標(biāo)題: Titlebook: Carcinogenicity; The Design, Analysis Harold C. Grice,Joseph L. Ciminera Book 1988Latest edition Springer-Verlag New York Inc. 1988 cancer. [打印本頁] 作者: 復(fù)雜 時(shí)間: 2025-3-21 19:55
書目名稱Carcinogenicity影響因子(影響力)
書目名稱Carcinogenicity影響因子(影響力)學(xué)科排名
書目名稱Carcinogenicity網(wǎng)絡(luò)公開度
書目名稱Carcinogenicity網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Carcinogenicity被引頻次
書目名稱Carcinogenicity被引頻次學(xué)科排名
書目名稱Carcinogenicity年度引用
書目名稱Carcinogenicity年度引用學(xué)科排名
書目名稱Carcinogenicity讀者反饋
書目名稱Carcinogenicity讀者反饋學(xué)科排名
作者: 松緊帶 時(shí)間: 2025-3-21 23:19
https://doi.org/10.1007/978-3-642-97450-2For simplicity, I will discuss assumptions about analysis of tumor incidence data, although what I have to say is just as relevant to analysis of incidence of nonneoplastic lesions.作者: 出處 時(shí)間: 2025-3-22 03:25
Business Cycles: Continuous Time,The presentations made in the first session were fairly general, which led to a spectrum of comments in the discussion period. Many of the questions raised were addressed in more detail in later sessions.作者: 健壯 時(shí)間: 2025-3-22 04:35 作者: 寬宏大量 時(shí)間: 2025-3-22 10:14 作者: 小步舞 時(shí)間: 2025-3-22 14:08
https://doi.org/10.1007/978-3-642-61364-7cancer; carcinogenesis; classification; pathology; tissue作者: 小步舞 時(shí)間: 2025-3-22 20:18 作者: 爭吵加 時(shí)間: 2025-3-22 23:58 作者: 鴕鳥 時(shí)間: 2025-3-23 01:39 作者: Heterodoxy 時(shí)間: 2025-3-23 07:23
Business Cycles: Discrete Space,ts, and those concerned with the biology of cancer and the basic nature of the test procedure (Table 2.1). Behind both is the question of why the experiment is being done in the first place. Is there an entirely academic interest in knowing if exposure to a substance under any conditions can produce作者: 沙發(fā) 時(shí)間: 2025-3-23 12:02
https://doi.org/10.1007/978-3-662-00754-9oups evaluated relative to those in unexposed controls (Bickis and Krewski, 1985a). The untreated animals are maintained on test at the same time as the treated animals and housed under the same conditions in the same laboratory. Because the concurrent controls are thus similar to the exposed animal作者: Ethics 時(shí)間: 2025-3-23 16:21
https://doi.org/10.1007/978-3-662-00754-9nmental chemicals or pharmaceutical agents. Such studies are generally performed in both sexes of two rodent species, typically rats and mice, over a period of about 24 months. Chronic toxicity studies are also carried out in larger laboratory animal species, such as monkeys or dogs. The duration of作者: embolus 時(shí)間: 2025-3-23 18:35
https://doi.org/10.1007/978-3-662-00754-9s presentation) were discussed. Some expressed the point of view that these inconsistencies made effective utilization of historical control data quite difficult. One way of overcoming the difficulty introduced by varied nomenclature and diagnostic criteria is to have the primary pathologist or seve作者: 大炮 時(shí)間: 2025-3-23 23:05 作者: 入會(huì) 時(shí)間: 2025-3-24 05:47 作者: Uncultured 時(shí)間: 2025-3-24 07:57 作者: Distribution 時(shí)間: 2025-3-24 11:47 作者: resistant 時(shí)間: 2025-3-24 18:21
Akio Matsumoto,Ferenc Szidarovszkyto assess the potential carcinogenic effect of compounds. Unfortunately, decades of carcinogenicity testing have failed to provide an unequivocal set of guidelines that determines the true carcinogenic potential of a compound in laboratory animals or humans. Furthermore, there is often considerable 作者: bypass 時(shí)間: 2025-3-24 22:18 作者: Narrative 時(shí)間: 2025-3-25 02:07
Steady Flow of Slightly Viscoelastic Fluids,m of development from hyperplasia through benign to malignant tumors has not been clearly demonstrated in many tissues, and we should not presume that this always occurs. Responses referred to the demonstrated multistage development of cancer and also to the fact that no assumption of progression of作者: FELON 時(shí)間: 2025-3-25 07:10
https://doi.org/10.1007/978-1-4684-1788-3 adverse effect. These studies are conducted in laboratory animals. One of the key elements in interpretation of these studies is the histopathologic evaluation of tissues from the test animals. From this evaluation, the incidences of various lesions observed can be compared between treated and cont作者: Cytokines 時(shí)間: 2025-3-25 08:19 作者: ESO 時(shí)間: 2025-3-25 13:48
Akio Matsumoto,Ferenc Szidarovszkyeral issues related to dose selection, including number and spacing of doses and selection of the highest dose, were mentioned during the formal presentations, the informal discussion centered primarily on the selection of the highest dose level.作者: Factorable 時(shí)間: 2025-3-25 16:33 作者: Foolproof 時(shí)間: 2025-3-25 20:29 作者: 拔出 時(shí)間: 2025-3-26 00:48
Statistical Tests with Historical Controlsoups evaluated relative to those in unexposed controls (Bickis and Krewski, 1985a). The untreated animals are maintained on test at the same time as the treated animals and housed under the same conditions in the same laboratory. Because the concurrent controls are thus similar to the exposed animal作者: ALLAY 時(shí)間: 2025-3-26 06:41
The Value of Historical Control Datanmental chemicals or pharmaceutical agents. Such studies are generally performed in both sexes of two rodent species, typically rats and mice, over a period of about 24 months. Chronic toxicity studies are also carried out in larger laboratory animal species, such as monkeys or dogs. The duration of作者: FLAIL 時(shí)間: 2025-3-26 09:16 作者: 最后一個(gè) 時(shí)間: 2025-3-26 12:54
Integration of Pharmacokinetics and Pathological Data in Dose Selection for Chronic Bioassays of pharmacokinetics to the design and interpretation of toxicology studies is the concept of dose-dependent or nonlinear kinetics. Many of the physiological and biochemical processes that affect the disposition of chemicals in the body are capacity limited (i.e., saturable). When any of the rate-li作者: 錯(cuò)事 時(shí)間: 2025-3-26 18:07 作者: 粘 時(shí)間: 2025-3-26 22:09
Dose Selectioneral issues related to dose selection, including number and spacing of doses and selection of the highest dose, were mentioned during the formal presentations, the informal discussion centered primarily on the selection of the highest dose level.作者: PANG 時(shí)間: 2025-3-27 03:42
Criteria for Classification of Neoplasms for Pathologists and Statisticiansed from rodent carcinogenesis studies (Greaves and Faccini, 1984). It is evident that statistical analysis of such pathology data will continue to be essential for the process of human risk estimation. Much of this data is tabulated (converted to numbers) on the basis of classification schemes selec作者: 并入 時(shí)間: 2025-3-27 06:09 作者: 難取悅 時(shí)間: 2025-3-27 12:15
Statistical Considerations in the Evaluation of Graded Responses in Carcinogenesis Studieslasms are observed in treated groups relative to controls (International Agency for Research on Cancer, 1980; Office of Science and Technology Policy, 1985). Related nonneoplastic lesions are also considered in the overall interpretation of the data.作者: 漫不經(jīng)心 時(shí)間: 2025-3-27 16:00
Criteria for Classifying Neoplasms and Use of Data on Nonneoplastic Lesionsm of development from hyperplasia through benign to malignant tumors has not been clearly demonstrated in many tissues, and we should not presume that this always occurs. Responses referred to the demonstrated multistage development of cancer and also to the fact that no assumption of progression of作者: 解脫 時(shí)間: 2025-3-27 18:24
Factors Affecting Histopathologic Interpretation of Toxicity—Carcinogenicity Studies adverse effect. These studies are conducted in laboratory animals. One of the key elements in interpretation of these studies is the histopathologic evaluation of tissues from the test animals. From this evaluation, the incidences of various lesions observed can be compared between treated and cont作者: infelicitous 時(shí)間: 2025-3-27 22:47 作者: Systemic 時(shí)間: 2025-3-28 03:12 作者: 忘恩負(fù)義的人 時(shí)間: 2025-3-28 06:47
https://doi.org/10.1007/978-3-662-00754-9e difficult. One way of overcoming the difficulty introduced by varied nomenclature and diagnostic criteria is to have the primary pathologist or several pathologists re-evaluate histological sections of the tissue in question from a defined series of historical control groups.作者: 豐滿有漂亮 時(shí)間: 2025-3-28 12:59 作者: 過濾 時(shí)間: 2025-3-28 17:07 作者: 裂口 時(shí)間: 2025-3-28 20:05 作者: Sinus-Node 時(shí)間: 2025-3-28 23:54 作者: Prologue 時(shí)間: 2025-3-29 04:45
https://doi.org/10.1007/978-3-662-00754-9nd/or activated metabolites may not be directly proportional to the administered dose. Instead, disproportionate increases or decreases may be observed with concurrent effects upon toxicity. Levy (1968) described some of the criteria that suggest that such saturation may be occurring:作者: Trochlea 時(shí)間: 2025-3-29 07:42 作者: CURL 時(shí)間: 2025-3-29 13:53
Integration of Pharmacokinetics and Pathological Data in Dose Selection for Chronic Bioassaysnd/or activated metabolites may not be directly proportional to the administered dose. Instead, disproportionate increases or decreases may be observed with concurrent effects upon toxicity. Levy (1968) described some of the criteria that suggest that such saturation may be occurring:作者: 手段 時(shí)間: 2025-3-29 19:39
Factors Affecting Histopathologic Interpretation of Toxicity—Carcinogenicity Studiesic evaluation is the responsibility of the pathologist. To understand the data generated by the pathologist, it is necessary to have a general understanding of pathology and to be aware of some of the factors which can affect the histopathologic interpretation of toxicity-carcinogenicity studies.作者: 植物茂盛 時(shí)間: 2025-3-29 22:08
Business Cycles: Discrete Space, tumors (and, if so, of what type), or is the objective the very practical need to reveal a carcinogenic hazard under particular experimental circumstances and to extrapolate to the risk of that action in a different target species under other conditions?
