標(biāo)題: Titlebook: Botulinum Neurotoxins; Andreas Rummel,Thomas Binz Book 2013 The Editor(s) (if applicable) and The Author(s), under exclusive license to Sp [打印本頁] 作者: GUAFF 時間: 2025-3-21 18:31
書目名稱Botulinum Neurotoxins影響因子(影響力)
作者: 配置 時間: 2025-3-21 21:22 作者: 堅(jiān)毅 時間: 2025-3-22 03:54 作者: 憲法沒有 時間: 2025-3-22 08:28 作者: Genome 時間: 2025-3-22 10:58 作者: 去掉 時間: 2025-3-22 13:14
Clostridial Neurotoxin Light Chains: Devices for SNARE Cleavage Mediated Blockade of Neurotransmissr peptide bond in one of the three SNARE proteins, which are the core of the membrane fusion apparatus for synaptic vesicles. SNARE cleavage causes the blockade of neurotransmitter release. This chapter details the molecular basis for the highly selective substrate recognition and cleavage mechanism of CNT.作者: 進(jìn)入 時間: 2025-3-22 17:36 作者: JOT 時間: 2025-3-22 21:46
Complexity of Botulinum Neurotoxins: Challenges for Detection Technology,gical, and spectrometric assays or combinations thereof have been developed, supplemented by DNA-based assays for the detection of the organism. In this review, advantages and limitations of the current technologies will be discussed, highlighting some of the intricacies of real sample analysis.作者: 悲觀 時間: 2025-3-23 03:30
Transforming the Domain Structure of Botulinum Neurotoxins into Novel Therapeutics,vidual domains is becoming clearer as significant advancements are made to exploit the unique biology of the catalytic and translocation domains. These opportunities and the status of their development will be reviewed in this chapter.作者: Charitable 時間: 2025-3-23 08:42
Botulinum Toxin: Application, Safety, and Limitations,ients are excluded from further treatment. A more recently approved second serotype (BoNT/B) could be effective in those secondary non-responders, however, due to less potency in humans higher doses have to be applied leading to an only transient successful treatment. Other serotypes as BoNT/A and B, e.g., BoNT/C should be approved as medicines.作者: NEX 時間: 2025-3-23 12:55 作者: abstemious 時間: 2025-3-23 15:52 作者: 通知 時間: 2025-3-23 19:06 作者: macular-edema 時間: 2025-3-23 22:34 作者: Misgiving 時間: 2025-3-24 03:49 作者: Aspirin 時間: 2025-3-24 07:15 作者: 欲望 時間: 2025-3-24 11:17 作者: NICE 時間: 2025-3-24 16:57
Barbro L?fgren,Esa Kokko,Jukka Sepp?l? intestinal epithelial barrier. This review provides an overview of current knowledge relating to the absorption of botulinum toxins (BoNT and BoNT complex) from the gastrointestinal tract, with particular emphasis on the interaction of these toxins with the intestinal epithelial barrier.作者: –LOUS 時間: 2025-3-24 20:55 作者: 針葉類的樹 時間: 2025-3-25 02:17 作者: obstinate 時間: 2025-3-25 05:00
Assembly and Function of the Botulinum Neurotoxin Progenitor Complex,en used with great success in the clinic. Accidental BoNT poisoning mainly occurs through oral ingestion of food contaminated with .. BoNTs are naturally produced in the form of progenitor toxin complexes (PTCs), which are high molecular weight (up to ~900?kDa) multiprotein complexes composed of BoN作者: Humble 時間: 2025-3-25 09:36 作者: Engaging 時間: 2025-3-25 14:07
Double Receptor Anchorage of Botulinum Neurotoxins Accounts for their Exquisite Neurospecificity,he interaction with two receptor components. TeNT and all BoNT bind first to complex polysialo-gangliosides abundantly present on the outer leaflet of neuronal membranes. The ganglioside binding occurs in BoNT/A, B, E, F and Gvia a conserved ganglioside binding pocket within the most carboxyl-termin作者: cogitate 時間: 2025-3-25 16:08
The Elusive Compass of Clostridial Neurotoxins: Deciding When and Where to Go?,r neuronal homeostasis and survival. Several pathogens and virulence factors use this route to gain access to the central nervous system, exploiting the complex and still poorly understood trafficking mechanisms that regulate the dynamics of their cellular receptors. Studying the intracellular trans作者: intercede 時間: 2025-3-25 23:28
Synchronized Chaperone Function of Botulinum Neurotoxin Domains Mediates Light Chain Translocation inhibit synaptic transmission. The di-chain protein is made up of the ~50?kD light chain and the ~100?kD heavy chain. The HC can be further subdivided into the N-terminal translocation domain (H.) and the C-terminal Receptor Binding Domain (H.). BoNT entry into neurons requires the toxin to utilize作者: Blemish 時間: 2025-3-26 00:53 作者: 向下 時間: 2025-3-26 04:38 作者: 下垂 時間: 2025-3-26 09:29
Persistence of , Neurotoxin Inactivation of Nerve Function,a biodefense nightmare. Understanding the mechanisms underlying BoNT persistence will offer new strategies for improving the efficacy and extending the applications of BoNT therapeutic agents as well as for treating the symptoms of botulism. Research indicates that the persistence of BoNT intoxicati作者: 誘惑 時間: 2025-3-26 14:53
Structure-Based Drug Discovery for Botulinum Neurotoxins,ilable is antibody treatment which will not be effective for post-exposure therapy. There are no drugs available for post-intoxication treatment. Accordingly, it is imperative to develop effective drugs to counter botulism. Available structural information on botulinum neurotoxins both alone and in 作者: acrobat 時間: 2025-3-26 19:23
Complexity of Botulinum Neurotoxins: Challenges for Detection Technology,ypes with more than 30 subtypes have been described, and even more subtypes are expected to be discovered. The fact that the BoNT molecules are released as large complexes of different size and composition adds further complexity to the issue. Currently, in the diagnostics of botulism, the mouse bio作者: 莊嚴(yán) 時間: 2025-3-26 23:31 作者: insurgent 時間: 2025-3-27 01:42
Transforming the Domain Structure of Botulinum Neurotoxins into Novel Therapeutics,ure and neurotoxin function have provided a number of opportunities to engineer innovative therapeutic proteins that utilise the neurotoxins and neurotoxin domains. For example, recent insights into the properties of the catalytic, translocation and binding domains open up opportunities to develop b作者: Obscure 時間: 2025-3-27 06:36 作者: 吞吞吐吐 時間: 2025-3-27 10:52 作者: Aerate 時間: 2025-3-27 16:23
Barbro L?fgren,Esa Kokko,Jukka Sepp?l?en used with great success in the clinic. Accidental BoNT poisoning mainly occurs through oral ingestion of food contaminated with .. BoNTs are naturally produced in the form of progenitor toxin complexes (PTCs), which are high molecular weight (up to ~900?kDa) multiprotein complexes composed of BoN作者: 背信 時間: 2025-3-27 18:42 作者: evaculate 時間: 2025-3-28 00:05
Simron Jit Singh,Helmut Haberl,Martin Schmidhe interaction with two receptor components. TeNT and all BoNT bind first to complex polysialo-gangliosides abundantly present on the outer leaflet of neuronal membranes. The ganglioside binding occurs in BoNT/A, B, E, F and Gvia a conserved ganglioside binding pocket within the most carboxyl-termin作者: 包庇 時間: 2025-3-28 05:37
Long Term Socio-Ecological Researchr neuronal homeostasis and survival. Several pathogens and virulence factors use this route to gain access to the central nervous system, exploiting the complex and still poorly understood trafficking mechanisms that regulate the dynamics of their cellular receptors. Studying the intracellular trans作者: grieve 時間: 2025-3-28 09:34
Simron Jit Singh,Helmut Haberl,Martin Schmid inhibit synaptic transmission. The di-chain protein is made up of the ~50?kD light chain and the ~100?kD heavy chain. The HC can be further subdivided into the N-terminal translocation domain (H.) and the C-terminal Receptor Binding Domain (H.). BoNT entry into neurons requires the toxin to utilize作者: BALE 時間: 2025-3-28 12:33
Long Term Socio-Ecological Researchrotoxin family. Like many other bacterial protein toxins they exhibit a modular structure. One domain mediates highly specific binding to target cells and endocytosis, while the second translocates the third, a catalytic domain across the endosomal membrane to the target cell cytosol. In case of Clo作者: annexation 時間: 2025-3-28 14:37
https://doi.org/10.1007/978-3-030-44511-9.-dependent exocytosis. After release and interaction with postsynaptic receptors, transmitters rapidly diffuse out of the synaptic cleft and are sequestered by plasma membrane transporters (in some cases following enzymatic conversion). SVs undergo endocytosis and are refilled by specific vesicular作者: 我邪惡 時間: 2025-3-28 19:55 作者: panorama 時間: 2025-3-29 02:36
https://doi.org/10.1007/978-3-030-44511-9ilable is antibody treatment which will not be effective for post-exposure therapy. There are no drugs available for post-intoxication treatment. Accordingly, it is imperative to develop effective drugs to counter botulism. Available structural information on botulinum neurotoxins both alone and in 作者: 憤怒歷史 時間: 2025-3-29 06:17 作者: GRATE 時間: 2025-3-29 10:57 作者: ornithology 時間: 2025-3-29 12:27 作者: FAST 時間: 2025-3-29 17:38 作者: 中止 時間: 2025-3-29 20:30
Andreas Rummel,Thomas BinzWritten by leading experts in the field botulinum neurotoxins.Provides the current status of basic botulinum neurotoxin research.Provides in depth articles on neurotoxins for further medical applicati作者: Interlocking 時間: 2025-3-30 02:08 作者: 鬧劇 時間: 2025-3-30 07:53
Botulinum Neurotoxins978-3-642-33570-9Series ISSN 0070-217X Series E-ISSN 2196-9965 作者: PHONE 時間: 2025-3-30 09:31 作者: Abominate 時間: 2025-3-30 12:41 作者: glans-penis 時間: 2025-3-30 18:31 作者: neutrophils 時間: 2025-3-31 00:42
Simron Jit Singh,Helmut Haberl,Martin Schmidraluminal domain 4 of the synaptic vesicle glycoprotein 2 (SV2) as protein receptor. Whereas the 50?kDa cell binding domain H. of BoNT/A interacts with all three SV2 isoforms, BoNT/E H. only binds SV2A and SV2B. Also, BoNT/D, F, and TeNT employ SV2 for binding and uptake. Thereafter, the synaptic ve作者: 壕溝 時間: 2025-3-31 01:25
