標(biāo)題: Titlebook: Camptothecins in Cancer Therapy; Val R. Adams,Thomas G. Burke Book 2005 Humana Press 2005 DNA.biochemistry.brain.brain tumors.cancer.cance [打印本頁] 作者: peak-flow-meter 時間: 2025-3-21 16:50
書目名稱Camptothecins in Cancer Therapy影響因子(影響力)
書目名稱Camptothecins in Cancer Therapy影響因子(影響力)學(xué)科排名
書目名稱Camptothecins in Cancer Therapy網(wǎng)絡(luò)公開度
書目名稱Camptothecins in Cancer Therapy網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Camptothecins in Cancer Therapy被引頻次
書目名稱Camptothecins in Cancer Therapy被引頻次學(xué)科排名
書目名稱Camptothecins in Cancer Therapy年度引用
書目名稱Camptothecins in Cancer Therapy年度引用學(xué)科排名
書目名稱Camptothecins in Cancer Therapy讀者反饋
書目名稱Camptothecins in Cancer Therapy讀者反饋學(xué)科排名
作者: 帶子 時間: 2025-3-21 21:08 作者: 種植,培養(yǎng) 時間: 2025-3-22 04:07
Neuroinflammation in Huntington’s Diseasecomplex (.). At this level, the action of CPT on TOP-I function is entirely analogous to those of several agents that inhibit the function of topoisomerase II, including 4-(9-acridinylamino)-.-(methanesulfonyl)-.-anisidine (m-AMSA), etoposide, and teniposide (.).作者: Strength 時間: 2025-3-22 07:25 作者: SPALL 時間: 2025-3-22 09:28
Progress in Inflammation Researchstases. In addition, if benign cases are considered, approximately 36,000 brain tumors would have been diagnosed in 2002. The age- and sex-adjusted incidence of primary tumors of the CNS is estimated to be approximately 19 per 100,000 persons per year (11.8 per 100,000 for symptomatic tumors and 7.3 per 100,000 for asymptomatic tumors) (.).作者: Hot-Flash 時間: 2025-3-22 15:45
Progress in Inflammation Researchrising, leveled off to the current incidence rate of 52.4 per 100,000. Overall, the 1-year survival rates for lung cancer have increased from 34% in 1975 to 42% in 1998, mainly because of improvements in surgical techniques. However, the 5-year relative survival rate for all stages is only 15% (.).作者: Hot-Flash 時間: 2025-3-22 19:11 作者: 主動 時間: 2025-3-23 01:06 作者: FLIRT 時間: 2025-3-23 02:54 作者: STIT 時間: 2025-3-23 07:38
Camptothecins in the Treatment of Primary Brain Tumorsstases. In addition, if benign cases are considered, approximately 36,000 brain tumors would have been diagnosed in 2002. The age- and sex-adjusted incidence of primary tumors of the CNS is estimated to be approximately 19 per 100,000 persons per year (11.8 per 100,000 for symptomatic tumors and 7.3 per 100,000 for asymptomatic tumors) (.).作者: 使長胖 時間: 2025-3-23 11:47
Camptothecins in the Treatment of Lung Cancerrising, leveled off to the current incidence rate of 52.4 per 100,000. Overall, the 1-year survival rates for lung cancer have increased from 34% in 1975 to 42% in 1998, mainly because of improvements in surgical techniques. However, the 5-year relative survival rate for all stages is only 15% (.).作者: Dysplasia 時間: 2025-3-23 17:01 作者: 職業(yè)拳擊手 時間: 2025-3-23 21:34
2196-9906 logy, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance.978-1-62703-816-4978-1-59259-866-3Series ISSN 2196-9906 Series E-ISSN 2196-9914 作者: 魔鬼在游行 時間: 2025-3-24 00:35
2196-9906 for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmaco作者: integral 時間: 2025-3-24 06:03
Golam M. Khandaker,Urs Meyer,Peter B. Jonestanding of the drug’s mechanism of action (.). The finding in 1985 that CPT specifically poisons Top1 has generated great interest to find water-soluble, more efficacious, and less toxic analogs of CPT.作者: Predigest 時間: 2025-3-24 09:33 作者: 彈藥 時間: 2025-3-24 11:17 作者: DENT 時間: 2025-3-24 17:37 作者: 準(zhǔn)則 時間: 2025-3-24 21:01
Cytotoxic Mechanisms of Topoisomerase 1 Inhibitorstanding of the drug’s mechanism of action (.). The finding in 1985 that CPT specifically poisons Top1 has generated great interest to find water-soluble, more efficacious, and less toxic analogs of CPT.作者: groggy 時間: 2025-3-25 00:06 作者: Liability 時間: 2025-3-25 04:22 作者: palliate 時間: 2025-3-25 09:13 作者: 符合規(guī)定 時間: 2025-3-25 13:11 作者: GRAZE 時間: 2025-3-25 18:07 作者: 先鋒派 時間: 2025-3-25 23:24 作者: spinal-stenosis 時間: 2025-3-26 02:23
Clinical Experience With 9-Aminocamptothecinical research. Thus a careful review of the early clinical and pharmacological trials of 9-AC may help us to understand why 9-AC has not shown more meaningful antitumor activity and may also provide important lessons for the future drug development of novel camptothecins and other topoisomerase I (TOP-I) targeting agents.作者: Sleep-Paralysis 時間: 2025-3-26 07:43
Irinotecan–.). In turn, SN-38 can be conjugated to SN-38 β-glucuronide (.,.). CPT-11 is also metabolized to an aminopentanocarboxylic (APC), metabolite (. Fig. 1), and other minor, mostly inactive, products by cytochrome P450 3A4/5 (.–.).作者: 任命 時間: 2025-3-26 11:29 作者: 整體 時間: 2025-3-26 15:56
Neuroinflammation in Alzheimer’s Diseaseication reaction (.). The rate of relegation is normally much faster than is the rate of cleavage (.). This ensures that the steady state concentration of the covalent 3′-phosphotyrosyl TOP-I-DNA complex is extremely low. Several DNA lesions and drugs, however, have been shown to stabilize the coval作者: 急性 時間: 2025-3-26 19:51
https://doi.org/10.1007/978-3-662-05426-0OH DNA end attacks the phosphotyrosyl bond to restore the phosphodiester backbone bond and liberate the enzyme. The formation of a covalent Top1p-DNA complex is the hallmark of topoisomerase-catalyzed reactions and acts to conserve the energy of the cleaved DNA bond such that the concerted nicking a作者: 鉤針織物 時間: 2025-3-27 00:49 作者: 賞心悅目 時間: 2025-3-27 03:48
The Role of Apoptosis in Neuroinflammation,ls that are actively replicating DNA (.,.,.). Because of their proliferating nature, cancerous cells spend more time in the S-phase relative to normal cells. Also, it has been shown that TOP-I is overexpressed in a variety of tumor lines (.,.). Logically, the accelerated rate of cell replication and作者: Concrete 時間: 2025-3-27 07:45 作者: 光滑 時間: 2025-3-27 09:55
Crystallographic Insight Into the Mechanism of Drug-Induced Topoisomerase I DNA Damageication reaction (.). The rate of relegation is normally much faster than is the rate of cleavage (.). This ensures that the steady state concentration of the covalent 3′-phosphotyrosyl TOP-I-DNA complex is extremely low. Several DNA lesions and drugs, however, have been shown to stabilize the coval作者: 贊美者 時間: 2025-3-27 15:23 作者: Intruder 時間: 2025-3-27 19:48 作者: 性行為放縱者 時間: 2025-3-28 00:41 作者: STERN 時間: 2025-3-28 05:26
Clinical Experience With Topotecanous (iv) infusion of 1.5 mg/m. daily for 5 days, which is repeated every 3 weeks. Topotecan is available as a parenteral preparation and is supplied in vials containing 4 mg, which is reconstituted in 4 mL sterile water. The resulting 1 mg/mL solution is further diluted with a 5% dextrose or 0.9% sa作者: Constituent 時間: 2025-3-28 07:42 作者: 做事過頭 時間: 2025-3-28 13:56 作者: ALB 時間: 2025-3-28 17:45
Neuroinflammation in Huntington’s Disease agent to the covalent binary complex formed between topoisomerase I (TOP-I) and DNA (Fig. 2) (.). Although the equilibrium between free enzyme and the enzyme-DNA binary complex normally lies far toward free enzyme and DNA, in the presence of CPT, the equilibrium is rapidly displaced toward ternary 作者: considerable 時間: 2025-3-28 22:27
Golam M. Khandaker,Urs Meyer,Peter B. Jones The sodium salt of CPT was found to be clinically active, but its use was discontinued in the 1970s because of severe side effects and lack of understanding of the drug’s mechanism of action (.). The finding in 1985 that CPT specifically poisons Top1 has generated great interest to find water-solub作者: OVER 時間: 2025-3-29 01:17
https://doi.org/10.1007/978-3-662-05426-0changes in DNA topology are important during cellular processes involving DNA, including DNA replication, recombination, transcription, and chromosome condensation (.–.). The monomeric Top1 enzyme, encoded by the . gene, binds to duplex DNA and catalyzes the transient cleavage and relegation of a si作者: Incise 時間: 2025-3-29 03:47 作者: 旋轉(zhuǎn)一周 時間: 2025-3-29 11:17 作者: Myosin 時間: 2025-3-29 13:16 作者: esculent 時間: 2025-3-29 19:36
Sleep Immune Cross Talk and Insomniaty against human colorectal cancer xenografts (.). This led to an extensive drug development program for 9-AC initially under the guidance of the National Cancer Institute, and later in cooperation with pharmaceutical industry sponsors. However, despite this impressive preclinical activity, 9-AC has作者: 最初 時間: 2025-3-29 19:56
Sleep Immune Cross Talk and Insomniaparent compound, CPT, derived from the bark of the . tree, was introduced into clinical trials in the late 1970s. Because of its poor water solubility, CPT was formulated in sodium bicarbonate, which opened the 20(S) lactone ring and caused significant toxicity and inconsistent clinical activity. He作者: 憎惡 時間: 2025-3-30 02:58
Il Bin Kim,Seon-Cheol Park,Yong-Ku Kim of the Chinese shrub .. The mechanism of action of camptothecin has been covered in other chapters of this book and need not be revisited here. However, it is pertinent to point out that CPT-11 itself is only a very weak stabilizer of the cleavable complex formed between DNA and topoisomerase I (TO作者: 迫擊炮 時間: 2025-3-30 05:08 作者: 和平主義 時間: 2025-3-30 09:51
Progress in Inflammation Researchon. The parent compound, CPT, was extracted from the leaves of . by Wall and Wani in 1957. The hydrophilic carboxylate salt entered clinical trials in the late 1960s. The lack of efficacy and unpredictable bone marrow and bladder toxicity halted its clinical development (.). When topoisomerase I (TO作者: Pseudoephedrine 時間: 2025-3-30 14:15 作者: ostrish 時間: 2025-3-30 18:28 作者: 性冷淡 時間: 2025-3-30 22:04
Progress in Inflammation Researchagnosed in the United States, and an estimated 157,200 deaths occurred from the disease. The incidence rate of lung cancer is declining in men, from a high of 102.1 per 100,000 in 1984 to 81.1 per 100,000 in 1999. In the late 1990s the incidence of lung cancer seen in women, which had been steadily 作者: Odyssey 時間: 2025-3-31 01:26
Brain Atlases and Neuroanatomic Imaginged (.–.). This is particularly true for the elderly, who account for the majority of cases of acute myelogenous leukemia (AML) (.,.). Because of unrelated medical problems, as well as a higher incidence of certain resistance mechanisms (e.g., overexpression of the mdr1 multidrug transporter), eradic作者: 侵蝕 時間: 2025-3-31 05:43
Val R. Adams,Thomas G. BurkeIncludes supplementary material: 作者: NAUT 時間: 2025-3-31 09:36
Cancer Drug Discovery and Developmenthttp://image.papertrans.cn/c/image/220974.jpg作者: 密碼 時間: 2025-3-31 14:25 作者: 舞蹈編排 時間: 2025-3-31 20:19
Camptothecins in Cancer Therapy978-1-59259-866-3Series ISSN 2196-9906 Series E-ISSN 2196-9914 作者: anaerobic 時間: 2025-3-31 22:54
Mechanism of Action of Topoisomerase 1 Poisonsndensation, and segregation (.–.). They perform their topological transformation reactions on DNA via a concerted breakage/religation mechanism (.,.–.). Because of their delicate act on DNA, topoisomerases can be double-edged swords. It is now well established that many xenobiotics, DNA lesions, and作者: semiskilled 時間: 2025-4-1 05:16 作者: Subjugate 時間: 2025-4-1 07:53
