標(biāo)題: Titlebook: Cancer Therapeutics; Experimental and Cli Beverly A. Teicher Book 1997 Springer Science+Business Media New York 1997 DNA.angiogenesis.cance [打印本頁] 作者: Baleful 時(shí)間: 2025-3-21 17:49
書目名稱Cancer Therapeutics影響因子(影響力)
書目名稱Cancer Therapeutics影響因子(影響力)學(xué)科排名
書目名稱Cancer Therapeutics網(wǎng)絡(luò)公開度
書目名稱Cancer Therapeutics網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Cancer Therapeutics被引頻次
書目名稱Cancer Therapeutics被引頻次學(xué)科排名
書目名稱Cancer Therapeutics年度引用
書目名稱Cancer Therapeutics年度引用學(xué)科排名
書目名稱Cancer Therapeutics讀者反饋
書目名稱Cancer Therapeutics讀者反饋學(xué)科排名
作者: 不斷的變動(dòng) 時(shí)間: 2025-3-21 23:42 作者: PAN 時(shí)間: 2025-3-22 00:55
The Enediynes-related and idiosyncratic types (.), and led to curtailment of preclinical and clinical studies of this drug in this country, and efforts to synthesize and isolate novel enediyne compounds that might not engender these difficulties. This chapter deals with the enediynes as a class. Because of its r作者: 無關(guān)緊要 時(shí)間: 2025-3-22 07:53
Book 1997ecules from the chemical industry, especially dyestuffs and warfare agents, and natural products from plants, microbes, and fungi have all been potential sources of pharmaceuticals, including anticancer agents. There is no shortage of molecules; the challenge has been and continues to be methods of 作者: Notify 時(shí)間: 2025-3-22 10:51
2196-9906 een potential sources of pharmaceuticals, including anticancer agents. There is no shortage of molecules; the challenge has been and continues to be methods of 978-1-61737-046-5978-1-59259-717-8Series ISSN 2196-9906 Series E-ISSN 2196-9914 作者: 痛苦一生 時(shí)間: 2025-3-22 15:10 作者: 痛苦一生 時(shí)間: 2025-3-22 19:42 作者: 學(xué)術(shù)討論會(huì) 時(shí)間: 2025-3-23 01:01
https://doi.org/10.1007/978-81-322-2089-3-related and idiosyncratic types (.), and led to curtailment of preclinical and clinical studies of this drug in this country, and efforts to synthesize and isolate novel enediyne compounds that might not engender these difficulties. This chapter deals with the enediynes as a class. Because of its r作者: 異端 時(shí)間: 2025-3-23 05:11 作者: forbid 時(shí)間: 2025-3-23 09:15 作者: 昏迷狀態(tài) 時(shí)間: 2025-3-23 12:32
Sequence-Selective Groove Bindersrugs. They exert their cytotoxic effect principally as a consequence of the lack of selectivity by damaging cellular DNA. Cytotoxic and antiproliferative drugs have played and will likely continue to play a major role in cancer chemotherapy.作者: 捏造 時(shí)間: 2025-3-23 16:29 作者: GULF 時(shí)間: 2025-3-23 21:20
Immunoconjugatesosera with well-defined antitumor reactivity. The isolation in 1967 of an agglutinin from wheat germ that identified a tumor-specific determinant on neoplastic cell surfaces . marked the first time that a pure molecular species was available for targeting of tumors.作者: bibliophile 時(shí)間: 2025-3-23 23:23 作者: 偽書 時(shí)間: 2025-3-24 06:20 作者: BOOM 時(shí)間: 2025-3-24 09:09
Mark S. Hybertsen,Michael Schlütermore, Hippocrates’ concept of a localized imbalance of “Humors” is essentially identical to our current understanding that extracellular matrix degradation and tumor cell migration are dependent on a critical balance between activated proteases and their endogenous inhibitors.作者: 彎曲的人 時(shí)間: 2025-3-24 12:21
Matrix Metalloproteinase Inhibitorsmore, Hippocrates’ concept of a localized imbalance of “Humors” is essentially identical to our current understanding that extracellular matrix degradation and tumor cell migration are dependent on a critical balance between activated proteases and their endogenous inhibitors.作者: 重疊 時(shí)間: 2025-3-24 16:22
2196-9906 and discover better therapies against cancer, investigators all over the world have increased our knowledge of cell biology, biochemistry, and molecular biology. The goal has been to define therapeuti- cally exploitable differences between normal and malignant cells. The result has been an increased作者: Meditative 時(shí)間: 2025-3-24 22:19
A. V. Karpov,V. I. Zagrebaev,W. GreinerFig. 1), are the only phosphorylated mustard compounds ordinarily prescribed for cancer treatment today (.). The developmental work that led to their prominent role in medicine and the outgrowth of prospective agents based on their structures and activities will be presented in this chapter.作者: 債務(wù) 時(shí)間: 2025-3-25 01:05 作者: superfluous 時(shí)間: 2025-3-25 06:58 作者: bisphosphonate 時(shí)間: 2025-3-25 08:48 作者: Employee 時(shí)間: 2025-3-25 13:26
Interferons and Other Cytokinesss biological activities that make them attractive for cancer therapy. Results of clinical trials to date indicate that cytokines may be used along with other current cancer therapies and may eventually replace some of these.作者: 迅速成長 時(shí)間: 2025-3-25 19:30 作者: Vulnerable 時(shí)間: 2025-3-25 23:28
H. Geissel,G. Münzenberg,C. Scheidenbergerion studies. These contributions are all discussed in the following chapter. Additionally, since the nitrosoureas are still under active investigation, it is reasonable to hope that further advances in basic research may lead to additional improvements in the clinical use of these agents.作者: 鋪?zhàn)?nbsp; 時(shí)間: 2025-3-26 02:14
Ramesh Babu Veegala,Shashi Vemurirugs. They exert their cytotoxic effect principally as a consequence of the lack of selectivity by damaging cellular DNA. Cytotoxic and antiproliferative drugs have played and will likely continue to play a major role in cancer chemotherapy.作者: 小木槌 時(shí)間: 2025-3-26 06:14
https://doi.org/10.1007/978-94-011-3190-2s common to the action of various pathways, with mention of individual agents as they exemplify these strategies. In addition, opportunities for interdigitation of “growth-factor directed” and “traditional” therapeutic agents will be considered.作者: nitric-oxide 時(shí)間: 2025-3-26 12:17
K. K. Kapiyangoda,R. H. Surangi Lewisosera with well-defined antitumor reactivity. The isolation in 1967 of an agglutinin from wheat germ that identified a tumor-specific determinant on neoplastic cell surfaces . marked the first time that a pure molecular species was available for targeting of tumors.作者: Confess 時(shí)間: 2025-3-26 13:30
Phosphoramide and Oxazaphosphorine Mustardsompounds, the aryl- and alkyl-bis(2-chloroethyl)amines, were covered in the previous chapter. Two oxazaphosphorines, cyclophosphamide and ifosfamide (Fig. 1), are the only phosphorylated mustard compounds ordinarily prescribed for cancer treatment today (.). The developmental work that led to their 作者: BARK 時(shí)間: 2025-3-26 19:13 作者: 阻擋 時(shí)間: 2025-3-26 21:51
Platinum Complexesncology physician. Interestingly, the chemical identity of cisplatin was first established in the mid-19th century (and known as Peyrone’s chloride) and, were it not for the well-documented serendipitous observations of Barnett Rosenberg while performing experiments investigating the effects of elec作者: 鑒賞家 時(shí)間: 2025-3-27 02:18 作者: Dysarthria 時(shí)間: 2025-3-27 08:44
Topoisomerase I Inhibitorss can also be coiled in circular DNA. This structure was called supercoiling. This finding was extended to linear DNA by Pettijohn and others (.). It is now known that practically all DNA in vivo is supercoiled (.). Because most of the functions of DNA require untwisting, the importance of the enzym作者: 夸張 時(shí)間: 2025-3-27 13:15 作者: watertight, 時(shí)間: 2025-3-27 15:39
Bis-Naphthalimidesicin and daunomycin, were originally isolated from natural sources, other compounds are synthetic organic molecules specifically designed as antineoplastic agents. Arcamone has classified these drugs on the basis of DNA interaction into:作者: Innovative 時(shí)間: 2025-3-27 19:26
The Enediynesnostatin” and was thereafter determined to be an antimitotic agent (.). What followed was a long series of structural and chemical studies of neocarzinostatin, largely spearheaded by Goldberg and his colleagues (reviewed in 3), and culminating in clinical trials in Japan and the US (.). The Japanese作者: CLEFT 時(shí)間: 2025-3-28 00:05
Matrix Metalloproteinase Inhibitorscribed invading tendrils of tumor tissue and the resulting destruction of bone and soft tissue, ascribed this behavior to an imbalance of the “Four Humors” resulting in a local excess of one of these, which he called “black bile” (.). This theory was later extended by Galen (131–203 .), who proposed作者: grudging 時(shí)間: 2025-3-28 04:28 作者: capillaries 時(shí)間: 2025-3-28 07:56
Discovery of TNP-470 and Other Angiogenesis Inhibitors cells. Because many normal tissues contain stem cells that also proliferate rapidly (e.g., bone marrow, hair follicles, intestines), these types of agents often cause many side effects, and thus, their clinical effectiveness is limited. For this reason, many in the cancer field have begun to pursue作者: Afflict 時(shí)間: 2025-3-28 11:22
Antisense Oligonucleotides, that have not been studied as potential drugs before and uses them to intervene in processes that, likewise, have not been studied as sites at which drugs might act. Although the field is still in its infancy, it has generated considerable enthusiasm because of the potential specificity of oligonu作者: Feigned 時(shí)間: 2025-3-28 15:26 作者: 可轉(zhuǎn)變 時(shí)間: 2025-3-28 21:27 作者: 刪除 時(shí)間: 2025-3-28 23:23
Bis-Naphthalimidesicin and daunomycin, were originally isolated from natural sources, other compounds are synthetic organic molecules specifically designed as antineoplastic agents. Arcamone has classified these drugs on the basis of DNA interaction into:作者: 南極 時(shí)間: 2025-3-29 03:30 作者: ascend 時(shí)間: 2025-3-29 08:56
Cancer Drug Discovery and Developmenthttp://image.papertrans.cn/c/image/221212.jpg作者: 清唱?jiǎng)?nbsp; 時(shí)間: 2025-3-29 13:09
https://doi.org/10.1007/978-3-319-44165-8The use of mustard gas in World War I dramatically demonstrated the biological potential of alkylating agents. In addition to the vesicant action of sulfur mustard to the skin, conjunctiva, and respiratory tract, the myelosuppressive and lymphocytolytic effects were first documented by Krumbhaar and Krumbhaar in 1919 (.).作者: 逢迎白雪 時(shí)間: 2025-3-29 18:33 作者: 填料 時(shí)間: 2025-3-29 23:18 作者: Protein 時(shí)間: 2025-3-30 02:32 作者: AVANT 時(shí)間: 2025-3-30 04:26 作者: 出生 時(shí)間: 2025-3-30 10:08 作者: hypertension 時(shí)間: 2025-3-30 14:50
A. V. Karpov,V. I. Zagrebaev,W. Greinerompounds, the aryl- and alkyl-bis(2-chloroethyl)amines, were covered in the previous chapter. Two oxazaphosphorines, cyclophosphamide and ifosfamide (Fig. 1), are the only phosphorylated mustard compounds ordinarily prescribed for cancer treatment today (.). The developmental work that led to their 作者: 間諜活動(dòng) 時(shí)間: 2025-3-30 18:48 作者: reserve 時(shí)間: 2025-3-30 22:13 作者: –scent 時(shí)間: 2025-3-31 02:47
J. H. Hamilton,A. V. Ramayya,E. H. Wangfort to discover other antibiotic substances for potential use in the treatment of malignancies. As a result, cancer chemotherapy was altered immeasurably more than 30 years ago by the independent discoveries by Grein (.), Dubost (.), and their colleagues of an anthracycline antibiotic, derived from作者: 車床 時(shí)間: 2025-3-31 05:51
https://doi.org/10.1007/978-3-319-44165-8s can also be coiled in circular DNA. This structure was called supercoiling. This finding was extended to linear DNA by Pettijohn and others (.). It is now known that practically all DNA in vivo is supercoiled (.). Because most of the functions of DNA require untwisting, the importance of the enzym作者: 爆米花 時(shí)間: 2025-3-31 11:20 作者: 四牛在彎曲 時(shí)間: 2025-3-31 14:06
