標題: Titlebook: Chemical Epigenetics; Antonello Mai Book 2020 Springer Nature Switzerland AG 2020 Epigenetic targets.HDAC inhibitors.cyclic peptides.SIRT [打印本頁] 作者: 獨裁者 時間: 2025-3-21 17:19
書目名稱Chemical Epigenetics影響因子(影響力)
書目名稱Chemical Epigenetics影響因子(影響力)學科排名
書目名稱Chemical Epigenetics網(wǎng)絡公開度
書目名稱Chemical Epigenetics網(wǎng)絡公開度學科排名
書目名稱Chemical Epigenetics被引頻次
書目名稱Chemical Epigenetics被引頻次學科排名
書目名稱Chemical Epigenetics年度引用
書目名稱Chemical Epigenetics年度引用學科排名
書目名稱Chemical Epigenetics讀者反饋
書目名稱Chemical Epigenetics讀者反饋學科排名
作者: 殘酷的地方 時間: 2025-3-21 22:56
Extreme Values and LIL Behavior,for studying HAT biology. In the present chapter, the main features of HAT enzymes and related diseases have been summarized, with a particular focus on HATi, analysing their structure-activity relationships, mechanisms of action and potential therapeutic applications.作者: CHIP 時間: 2025-3-22 03:53
Some recent results on empirical processes,2). As LSD1/2 are involved in various diseases, their inhibitors are considered useful not only as a chemical tool for probing the biology of LSD1/2 but also as therapeutic agents. In this chapter, the biology, pharmacology, and inhibitors of LSD1/2 are presented, and the potential of LSD inhibitors as therapeutic agents is discussed.作者: 難解 時間: 2025-3-22 05:57 作者: 仲裁者 時間: 2025-3-22 10:22
Histone Acetyltransferase Enzymes: From Biological Implications to Most Relevant Inhibitors,for studying HAT biology. In the present chapter, the main features of HAT enzymes and related diseases have been summarized, with a particular focus on HATi, analysing their structure-activity relationships, mechanisms of action and potential therapeutic applications.作者: indubitable 時間: 2025-3-22 16:04 作者: indubitable 時間: 2025-3-22 18:35 作者: Mosaic 時間: 2025-3-22 22:00 作者: Mnemonics 時間: 2025-3-23 01:23 作者: 無辜 時間: 2025-3-23 09:27 作者: 離開真充足 時間: 2025-3-23 12:19 作者: 名詞 時間: 2025-3-23 17:01 作者: growth-factor 時間: 2025-3-23 21:28 作者: gain631 時間: 2025-3-23 23:10
https://doi.org/10.1007/b138932nt of epigenetic inhibitors are collected. The presented examples give an overview of successfully applied strategies and emphasize the advantage of guidance and rationalization of experimental data with computational means.作者: Constitution 時間: 2025-3-24 02:56 作者: 口訣法 時間: 2025-3-24 09:23 作者: anatomical 時間: 2025-3-24 13:55
Chemical Compounds Targeting DNA Methylation and Hydroxymethylation,c in their location and context (tissues, diseases, etc.). We review the major enzymes involved in DNA methylation and oxidation, with a focus on the DNA methyltransferases and TET enzymes. The principal compounds that inhibit these enzymes are presented since they will help address these questions.作者: Offbeat 時間: 2025-3-24 18:05 作者: GEM 時間: 2025-3-24 21:44 作者: BIBLE 時間: 2025-3-25 03:02
Chemical Epigenetics978-3-030-42982-9Series ISSN 1862-2461 Series E-ISSN 1862-247X 作者: obtuse 時間: 2025-3-25 06:26 作者: 炸壞 時間: 2025-3-25 08:50 作者: 閑蕩 時間: 2025-3-25 11:46 作者: BLA 時間: 2025-3-25 16:05 作者: negligence 時間: 2025-3-25 21:23
https://doi.org/10.1007/BFb0082336n critical biological processes such as gene silencing, DNA repair, and chromosomal stability and longevity. Sirtuins play crucial roles in many signaling pathways and are regarded as potential therapeutic targets in several pathological conditions, such as cancer, metabolic disorders, and also card作者: 公理 時間: 2025-3-26 01:09
Extreme Values and LIL Behavior,ansferases (HATs) that plays a crucial role in several biological settings. The deregulation of this enzymatic activity is implicated in many disease conditions such as cancer and inflammatory and neurological disorders. Despite many histone acetyltransferase inhibitors (HATi) have been identified s作者: 大氣層 時間: 2025-3-26 07:15 作者: 職業(yè) 時間: 2025-3-26 10:26
Continuous parameter uniform amarts,ific community over the past two decades. Arginine methylation is performed by the dedicated family of protein arginine methyltransferases and is known to be involved in a plethora of cellular pathways and biochemical mechanisms in both healthy and disease states. The development of inhibitors for t作者: mechanism 時間: 2025-3-26 12:52 作者: 不舒服 時間: 2025-3-26 17:32 作者: craven 時間: 2025-3-26 21:06 作者: 愛哭 時間: 2025-3-27 03:19 作者: Extort 時間: 2025-3-27 05:28 作者: NAUT 時間: 2025-3-27 11:56
https://doi.org/10.1007/b138932pacity to act as “backstage” sculptors of the epigenetic landscape by interacting with chromatin-modifying proteins and directing their activities. LncRNAs can thereby modulate locus-specific chromatin marks as well as arrange the three-dimensional configurations of entire chromosomes. They may also作者: Confirm 時間: 2025-3-27 16:36
https://doi.org/10.1007/b138932obstructive pulmonary disease (COPD) each year. Additionally, lung cancer is the most common cause of cancer death, causing over 1.5 million deaths per year. A promising direction for new therapies for these and other lung diseases, like asthma, comes from the notion that deranged intracellular sign作者: 懦夫 時間: 2025-3-27 18:18 作者: Incompetent 時間: 2025-3-28 00:31
https://doi.org/10.1007/b138932scription factor binding, and recruiting chromatin-modifying enzymes. DNA methylation marks are introduced in both strands of DNA by DNA methyltransferases, allowing for heritable gene silencing. In addition to 5-methylcytosine, cells contain its oxidized forms 5-hydroxymethylcytosine, 5-formylcytos作者: 乞討 時間: 2025-3-28 05:58
Antonello MaiOffers a comprehensive review of the chemical mechanisms involved in epigenetics.Covers the significant findings about epigenetic targets.Explores the design, synthesis and biological validation of ep作者: 睨視 時間: 2025-3-28 09:05 作者: heterodox 時間: 2025-3-28 12:47
Targeting the Zinc-Dependent Histone Deacetylases (HDACs) for Drug Discovery,ionally modified acyl-lysine residues back to lysine. At the epigenetic level, HDACs have a critical gene silencing effect, promoting the compaction of histone tails with DNA to prevent transcription. In addition, HDACs deacylate many nonhistone substrates in diverse cellular compartments to profoun作者: 符合規(guī)定 時間: 2025-3-28 16:57 作者: EWE 時間: 2025-3-28 20:26 作者: pester 時間: 2025-3-29 02:30 作者: exceed 時間: 2025-3-29 06:16
Lysine Methyltransferases and Their Inhibitors,ing body of literature is indicating that lysine methyltransferases (KMTs) play a crucial role for transcriptional regulation and are involved in cancer and various other human diseases, thus being of high interest as potential therapeutic targets..In this book chapter, we highlight the discovery, c作者: cortisol 時間: 2025-3-29 09:14 作者: 慢慢沖刷 時間: 2025-3-29 11:30
Lysine-Specific Histone Demethylases 1/2 (LSD1/2) and Their Inhibitors,une response, and signal transduction. Histone methylation is closely associated with the oncogenesis and proliferation of cancer cells, and its alteration has been identified in many cancer cells. In addition, histone methylation is involved in such non-cancerous diseases as globin disorders and ne作者: 飲料 時間: 2025-3-29 18:31
Inhibitors of JmjC-Containing Histone Demethylases,hylation and dysregulation of KDMs have been linked to multiple diseases, and KDMs are emerging as promising therapeutic targets. This chapter provides an overview of JmjC-domain-containing KDMs (JmjC-KDMs), with a particular focus on recent advances in JmjC-KDM inhibitor development from a structur作者: Ophthalmologist 時間: 2025-3-29 20:29 作者: 食道 時間: 2025-3-30 01:38 作者: Dedication 時間: 2025-3-30 06:53
Methyl-Readers and Inhibitors,mall-molecule intervention. Within this book chapter, the biological role and the associated development of potent small molecules inhibiting the protein-protein interaction of methyllysine readers (Tudor, malignant brain tumor, chromo-, and PHD domain) will be discussed. The druggability of these r作者: 拘留 時間: 2025-3-30 10:41 作者: uncertain 時間: 2025-3-30 14:10
Acetylation and Methylation in Asthma, COPD, and Lung Cancer,obstructive pulmonary disease (COPD) each year. Additionally, lung cancer is the most common cause of cancer death, causing over 1.5 million deaths per year. A promising direction for new therapies for these and other lung diseases, like asthma, comes from the notion that deranged intracellular sign作者: 先兆 時間: 2025-3-30 18:44 作者: CHART 時間: 2025-3-30 22:25
