標(biāo)題: Titlebook: COX-2 Blockade in Cancer Prevention and Therapy; Randall E. Harris Book 2003 Springer Science+Business Media New York 2003 Prevention of b [打印本頁(yè)] 作者: 恰當(dāng) 時(shí)間: 2025-3-21 18:07
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作者: paroxysm 時(shí)間: 2025-3-21 22:16 作者: Folklore 時(shí)間: 2025-3-22 03:12 作者: 負(fù)擔(dān) 時(shí)間: 2025-3-22 05:19 作者: 厚顏無(wú)恥 時(shí)間: 2025-3-22 10:48
Role of Synthetic and Naturally Occurring Cyclooxygenase Inhibitors in Colon Cancer Preventionents at critical points in carcinogenesis. Chemopreventive agents that can retard, block, or reverse the process of carcinogenesis, or reduction of the underlying risk factors can be applied across a continuum of the general population as preventive strategies. Understanding the mechanisms that acco作者: 寬容 時(shí)間: 2025-3-22 13:36
The Role of Cyclooxygenase-2 in the Prevention and Therapy of Lung CancerSCLC) frequently overexpress cyclooxygenase-2 (COX-2), a trend particularly prominent in PAC .. This enzyme converts arachidonic acid (AA) into several metabolites, some of which have been identified as modulators of mitogenesis, angiogenesis, and apoptosis .. Accordingly, the AA cascade and COX-2 a作者: 寬容 時(shí)間: 2025-3-22 21:03
Nature Management by Grazing and Cuttingin the formation of prostaglandin G. (PGG.). This COX reaction is rapidly followed by a hydroperoxidase reaction, occurring at a distinct site on the prostaglandin synthase/COX enzyme, to convert PGG. to PGH.. PGH. is the common intermediate for the synthesis of the various prostaglandins (e.g., PGE作者: obeisance 時(shí)間: 2025-3-23 00:58
https://doi.org/10.1007/978-94-009-6957-5ckade in animal models of mammary carcinogenesis, summarize data from epidemiologic studies of NSAIDs and breast cancer, and present a novel working model of breast cancer development featuring aberrant induction and upregulation of . genetic expression. Extensive epidemiologic evidence and other fi作者: 嫌惡 時(shí)間: 2025-3-23 02:41 作者: 牛馬之尿 時(shí)間: 2025-3-23 08:07
Kant on the Foundations of ScienceSCLC) frequently overexpress cyclooxygenase-2 (COX-2), a trend particularly prominent in PAC .. This enzyme converts arachidonic acid (AA) into several metabolites, some of which have been identified as modulators of mitogenesis, angiogenesis, and apoptosis .. Accordingly, the AA cascade and COX-2 a作者: meditation 時(shí)間: 2025-3-23 12:14 作者: Cerebrovascular 時(shí)間: 2025-3-23 14:55
Cyclooxygenase-2 and Cancer malignant conditions and/or recurrence. Additionally, COX-2 inhibitors are being tested in combination with standard cytotoxics, radiation, and molecular targeted agents to explore whether combination modalities enhance efficacy of anticancer agents.作者: fatty-streak 時(shí)間: 2025-3-23 22:03 作者: EVEN 時(shí)間: 2025-3-24 02:04 作者: 項(xiàng)目 時(shí)間: 2025-3-24 04:48 作者: 向宇宙 時(shí)間: 2025-3-24 07:21
Epidemiology of Nonsteroidal Anti-Inflammatory Drugs and Colorectal Cancers did the potential efficacy and safety of NSAIDs as anticancer agents begin to be explored systematically in humans by epidemiologic studies in the general population and randomized clinical trials in high-risk groups.作者: GILD 時(shí)間: 2025-3-24 12:11
Cyclooxygenase-1 and Cyclooxygenase-2 Knockout Mice Provide Insights into Beneficial and Adverse Effveloped. As COX-1 was the isoform believed to generate PGs associated with house keeping functions, and COX-2 was the isoform believed to produce PGs associated with the development of several diseases, the emphasis has been to develop NSAIDs with increased selectivity for COX-2.作者: Lyme-disease 時(shí)間: 2025-3-24 18:40 作者: Genetics 時(shí)間: 2025-3-24 22:30
https://doi.org/10.1007/978-94-009-2255-6unsaturated fatty acids such as alpha-linolenic acid (C 18:3,n-3), eicosapentaenoic acid (C20:5, n-3), docosapentaenoic acid (C22:5,n-3), and docosahexaenoic acid (C22:6, n-3) do not promote carcinogenesis and may have inhibitory effects in development and progression of different cancers ..作者: sundowning 時(shí)間: 2025-3-25 01:00
https://doi.org/10.1007/978-94-009-6957-5omes from recent epidemiological and experimental studies, which suggest that regular intake of nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of many cancers, including breast cancer ..作者: 天氣 時(shí)間: 2025-3-25 06:10 作者: 凝乳 時(shí)間: 2025-3-25 07:58
https://doi.org/10.1007/978-3-319-05410-0 a viable approach for the chemoprevention of colorectal cancer. This chapter will begin with a review of some of the key findings that led to the hypothesis that COX-2 inhibitor therapy inhibits colorectal cancer development followed by a discussion of the prostaglandin (PG) signaling pathways that have been linked to the carcinogenic process.作者: 放棄 時(shí)間: 2025-3-25 13:06 作者: 分開 時(shí)間: 2025-3-25 19:14
2196-9906 onized cancer research. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op- portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly into five areas. First, an historical over作者: tolerance 時(shí)間: 2025-3-25 21:32 作者: 配偶 時(shí)間: 2025-3-26 03:25
Regulation of Expression and Potential Carcinogenic Role of Cyclooxygenase-2 . to the biologically active end products, PGD., PGE., PGF., PGI. (prostacyclin), and other related eicosanoids. These prostanoids contribute to many normal physiological processes including inflammation, pain and fever, and various cancers .作者: 燦爛 時(shí)間: 2025-3-26 06:50 作者: 整潔漂亮 時(shí)間: 2025-3-26 09:37 作者: 食物 時(shí)間: 2025-3-26 15:27 作者: Suggestions 時(shí)間: 2025-3-26 20:19
Cyclooxygenase-2, Prostaglandins, and Colorectal Carcinogenesis a viable approach for the chemoprevention of colorectal cancer. This chapter will begin with a review of some of the key findings that led to the hypothesis that COX-2 inhibitor therapy inhibits colorectal cancer development followed by a discussion of the prostaglandin (PG) signaling pathways that have been linked to the carcinogenic process.作者: 無(wú)力更進(jìn) 時(shí)間: 2025-3-26 23:39
Association of COX-2 and PPARs in Carcinogenesis and Chemopreventionreceptors in human malignancies, involvement of PPARs in tumorigenesis, and use of receptor antagonists or agonists for differentiation therapy and chemoprevention. It is proposed that PPARy agonists or PPARS antagonists may serve as more specific and less toxic agents for chemoprevention.作者: 借喻 時(shí)間: 2025-3-27 03:02 作者: Parley 時(shí)間: 2025-3-27 09:00
Dietary Fatty Acids, COX-2 Blockade, and Carcinogenesispment of several human cancers. Specifically, polyunsaturated fatty acids such as linoleic acid (C18:2,n-6) and arachidonic acid (C20:4,n-6) enhance experimental carcinogenesis, tumor development, and tumor progression. In contrast, monounsaturated fatty acids such as oleic acid (C18:1, n-9) or poly作者: 遭受 時(shí)間: 2025-3-27 09:44
Historical Aspects of COX-2 of polyunsaturated fatty acids (PUFAs) can serve as precursors to the eicosanoids, the bulk of the prostanoids and leukotrienes are derived from arachidonic acid (AA). Precursor AA does not exist free in cells; AA is present in membrane bound glycerophospholipids. When cells receive an appropriate 作者: insincerity 時(shí)間: 2025-3-27 15:14 作者: 不發(fā)音 時(shí)間: 2025-3-27 20:38
Epidemiology of Breast Cancer and Nonsteroidal Anti-Inflammatory Drugsagainst human disease. Aspirin, the prototype NSAID, is recommended for the chemoprevention of myocardial infarction (MI) and stroke .. Animal models of carcinogenesis provide strong evidence that NSAIDs inhibit tumor development in the colon and breast (., Chapters 5 and 6), and human epidemiologic作者: dissolution 時(shí)間: 2025-3-27 21:59 作者: Glutinous 時(shí)間: 2025-3-28 04:28
Chemoprevention of Breast Cancer by Nonsteroidal Anti-Inflammatory Drugs and Selective COX-2 Blockads and improved screening methods for early detection and treatment, breast cancer mortality has remained persistently constant for more than half a century. Novel preventive approaches are needed that deter or arrest mammary carcinogenesis .. A promising new lead for the control of this malignancy c作者: 不足的東西 時(shí)間: 2025-3-28 08:59 作者: neutral-posture 時(shí)間: 2025-3-28 11:31
Nonsteroidal Anti-Inflammatory Drugs, Prostaglandins, and ,-Driven Intestinal Tumorigenesish respect to the genetic mutations that contribute to its development and progression to fatal malignancy .. Most cases of colorectal cancer occur spontaneously, but in some families germline mutations that affect either the adenomatous polyposis coli (.) gene or one of the mismatch DNA repair genes作者: Alpha-Cells 時(shí)間: 2025-3-28 16:44
Cyclooxygenase-1 and Cyclooxygenase-2 Knockout Mice Provide Insights into Beneficial and Adverse Efftaglandins (PGs), i.e., PGE., PGD., PGI., PGF., and thromboxane A2 . Both isoforms are biological targets for the widely used class of medicines known as nonsteroidal anti-inflammatory drugs (NSAIDs); and NSAIDs are believed to cause their biological effects by effectively reducing PG production. Ho作者: invulnerable 時(shí)間: 2025-3-28 20:39
Cyclooxygenase-2, Prostaglandins, and Colorectal Carcinogenesiso approx 550,00 annual deaths worldwide. This failure in treatment has led to a search for novel, nontoxic agents that could possibly be utilized to prevent the development of the disease. Recently, inhibitors of the cyclooxygenase-2 (COX-2) enzyme have emerged as a class of drugs that may represent作者: 北極人 時(shí)間: 2025-3-29 01:29 作者: insincerity 時(shí)間: 2025-3-29 06:34
Cyclooxygenase-2 and CancerX-2 involvement in transformation, maintenance of tumor growth, viability, and metastasis. Included are descriptions of the chronic upregulation of COX-2 in multiple human tumors, as well as the pharmacological evidence of the anti-angiogenic activity of COX-2 inhibitors in animal models. Collective作者: landfill 時(shí)間: 2025-3-29 08:05
Interactions of Cyclooxygenase and Aromatase Pathways in Normal and Malignant Breast Cells 40,800 women in the United States will die from breast cancer in 2001. Currently, one out of eight American women will develop breast cancer in her lifetime (1). The rate of breast cancer incidence has increased 2–3% per year over the past decade in both premenopausal and postmenopausal women.作者: analogous 時(shí)間: 2025-3-29 13:42 作者: negligence 時(shí)間: 2025-3-29 16:20 作者: 向宇宙 時(shí)間: 2025-3-29 20:24
https://doi.org/10.1007/978-94-009-2255-6pment of several human cancers. Specifically, polyunsaturated fatty acids such as linoleic acid (C18:2,n-6) and arachidonic acid (C20:4,n-6) enhance experimental carcinogenesis, tumor development, and tumor progression. In contrast, monounsaturated fatty acids such as oleic acid (C18:1, n-9) or poly作者: 縮短 時(shí)間: 2025-3-30 03:21 作者: ungainly 時(shí)間: 2025-3-30 05:43 作者: CODE 時(shí)間: 2025-3-30 08:43
https://doi.org/10.1007/978-94-009-6957-5against human disease. Aspirin, the prototype NSAID, is recommended for the chemoprevention of myocardial infarction (MI) and stroke .. Animal models of carcinogenesis provide strong evidence that NSAIDs inhibit tumor development in the colon and breast (., Chapters 5 and 6), and human epidemiologic作者: constellation 時(shí)間: 2025-3-30 14:35
Kant on the Foundations of Scienceted States .;and therefore is a major public health problem .. An impressive body of evidence supports the concept that chemoprevention has the potential to be a major component of colorectal cancer control. Chemoprevention refers to the administration of chemical agents, those naturally occurring i作者: choleretic 時(shí)間: 2025-3-30 16:35 作者: 吹氣 時(shí)間: 2025-3-30 21:20
Kant on the Foundations of Science .. According to a recent report by the United States Surgeon General, lung cancer in women has increased 600% since 1950 and has clearly reached epidemic proportions .. Pulmonary adenocarcinoma (PAC) was once a rare form of lung cancer, but has risen dramatically during the last three decades to be
