標(biāo)題: Titlebook: Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications; Susan C. Frost,Robert McKenna Book 2014 Springer [打印本頁] 作者: 熱情美女 時(shí)間: 2025-3-21 17:38
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書目名稱Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications被引頻次
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書目名稱Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications讀者反饋
書目名稱Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications讀者反饋學(xué)科排名
作者: muster 時(shí)間: 2025-3-21 20:19
Vasile Marinca,Nicolae Herisanuor novel carbonic anhydrase inhibitors. This chapter will highlight the recent and growing interest in carbonic anhydrase inhibitors sourced from nature, demonstrating that natural product chemical space presents a rich source of potential alternate chemotypes for the discovery of novel drug-like carbonic anhydrase inhibitors.作者: 燕麥 時(shí)間: 2025-3-22 01:43
Prokaryotic Carbonic Anhydrases of Earth’s Environmentes decomposing the photosynthate back to CO. thereby closing the global carbon cycle. This review focuses on the physiology and biochemistry of carbonic anhydrases from prokaryotes belonging to the domains . and . that play key roles in the ecology of Earth’s biosphere.作者: 行業(yè) 時(shí)間: 2025-3-22 07:06 作者: Implicit 時(shí)間: 2025-3-22 11:23 作者: Glaci冰 時(shí)間: 2025-3-22 14:11
Dmitry E. Pelinovsky,Aaron Saalmannure and catalytic mechanism of the other CA classes. The overall catalytic site structure and geometry of α-CAs are described in the first section of this chapter followed by the kinetic studies, binding of CO., and the proton shuttle network.作者: Glaci冰 時(shí)間: 2025-3-22 19:38
Catastrophe Theory and Economic Dynamics, is discussed. Both antibodies and small molecular weight compounds have been used for targeted imaging of CAIX expression. The use of CAIX expression as an attractive and promising candidate marker for systemic anticancer therapy is also discussed.作者: 遭受 時(shí)間: 2025-3-22 22:20
Catalytic Mechanism of α-Class Carbonic Anhydrases: CO2 Hydration and Proton Transferure and catalytic mechanism of the other CA classes. The overall catalytic site structure and geometry of α-CAs are described in the first section of this chapter followed by the kinetic studies, binding of CO., and the proton shuttle network.作者: 抗體 時(shí)間: 2025-3-23 01:29
Carbonic Anhydrase IX as an Imaging and Therapeutic Target for Tumors and Metastases is discussed. Both antibodies and small molecular weight compounds have been used for targeted imaging of CAIX expression. The use of CAIX expression as an attractive and promising candidate marker for systemic anticancer therapy is also discussed.作者: Pamphlet 時(shí)間: 2025-3-23 08:54 作者: Paleontology 時(shí)間: 2025-3-23 12:05 作者: 反饋 時(shí)間: 2025-3-23 17:42
0306-0225 rs at the forefront of the carbonic anhydrase field.Mix of tThe study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contr作者: aristocracy 時(shí)間: 2025-3-23 22:01 作者: intrigue 時(shí)間: 2025-3-24 01:50
Structure and Catalytic Mechanism of β-Carbonic Anhydrasesthat produce or utilize CO. or HCO... β-CA is required for normal growth for many organisms. Unique among the five different families of carbonic anhydrases, β-CA is the only family of carbonic anhydrase to exhibit allostery. This chapter summarizes the structure, catalytic mechanism, and allosteric regulation of β-CA.作者: 藥物 時(shí)間: 2025-3-24 02:23 作者: 去才蔑視 時(shí)間: 2025-3-24 07:28
978-94-024-0250-6Springer Science+Business Media Dordrecht 2014作者: 殺子女者 時(shí)間: 2025-3-24 12:26 作者: 微不足道 時(shí)間: 2025-3-24 17:34 作者: 天賦 時(shí)間: 2025-3-24 19:31 作者: GLADE 時(shí)間: 2025-3-25 00:04
Christian Klein,Jean-Claude Sautsive, as only a few of the lead researchers around the world contributed; it serves only to show that the CA field is still pushing the boundaries of research as it has done since its discovery, and will do for a long time to come.作者: Patrimony 時(shí)間: 2025-3-25 04:06 作者: 表被動(dòng) 時(shí)間: 2025-3-25 11:29
Christian Klein,Jean-Claude Sautsive, as only a few of the lead researchers around the world contributed; it serves only to show that the CA field is still pushing the boundaries of research as it has done since its discovery, and will do for a long time to come.作者: Enteropathic 時(shí)間: 2025-3-25 11:49 作者: Digest 時(shí)間: 2025-3-25 17:00
Dmitry E. Pelinovsky,Aaron Saalmannn of bicarbonate (HCO..) in a two-step ping-pong mechanism: .CAs are ubiquitous enzymes and are categorized into five distinct classes (α, β, γ, δ and ζ). The α-class is found primarily in vertebrates (and the only class of CA in mammals), β is observed in higher plants and some prokaryotes, γ is pr作者: FELON 時(shí)間: 2025-3-25 22:23 作者: indecipherable 時(shí)間: 2025-3-26 01:58
Nonlinear Dynamic Phenomena in Mechanicsen described for which one or more are found in nearly every cell type underscoring the general importance of this ubiquitous enzyme in Nature. The bulk of research to date has centered on the enzymes from mammals and plants with less emphasis on prokaryotes. Prokaryotic carbonic anhydrases play imp作者: IDEAS 時(shí)間: 2025-3-26 08:14
Solid Mechanics and Its ApplicationsHowever, converting bicarbonate into carbon dioxide – the form required by RubisCO – would result in its rapid escape through cellular membranes. These organisms resolve this dilemma by sequestering RubisCO behind a semi-permeable protein shell; the resulting large insoluble bodies are known as carb作者: facilitate 時(shí)間: 2025-3-26 12:31 作者: DEAF 時(shí)間: 2025-3-26 15:27 作者: 值得贊賞 時(shí)間: 2025-3-26 17:20 作者: MEEK 時(shí)間: 2025-3-26 22:54 作者: Morphine 時(shí)間: 2025-3-27 03:18 作者: 復(fù)習(xí) 時(shí)間: 2025-3-27 08:49
Catastrophe Theory and Economic Dynamics,tutively up-regulated in several cancer types and has an important role in tumor progression, acidification and metastasis. High expression of CAIX generally correlates with poor prognosis and is related to a decrease in the disease-free interval following successful therapy. Therefore, it is consid作者: gratify 時(shí)間: 2025-3-27 11:30 作者: 鄙視讀作 時(shí)間: 2025-3-27 15:45
Nonlinear Dynamical Systems in Economicsenerated “extrinsically” via mechanisms that regulate the acid–base status of the whole organism; and “intrinsically”, by activity-induced transmembrane fluxes and . generation of acid–base equivalents. The effects of pH changes on neuronal excitability are mediated by diverse, largely synergistical作者: DIS 時(shí)間: 2025-3-27 20:41 作者: MILK 時(shí)間: 2025-3-27 22:31
Vasile Marinca,Nicolae Herisanuts as molecular probes. Almost all reported carbonic anhydrase inhibitors comprise a zinc binding group in their structure of which the primary sulfonamide moiety (-SO.NH.) is the foremost example and to a lesser extent the primary sulfamate (-O-SO.NH.) and sulfamide (-NH-SO.NH.) groups. Natural pro作者: oracle 時(shí)間: 2025-3-28 03:21
Optimal Parametric Iteration Method,eople and characterized by an elevated intraocular pressure (IOP). At least three isoforms, CA II, IV and XII are targeted by the sulfonamide inhibitors, some of which are clinically used drugs. Acetazolamide, methazolamide and dichlorophenamide are first generation CA inhibitors (CAIs) still used a作者: 惡臭 時(shí)間: 2025-3-28 09:25
Overview of the Carbonic Anhydrase Familysive, as only a few of the lead researchers around the world contributed; it serves only to show that the CA field is still pushing the boundaries of research as it has done since its discovery, and will do for a long time to come.作者: 不能強(qiáng)迫我 時(shí)間: 2025-3-28 13:13
Physiological Functions of the Alpha Class of Carbonic Anhydrasesound in the deepest of branches of the evolutionary tree. Of the five different classes of carbonic anhydrases, the alpha class has perhaps received the most attention because of its role in human pathology. This review focuses on the physiological function of this class of carbonic anhydrases organized by their cellular location.作者: GROVE 時(shí)間: 2025-3-28 15:17 作者: Intuitive 時(shí)間: 2025-3-28 19:57
Physiological Functions of the Alpha Class of Carbonic Anhydrasesound in the deepest of branches of the evolutionary tree. Of the five different classes of carbonic anhydrases, the alpha class has perhaps received the most attention because of its role in human pathology. This review focuses on the physiological function of this class of carbonic anhydrases organ作者: Polydipsia 時(shí)間: 2025-3-29 02:49 作者: Palpate 時(shí)間: 2025-3-29 03:37
Structure and Catalytic Mechanism of β-Carbonic Anhydrases, and invertebrates. Like all carbonic anhydrases, β-CAs catalyze the reaction CO. + H.O ? HCO.. + H., and is typically associated with other enzymes that produce or utilize CO. or HCO... β-CA is required for normal growth for many organisms. Unique among the five different families of carbonic anhy作者: Conscientious 時(shí)間: 2025-3-29 09:34 作者: FIN 時(shí)間: 2025-3-29 13:06 作者: Iatrogenic 時(shí)間: 2025-3-29 18:44
Carbonic Anhydrases and Their Interplay with Acid/Base-Coupled Membrane Transportersr consume protons and bicarbonate, but also as intra- and extracellular proteins, which facilitate transport function of many acid/base transporting membrane proteins, coined ‘transport metabolon’. Functional interaction between CAs and acid/base transporters, such as chloride/bicarbonate exchanger 作者: 舔食 時(shí)間: 2025-3-29 21:54 作者: Arthropathy 時(shí)間: 2025-3-30 02:13 作者: 放逐某人 時(shí)間: 2025-3-30 06:48
Carbonic Anhydrase Expression in Kidney and Renal Cancer: Implications for Diagnosis and Treatmentt nephron segments, emphasizing the critical role carbonic anhydrases play in maintaining the homeostasis of this crucial organ..Whereas the localization of carbonic anhydrases in the kidney has been long established, interest in carbonic anhydrases has increased dramatically for renal cancer, in pa作者: 得體 時(shí)間: 2025-3-30 08:26 作者: 舉止粗野的人 時(shí)間: 2025-3-30 14:28
Carbonic Anhydrase IX as an Imaging and Therapeutic Target for Tumors and Metastasestutively up-regulated in several cancer types and has an important role in tumor progression, acidification and metastasis. High expression of CAIX generally correlates with poor prognosis and is related to a decrease in the disease-free interval following successful therapy. Therefore, it is consid作者: SSRIS 時(shí)間: 2025-3-30 20:17 作者: forthy 時(shí)間: 2025-3-30 22:58 作者: saphenous-vein 時(shí)間: 2025-3-31 02:33 作者: 異教徒 時(shí)間: 2025-3-31 08:16 作者: 分發(fā) 時(shí)間: 2025-3-31 10:30
