作者: SHOCK 時(shí)間: 2025-3-21 20:55
Evaluation of Different Methods for Determining Serum Concentrations of Cardiac Glycosides,al patients have included: the isolation of highly purified cardenolides, the recognition of the effects of digitalis on the electrocardiogram, a better definition of the effects of cardiac glycosides on myocardial contractility, conduction, and automaticity, and an appreciation of the role of elect作者: 留戀 時(shí)間: 2025-3-22 04:08
Studies of the Metabolism of Digoxin and Digitoxin Using Double Isotope Dilution Derivative Methodsg the subsequent 9 days with a half-life of 1.4 days in one subject and 1.6 days in the other; 23%–56% of the calculated body pool of the drug was cumulatively excreted in the urine and stool, and digoxin was the only acid-hydrolyzable derivative of digoxigenin recovered..Biotransformation of orally作者: 釋放 時(shí)間: 2025-3-22 07:17
Dihydrodigitoxin, a Metabolite of Digitoxin in Humans,rmacokinetics and metabolism with radioactively labeled cardiac glycosides were examined for the first time in the 1950s and 1960s. In the meantime, methods have become available which also make the determination of concentrations of nonlabeled digitalis glycosides in blood and urine possible. Rubid作者: Arthritis 時(shí)間: 2025-3-22 09:54 作者: CAGE 時(shí)間: 2025-3-22 15:53
Tissue Distribution of Cardiac Glycosides,since the psychotic state outlasted the cardiac side-effects of digoxin intoxication. Four days af ter digoxin administration was stopped, a normalization of heart rate and sinus rhythm without extrasystoles in the ECG was observed. In contrast, the central side-effects such as anorexia, dizziness, 作者: CAGE 時(shí)間: 2025-3-22 19:26 作者: 銀版照相 時(shí)間: 2025-3-22 22:23 作者: insipid 時(shí)間: 2025-3-23 03:26 作者: STALL 時(shí)間: 2025-3-23 07:33
Effect of Jejunoileal Bypass on the Bioavailability of Digoxin in Man,作者: 倔強(qiáng)不能 時(shí)間: 2025-3-23 12:02
Fumihiro Ishikawa,Hideaki Kakeyaal patients have included: the isolation of highly purified cardenolides, the recognition of the effects of digitalis on the electrocardiogram, a better definition of the effects of cardiac glycosides on myocardial contractility, conduction, and automaticity, and an appreciation of the role of elect作者: 花爭(zhēng)吵 時(shí)間: 2025-3-23 16:32 作者: murmur 時(shí)間: 2025-3-23 20:46
https://doi.org/10.1007/978-3-0348-7327-7rmacokinetics and metabolism with radioactively labeled cardiac glycosides were examined for the first time in the 1950s and 1960s. In the meantime, methods have become available which also make the determination of concentrations of nonlabeled digitalis glycosides in blood and urine possible. Rubid作者: Chameleon 時(shí)間: 2025-3-24 01:10 作者: 雄偉 時(shí)間: 2025-3-24 04:27
L. Donald Partridge,Dieter Swandullasince the psychotic state outlasted the cardiac side-effects of digoxin intoxication. Four days af ter digoxin administration was stopped, a normalization of heart rate and sinus rhythm without extrasystoles in the ECG was observed. In contrast, the central side-effects such as anorexia, dizziness, 作者: Mets552 時(shí)間: 2025-3-24 10:28 作者: 刺激 時(shí)間: 2025-3-24 13:55
Nonselfadjoint Operators and Related Topicstreatment for atrial fibrillation with digoxin in tablet form, had a plasma digoxin level of 0 ng/ml. Changing the brand of tablet digoxin subsequently produced a satisfactory blood level, and this led us to inform the manufacturer that their digoxin tablets could not be absorbed satisfactorily (a s作者: ZEST 時(shí)間: 2025-3-24 17:34 作者: Duodenitis 時(shí)間: 2025-3-24 21:43 作者: Stress 時(shí)間: 2025-3-25 02:11
Cardiac Glycosides978-3-642-66904-0Series ISSN 0173-0282 作者: 脫毛 時(shí)間: 2025-3-25 05:36 作者: 易受刺激 時(shí)間: 2025-3-25 09:10
Marie-Cécile Wellner,Gerrit Isenbergction of the cardiac glycosides. These drugs are widely used in clinical practice, for the treatment of patients with heart failure and cardiac dysrhythmias. Despite a widespread use of digoxin, relatively little information is available concerning factors which effect the response of the heart to such medication.作者: 占卜者 時(shí)間: 2025-3-25 12:44 作者: GUILT 時(shí)間: 2025-3-25 16:13
Significance of Plasma Concentration of Digoxin in Relation to the Myocardial Concentration of the ction of the cardiac glycosides. These drugs are widely used in clinical practice, for the treatment of patients with heart failure and cardiac dysrhythmias. Despite a widespread use of digoxin, relatively little information is available concerning factors which effect the response of the heart to such medication.作者: 樹(shù)木中 時(shí)間: 2025-3-25 21:11 作者: 運(yùn)氣 時(shí)間: 2025-3-26 00:55 作者: 陶瓷 時(shí)間: 2025-3-26 04:52 作者: 時(shí)間等 時(shí)間: 2025-3-26 08:49 作者: Rodent 時(shí)間: 2025-3-26 16:13 作者: obviate 時(shí)間: 2025-3-26 18:26
Yunqiu Chen,Ryan A. McClure,Neil L. Kelleher A similar pattern of methyldigoxin was described by Rietbrock and Abshagen (1973) and Abshagen et al. (1974). The chemical nature of these polar metabolites were thought to be the sulfuric and glucuronic acid conjugates of the bis- and monoglycosides and of aglucone, as first proposed by Repke et a作者: 使閉塞 時(shí)間: 2025-3-26 21:14
https://doi.org/10.1007/978-1-349-00412-6bjects maintained on the drug in standard oral tablet form. Only 21%–55% of the daily dose was excreted in the urine and feces as the chemically intact glycoside; the rest was biotransformed. Since the only acid-hydrolyzable derivative of digoxigenin that was recovered from urine and feces was digox作者: 甜得發(fā)膩 時(shí)間: 2025-3-27 04:56 作者: 尊嚴(yán) 時(shí)間: 2025-3-27 07:39
Christoph Korbmacher,Colin J. Barnstable al., 1970; Lahrtz et al., 1969; Okita et al., 1953,1955; V?hringer and Rietbrock, 1974; Weissler et al., 1966) as well as from multiple dose studies (Jelliffe, 1967; Lukas, 1971,1973; Peters et al., 1975; Solomon et al., 1971; Storstein, 1974; Wirth et al., 1976) using different methods, can be cha作者: 漂浮 時(shí)間: 2025-3-27 09:39 作者: 終止 時(shí)間: 2025-3-27 17:04 作者: 典型 時(shí)間: 2025-3-27 18:52
L. Donald Partridge,Dieter Swandullade-effects of cardiac glycosides can be categorized into two generai classes, those of a neurologic nature including fatigue, loss of appetite, vomiting, color vision, central scotoma, states of confusion and delirium, and those of a cardiac nature, primarily those of alterations in cardiac rate and作者: linguistics 時(shí)間: 2025-3-27 23:36 作者: 不透氣 時(shí)間: 2025-3-28 04:38 作者: Conflict 時(shí)間: 2025-3-28 07:17 作者: 使虛弱 時(shí)間: 2025-3-28 14:26
Gene Christner,Kin Y. Li,James Rovnyakaum et. al., 1971). On the other hand, only few studies are available about the absorption of digoxin under pathological conditions. Therefore, in the present study, three different studies were performed. In the first study, different pharmacokinetic parameters after oral administration of digoxin 作者: 油氈 時(shí)間: 2025-3-28 14:50 作者: Osteoporosis 時(shí)間: 2025-3-28 20:29 作者: 充氣女 時(shí)間: 2025-3-29 02:29 作者: 煞費(fèi)苦心 時(shí)間: 2025-3-29 03:27
Connections Between Systems and Processes,ont the clinician as well as the research investigator. The narrow margin between therapeutic and toxic doses of digitalis, resulting in a high incidence of digitalis toxicity in clinical practice, has stimulated the development of improved methods for measuring the circulating concentrations of the作者: 頌揚(yáng)本人 時(shí)間: 2025-3-29 10:44
Conference proceedings 1978ist, the biochemist, and colleagues in other diciplines of theoretic medicine. When a drug, however, has so many attractive facets, it seems proper and aJvis- able for the success of a scientific meeting to focus on a number of well-defined aspects. This symposium was devoted to pharmacokinetics, dr作者: 散布 時(shí)間: 2025-3-29 11:54
Yunqiu Chen,Ryan A. McClure,Neil L. Kelleherl. (Herrmann & Repke, 1962; Lauterbach & Repke, 1960; Repke, 1970). The data have been confirmed by results of other authors in animais and man (Bergmann et al., 1972; Brown et al., 1956; Cox & Wright, 1959; Doherty & Perkins, 1962; Lage & Spratt, 1965).作者: ODIUM 時(shí)間: 2025-3-29 18:57
https://doi.org/10.1007/978-1-349-00412-6with chloroform. Ten hours after, this fraction decreases to a very low level. The purpose of this study is to describe the time-dependent occurrence of the polar fraction after digoxin, and to compare it with the behavior of digitoxin. Further, we have carried out some analytic work in the polar metabolites of digoxin.作者: 離開(kāi)真充足 時(shí)間: 2025-3-29 23:36
J. William Helton,John J. Wavrikdigitalis drugs and will take as a theme the suggestion that we should be working toward greater precision with digitalis therapy since it remains the commonest cause of adverse drug effects. Precision could be increased by several means:作者: mitten 時(shí)間: 2025-3-30 02:47 作者: 間接 時(shí)間: 2025-3-30 08:00
Chloroform-Extractable and Polar Metabolites Examined With Different Assays,l. (Herrmann & Repke, 1962; Lauterbach & Repke, 1960; Repke, 1970). The data have been confirmed by results of other authors in animais and man (Bergmann et al., 1972; Brown et al., 1956; Cox & Wright, 1959; Doherty & Perkins, 1962; Lage & Spratt, 1965).作者: Pseudoephedrine 時(shí)間: 2025-3-30 10:29
Occurence and Chemical Nature of Polar Water-Soluble Digoxin Metabolites,with chloroform. Ten hours after, this fraction decreases to a very low level. The purpose of this study is to describe the time-dependent occurrence of the polar fraction after digoxin, and to compare it with the behavior of digitoxin. Further, we have carried out some analytic work in the polar metabolites of digoxin.作者: Spirometry 時(shí)間: 2025-3-30 12:30
Bioavailability Studies: Their Influence on the Clinical Use of Digitalis,digitalis drugs and will take as a theme the suggestion that we should be working toward greater precision with digitalis therapy since it remains the commonest cause of adverse drug effects. Precision could be increased by several means:作者: Adenoma 時(shí)間: 2025-3-30 18:06
Clinical Interpretation of Serum Concentrations of Cardiac Glycosides,se drugs. To facilitate the interpretation of serum or plasma cardiac glycoside concentrations in the clinical context, we review in the present communication the available data regarding the relationship between serum concentrations of cardiac glycosides and their therapeutic and toxic effects.作者: 雜色 時(shí)間: 2025-3-30 21:01 作者: 闡明 時(shí)間: 2025-3-31 04:36
Maria I. Vizcaino,Jason M. Crawfordfying the announcement of a new assay for determining digoxin levels. Because the ELISA will always be compared with the RIA, some information on the RIA is also given in this report. This ELISA was developed by my colleague Dr. Kleinhammer.作者: 解決 時(shí)間: 2025-3-31 07:47 作者: 脆弱吧 時(shí)間: 2025-3-31 10:40
A New Simple Assay for Determining Digoxin Serum Levels,fying the announcement of a new assay for determining digoxin levels. Because the ELISA will always be compared with the RIA, some information on the RIA is also given in this report. This ELISA was developed by my colleague Dr. Kleinhammer.作者: defenses 時(shí)間: 2025-3-31 14:47
Plasma-Tissue Distribution of Different Cardiac Glycosides,-state” serum concentrations. Since the relationship between steady-state serum glycoside concentration and cardiac effect is still controversial, glycoside concentrations were determined in various human tissues in order to analyze the corrélation between serum concentration and tissue concentration.作者: Blood-Vessels 時(shí)間: 2025-3-31 20:18
Gene Christner,Kin Y. Li,James Rovnyakusly to another group of patients in the same decompensated clinical conditions. From these two studies then an absolute biovailability was calculated. In a third study, the absolute bioavailability was studied in patients with severe renal failure.作者: AVOID 時(shí)間: 2025-3-31 23:52 作者: WATER 時(shí)間: 2025-4-1 03:48 作者: persistence 時(shí)間: 2025-4-1 06:29
Digoxin Pharmacokinetics and Their Relation to Clinical Dosage Parameters,cal basis (Augsberger, 1951, 1954). It is particularly noteworthy that these calculations were performed without any knowledge of drug concentrations but by the use of analysis of clinical data on drug effects only; this is a rather modern approach.作者: 哀悼 時(shí)間: 2025-4-1 13:42 作者: Hiatal-Hernia 時(shí)間: 2025-4-1 15:52
A New Simple Assay for Determining Digoxin Serum Levels,r now). In the meantime, work on an enzyme immunoassay has been completed; therefore, we found it more appropriate to report on this assay, thus justifying the announcement of a new assay for determining digoxin levels. Because the ELISA will always be compared with the RIA, some information on the 作者: 消散 時(shí)間: 2025-4-1 20:04
Chloroform-Extractable and Polar Metabolites Examined With Different Assays, A similar pattern of methyldigoxin was described by Rietbrock and Abshagen (1973) and Abshagen et al. (1974). The chemical nature of these polar metabolites were thought to be the sulfuric and glucuronic acid conjugates of the bis- and monoglycosides and of aglucone, as first proposed by Repke et a作者: PAN 時(shí)間: 2025-4-2 02:23 作者: Hyperplasia 時(shí)間: 2025-4-2 05:15
Occurence and Chemical Nature of Polar Water-Soluble Digoxin Metabolites,etabolite fraction detectable in the urine, this phenomenon being first described in 1972 by Dwenger-Haberland (Dwenger and Haberland, 1972). The polar fraction in urine increases to a maximum 4 h after ingestion of the glycoside. At this time, half of the renally excreted amount is not extractable
