標(biāo)題: Titlebook: Chemical Genomics; Small Molecule Probe S. Jaroch,H. Weinmann Conference proceedings 2006 Springer-Verlag Berlin Heidelberg 2006 Chemical b [打印本頁(yè)] 作者: 漏出 時(shí)間: 2025-3-21 17:57
書目名稱Chemical Genomics影響因子(影響力)
作者: 高興去去 時(shí)間: 2025-3-21 21:40 作者: 敲詐 時(shí)間: 2025-3-22 02:25
Tamoxifen-Based Probes for the Study of Estrogen Receptor-Mediated Transcription,y pathways, analogs of 4-hydroxytamoxifen were synthesized with variations in the basic side chain. In vitro binding assays and cell-based luciferase reporter gene assays confirm that all the derivatives have high affinity for the receptor and high potency at repressing direct estrogen receptor-mediated transcription.作者: Frenetic 時(shí)間: 2025-3-22 07:39 作者: 憂傷 時(shí)間: 2025-3-22 10:25 作者: Germinate 時(shí)間: 2025-3-22 16:11 作者: Germinate 時(shí)間: 2025-3-22 20:38 作者: modish 時(shí)間: 2025-3-23 00:53 作者: meditation 時(shí)間: 2025-3-23 02:42 作者: Cholesterol 時(shí)間: 2025-3-23 05:37
Protein Structure Similarity Clustering and Natural Product Structure as Guiding Principles for Cheoid dehydrogenases based on the structure of a naturally occurring Cdc25 inhibitor. The efficiency of making use of the scaffolds of natural products as biologically prevalidated starting points for the design of compound libraries is further highlighted by the development of benzopyran-based FXR ligands.作者: ingestion 時(shí)間: 2025-3-23 11:01 作者: extract 時(shí)間: 2025-3-23 16:59 作者: Rankle 時(shí)間: 2025-3-23 22:00
Gasstoffwechsel und Elektrolyte,target. Because of the almost infinite number of drug-like organic molecules, this is an impossible task. Therefore chemogenomics has been defined as the investigation of classes of compounds (libraries) against families of functionally related proteins. In this definition, chemogenomics deals with 作者: explicit 時(shí)間: 2025-3-24 01:54 作者: 改良 時(shí)間: 2025-3-24 02:28 作者: Duodenitis 時(shí)間: 2025-3-24 06:58 作者: wreathe 時(shí)間: 2025-3-24 13:27 作者: mutineer 時(shí)間: 2025-3-24 18:21
Beitr?ge zur Kardiologie und Angiologieanscription though a number of different pathways. As part of an effort to develop reagents that selectively target specific transcriptional regulatory pathways, analogs of 4-hydroxytamoxifen were synthesized with variations in the basic side chain. In vitro binding assays and cell-based luciferase 作者: CREEK 時(shí)間: 2025-3-24 21:08
Beitr?ge zur Kardiologie und Angiologietopology in the ligand-sensing cores of protein domains can be exploited for the design of small-molecule libraries in the development of inhibitors and ligands. Thus, a novel strategy of clustering protein domain cores based exclusively on structure similarity considerations (protein structure simi作者: Ancillary 時(shí)間: 2025-3-25 02:22 作者: 牽連 時(shí)間: 2025-3-25 07:16 作者: 恃強(qiáng)凌弱 時(shí)間: 2025-3-25 10:39 作者: 食料 時(shí)間: 2025-3-25 13:19
Chemical Genomics978-3-540-37635-4Series ISSN 0947-6075 作者: 錢財(cái) 時(shí)間: 2025-3-25 18:21
Gasstoffwechsel und Elektrolyte,et and ligand clusters are linked by generating binding affinity profiles of chemotypes vs a target panel. The application of this multidimensional similarity paradigm will be described in the context of Lead Generation to identify novel chemical hit classes for G-protein coupled receptors.作者: 我要威脅 時(shí)間: 2025-3-25 23:44 作者: 無(wú)法治愈 時(shí)間: 2025-3-26 02:52
Chemogenomics Strategies for G-Protein Coupled Receptor Hit Finding,et and ligand clusters are linked by generating binding affinity profiles of chemotypes vs a target panel. The application of this multidimensional similarity paradigm will be described in the context of Lead Generation to identify novel chemical hit classes for G-protein coupled receptors.作者: 供過(guò)于求 時(shí)間: 2025-3-26 06:44
Probing Protein Function with Small Molecules, is providing the chemical means to understand biological systems not easily accessible using classical genetic manipulations. In this article, we will discuss how natural product mode of action studies and novel bio-organic manipulation of intracellular protein levels are proving useful in the exploration of cell biology.作者: 熟練 時(shí)間: 2025-3-26 10:27
Gasstoffwechsel und Elektrolyte,tructures” has been defined for scaffolds, such as the benzodiazepines, which very often produce biologically active analogs in a target family, in this case in the class of G-protein-coupled receptors. The SOSA approach is a strategy to modify the selectivity of biologically active compounds, gener作者: affect 時(shí)間: 2025-3-26 15:15
Probleme der Intensivbehandlungds (termed chemoprints) are identified using homology modeling, molecular docking, and experimental profiling. These chemoprints can support the design and synthesis of compound libraries tailor-made for a novel GPCR target.作者: 濕潤(rùn) 時(shí)間: 2025-3-26 17:19
https://doi.org/10.1007/978-3-642-72296-7eadout for very high data quality. SpeedScreen is a highly miniaturized and automated screening system for high-throughput affinity-selection of compounds. In practice, pools of compounds are incubated with the target protein and the unbound chemical compounds are removed from the target-compound co作者: AGGER 時(shí)間: 2025-3-27 00:26 作者: Adornment 時(shí)間: 2025-3-27 02:07 作者: AND 時(shí)間: 2025-3-27 06:21 作者: 青少年 時(shí)間: 2025-3-27 13:07 作者: Introvert 時(shí)間: 2025-3-27 16:14
Chemogenomics Strategies for G-Protein Coupled Receptor Hit Finding,et and ligand clusters are linked by generating binding affinity profiles of chemotypes vs a target panel. The application of this multidimensional similarity paradigm will be described in the context of Lead Generation to identify novel chemical hit classes for G-protein coupled receptors.作者: 高腳酒杯 時(shí)間: 2025-3-27 18:17
Chemogenomics Approaches to G-Protein Coupled Receptor Lead Finding,t screening (HTS) is often complemented by rational chemogenomics lead finding approaches. We have compiled a GPCR directed screening set by ligand-based virtual screening of our corporate compound database. This set of compounds is supplemented with novel libraries synthesized around proprietary sc作者: Conduit 時(shí)間: 2025-3-28 01:36 作者: 溝通 時(shí)間: 2025-3-28 06:09
Probing Protein Function with Small Molecules, is providing the chemical means to understand biological systems not easily accessible using classical genetic manipulations. In this article, we will discuss how natural product mode of action studies and novel bio-organic manipulation of intracellular protein levels are proving useful in the expl作者: 骨 時(shí)間: 2025-3-28 07:21 作者: prick-test 時(shí)間: 2025-3-28 11:20
Protein Structure Similarity Clustering and Natural Product Structure as Guiding Principles for Chetopology in the ligand-sensing cores of protein domains can be exploited for the design of small-molecule libraries in the development of inhibitors and ligands. Thus, a novel strategy of clustering protein domain cores based exclusively on structure similarity considerations (protein structure simi作者: 徹底檢查 時(shí)間: 2025-3-28 18:28
Tackling the Chemogenomic Space by Novel Screening Technologies,ilable chemical compounds for screening, but also the number of molecular targets used for screening has increased significantly. This has triggered the need for very fast, efficient, and effective novel readout technologies for compound testing. Novartis has developed two novel high-throughput scre
