylationverall process. This converts the oxidized form of cofactor, a quinoid dihydropterin., back to the starting tetrahydrobiopterin at the expense of NADH allowing cofactor to be used catalytically. The clinical symptoms of patients with a deficiency of DHPR have shown that cofactor regeneration is essential..作者: adduction 時間: 2025-3-25 13:22
Mechanistic Studies of Tyrosine Hydroxylasefunction of the central nervous system has resulted in a great deal of interest in the enzyme over the years, very little is known about the actual mechanism of catalysis. This report describes recent studies towards elucidating the mechanism of this important monooxygenase.作者: 治愈 時間: 2025-3-25 19:02 作者: AVANT 時間: 2025-3-25 20:41 作者: GUEER 時間: 2025-3-26 02:52
Identification, Stereoconfiguration, Chromatographic and Fluorescence Properties of Natural Pterinss.. The present paper briefly reports an aspect of the method dealing with the fluorescence quantum yields of pterins and describes one application which answers the following questions : what is the stereoconfiguration of urinary monapterin ? Are there any differences in human urine from cancer and作者: phytochemicals 時間: 2025-3-26 06:05
Expression of Wild Type and Mutant Forms of Human Phenylalanine Hydroxylase in ,. ,able forms of PAH in such . systems., and therefore only a few mutant forms have been further characterized so far. This led us to clone and express the normal and several mutated forms of human PAH cDNA into the pET-plasmid system of .. . (Novagen). Here we report the expression of both normal and 作者: 猛烈責(zé)罵 時間: 2025-3-26 10:06
Alleviation of Catecholamine Inhibition of Tyrosine Hydroxylase by Phosphorylation at Serine40d, and increases the Vmax value up to threefold. Much less work has been done with the physiological substrate tetrahydrobiopterin at the physiological pH of 7. Under these assay conditions with partially or fully purified enzyme, the effect on the KBH4 value is reported to be about threefold, while作者: BOLUS 時間: 2025-3-26 12:53
Glyceryl Ether Monooxygenase [EC 1.14.16.5]: Stoichiometry and Inhibition same. The second report was by K?tting, Unger and Eibl. who determined the stoichiometry of the reaction in a coupled reaction with DHPR and NADH, and showed that the amount of NADH oxidised after one minute was equivalent to the total amount of fatty aldehyde, alcohol and acid produced.. Since the作者: 做作 時間: 2025-3-26 18:38
0065-2598 are a reflection of the significant advances made since the Ninth International Symposium held in Zurich in 1989. Since the 7th International Symposium in St. 978-1-4613-6287-6978-1-4615-2960-6Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: 脊椎動物 時間: 2025-3-26 23:01 作者: nominal 時間: 2025-3-27 02:30
Quantitative Assessment in Arms Controlable forms of PAH in such . systems., and therefore only a few mutant forms have been further characterized so far. This led us to clone and express the normal and several mutated forms of human PAH cDNA into the pET-plasmid system of .. . (Novagen). Here we report the expression of both normal and 作者: Pepsin 時間: 2025-3-27 07:07 作者: parasite 時間: 2025-3-27 10:18
Training Programs for Blood Bank Personnel same. The second report was by K?tting, Unger and Eibl. who determined the stoichiometry of the reaction in a coupled reaction with DHPR and NADH, and showed that the amount of NADH oxidised after one minute was equivalent to the total amount of fatty aldehyde, alcohol and acid produced.. Since the作者: 夸張 時間: 2025-3-27 15:21
Natural Pteridines -A Chemical Hobbyery large extent ever since Frederick Gowland Hopkins has focussed for the first time more than 100 years ago. the attention to butterfly pigments in trying to isolate the yellow pigments from the English brimstone butterfly and the white pigment from the cabbage butterfly six years later.. The unus作者: 大溝 時間: 2025-3-27 21:48
Properties and Reactions of Pteridines Carrying Functionalised Side Chains at the 3-Positionnce of a pteridine can cause widespread but random cleavage of the DNA chain. The chemistry described here arose out of a requirement to attach a pteridine to a synthetic oligonucleotide for purposes of inducing a photochemical lesion on a DNA chain at a specific targeted position. This paper report作者: Commentary 時間: 2025-3-27 23:53
,-(,,,-Dimethylaminomethylene)-,,-(2-,-Nitrophenyl. Ethyl)-Biopterin: A Versatile Intermediate for iboside . from a blue alga, ... For the structural proof, some efforts to prepare these compounds were made by direct glycosidation. However, the overall yields remained unsatisfactory; ...., . and . were produced in less than a 1% yield by the condensation of biopterin . respectively with D-glucose作者: 卜聞 時間: 2025-3-28 05:15
The Synthesis of Fluorine-Containing Pterinshis effect is clearly demonstrated through the action of 5-fluorouracil and its nucleosides as inhibitors of thymidylate synthetase. In folic acid derivatives, fluorine has been introduced into the glutamate side chain. and into the aminobenzoic acid ring to promote nmr observations of interactions 作者: larder 時間: 2025-3-28 09:45 作者: 孵卵器 時間: 2025-3-28 12:21 作者: 松軟無力 時間: 2025-3-28 16:32 作者: 開始發(fā)作 時間: 2025-3-28 21:29 作者: Benign 時間: 2025-3-29 00:09
Expression of Wild Type and Mutant Forms of Human Phenylalanine Hydroxylase in ,. ,ne hydroxylase (phenylalanine 4-monooxygenase, EC 1.14.16.1, PAH). The loss of enzymatic activity found in PKU patients is a result of single base substitutions or small deletions in the PAH gene. Presently, more than 70 different mutations associated with the disease are known. PKU and non-PKU hype作者: 蕨類 時間: 2025-3-29 06:42
A Re-Examination of the Metal Requirement of , Phenylalanine Hydroxylaseand tryptophan hydroxylase. All of the mammalian forms of these enzymes have a non-heme iron required for activity. . Though no direct experimental evidence ascribes a mechanistic role to the metal, it is thought that the metal ion is required to be in its lower oxidation state for activity..作者: FORGO 時間: 2025-3-29 10:12 作者: 赤字 時間: 2025-3-29 12:52
Characterization of the Iron Environment in Recombinant Human Tyrosine Hydroxylase, Using M?ssbauer the biosynthesis of catecholamines.. The enzyme isolated either from bovine adrenals or rat pheochromocytoma cells contains approximately one atom of tightly bound non-heme iron/subunit.. However, the ligands to the iron or its catalytic function is not known. An important question has been the red作者: NAVEN 時間: 2025-3-29 18:33
Interaction of Substrate and Pterin Cofactor with the Metal of Human Tyrosine Hydroxylase as Determiorms (hTHl to hTH4) which have been expressed in .. ... The purified apoenzymes are rapidly activated (up to 40-fold) by the incorporation of stoichiometric amounts of Fe.. All isozymes are competitively inhibited by other divalent metal ions, e.g. Zn., Co. and Ni. which bind with similar affinity a作者: 友好關(guān)系 時間: 2025-3-29 20:38
Mechanistic Studies of Tyrosine Hydroxylaseydroxyphenylalanine.. The other substrates for the reaction are molecular oxygen and a tetrahydropterin. In addition, tyrosine hydroxylase requires one atom of ferrous iron per active site for activity.; the role of the iron atom is unknown. While the central position of tyrosine hydroxylase in the 作者: 反抗者 時間: 2025-3-30 01:30
Alleviation of Catecholamine Inhibition of Tyrosine Hydroxylase by Phosphorylation at Serine40-dihydroxyphenylalanine with the oxidation of tetrahydrobiopterin to dihydrobiopterin.. The activity of TYH is highly regulated. Tyrosine hydroxylase is inhibited by catecholamines and high levels of tyrosine, and activated by anions, polyanions, phospholipids and phosphorylation.. cAMP-Dependent pr作者: 夸張 時間: 2025-3-30 05:46
Glyceryl Ether Monooxygenase [EC 1.14.16.5]: Stoichiometry and Inhibitiony alcohols. The reaction requires oxygen and a tetrahydropterin cofactor. It is a mixed-function oxidase and by analogy with phenylalanine hydroxylase the reaction shown in Scheme . was postulated.1 We investigated aspects of the stoichiometry of the oxygenase because two earlier reports were not en作者: Projection 時間: 2025-3-30 11:06 作者: tinnitus 時間: 2025-3-30 15:16 作者: Blood-Clot 時間: 2025-3-30 19:15 作者: 拍翅 時間: 2025-3-30 22:59 作者: HUSH 時間: 2025-3-31 03:34 作者: 單色 時間: 2025-3-31 07:22
Aspects of the MBFR NegotiationsThere is a paucity of detailed structural information on mammalian phenylalanine hydroxylase (PAH) mainly due to the fact that this enzyme has been difficult to crystallize. Equally there is a paucity of knowledge of the amino acids residues necessary for function. The main structural features described so far are shown in Table 1.作者: Infect 時間: 2025-3-31 10:29 作者: Mechanics 時間: 2025-3-31 17:17 作者: amnesia 時間: 2025-3-31 21:19
A Re-Examination of the Metal Requirement of , Phenylalanine Hydroxylaseand tryptophan hydroxylase. All of the mammalian forms of these enzymes have a non-heme iron required for activity. . Though no direct experimental evidence ascribes a mechanistic role to the metal, it is thought that the metal ion is required to be in its lower oxidation state for activity..作者: 無動于衷 時間: 2025-4-1 01:23 作者: Ointment 時間: 2025-4-1 05:17 作者: 靈敏 時間: 2025-4-1 07:28
978-1-4613-6287-6The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
