標(biāo)題: Titlebook: Checkpoint Responses in Cancer Therapy; Wei Dai Book 2008 Humana Press 2008 DNA.apoptosis.biotechnology.cancer.cancer research.cancer ther [打印本頁(yè)] 作者: Constrict 時(shí)間: 2025-3-21 17:04
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書(shū)目名稱(chēng)Checkpoint Responses in Cancer Therapy讀者反饋
書(shū)目名稱(chēng)Checkpoint Responses in Cancer Therapy讀者反饋學(xué)科排名
作者: 一加就噴出 時(shí)間: 2025-3-21 22:45 作者: PACT 時(shí)間: 2025-3-22 03:17 作者: SKIFF 時(shí)間: 2025-3-22 05:51 作者: analogous 時(shí)間: 2025-3-22 12:37
Advanced and Alternate MapReduce Techniques,se drugs in eliciting apoptosis in cultured cancer cells. Therefore, quantitative differences in the strength of the spindle checkpoint may influence the efficacy of antimitotic drugs in cancer chemotherapy.作者: FRONT 時(shí)間: 2025-3-22 14:47 作者: FRONT 時(shí)間: 2025-3-22 18:48
DNA Topoisomerases as Targets for the Chemotherapeutic Treatment of Cancer,r with many aspects of topoisomerase enzymology and cell biology, their interactions with anticancer drugs, and the cellular consequences of topoisomerase-mediated DNA strand breaks. It also will discuss the checkpoint functions and repair pathways that are triggered in response to topoisomerase-generated DNA damage.作者: 沙草紙 時(shí)間: 2025-3-23 00:19
Targeting the Spindle Checkpoint in Cancer Chemotherapy,se drugs in eliciting apoptosis in cultured cancer cells. Therefore, quantitative differences in the strength of the spindle checkpoint may influence the efficacy of antimitotic drugs in cancer chemotherapy.作者: curettage 時(shí)間: 2025-3-23 02:25
Do Histone Deacetylase Inhibitors Target Cell Cycle Checkpoints that Monitor Heterochromatin StructThe ability of cells to detect and respond to perturbations in heterochromatin structure is likely to be critical in determining cell fate, and its disruption in cancers would permit the silencing and unsilencing of genes often observed in modified transcriptomes of cancer cells as compared to their normal tissue counterparts.作者: CRAFT 時(shí)間: 2025-3-23 06:11 作者: Pessary 時(shí)間: 2025-3-23 11:53 作者: Gerontology 時(shí)間: 2025-3-23 14:58 作者: 蘆筍 時(shí)間: 2025-3-23 22:02 作者: STANT 時(shí)間: 2025-3-23 22:46
Cancer Drug Discovery and Developmenthttp://image.papertrans.cn/c/image/224213.jpg作者: 尖酸一點(diǎn) 時(shí)間: 2025-3-24 05:28
https://doi.org/10.1007/978-1-4302-1834-0 end, RB function is commonly abrogated in tumorigenesis, thereby contributing to the uncontrolled proliferation of cancer cells. However, it is becoming increasingly clear that RB is not only involved in the etiology and progression of cancer, but also modifies the response to specific therapeutic 作者: 有毛就脫毛 時(shí)間: 2025-3-24 08:11
https://doi.org/10.1007/978-1-4302-1834-0structure of DNA in the cell, regulate under- and overwinding of the double helix, and remove knots and tangles from the genetic material. In order to perform their critical cellular functions, topoisomerases generate DNA strand breaks as requisite intermediates in their catalytic cycles. Consequent作者: 矛盾 時(shí)間: 2025-3-24 12:26
https://doi.org/10.1007/978-1-4302-1834-0sm of the G2 checkpoint s cascade. In addition, screening procedures to identify candidate compounds, currently available compounds, and compounds in clinical trials with G2 checkpoint-abrogating potential are discussed.作者: Decrepit 時(shí)間: 2025-3-24 14:58 作者: GEM 時(shí)間: 2025-3-24 19:27 作者: 史前 時(shí)間: 2025-3-25 01:30
Advanced and Alternate MapReduce Techniques,indle checkpoint is a cell-cycle surveillance mechanism that prevents premature sister-chromatid separation and ensures the fidelity of chromosome segregation. A defective spindle checkpoint results in aneuploidy and contributes to tumorigenesis. On the other hand, many tumor cells still exhibit a p作者: outskirts 時(shí)間: 2025-3-25 04:26
MapReduce Details for Multimachine Clusters,a A regulates centrosome maturation and spindle assembly while Aurora B (and C) a chromosome passenger protein (CPP) regulates chromosome orientation on the spindle and cytokinesis. All 3 Auroras are overexpressed in a multitude of human cancers with an associated polyploid phenotype containing mult作者: Motilin 時(shí)間: 2025-3-25 09:07
Advanced and Alternate MapReduce Techniques,than protein tyrosine kinases among the molecular entities that regulate cell proliferation. They have been extensively explored to determine their effectiveness as targets for discovery of novel anticancer agents. Polo-like kinases (Plks) comprise a family of conserved proteins that mediate numerou作者: 星星 時(shí)間: 2025-3-25 13:44
Advanced and Alternate MapReduce Techniques,f cancer cell lines, and inhibit tumor growth in vivo. The antiproliferative effects of HDACis are caused by drug induced G1 or G2 phase cell cycle arrests. They also promote aberrant mitosis, which in cycling cells can result in the rapid onset of apoptosis. Hyperacetylation of the constitutive cen作者: indigenous 時(shí)間: 2025-3-25 16:01
The Basics of Multimachine Clusters,Mitotic kinesins are essential for the formation and function of the mitotic spindle during mitosis. The following pages describe some of the different roles of this class of enzymes on cell division and our current understanding of kinesin inhibitors in anticancer drug development.作者: Junction 時(shí)間: 2025-3-25 23:54
Kinesin Motor Inhibitors as Effective Anticancer Drugs,Mitotic kinesins are essential for the formation and function of the mitotic spindle during mitosis. The following pages describe some of the different roles of this class of enzymes on cell division and our current understanding of kinesin inhibitors in anticancer drug development.作者: 抱怨 時(shí)間: 2025-3-26 00:07 作者: 躺下殘殺 時(shí)間: 2025-3-26 05:07 作者: 炸壞 時(shí)間: 2025-3-26 11:12
Checkpoint Responses in Cancer Therapy978-1-59745-274-8Series ISSN 2196-9906 Series E-ISSN 2196-9914 作者: 苦澀 時(shí)間: 2025-3-26 14:48
https://doi.org/10.1007/978-1-4302-1834-0sm of the G2 checkpoint s cascade. In addition, screening procedures to identify candidate compounds, currently available compounds, and compounds in clinical trials with G2 checkpoint-abrogating potential are discussed.作者: nerve-sparing 時(shí)間: 2025-3-26 17:46 作者: 確定 時(shí)間: 2025-3-26 21:02 作者: colostrum 時(shí)間: 2025-3-27 02:48 作者: Polydipsia 時(shí)間: 2025-3-27 06:04
Antiproliferation Inhibitors Targeting Aurora Kinases,and several small molecular ATP-site competitive inhibitors. The availability of several crystal structures with bound ADP, several drugs and peptide fragments from interacting proteins have provided a detailed insight of the active site, biological functions, rationale for the mode of binding of a 作者: 寬大 時(shí)間: 2025-3-27 10:03
Plks as Novel Targets for Cancer Drug Design,ors of various cell-cycle checkpoints. Deregulation of Plks occurs in a variety of human malignancies. During the past decade, much effort has been directed toward the discovery of novel chemical agents that target Plks specifically. We attempt to summarize recent developments in this field and disc作者: 繁榮中國(guó) 時(shí)間: 2025-3-27 17:09 作者: Cognizance 時(shí)間: 2025-3-27 20:20 作者: muffler 時(shí)間: 2025-3-28 00:07
MapReduce Details for Multimachine Clusters,and several small molecular ATP-site competitive inhibitors. The availability of several crystal structures with bound ADP, several drugs and peptide fragments from interacting proteins have provided a detailed insight of the active site, biological functions, rationale for the mode of binding of a 作者: 真實(shí)的你 時(shí)間: 2025-3-28 03:50
Advanced and Alternate MapReduce Techniques,ors of various cell-cycle checkpoints. Deregulation of Plks occurs in a variety of human malignancies. During the past decade, much effort has been directed toward the discovery of novel chemical agents that target Plks specifically. We attempt to summarize recent developments in this field and disc作者: 記憶法 時(shí)間: 2025-3-28 08:17 作者: crumble 時(shí)間: 2025-3-28 14:05 作者: Constrain 時(shí)間: 2025-3-28 18:01 作者: flaunt 時(shí)間: 2025-3-28 20:45
CDK Inhibitors as Anticancer Agents, driven reactions that result in cell division and the generation of new cells. The cell cycle is regulated by kinases such as cyclin-dependent kinases (CDKs), and non-CDKs, which include the Aurora and Polo-like kinases, as well as checkpoint proteins and mitotic kinesins. The CDK family of serine-作者: 挑剔為人 時(shí)間: 2025-3-28 23:08 作者: Arresting 時(shí)間: 2025-3-29 06:32 作者: 受辱 時(shí)間: 2025-3-29 08:21 作者: 價(jià)值在貶值 時(shí)間: 2025-3-29 14:44 作者: 喃喃而言 時(shí)間: 2025-3-29 16:06
Do Histone Deacetylase Inhibitors Target Cell Cycle Checkpoints that Monitor Heterochromatin Structf cancer cell lines, and inhibit tumor growth in vivo. The antiproliferative effects of HDACis are caused by drug induced G1 or G2 phase cell cycle arrests. They also promote aberrant mitosis, which in cycling cells can result in the rapid onset of apoptosis. Hyperacetylation of the constitutive cen作者: Lignans 時(shí)間: 2025-3-29 19:47
10樓作者: opprobrious 時(shí)間: 2025-3-30 01:05
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