標題: Titlebook: Cellular Peptidases in Immune Functions and Diseases 2; Jürgen Langner,Siegfried Ansorge Book 2002 The Editor(s) (if applicable) and The A [打印本頁] 作者: SPARK 時間: 2025-3-21 16:40
書目名稱Cellular Peptidases in Immune Functions and Diseases 2影響因子(影響力)
書目名稱Cellular Peptidases in Immune Functions and Diseases 2影響因子(影響力)學科排名
書目名稱Cellular Peptidases in Immune Functions and Diseases 2網絡公開度
書目名稱Cellular Peptidases in Immune Functions and Diseases 2網絡公開度學科排名
書目名稱Cellular Peptidases in Immune Functions and Diseases 2被引頻次
書目名稱Cellular Peptidases in Immune Functions and Diseases 2被引頻次學科排名
書目名稱Cellular Peptidases in Immune Functions and Diseases 2年度引用
書目名稱Cellular Peptidases in Immune Functions and Diseases 2年度引用學科排名
書目名稱Cellular Peptidases in Immune Functions and Diseases 2讀者反饋
書目名稱Cellular Peptidases in Immune Functions and Diseases 2讀者反饋學科排名
作者: 描述 時間: 2025-3-21 22:20
Unterschenkel und oberes Sprunggelenk,nce of appropriate protease inhibitors..Clinical implications of peptide processing by DPP IV include that the therapeutic potential of peptides that are degraded by DPP IV may largely be enhanced by creating DPP IV-resistant, active analogues, and that the most suitable NH2-terminal modification ma作者: LUCY 時間: 2025-3-22 02:36
Unterschenkel und oberes Sprunggelenk,-induced signalling pathways, including Ca2+ mobilisation, MEK1-, Erk1/2-and PKB-activation, can be strongly affected by DP IV inhibition. Thus, the enzymatic activity or at least the interaction of effectors with the catalytic domain of CD26 seems to be important for crucial functions of this cell 作者: Airtight 時間: 2025-3-22 05:53
Review: The Role of Membrane Peptidase in Immune Functions作者: COST 時間: 2025-3-22 12:22 作者: Coronary-Spasm 時間: 2025-3-22 16:51
Cell-Cell Contact Between Lymphocytes and Fibroblast-Like Synovioctyes Induces Lymphocytic Expressio作者: Coronary-Spasm 時間: 2025-3-22 20:56 作者: ensemble 時間: 2025-3-22 21:14
Transforming Growth Factor-β Increases the Expression of Aminopeptidase N/CD13 mRNA and Protein in M In experiments with actinomycin D- treated cells was found a stabilization of APN/CD13 mRNA by TGF-β1. Contrary to the IL-4-induc edexpression of APN/CD13 as well as of MHC class II in monocytic cells, we could show that TGF-β is able to augment the APN/CD13 expression but decreases the MHC class I作者: 墻壁 時間: 2025-3-23 03:43
Natural Substrates of Dipeptidyl Peptidase IVnce of appropriate protease inhibitors..Clinical implications of peptide processing by DPP IV include that the therapeutic potential of peptides that are degraded by DPP IV may largely be enhanced by creating DPP IV-resistant, active analogues, and that the most suitable NH2-terminal modification ma作者: 類人猿 時間: 2025-3-23 06:33 作者: 異端邪說下 時間: 2025-3-23 12:11 作者: 有危險 時間: 2025-3-23 15:02 作者: 過多 時間: 2025-3-23 20:42 作者: troponins 時間: 2025-3-23 23:03 作者: anaphylaxis 時間: 2025-3-24 02:37
Unterschenkel und oberes Sprunggelenk,r domain of DP IV. These data led us to suggest that in DP IV and related peptidases ligand and antibody binding sites are non-linear and that enzyme activity depends on charged sidechains that surround the entrance to the central tunnel of the β-propeller.作者: biosphere 時間: 2025-3-24 10:26 作者: 極深 時間: 2025-3-24 14:36
https://doi.org/10.1007/978-3-540-48499-8ucidate the molecular conformation of a series of Tat nonapeptides. Conformational backbone differences of these peptides as well as the nature and the arrangement of the side chains . at significant positions preventing effective binding to DP IV might explain their different inhibitory activity on DP IV.作者: Watemelon 時間: 2025-3-24 17:24 作者: EWE 時間: 2025-3-24 22:30
https://doi.org/10.1007/978-3-540-48499-8V inhibitors suppress T cell proliferation and pro-inflammatory cytokine production in response to myelin antigens. Further studies will evaluate the role of DP IV inhibition in T cell-mediated inflammatory disease of the central nervous system.作者: 摘要記錄 時間: 2025-3-25 02:44 作者: miniature 時間: 2025-3-25 06:35 作者: 群島 時間: 2025-3-25 11:28
Lecture Notes in Physics Monographsinhibitors Lys[Z(NO.)]-thiazolidide and -pyrrolidide suppress the DNA synthesis of these cells in a dose-dependent manner. These data demonstrate that CD26 is also involved in the regulation of DNA synthesis of keratinocytes and that the enzymatic activity is required for mediating these effects.作者: 聲明 時間: 2025-3-25 12:22 作者: 暖昧關系 時間: 2025-3-25 19:17 作者: allergen 時間: 2025-3-25 21:34
Effects of Nonapeptides Derived From the N-terminal Structure of Human Immunodeficiency Virus-1 (HIVimulated PBMC. This correlation suggests that Tat(l-9)-deduced peptides mediate antiproliferative effects at least in part via specific DP IV interactions and supports the hypothesis that CD26 plays a key role in the regulation of lymphocyte growth.作者: annexation 時間: 2025-3-26 01:54
DNA Synthesis in Cultured Human Keratinocytes and Hacat Kerationcytes is Reduced by Specific Inhibitinhibitors Lys[Z(NO.)]-thiazolidide and -pyrrolidide suppress the DNA synthesis of these cells in a dose-dependent manner. These data demonstrate that CD26 is also involved in the regulation of DNA synthesis of keratinocytes and that the enzymatic activity is required for mediating these effects.作者: Landlocked 時間: 2025-3-26 07:40
Unterschenkel und oberes Sprunggelenk,n addition, expression of GSK-? an inherent component of the Wnt-pathway, was found to be increased in response to activation, but suppressed by actinonin at both the mRNA and protein level. These findings may provide a rationale for the strong growth inhibitory effects resulting from an inhibition of alanylaminopeptidase expression or activity.作者: Mosaic 時間: 2025-3-26 11:01 作者: 使人煩燥 時間: 2025-3-26 16:13
Unterschenkel und oberes Sprunggelenk,binding mechanism with inhibition constants in the nanomolare range. On the other hand, diaryl dipeptide phosphonates inhibit irreversibly. In conclusion, this work shows, that the mechanism of inhibition of DP IV depends on the structure of the investigated compounds.作者: Monotonous 時間: 2025-3-26 20:52 作者: probate 時間: 2025-3-26 22:26
A New Type of Fluorogenic Substrates for Determination of Cellular Dipeptidyl Peptidese IV (DP IV/CDthe catalytic site of DP IV. The compounds are characterized as sensitive substrates of cell surface associated DP IV of DP IV rich U-937 cells. The binding of the enzymatically released R110-Y on cells results in a stable cellular fluorescence. This way, the quantitative determination of cell surface associated DP IV activity is possible.作者: anthesis 時間: 2025-3-27 01:59 作者: 實施生效 時間: 2025-3-27 09:12
Modulation of WNT-5At Eexpression by Actinonin: Linkage of APN to the WNT-Pathway?g theseeffects are not known as yet. Applying the cDNA array technique we identified the proto-oncogen Wnt-5a strongly affected by APN-inhibition Wnt-5a and other members of the Wnt family of secreted factors are implicated in cell growth and differentiation. Wnt-5a was moderately expressed in resti作者: overwrought 時間: 2025-3-27 10:43
Transforming Growth Factor-β Increases the Expression of Aminopeptidase N/CD13 mRNA and Protein in Mcells and during most developmental stages of myeloid cells. Because APN/CD13 has been implicated in the trimming on the cell surface of peptides that protrude out of MHC class II molecules, we wanted to study the regulation of this membrane peptidase in antigen presenting cells by TGF-β, TGF-β is a作者: 罵人有污點 時間: 2025-3-27 16:33
Natural Substrates of Dipeptidyl Peptidase IVion and physiological circumstances. It is at present impossible to depict a certain chain length as the maximal acceptable substrate size as it turns out that the immediate surrounding and surface accessibility of the NH.-terminal dipeptide are determining the susceptibility for cleavage of a pepti作者: 苦惱 時間: 2025-3-27 19:11 作者: 該得 時間: 2025-3-27 22:23 作者: 敏捷 時間: 2025-3-28 05:41 作者: Accomplish 時間: 2025-3-28 08:26
A New Type of Fluorogenic Substrates for Determination of Cellular Dipeptidyl Peptidese IV (DP IV/CDtion of fluorophores. Rhodamine 110 (Rl10), a highly fluorescent Athene dye, was used to synthesize nonfluorescent dipeptidyl peptidase IV (DP IV) substrates Xaa-Pro-R110-Y allowing the stable covalent binding of the enzymatically released fluorescent R110- on cells. All compounds have been characte作者: sparse 時間: 2025-3-28 13:12 作者: 搖擺 時間: 2025-3-28 18:05
N-Terminal HIV-1 Tat Nonapeptides as Inhibitors of Dipeptidyl Peptidase IV. Conformational Characterffects of HIV-1 Tat, the Ile. and Leu. analogues showed strongly reduced inhibitory activity. Interestingly, replacement of Asp. with Gly or Lys led to compounds with considerably enhanced inhibition. Therefore, we have applied .H NMR spectroscopy and restrained molecular dynamics calculations to el作者: Ligament 時間: 2025-3-28 21:33 作者: 完成 時間: 2025-3-29 00:51 作者: 偶像 時間: 2025-3-29 03:10
Dipeptidyl Peptidase IV in Inflammatory CNS Disease autoimmune response is involved in the disease process. One of the primary goals in the in the development of immunotherapies for autoimmune diseases has been to achieve inactivation of disease-inducing lymphocytes either by direct inhibition or suppression through regulatory cells and/or cytokines作者: 迅速成長 時間: 2025-3-29 08:42
Dipeptidyl Peptidase IV (CD26): Role in T Cell Activation and Autoimmune Disease show by flow cytometry and by enzymatic DP IV assay that myelin basic protein (MBP)-specific, CD4. T cell clones (TCC) derived from patients with multiple sclerosis (MS) express high levels of DP IV/CD26. The enzymatic activity of resting TCC was found to be three to fourfold higher than on resting作者: 琺瑯 時間: 2025-3-29 14:32 作者: 角斗士 時間: 2025-3-29 19:08
DNA Synthesis in Cultured Human Keratinocytes and Hacat Kerationcytes is Reduced by Specific Inhibiten shown that this enzyme is involved in the regulation of DNA synthesis and in production of various cytokines in lymphocytes. The aim of the present work was to investigate the expression of DP IV/CD26 on human keratinocytes and to answer the question, whether the proliferation (DNA synthesis) of 作者: 貪心 時間: 2025-3-29 21:00
Cellular Peptidases in Immune Functions and Diseases 2978-0-306-46826-1Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: Ordnance 時間: 2025-3-30 03:10
0065-2598 Overview: 978-1-4757-8649-1978-0-306-46826-1Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: Brochure 時間: 2025-3-30 06:39 作者: 淺灘 時間: 2025-3-30 11:31 作者: hypnogram 時間: 2025-3-30 14:51
978-1-4757-8649-1The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines作者: 圖畫文字 時間: 2025-3-30 18:57
Unterschenkel und oberes Sprunggelenk,g theseeffects are not known as yet. Applying the cDNA array technique we identified the proto-oncogen Wnt-5a strongly affected by APN-inhibition Wnt-5a and other members of the Wnt family of secreted factors are implicated in cell growth and differentiation. Wnt-5a was moderately expressed in resti作者: 植物群 時間: 2025-3-31 00:34 作者: Eviction 時間: 2025-3-31 03:13 作者: 砍伐 時間: 2025-3-31 08:15
Unterschenkel und oberes Sprunggelenk,Point mutations at either Leu294 or Val341 ablated ADA binding. Binding by mAbs that inhibit ADA binding was found to involve both Leu340 to Arg343 and Thr440/Lys441. Glu205 and Glu206 were found to be essential for enzyme activity. All residues of interest were mapped onto a model of the β-propelle作者: Cacophonous 時間: 2025-3-31 13:12 作者: EXUDE 時間: 2025-3-31 16:49
https://doi.org/10.1007/978-3-540-48499-8rate. In addition many studies have used inhibitors of DP IV enzyme activity. The characterisation of a novel DP IV like protein, DPP4R, and of other proteases which have a substrate specificity similar to DP IV or that bind DP IV inhibitors suggests that these studies require further evaluation.作者: 鞏固 時間: 2025-3-31 18:35
Anamnese und klinische Untersuchung,tion of fluorophores. Rhodamine 110 (Rl10), a highly fluorescent Athene dye, was used to synthesize nonfluorescent dipeptidyl peptidase IV (DP IV) substrates Xaa-Pro-R110-Y allowing the stable covalent binding of the enzymatically released fluorescent R110- on cells. All compounds have been characte作者: GULP 時間: 2025-4-1 01:03
