作者: Fibroid 時間: 2025-3-22 00:18 作者: forebear 時間: 2025-3-22 03:04
Nonconvex Optimization and Its Applicationsh cannot be studied at physiological concentrations of Mg.. By using reconstituted human red cell ghosts containing ATP and little Mg., it is possible to evaluate the side-specificity of those effects of Na. and K. which have been observed in porous ghosts. Some of the following data are detailed in previous papers (5, 6).作者: 拱形大橋 時間: 2025-3-22 08:03 作者: RADE 時間: 2025-3-22 11:17
Binding and release of ouabain at low Mg2+ in reconstituted human red blood cell ghostsh cannot be studied at physiological concentrations of Mg.. By using reconstituted human red cell ghosts containing ATP and little Mg., it is possible to evaluate the side-specificity of those effects of Na. and K. which have been observed in porous ghosts. Some of the following data are detailed in previous papers (5, 6).作者: Compatriot 時間: 2025-3-22 16:38
Proximal Calculus in Hilbert Space,ort account of the development of the knowledge on digitalis effects, which was based on older similarly formed ideas like those in the German literature; the historical reports by Horst Wirth, Günther Baumgarten and Werner F?rster, not to mention other very important papers in the English speaking literature.作者: Compatriot 時間: 2025-3-22 18:10 作者: cornucopia 時間: 2025-3-23 00:37
Ji?i Outrata,Michal Ko?vara,Jochem Zowessociation constants are seen to fit the experimental points well..Ouahain binding data obtained before and after treatment of Na,K-ATPase from ox brain with pyrithiamin are thus compatible with a model assuming two independent populations of receptors (and thus enzymes) in this preparation.作者: 磨坊 時間: 2025-3-23 04:03 作者: tinnitus 時間: 2025-3-23 07:20 作者: 四溢 時間: 2025-3-23 09:42
Nonsmooth Equations in Optimizationhe onset of toxicity was compared to that which the non-inhibited pump would have achieved had it been stimulated by corresponding amounts of intracellular sodium. Six different cardiac steroids were tested by this procedure and showed quite similar pump inhibitions of approx. 58% (range: 52.8%–65.5%) at the onset of toxicity.作者: 墊子 時間: 2025-3-23 14:05 作者: Indebted 時間: 2025-3-23 19:20 作者: 獨輪車 時間: 2025-3-23 22:48
Fruitful routes and blind alleys taken by digitalis therapy since its introduction by Witheringort account of the development of the knowledge on digitalis effects, which was based on older similarly formed ideas like those in the German literature; the historical reports by Horst Wirth, Günther Baumgarten and Werner F?rster, not to mention other very important papers in the English speaking literature.作者: PHIL 時間: 2025-3-24 05:31
The function of Na+,K+-ATPase and its importance for drug action in Na. influx rate elevates [Na.]. and therefore intracellular Ca. via Na./Ca. exchange. The subsequent loading of the sarcoplasmic reticulum by Cat+ and an enhanced Ca. release upon membrane excitation appear to be responsible for the positive inotropic effect of a Na.,K.-ATPase inhibitor.作者: Incompetent 時間: 2025-3-24 07:11
Isoenzymes of Na,K-ATPase identified by pyrithiaminssociation constants are seen to fit the experimental points well..Ouahain binding data obtained before and after treatment of Na,K-ATPase from ox brain with pyrithiamin are thus compatible with a model assuming two independent populations of receptors (and thus enzymes) in this preparation.作者: intricacy 時間: 2025-3-24 12:50 作者: 審問,審訊 時間: 2025-3-24 16:11
Conference proceedings 1986ccasion to analyze the state of the art. Cardiac glycosides in 1985 are considered tobe the basis for medical treatment of myocardial failure, together with diuretics and vasodilators in the more severe cases. Nevertheless, the controversy as to their exact place in the treatment of heart failure wi作者: 被告 時間: 2025-3-24 19:44
https://doi.org/10.1007/978-3-662-11292-2anesthesia; artery; atrial fibrillation; drugs; electrocardiogram (ECG); heart; heart disease; heart failur作者: Expediency 時間: 2025-3-25 00:08 作者: Flavouring 時間: 2025-3-25 06:00
Nonsmooth Analysis and Control TheoryDigitalis has been known since the Middle Ages and used mainly by external application. Oral application, however, was mentioned before William Withering..The priority of publication of the use of digitalis in dropsy is discussed between William Withering and Erasmus Darwin.作者: PRISE 時間: 2025-3-25 09:40
Analysis of Generalized Derivatives,The paper briefly surveys the recent state of the authors’ research into the biochemical basis for the targeted synthesis of cardiac glycosides with selective action.作者: cauda-equina 時間: 2025-3-25 12:04
Therapeutic use of digitalis until the time of William WitheringDigitalis has been known since the Middle Ages and used mainly by external application. Oral application, however, was mentioned before William Withering..The priority of publication of the use of digitalis in dropsy is discussed between William Withering and Erasmus Darwin.作者: Obituary 時間: 2025-3-25 18:03
Biochemical basis for the targeted synthesis of cardiac glycosides with selective actionThe paper briefly surveys the recent state of the authors’ research into the biochemical basis for the targeted synthesis of cardiac glycosides with selective action.作者: 清晰 時間: 2025-3-25 23:22 作者: 盡忠 時間: 2025-3-26 03:03
Proximal Calculus in Hilbert Space,ress the subject of digitalis therapy and all its problems. Not only was he a prominent expert in this field, but he had also studied the history of digitalis in the last years of his life. Unfortunately he died in 1981. Therefore, Professor Kurt Greeff (born 1920) and I published some time ago a sh作者: anesthesia 時間: 2025-3-26 07:56
Discrete Approximations in Optimal Control,lar Ca. concentration is markedly affected by the balance between Na.,K.-ATPase activity (capacity of the sodium pump) and Na. influx rate. The sodium pump in cardiac muscle has a substantial reserve capacity under normal conditions; however, a relatively modest sodium pump inhibition or an increase作者: affluent 時間: 2025-3-26 08:30 作者: 解開 時間: 2025-3-26 16:17 作者: 面包屑 時間: 2025-3-26 17:51
Ji?i Outrata,Michal Ko?vara,Jochem Zowehe interaction of cardiac glycosides with Na/K-ATPase of intact myocardium were quantitatively considered and combined: 1. Cardiac glycoside binding depends on the turnover rate of Na/K-ATPase, and 2. occupation and inhibition of a fraction of Na/K-ATPases by cardiac glycoside leads to an increased 作者: 清唱劇 時間: 2025-3-27 00:50
Ji?i Outrata,Michal Ko?vara,Jochem Zowesults were obtained:.The differences in ouabain receptor regulation in erythrocytes and heart muscle cells may be attributable to the lack of a “sodium pump reserve” in erythrocytes. Such variations in receptor regulation indicate that the human erythrocyte is not a suitable model for the ouabain re作者: 解脫 時間: 2025-3-27 04:53
Nonconvex Optimization and Its Applicationsase in porous and reconstituted human red blood cell ghosts. At low Mg., conformational changes become evident in the presence of various ligands which cannot be studied at physiological concentrations of Mg.. By using reconstituted human red cell ghosts containing ATP and little Mg., it is possible作者: MORPH 時間: 2025-3-27 09:08
https://doi.org/10.1007/978-0-387-09653-7e molecular basis for the increased digitalis sensitivity of the conducting system. .H-ouabain binding has the following characteristics:.(1) in sheep left ventricular cell membranes, specific binding was of high affinity (K. 1.9 × 10.M at 37°); was coincident with an inhibition of (Na. + K.)-ATPase作者: Prophylaxis 時間: 2025-3-27 12:37
Advances in Mechanics and Mathematicsce an initial prolongation of the action potential due to inhibition of the electrogenic Na-K pump current. This is then followed by a gradual decrease of action potential duration to less than control length. The origin of this decrease is uncertain. Cardiac glycosides also produce a transient depo作者: 場所 時間: 2025-3-27 15:36
Nonsmooth Equations in Optimizationum-sensitive microelectrodes, sodium pump activities could be described quantitatively in sheep heart Purkinje fibres. In the presence of cardiac steroids, partial sodium pump inhibition caused intracellular sodium to rise, thus presumably stimulating non-inhibited pumping sites. At the transition t作者: thwart 時間: 2025-3-27 19:57
Parametric Optimization Problems,on by ouabain occurs in the same range of concentrations as pharmacologically active doses in various species including rat. In this species, it has been shown that the sensitivity of Na/K-ATPase to ouabain was heterogeneous with high and low sensitivity forms (K. 10., 10. M and 10., 10. M, respecti作者: GROUP 時間: 2025-3-27 22:59 作者: Cerebrovascular 時間: 2025-3-28 06:04
Analysis of Generalized Derivatives,. ~ 0.3–0.5 .M, “high dose” effect ED. > 10 .M. The “l(fā)ow-dose” (high affinity?) effect was masked by high Ca. (2 mM) and emphasized in low Ca. (0.5 mM). The “l(fā)ow-dose” inotropic effect in rat ventricular strips was significantly diminished by repeated exposure to high ouabain concentrations as was .作者: Phenothiazines 時間: 2025-3-28 08:31 作者: 直覺沒有 時間: 2025-3-28 12:28 作者: conceal 時間: 2025-3-28 17:45 作者: 侵害 時間: 2025-3-28 22:21
The human red blood cell: A model for ouabain receptor regulation in the heart?sults were obtained:.The differences in ouabain receptor regulation in erythrocytes and heart muscle cells may be attributable to the lack of a “sodium pump reserve” in erythrocytes. Such variations in receptor regulation indicate that the human erythrocyte is not a suitable model for the ouabain receptor in the human heart.作者: exorbitant 時間: 2025-3-28 23:27 作者: 舞蹈編排 時間: 2025-3-29 03:44
Ji?i Outrata,Michal Ko?vara,Jochem Zowesults were obtained:.The differences in ouabain receptor regulation in erythrocytes and heart muscle cells may be attributable to the lack of a “sodium pump reserve” in erythrocytes. Such variations in receptor regulation indicate that the human erythrocyte is not a suitable model for the ouabain receptor in the human heart.作者: 外科醫(yī)生 時間: 2025-3-29 07:17
William Withering — The man and his workopsy and other Diseases” (6). This is a critical analysis of the effect of digitalis on dropsy based on ten years of observations with reports of 163 cases treated by Withering, and a number of cases treated by colleagues. Detailed instructions are given on how to use digitalis, on the dosage, on th作者: Junction 時間: 2025-3-29 13:20
Fruitful routes and blind alleys taken by digitalis therapy since its introduction by Witheringress the subject of digitalis therapy and all its problems. Not only was he a prominent expert in this field, but he had also studied the history of digitalis in the last years of his life. Unfortunately he died in 1981. Therefore, Professor Kurt Greeff (born 1920) and I published some time ago a sh作者: 官僚統(tǒng)治 時間: 2025-3-29 18:38
The function of Na+,K+-ATPase and its importance for drug actionlar Ca. concentration is markedly affected by the balance between Na.,K.-ATPase activity (capacity of the sodium pump) and Na. influx rate. The sodium pump in cardiac muscle has a substantial reserve capacity under normal conditions; however, a relatively modest sodium pump inhibition or an increase作者: Celiac-Plexus 時間: 2025-3-29 22:23 作者: corpus-callosum 時間: 2025-3-30 01:09 作者: Hiatal-Hernia 時間: 2025-3-30 06:53
Interaction of cardiac glycosides with Na/K-ATPase in intact myocardiumhe interaction of cardiac glycosides with Na/K-ATPase of intact myocardium were quantitatively considered and combined: 1. Cardiac glycoside binding depends on the turnover rate of Na/K-ATPase, and 2. occupation and inhibition of a fraction of Na/K-ATPases by cardiac glycoside leads to an increased 作者: Clumsy 時間: 2025-3-30 08:50
The human red blood cell: A model for ouabain receptor regulation in the heart?sults were obtained:.The differences in ouabain receptor regulation in erythrocytes and heart muscle cells may be attributable to the lack of a “sodium pump reserve” in erythrocytes. Such variations in receptor regulation indicate that the human erythrocyte is not a suitable model for the ouabain re作者: 躲債 時間: 2025-3-30 12:36 作者: SLUMP 時間: 2025-3-30 19:02
The ouabain receptor in the myocardium and conduction system of the sheep hearte molecular basis for the increased digitalis sensitivity of the conducting system. .H-ouabain binding has the following characteristics:.(1) in sheep left ventricular cell membranes, specific binding was of high affinity (K. 1.9 × 10.M at 37°); was coincident with an inhibition of (Na. + K.)-ATPase作者: Keratectomy 時間: 2025-3-31 00:27
Electrophysiological effects of cardiac glycosidesce an initial prolongation of the action potential due to inhibition of the electrogenic Na-K pump current. This is then followed by a gradual decrease of action potential duration to less than control length. The origin of this decrease is uncertain. Cardiac glycosides also produce a transient depo作者: 哪有黃油 時間: 2025-3-31 01:40 作者: PRO 時間: 2025-3-31 08:59
Rat cardiac hypertrophy: contribution of heteregeneous digitalis receptor formson by ouabain occurs in the same range of concentrations as pharmacologically active doses in various species including rat. In this species, it has been shown that the sensitivity of Na/K-ATPase to ouabain was heterogeneous with high and low sensitivity forms (K. 10., 10. M and 10., 10. M, respecti作者: 無價值 時間: 2025-3-31 12:38 作者: 音樂等 時間: 2025-3-31 13:26 作者: overreach 時間: 2025-3-31 19:55
The influence of ,-tocopherol-nicotinate (Renascin,) on cardiac glycoside effectsto guinea-pig heart homogenate was investigated...-tocopherol-nicotinate and dodecanoic acid had an inhibitory effect on the positive inotropic action of digoxin but not on that of ouabain. This effect was parallel to their inhibitory effect of digoxin and not ouabain binding to heart homogenate. Th作者: 復(fù)習(xí) 時間: 2025-3-31 23:16 作者: subacute 時間: 2025-4-1 02:44
The “endogenous cardiac glycoside”ular Na.-concentration may also mediate hormonal effects on cellular processes (66). Provided this concept is right, the sodium pump must also be considered as a receptor of hormones and as a mediator of hormonal action (3). Alterations of the intracellular sodium concentration are considered to be 作者: 商業(yè)上 時間: 2025-4-1 08:38 作者: Altitude 時間: 2025-4-1 12:42 作者: SEVER 時間: 2025-4-1 18:20
Electrophysiological effects of cardiac glycosidesf s. r. function such as caffeine and ryanodine. As well as these oscillations of [Ca.]. which follow repolarization, there are also spontaneous oscillations in the absence of stimulation. These spontaneous oscillations, which also result from release of Ca from the sarcoplasmic reticulum, interfere作者: 騎師 時間: 2025-4-1 19:20
Rat cardiac hypertrophy: contribution of heteregeneous digitalis receptor formsduced hypertrophied rat hearts working under isovolumic conditions in the presence of 0.25 mM [Ca]...Under these conditions, as compared to normal hearts, the inotropic response of hypertrophied hearts to ouabain appeared to be depressed and mainly prolonged. This delayed recovery of normal contract作者: HILAR 時間: 2025-4-2 02:11
Digitalis receptors in normal and hypertrophied rat hearts. Differential effects of a Ca2+ free perfts. The pressure-overload induced hypertrophy represented a suitable model in that the movements of Ca. appeared to be slowed..When the heart was maintained at a physiological calcium level (2.5 mM), hypertrophied and normal cardiac preparations had heterogeneous ouabain binding sites: H. A. (K. 3 ×作者: convert 時間: 2025-4-2 03:49
Biphasic contractile response to ouabain: Species specific? Calcium dependent? Altered sensitivity?onse to high ouabain concentrations was identical in both exposures. In Langendorff perfused rat heart preparations the “l(fā)ow-dose” response was not diminished by repeated ouabain exposure and .H-ouabain binding was not altered. The “l(fā)ow-dose” effect was not present in rat atrial strip preparations..
