標題: Titlebook: Cancer Driver Genes; Methods and Protocol Timothy K. Starr Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 thr [打印本頁] 作者: Extraneous 時間: 2025-3-21 19:01
書目名稱Cancer Driver Genes影響因子(影響力)
書目名稱Cancer Driver Genes影響因子(影響力)學科排名
書目名稱Cancer Driver Genes網(wǎng)絡公開度
書目名稱Cancer Driver Genes網(wǎng)絡公開度學科排名
書目名稱Cancer Driver Genes被引頻次
書目名稱Cancer Driver Genes被引頻次學科排名
書目名稱Cancer Driver Genes年度引用
書目名稱Cancer Driver Genes年度引用學科排名
書目名稱Cancer Driver Genes讀者反饋
書目名稱Cancer Driver Genes讀者反饋學科排名
作者: Emmenagogue 時間: 2025-3-21 21:05
Role of the Cell in Neutralization,s are only prescribed to patients that express the tyrosine kinase protein on their cancer cells. Likewise, a genetically unstable cancer is predictive for successful immunotherapy. Knowledge of the specific genetic changes that result in overproduction of oncogenes and reduced production of tumor s作者: euphoria 時間: 2025-3-22 01:07
Event Reconstruction and Data Selection,quencing data. Moreover, researchers can use the “Gene” section to explore a single driver gene in all cancers by different kinds of aspects after identifying the specific driver genes by “Meta-Analysis.” DriverDB is available at ..作者: 蚊帳 時間: 2025-3-22 07:56 作者: FAWN 時間: 2025-3-22 10:56
https://doi.org/10.1007/978-4-431-55462-2nes that promote growth factor independence and transformation of murine Ba/F3 cells. Here we describe a method for performing ex vivo .-mediated mutagenesis screens in these cells, which may be adapted for the acquisition of many different phenotypes in distinct cell types.作者: BORE 時間: 2025-3-22 16:31 作者: BORE 時間: 2025-3-22 17:52 作者: muscle-fibers 時間: 2025-3-23 00:58
Cancer Gene Discovery: Past to Present,s are only prescribed to patients that express the tyrosine kinase protein on their cancer cells. Likewise, a genetically unstable cancer is predictive for successful immunotherapy. Knowledge of the specific genetic changes that result in overproduction of oncogenes and reduced production of tumor s作者: LINES 時間: 2025-3-23 04:34 作者: 失敗主義者 時間: 2025-3-23 05:42 作者: 減弱不好 時間: 2025-3-23 11:14 作者: 咒語 時間: 2025-3-23 15:22
Cancer Gene Discovery Utilizing , Transposon Mutagenesise efforts that have been directed toward identifying how genes and environmental factors influence human health in recent years. In the age of personalized medicine, the versatility of . provides numerous genetic engineering avenues for answering novel questions in basic and applied research. This c作者: 耕種 時間: 2025-3-23 21:59 作者: mastoid-bone 時間: 2025-3-24 01:23 作者: 描述 時間: 2025-3-24 03:47
Book 2019cer Driver Genes: Methods and Protocols .aims to provide?protocols that will be used and adapted by cancer researchers to expand the knowledge base of molecular mechanisms contributing to initiation, progression, and metastasis of cancer...?..?.作者: CRP743 時間: 2025-3-24 06:42 作者: 想象 時間: 2025-3-24 13:35 作者: AVOID 時間: 2025-3-24 15:54 作者: irreparable 時間: 2025-3-24 20:55 作者: 的闡明 時間: 2025-3-25 02:42
Neutrino Mass, Mixing, and Flavor Change,ategy relies on identifying protein-interaction interfaces that are unexpectedly biased toward nonsynonymous mutations, which suggests that these interfaces are subject to positive selection during tumorigenesis, implicating the interacting proteins as candidate drivers.作者: Bravura 時間: 2025-3-25 06:57 作者: ATP861 時間: 2025-3-25 10:14 作者: Confess 時間: 2025-3-25 15:14
KARMEN: Neutrino Physics at ISIS. In this protocol we describe a method of chromosomal engineering in mice that allows modeling of chromosomal duplications and deficiencies. This method faithfully recapitulates several aspects of chromosomal loss and gain in human cancers and can reveal cancer drivers difficult to identify by other means.作者: 迫擊炮 時間: 2025-3-25 17:07 作者: Distribution 時間: 2025-3-25 22:38 作者: 字形刻痕 時間: 2025-3-26 03:55
Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Linese monitored over time through high-throughput sequencing of the integrated sgRNA expression cassettes. Using this technique, we outline strategies for the identification of cancer driver genes and genes mediating drug response.作者: 透明 時間: 2025-3-26 05:06 作者: inhumane 時間: 2025-3-26 09:02
1064-3745 ation advice from the experts.This book presents protocols for identification of genetic drivers of cancer. Chapters guide readers through a brief history of cancer gene discovery,?.in silico.?approaches,?.in vitro.?approaches, and?.in vivo.?approaches using forward genetic screens in mice.?Written 作者: Desert 時間: 2025-3-26 13:26 作者: Coma704 時間: 2025-3-26 18:54 作者: Camouflage 時間: 2025-3-26 23:36 作者: 聯(lián)合 時間: 2025-3-27 02:14 作者: landmark 時間: 2025-3-27 05:30
Arrayed shRNA Screening to Identify Suppressors of Anchorage-Independent Growthd in 96-well plates. These modifications decrease hands-on time, increase fidelity of the assay, and make it possible to screen 500–1000 short-hairpin RNAs (shRNA) in “one-shRNA-one-well” format in parallel. These protocols can also be used to conduct functional cDNA or CRISPR screens for modulators of anchorage-independent growth.作者: Neutropenia 時間: 2025-3-27 11:55
CRISPR/Cas9-Based Positive Screens for Cancer-Related Traitsnew example is the application of CRISPR/Cas9-based library screening for cancer-related traits in cell lines. Such screens can reveal genome-wide suppressors of tumorigenesis and metastasis. Here we describe the use of widely available lentiviral libraries for such screens in cultured cell lines.作者: 情感 時間: 2025-3-27 14:04
Cancer Gene Discovery: Past to Present, death from cancer. Attempts have been made to define the phenotypic and genetic “hallmarks” of cancer, but many of these “hallmarks” remain descriptive, while the underlying mechanisms responsible for these hallmarks remain elusive. For decades, cancer researchers have been methodically identifying作者: engagement 時間: 2025-3-27 17:58
Identification of Cancer Driver Genes from a Custom Set of Next Generation Sequencing Dataver mutated genes that confer a selective advantage for cancer cells. Numerous computational algorithms have been developed to find genes that drive cancer based on their patterns of mutation in a patient cohort. It has been noted that the distinct features of driver gene alterations in different su作者: inveigh 時間: 2025-3-28 01:24 作者: 表狀態(tài) 時間: 2025-3-28 03:30 作者: 事情 時間: 2025-3-28 07:25 作者: Vulnerary 時間: 2025-3-28 12:00 作者: Catheter 時間: 2025-3-28 14:35
Engineering a Bioartificial Human Colon Model Through Decellularization and Recellularization. The protocols used to de/recellularize various organs and tissues are largely different. Here we describe a method to effectively engineer a bioartificial colon by completely removing original cells from human intestinal tissues followed by repopulating the acellular tissue matrix with cell cultur作者: 孤獨無助 時間: 2025-3-28 20:30 作者: ALTER 時間: 2025-3-29 01:24 作者: CHOIR 時間: 2025-3-29 06:01 作者: 衰弱的心 時間: 2025-3-29 11:19
CRISPR/Cas9-Based Positive Screens for Cancer-Related Traitsnd the world have been working to make this data useful. Data like these can be made more useful by comparison with complementary . genomic data. One new example is the application of CRISPR/Cas9-based library screening for cancer-related traits in cell lines. Such screens can reveal genome-wide sup作者: GRILL 時間: 2025-3-29 13:44
Ex Vivo Transposon-Mediated Genetic Screens for Cancer Gene Discoverygenetic screens have proven to be valuable for cancer gene identification, they are also time consuming and resource intensive. To facilitate the rapid and cost-effective identification of genes that regulate tumor-promoting pathways, we developed a complementary ex vivo transposon mutagenesis appro作者: 無思維能力 時間: 2025-3-29 19:13 作者: Pituitary-Gland 時間: 2025-3-29 20:59
PiggyBac Transposon-Based Insertional Mutagenesis in Miceof epigenetically, transcriptionally or posttranslationally dysregulated genes remains a challenge. Transposon-based genetic screening in mice has proven to be a powerful approach to address this challenge. Insertional mutagenesis directly flags biologically relevant genes and, combined with the tra作者: 躲債 時間: 2025-3-30 01:05 作者: BORE 時間: 2025-3-30 04:53 作者: Defiance 時間: 2025-3-30 10:40
Role of the Cell in Neutralization, death from cancer. Attempts have been made to define the phenotypic and genetic “hallmarks” of cancer, but many of these “hallmarks” remain descriptive, while the underlying mechanisms responsible for these hallmarks remain elusive. For decades, cancer researchers have been methodically identifying作者: tooth-decay 時間: 2025-3-30 13:43 作者: 吹牛大王 時間: 2025-3-30 18:03
,Comment on R. D. Schuiling’s Paper,somatic mutations in tumor samples; thus various computational methods for predicting cancer genes have been developed based on “significantly mutated genes.” However, this approach is intrinsically limited by the fact that there are many cancer genes infrequently mutated in cancer genomes. Therefor作者: Aerate 時間: 2025-3-30 22:56
Neutrino Mass, Mixing, and Flavor Change, growth and progression. Therefore, determining causal driver mutations and the genes they target is becoming an important challenge in cancer genomics. Here we describe an approach for mapping somatic mutations onto 3D structures of human proteins in complex to identify “driver interfaces.” Our str作者: anesthesia 時間: 2025-3-31 03:49
Springer Tracts in Modern PhysicsDNA transposon to generate random mutations within the murine genome that cause cancer. Identification of the insertion sites, either via RNA sequencing or DNA sequencing, is required for cancer gene discovery. Multiple sequencing-based approaches have been utilized to identify locations of transpos作者: 廚房里面 時間: 2025-3-31 05:42
A Bayesian Analysis of Solar Neutrino Datan and characterization of matched pairs of chemotherapy-sensitive/chemotherapy-resistant cancer cell lines. In this protocol we are using endometrial cancer cell lines treated with carboplatin and paclitaxel, which are first-line chemotherapies for gynecologic malignancies. The chemoresistant cells 作者: Strength 時間: 2025-3-31 09:49
https://doi.org/10.1007/978-1-4899-1564-1. The protocols used to de/recellularize various organs and tissues are largely different. Here we describe a method to effectively engineer a bioartificial colon by completely removing original cells from human intestinal tissues followed by repopulating the acellular tissue matrix with cell cultur作者: 會議 時間: 2025-3-31 15:50
LSND Neutrino Oscillation Resultsts in metastasis and is lethal. However, the mechanisms whereby PC progresses from androgen dependence to androgen independence are not completely understood. Mutagenesis screens to identify novel genes involved in the progression to AIPC have been performed using replication-incompetent lentiviral 作者: vasculitis 時間: 2025-3-31 19:21 作者: noxious 時間: 2025-3-31 22:40
Interferometry for Gravity Wave Detectionues, and packaged into lentiviral particles. Target cells of interest are transduced with the lentiviral sgRNA pools to generate a collection of knockout mutants—via Cas9-mediated genomic cleavage—and screened for a phenotype of interest. The relative abundance of each mutant in the population can b作者: 滔滔不絕地講 時間: 2025-4-1 05:19
A Bayesian Analysis of Solar Neutrino Datand the world have been working to make this data useful. Data like these can be made more useful by comparison with complementary . genomic data. One new example is the application of CRISPR/Cas9-based library screening for cancer-related traits in cell lines. Such screens can reveal genome-wide sup作者: 谷類 時間: 2025-4-1 09:35 作者: 反復拉緊 時間: 2025-4-1 11:23
Generation Mixing and Heavy Neutrinoshas been functionally harnessed and separated into two distinct DNA transposon components: the terminal inverted repeat sequences that flank genetic cargo to be mobilized and a transposase enzyme capable of recognizing the terminal inverted repeat sequences and catalyzing the transposition reaction.作者: MUMP 時間: 2025-4-1 17:44
Hans Volker Klapdor,Bogdan Povhof epigenetically, transcriptionally or posttranslationally dysregulated genes remains a challenge. Transposon-based genetic screening in mice has proven to be a powerful approach to address this challenge. Insertional mutagenesis directly flags biologically relevant genes and, combined with the tra作者: thrombus 時間: 2025-4-1 21:18
Searches for Lepton-Flavor Violationnd unbiased genetic editing tool that can be used for rapid screening of candidate liver cancer driver genes. Manipulating their expression level using a reverse genetic mouse model involving hydrodynamic tail-vein injection delivery can rapidly elucidate the role of these candidate genes in liver c
