標(biāo)題: Titlebook: Cancer Biology and the Nuclear Envelope; Recent Advances May Eric C. Schirmer,Jose I. de las Heras Book 2014 The Editor(s) (if applicable) [打印本頁] 作者: 監(jiān)管 時間: 2025-3-21 16:35
書目名稱Cancer Biology and the Nuclear Envelope影響因子(影響力)
書目名稱Cancer Biology and the Nuclear Envelope影響因子(影響力)學(xué)科排名
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書目名稱Cancer Biology and the Nuclear Envelope網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Cancer Biology and the Nuclear Envelope被引頻次
書目名稱Cancer Biology and the Nuclear Envelope被引頻次學(xué)科排名
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書目名稱Cancer Biology and the Nuclear Envelope讀者反饋
書目名稱Cancer Biology and the Nuclear Envelope讀者反饋學(xué)科排名
作者: mastopexy 時間: 2025-3-21 20:37
978-1-4939-5481-0The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines作者: maverick 時間: 2025-3-22 03:09
Eric C. Schirmer,Jose I. de las HerasDetailed overview of the wide range of nuclear envelope functions that can and do impact cancer.Timely volume that addresses a re-emerging hot topic, juxtaposing some of the historical and contemporar作者: 人類 時間: 2025-3-22 06:26
Advances in Experimental Medicine and Biologyhttp://image.papertrans.cn/c/image/221047.jpg作者: obstruct 時間: 2025-3-22 11:51
Cancer Biology and the Nuclear Envelope978-1-4899-8032-8Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: Frequency 時間: 2025-3-22 14:40
Contributions to Psychology and Medicine allowed detailed specimen observations. It was soon noted that cancer cells often possessed nuclei that were altered in size and/or shape. This became an important criterion for cancer diagnosis that continues to be used today. The mechanisms linking nuclear abnormalities and cancer only started to作者: Frequency 時間: 2025-3-22 18:41 作者: 蓋他為秘密 時間: 2025-3-23 00:16
Diabetes and Adaptations in Family Systemslogically distinctive alterations in the nuclear envelope (NE). With the expectation that diagnostic NE changes will have biological relevance to cancer, a classification of the various types of NE structural changes into three groups is proposed. The first group predicts chromosomal instability. Th作者: 冥界三河 時間: 2025-3-23 03:50 作者: 令人悲傷 時間: 2025-3-23 08:09
Heinrich H. Bülthoff,Alexa I. Ruppertsbergicroscopy in a cytologic diagnosis of cancer. The biological determinants of nuclear shape irregularities are not clarified, so, rather than on the genesis of nuclear irregularities, we here focus our attention on a descriptive analysis of nuclear pleomorphism. We keep in mind that evaluation of nuc作者: maintenance 時間: 2025-3-23 11:08
https://doi.org/10.1007/978-3-662-08957-6utation are dystrophic in nature, often limiting the proliferation potential of affected cells in vivo and in vitro. Nevertheless, these lamin mutations, particularly in the . gene that encodes A-type lamins, have provided an interesting tool set to understand functions of nuclear intermediate filam作者: 固定某物 時間: 2025-3-23 13:54
Heinrich H. Bülthoff,Alexa I. Ruppertsbergwith the DNA associated protein, Barrier-to-Autointegration Factor (BAF). Most of the LEM proteins are integral proteins of the inner nuclear membrane and associate with the nuclear lamina, a structural scaffold of lamin intermediate filament proteins at the nuclear periphery, which is involved in n作者: Cholagogue 時間: 2025-3-23 19:33
Zerebrale Blindheit und Gesichtsfeldausf?lleor pRb and nuclear envelope breakdown in mitosis, many other nuclear envelope proteins influence the cell cycle through regulatory or structural functions. Of particular note among these are the nuclear envelope transmembrane proteins (NETs) that appear to influence cell cycle regulation through mul作者: 侵略 時間: 2025-3-23 22:55
Methoden der kognitiven Neurowissenschaften mediated primarily through changes in gene expression. The evolution of the nuclear envelope and the consequent compartmentalization of the genome, which is a defining feature of eukaryotes, introduced a physical barrier to the free access of genes. Initially regarded as nothing more than this, a p作者: 混合 時間: 2025-3-24 03:04 作者: obviate 時間: 2025-3-24 10:06
Visuelle Wahrnehmung: Was, Wo und Wie,cellular organisms and in plants. Lamins form a proteinaceous meshwork that outlines the nucleoplasmic side of the inner nuclear membrane, while a small fraction of lamin molecules is also present in the nucleoplasm. They provide structural support for the nucleus and help regulate many other nuclea作者: 悄悄移動 時間: 2025-3-24 13:02 作者: lambaste 時間: 2025-3-24 17:46
Paul Hoff,Anastasia Theodoridouchromatin silencing, transcriptional regulation, and DNA damage repair. Nucleoporins, the structural components of the NPC, have been linked to a multitude of cancers through chromosomal translocations generating fusion proteins, changes in protein expression levels, and single point mutations. Only作者: 混亂生活 時間: 2025-3-24 19:36 作者: 音樂等 時間: 2025-3-25 00:16
Neuropsychologie der Schizophrenierly during nuclear formation and has important roles during the eukaryotic cell cycle, where it regulates mitotic spindle assembly, nuclear envelope formation and cell cycle checkpoint control. Like other GTPases, Ran relies on the cycling between GTP-bound and GDP-bound conformations to interact wi作者: LAIR 時間: 2025-3-25 03:54
Book 2014understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE? is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA traff作者: LUCY 時間: 2025-3-25 11:32
Contributions to Psychology and Medicineery important functional hub for many cellular processes. In this review we give an overview of the links between cancer biology and nuclear envelope, from the early days of microscopy until the present day’s understanding of some of the molecular mechanisms behind those links.作者: 子女 時間: 2025-3-25 15:04
https://doi.org/10.1007/978-3-662-08957-6ith several important signal transduction pathways. Here we describe the current state of knowledge and speculate that lamins may be intimately involved in the regulation of cell proliferation, acting at the interface between cancer and aging.作者: insomnia 時間: 2025-3-25 16:56
Zerebrale Blindheit und Gesichtsfeldausf?lleM populations, sometimes associated with the induction of senescence. Intriguingly, most of the NETs linked to the cell cycle are highly restricted in their tissue expression; thus, their misregulation in cancer could contribute to the many tissue-specific types of cancer.作者: 音的強(qiáng)弱 時間: 2025-3-25 22:55 作者: 完全 時間: 2025-3-26 02:20 作者: 委派 時間: 2025-3-26 06:08 作者: 包租車船 時間: 2025-3-26 11:52
NETs and Cell Cycle RegulationM populations, sometimes associated with the induction of senescence. Intriguingly, most of the NETs linked to the cell cycle are highly restricted in their tissue expression; thus, their misregulation in cancer could contribute to the many tissue-specific types of cancer.作者: 壯觀的游行 時間: 2025-3-26 14:54
Studying Lamins in Invertebrate Modelsomote such studies. Here we provide an overview of recent advances in the biology of invertebrate nuclear lamins, with special emphasis on their assembly, cellular functions and as models for studying the molecular basis underlying the pathology of human heritable diseases caused by mutations in lamins A/C.作者: 易于交談 時間: 2025-3-26 20:33 作者: Definitive 時間: 2025-3-26 23:53
Roles of the Nucleoporin Tpr in Cancer and Agingscription, and mitosis. More recently, Tpr function has been linked to events including p53 signaling and premature aging in Hutchinson–Gilford Progeria Syndrome (HGPS). Here we provide an overview of the various processes that involve Tpr, and discuss how the levels and localization of a single protein can affect diverse pathways in the cell.作者: 低位的人或事 時間: 2025-3-27 01:50
0065-2598 ot topic, juxtaposing some of the historical and contemporar."Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE im作者: 抱怨 時間: 2025-3-27 06:25 作者: Palpable 時間: 2025-3-27 10:45
Diabetes and Adaptations in Family Systemsthe clonal evolution of genetically unstable tumors. Two examples of this group include increased ratio of nuclear volume to cytoplasmic volume and the relatively fragile nuclei of small-cell carcinomas. The third and most interesting group develops in a near-diploid, genetically stable background. 作者: 漂浮 時間: 2025-3-27 15:58 作者: forbid 時間: 2025-3-27 21:36
Heinrich H. Bülthoff,Alexa I. Ruppertsberg tissue sections by employing immunoperoxidase staining for emerin. Direct detection of nuclear envelope irregularities by tagging nuclear membrane proteins such as lamin B and emerin has resulted in a more objective definition of the shape of the nucleus. In this review we discuss in detail methodo作者: Felicitous 時間: 2025-3-27 22:38 作者: CLASP 時間: 2025-3-28 05:36 作者: 有抱負(fù)者 時間: 2025-3-28 09:43
Neuronale Grundlagen der Merkmalsintegrationuclear periphery, and sequester transcription factors away from the nuclear interior. On the other hand, proteins of the nuclear pores anchor as well as help generate active chromatin, promote transcription, and coordinate gene expression with mRNA export. The importance of these functions is unders作者: Loathe 時間: 2025-3-28 13:36
Visuelle Wahrnehmung: Was, Wo und Wie,nvelope defects can restore proper gene positioning and expression in both disease situations..Although spatial positioning of the genome probably does not entirely control expression of genes, it appears that spatio-epigenetics may enhance the control over gene expression globally and/or is deeply 作者: 憂傷 時間: 2025-3-28 16:30
Paul Hoff,Anastasia Theodoridoum or nucleoplasm while others are incorporated into the NPC, and in all these cases they are thought to misregulate signaling pathways and transcription through either altered or diminished nucleoporin functionality. Intriguingly, many viruses target the same cancer-linked nucleoporins, often causin作者: defendant 時間: 2025-3-28 22:03 作者: 多產(chǎn)魚 時間: 2025-3-29 00:30
The Role of the Nuclear Lamina in Cancer and Apoptosisrentiation and the appearance of A-type lamins in a tumor likely relates the proliferative capacity of the tumor to its differentiation state..While lamins are targets for degradation in the apoptotic process, and accordingly are often used as markers for apoptosis, intriguing studies on an active r作者: Adjourn 時間: 2025-3-29 04:39
The Diagnostic Pathology of the Nuclear Envelope in Human Cancersthe clonal evolution of genetically unstable tumors. Two examples of this group include increased ratio of nuclear volume to cytoplasmic volume and the relatively fragile nuclei of small-cell carcinomas. The third and most interesting group develops in a near-diploid, genetically stable background. 作者: 不出名 時間: 2025-3-29 08:18
Nuclear Morphometry, Epigenetic Changes, and Clinical Relevance in Prostate Cancerges in the cancer-driven epigenetic process at the molecular level and correlates these alterations to nuclear morphological quantitative measurements. Finally, we address how we can best utilize this knowledge to improve the efficacy of personalized treatment of cancer.作者: 無法解釋 時間: 2025-3-29 12:08 作者: 小卒 時間: 2025-3-29 18:35 作者: debacle 時間: 2025-3-29 20:52 作者: Anemia 時間: 2025-3-30 02:18
Nuclear Envelope: Connecting Structural Genome Organization to Regulation of Gene Expressionuclear periphery, and sequester transcription factors away from the nuclear interior. On the other hand, proteins of the nuclear pores anchor as well as help generate active chromatin, promote transcription, and coordinate gene expression with mRNA export. The importance of these functions is unders作者: Lacerate 時間: 2025-3-30 07:03
The Non-random Repositioning of Whole Chromosomes and Individual Gene Loci in Interphase Nuclei and nvelope defects can restore proper gene positioning and expression in both disease situations..Although spatial positioning of the genome probably does not entirely control expression of genes, it appears that spatio-epigenetics may enhance the control over gene expression globally and/or is deeply 作者: 卜聞 時間: 2025-3-30 11:09 作者: tympanometry 時間: 2025-3-30 14:22
Ran GTPase in Nuclear Envelope Formation and Cancer Metastasis Ran also has been identified as an essential protein in nuclear envelope formation in eukaryotes. This mechanism is dependent on importin-β, which regulates the assembly of further complexes important in this process, such as Nup107–Nup160. A strong body of evidence is emerging implicating Ran as a作者: 用不完 時間: 2025-3-30 18:42 作者: recession 時間: 2025-3-30 22:14
Book 2014tecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues f作者: 討好美人 時間: 2025-3-31 01:53 作者: ARC 時間: 2025-3-31 08:56 作者: coddle 時間: 2025-3-31 11:42 作者: engrossed 時間: 2025-3-31 15:21
Nuclear Morphometry, Epigenetic Changes, and Clinical Relevance in Prostate Cancerc (DNA methylation and histone modifications) events that dramatically and dynamically spatially change chromatin, nuclear body, and chromosome organization. In prostate cancer (CaP) there appears to be early (<50 years) versus late (>60 years) onset clinically significant cancers, and we have yet t作者: Common-Migraine 時間: 2025-3-31 19:22 作者: Intractable 時間: 2025-3-31 22:11
