標(biāo)題: Titlebook: Chemical Protein Synthesis; Xuechen Li Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Scie [打印本頁(yè)] 作者: ambulance 時(shí)間: 2025-3-21 16:44
書目名稱Chemical Protein Synthesis影響因子(影響力)
書目名稱Chemical Protein Synthesis影響因子(影響力)學(xué)科排名
書目名稱Chemical Protein Synthesis網(wǎng)絡(luò)公開(kāi)度
書目名稱Chemical Protein Synthesis網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書目名稱Chemical Protein Synthesis被引頻次
書目名稱Chemical Protein Synthesis被引頻次學(xué)科排名
書目名稱Chemical Protein Synthesis年度引用
書目名稱Chemical Protein Synthesis年度引用學(xué)科排名
書目名稱Chemical Protein Synthesis讀者反饋
書目名稱Chemical Protein Synthesis讀者反饋學(xué)科排名
作者: Ccu106 時(shí)間: 2025-3-22 00:01
Computer Graphics, the Fun, Easy Wayshown to be practically useful under suitable conditions. Herein, we describe the methods of using VyPAL2 for protein macrocyclization and labeling at an Asp residue as well as for protein dual labeling through orthogonal Asp- and Asn-directed ligations. We also describe a method for cell-surface pr作者: Malfunction 時(shí)間: 2025-3-22 00:34
,Improved Handling of Peptide Segments Using Side Chain-Based “Helping Hand” Solubilizing Tools,ng block, Fmoc-Glu(AlHx)-OH, which can be prepared in an efficient process over two purifications. Solubilizing sequences are introduced directly on-resin and later cleaved with palladium-catalyzed transfer under aqueous conditions to restore a native Glu side chain. These two chemical tools are str作者: 惡意 時(shí)間: 2025-3-22 07:43 作者: JUST 時(shí)間: 2025-3-22 09:12 作者: 使痛苦 時(shí)間: 2025-3-22 14:02
Total Chemical Synthesis of a SARS-CoV-2 Miniprotein Inhibitor LCB1,tion of traditional solid-phase peptide synthesis. It can achieve high-efficient chemical synthesis of proteins containing more than 300 amino acid residues. Peptide hydrazide, as a valuable reagent equivalent to a thioester peptide, can be easily and efficiently prepared by the Fmoc-based SPPS meth作者: 使痛苦 時(shí)間: 2025-3-22 19:36 作者: 不怕任性 時(shí)間: 2025-3-22 22:52 作者: ANN 時(shí)間: 2025-3-23 02:03 作者: Crumple 時(shí)間: 2025-3-23 08:29
Ynamide-Mediated Synthetic Approach to Thioamide-Substituted Peptides,proteins by replacing a carbonyl oxygen atom of an amide bond by an sp.-hybridized sulfur atom to precisely introduce a thioamide bond Ψ[CS-NH] into a peptide backbone. The .-thioacyloxyenamide intermediates, originating from ynamide coupling reagent and proteinogenic amino monothioacids, are proved作者: 含沙射影 時(shí)間: 2025-3-23 13:34 作者: Keratin 時(shí)間: 2025-3-23 15:02 作者: effrontery 時(shí)間: 2025-3-23 20:56 作者: Encephalitis 時(shí)間: 2025-3-23 23:32
Preparation of Site-Specific Succinylated Histone Mimics to Investigate Its Impact on Nucleosome Dycture. Lysine succinylation is a recently discovered PTM that plays critical roles in metabolism, epigenetic signaling, and is correlated with several diseases. One significant challenge in studying the effects of this modification on nucleosome dynamics is to obtain site-specifically modified histo作者: 打算 時(shí)間: 2025-3-24 02:33 作者: 額外的事 時(shí)間: 2025-3-24 10:27
Sulfonium-Tethered Peptide,a series of methods including CIH, TD coupling, Met-Met, and Cys-Met bis-alkylation strategy to switch peptides’ secondary structure and enhance their stability and cellular uptake. Here we focus on the peptide macrocyclization method of Met-Met and Cys-Met bis-alkylation strategy to generate more s作者: QUAIL 時(shí)間: 2025-3-24 11:08
PAL-Mediated Ligation for Protein and Cell-Surface Modification,ficiency and mild aqueous reaction conditions, these ligases have emerged as powerful biotechnological tools for protein manipulation in recent years. PALs are enzymes of the asparaginyl endopeptidase (AEP) superfamily but have predominant transpeptidase activity as opposed to typical AEPs which are作者: 現(xiàn)任者 時(shí)間: 2025-3-24 16:11
Development of a Glycoform Library-based Strategy to Decipher the Role of Protein Glycosylation,forms). The study of glycosylation is significantly impeded because of the heterogeneous nature of glycoproteins. To overcome this challenge, we developed and optimized a glycoform library-based strategy to investigate the role of protein glycosylation. In this strategy, chemical synthesis was used 作者: Legion 時(shí)間: 2025-3-24 23:01
A Selenium-based Cysteine Surrogate for Protein Chemical Synthesis,medium. SetCys does not interfere with the native chemical ligation reaction under mild reducing conditions, that is in the absence of tris(2-carboxyethyl)phosphine (TCEP). In contrast, subjecting SetCys to TCEP results in the spontaneous loss of its .-selenoethyl appendage and thus to its conversio作者: 學(xué)術(shù)討論會(huì) 時(shí)間: 2025-3-24 23:41 作者: MOAN 時(shí)間: 2025-3-25 06:51 作者: –LOUS 時(shí)間: 2025-3-25 08:33 作者: Diaphragm 時(shí)間: 2025-3-25 15:36 作者: Brocas-Area 時(shí)間: 2025-3-25 18:33
Xuechen LiIncludes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts作者: Acetaminophen 時(shí)間: 2025-3-25 20:50 作者: hair-bulb 時(shí)間: 2025-3-26 04:07
https://doi.org/10.1007/978-3-540-68583-8e of synthetic protein is greatly expanded. Proteoglycans are a class of sulfated glycoproteins widely distributed on the cell surface and in the extracellular matrix, which are extensively engaged in cellular communication events. Consisting of protein backbone and glycosaminoglycan(s) side chain, 作者: COW 時(shí)間: 2025-3-26 04:45 作者: 名詞 時(shí)間: 2025-3-26 11:39
Defining the strategic businesseswith C-terminus salicylaldehyde esters and unprotected peptides with N-terminus serine/threonine or cysteine/penicillamine, which serve as powerful tools for cyclic peptide natural product and chemical protein synthesis. Herein, we introduce the preparation of C-terminal peptide salicylaldehyde este作者: 聽(tīng)寫 時(shí)間: 2025-3-26 14:05
Development of strategic planningve compounds compared with normal peptides because they can enhance oral bioavailability, cell membrane?permeability, and stability against enzymatic degradation. In our developed flow synthesis, a variety of .-methylated dipeptides is obtained in high yields without severe racemization from equival作者: Ischemic-Stroke 時(shí)間: 2025-3-26 17:09
Corporate strategy development processwith WIP through its second SH3 domain (Nck-SH3.2). Recently we have developed a preventative antibacterial mechanism that safeguards intestinal cells by shutting down this intracellular signal through a site-selective covalent peptide–protein reaction, a new antibacterial strategy that acts on the 作者: Occupation 時(shí)間: 2025-3-27 00:12 作者: NEXUS 時(shí)間: 2025-3-27 01:47 作者: absolve 時(shí)間: 2025-3-27 07:53
Long-Range Dependence in Heartbeat Dynamicsand function of proteins and peptide design as well as bioconjugation. Furthermore, .-thiolated/selenolated amino acids are important motifs in native chemical ligation-dechalcogenation strategy for protein synthesis. However, a universal method to access enantiopure .-thiolated/selenolated amino ac作者: Hla461 時(shí)間: 2025-3-27 11:42 作者: 改變立場(chǎng) 時(shí)間: 2025-3-27 14:34 作者: 制定法律 時(shí)間: 2025-3-27 20:41
https://doi.org/10.1007/978-1-4302-0310-0urrently available C-terminus functionalization strategies, we established an approach based on a small molecule cyanylating reagent that chemically activates a cysteine in a recombinant protein at its N-side amide for undergoing nucleophilic acyl substitution with amines. We demonstrated the versat作者: angiography 時(shí)間: 2025-3-28 01:14
Computer Graphics, the Fun, Easy Waya series of methods including CIH, TD coupling, Met-Met, and Cys-Met bis-alkylation strategy to switch peptides’ secondary structure and enhance their stability and cellular uptake. Here we focus on the peptide macrocyclization method of Met-Met and Cys-Met bis-alkylation strategy to generate more s作者: antecedence 時(shí)間: 2025-3-28 04:10
Computer Graphics, the Fun, Easy Wayficiency and mild aqueous reaction conditions, these ligases have emerged as powerful biotechnological tools for protein manipulation in recent years. PALs are enzymes of the asparaginyl endopeptidase (AEP) superfamily but have predominant transpeptidase activity as opposed to typical AEPs which are作者: 鐵塔等 時(shí)間: 2025-3-28 10:15
Computer Graphics, the Fun, Easy Wayforms). The study of glycosylation is significantly impeded because of the heterogeneous nature of glycoproteins. To overcome this challenge, we developed and optimized a glycoform library-based strategy to investigate the role of protein glycosylation. In this strategy, chemical synthesis was used 作者: recede 時(shí)間: 2025-3-28 14:07
https://doi.org/10.1007/978-1-4302-0310-0medium. SetCys does not interfere with the native chemical ligation reaction under mild reducing conditions, that is in the absence of tris(2-carboxyethyl)phosphine (TCEP). In contrast, subjecting SetCys to TCEP results in the spontaneous loss of its .-selenoethyl appendage and thus to its conversio作者: Germinate 時(shí)間: 2025-3-28 18:04
Computer Graphics, the Fun, Easy Waymirror-image proteins) that are difficult to obtain through the recombinant expression technology. The difficulty of chemical synthesis of hydrophobic proteins stems from the hydrophobic nature. Removable backbone modificaiton (RBM) strategy has been developed for solubilizing the hydrophobic peptid作者: indemnify 時(shí)間: 2025-3-28 22:10 作者: 的’ 時(shí)間: 2025-3-29 00:36 作者: Phonophobia 時(shí)間: 2025-3-29 07:04
Development of strategic planningent amounts of amino acids. The addition of a strong Br?nsted acid is critical to generate the highly reactive .-methylimidazolium cation species to accelerate the amidation. The developed approach enabled the synthesis of a bulky peptide with a higher yield in a shorter amount of time compared with the results of conventional amidation.作者: MURKY 時(shí)間: 2025-3-29 07:55 作者: 蜿蜒而流 時(shí)間: 2025-3-29 11:54 作者: 褻瀆 時(shí)間: 2025-3-29 18:54 作者: dysphagia 時(shí)間: 2025-3-29 23:46
Computer Graphics, the Fun, Easy Waynes. Here, we report the rapid site-specific incorporation of a succinylation mimic into histones, which facilitates the characterization of its impact on nucleosome dynamics with a F?rster resonance energy transfer (FRET) approach.作者: 支柱 時(shí)間: 2025-3-30 02:38 作者: 雪白 時(shí)間: 2025-3-30 08:00 作者: Temporal-Lobe 時(shí)間: 2025-3-30 08:50
https://doi.org/10.1007/978-1-4302-0310-0led procedures for the synthesis of Fmoc-protected SetCys residue and for its incorporation into peptides using standard solid-phase peptide synthesis protocols. We also describe its use for the chemical synthesis of proteins through the redox-controlled assembly of three peptide segments in one-pot.作者: craving 時(shí)間: 2025-3-30 12:24 作者: 一美元 時(shí)間: 2025-3-30 18:24 作者: TAG 時(shí)間: 2025-3-30 21:20 作者: Obverse 時(shí)間: 2025-3-31 03:51 作者: 附錄 時(shí)間: 2025-3-31 08:06
Continuous-Flow Synthesis of ,-Methylated Peptides via Generation of an Acyl ,-Methylimidazolium Caent amounts of amino acids. The addition of a strong Br?nsted acid is critical to generate the highly reactive .-methylimidazolium cation species to accelerate the amidation. The developed approach enabled the synthesis of a bulky peptide with a higher yield in a shorter amount of time compared with the results of conventional amidation.作者: Malleable 時(shí)間: 2025-3-31 11:11
,Covalent Reactive Peptides to Block Protein–Protein Interactions and Inhibit Microbe–Host Interactihost cells instead of bacterium cells. Here we present the experimental details of the design and synthesis of cysteine-reactive peptides to selectively block Nck-SH3.2 but not the other two SH3 domains. Procedures of EPEC infection, covalent reaction inside Caco-2 cells, and bacterial counting to check the antibacterial effect are also described.作者: 搖曳 時(shí)間: 2025-3-31 16:42 作者: 昏睡中 時(shí)間: 2025-3-31 18:04
Side-Chain Anchoring Strategies for the Synthesis of Peptide Thioesters and Selenoesters,y. Importantly, this methodology overcomes solubility issues and epimerization of the C-terminal amino acid residue that can occur using solution-phase approaches. Detailed methods for the solid-phase synthesis of peptide thioesters and selenoesters using a side-chain anchoring approach are outlined in this article.
