標題: Titlebook: Bone Toxicology; Susan Y. Smith,Aurore Varela,Rana Samadfam Book 2017 Springer International Publishing AG 2017 Bone Pharmacology.Bone Phy [打印本頁] 作者: 手或腳 時間: 2025-3-21 18:06
書目名稱Bone Toxicology影響因子(影響力)
書目名稱Bone Toxicology影響因子(影響力)學科排名
書目名稱Bone Toxicology網(wǎng)絡公開度
書目名稱Bone Toxicology網(wǎng)絡公開度學科排名
書目名稱Bone Toxicology被引頻次
書目名稱Bone Toxicology被引頻次學科排名
書目名稱Bone Toxicology年度引用
書目名稱Bone Toxicology年度引用學科排名
書目名稱Bone Toxicology讀者反饋
書目名稱Bone Toxicology讀者反饋學科排名
作者: AGGER 時間: 2025-3-21 20:34
Bone Physiology and Biologybasic function attributed to the cellular components, the osteoblasts osteocytes and osteoclasts. In the second section, the interplay between these matrix components and the cells will be discussed in the context of skeletal growth, skeletal adaptation (modeling), and skeletal maintenance (bone rem作者: 具體 時間: 2025-3-22 01:35
Specific Considerations for Bone Evaluations for Pediatric Therapeuticsin the requirements for juvenile toxicity testing of pharmaceuticals and biopharmaceuticals since 1998, with regulatory agencies commonly requiring nonclinical studies; particular emphasis is often being placed on evaluations of growth and the development of the skeleton. A number of therapeutic cla作者: custody 時間: 2025-3-22 05:50
Animal Models in Bone Researchlating those effects into effects in humans is required, because of the skeletal intermediary organization that only exists in vivo. Bone cells function in vivo within the intermediary organizations of modeling, which controls bone growth and shape changes, and remodeling, which controls bone renewa作者: MEET 時間: 2025-3-22 08:46
Biochemical Markers of Bone Turnovere skeleton level and to investigate potential mechanisms. The goal of this chapter is to describe the biochemical markers of bone turnover, consisting of markers of bone formation and bone resorption, considered important when conducting safety assessments in a preclinical setting. The bone formatio作者: 僵硬 時間: 2025-3-22 15:40 作者: Anthrp 時間: 2025-3-22 20:22 作者: 搏斗 時間: 2025-3-23 00:20 作者: sulcus 時間: 2025-3-23 03:04 作者: 平常 時間: 2025-3-23 05:35
Pituitary Hormone-Driven Mechanism for Skeletal Loss over the past decade that these hormones and their receptors have more ubiquitous functions. Organs, such as the skeleton, are regulated by and respond to pituitary hormones, particularly when circulating levels are perturbed in disease. Additionally, certain pituitary hormones are also expressed i作者: 尖 時間: 2025-3-23 13:18
Kidney–Bone: Interactionfrom the intracellular cell signaling to the energy metabolism and skeletal mineralization. Kidney, as a primary avenue for the regulating extracellular fluid and electrolyte homeostasis, participates to the maintenance of the continuous bone turnover and mineralization. At the same time, bone is th作者: 木質(zhì) 時間: 2025-3-23 17:30 作者: DAMP 時間: 2025-3-23 21:07
Bone and the Central Nervous Systemty and to transfer muscle forces during movement. The brain is well established as a master regulator of homeostasis in peripheral tissues. The discovery of bone regulation by central nervous system represents a growing area of study that is identifying novel regulatory axes between the nervous syst作者: 細絲 時間: 2025-3-23 23:51
Intestinal Microbiota and Bone Health: The Role of Prebiotics, Probiotics, and Dietas inflammatory bowel disease. In addition to a local intestinal effect, emerging evidence has demonstrated the potential for the microbiota to modulate systemic bone health via a gut-bone axis. In the present chapter, we discuss how diet can affect the composition of the intestinal microbiota, thro作者: GNAT 時間: 2025-3-24 03:53 作者: obviate 時間: 2025-3-24 09:36
Susan Y. Smith,Aurore Varela,Rana SamadfamComparative bone biology of animal species commonly used in toxicology studies with humans.Special considerations highlighted for Juvenile toxicology.Collection of chapters on bone interactions with o作者: 抵消 時間: 2025-3-24 11:57 作者: 舔食 時間: 2025-3-24 16:59
https://doi.org/10.1007/978-3-319-56192-9Bone Pharmacology; Bone Physiology; Bone Toxicology; Energy Metabolism; Integrated System Toxicology; Juv作者: 來自于 時間: 2025-3-24 22:50
978-3-319-85848-7Springer International Publishing AG 2017作者: Inculcate 時間: 2025-3-25 02:43 作者: 內(nèi)行 時間: 2025-3-25 06:16 作者: 充氣女 時間: 2025-3-25 09:29 作者: MEAN 時間: 2025-3-25 14:15 作者: 祝賀 時間: 2025-3-25 18:59 作者: 吞噬 時間: 2025-3-25 23:03
The Emergence of Living Lab Methodslating those effects into effects in humans is required, because of the skeletal intermediary organization that only exists in vivo. Bone cells function in vivo within the intermediary organizations of modeling, which controls bone growth and shape changes, and remodeling, which controls bone renewa作者: figure 時間: 2025-3-26 02:14
In-Situ and Mixed-Design Interventionse skeleton level and to investigate potential mechanisms. The goal of this chapter is to describe the biochemical markers of bone turnover, consisting of markers of bone formation and bone resorption, considered important when conducting safety assessments in a preclinical setting. The bone formatio作者: 星星 時間: 2025-3-26 04:34 作者: 冒失 時間: 2025-3-26 09:04
Arjan van Timmeren,David V. Keysonrties in pharmaceutical testing is critical to understanding the potential effects of that pharmaceutical on bone health and fracture risk. The specific objectives of each study are factors to be considered in deciding which preclinical model and test type(s) to utilize, and it is important to maint作者: judicial 時間: 2025-3-26 15:46
The Law of Love and the Love of Law,cases, qualitative histopathology has sufficient sensitivity to detect test article-related effects on bone marrow and growth plates in standard toxicity studies, it may lack the sensitivity to detect effects of test articles on key physiological processes in bone tissue such as bone formation, mine作者: 生命層 時間: 2025-3-26 17:55
Living Longer and Healthier at Older Agesfect other tissues, including bone, via secreting factors within the microenvironment to modulate their biological functions. Thus muscle is essential for bone development, modeling, and remodeling. Similar to muscle, bone can also be considered an endocrine organ targeting other tissues such as mus作者: 做事過頭 時間: 2025-3-27 00:20 作者: 疾馳 時間: 2025-3-27 04:53
https://doi.org/10.1007/978-3-031-69773-9from the intracellular cell signaling to the energy metabolism and skeletal mineralization. Kidney, as a primary avenue for the regulating extracellular fluid and electrolyte homeostasis, participates to the maintenance of the continuous bone turnover and mineralization. At the same time, bone is th作者: pessimism 時間: 2025-3-27 07:11 作者: 含鐵 時間: 2025-3-27 09:55 作者: vibrant 時間: 2025-3-27 13:56 作者: 壯觀的游行 時間: 2025-3-27 19:41 作者: TRACE 時間: 2025-3-27 21:56
Introduction and Considerations in Bone Toxicologyd-points. The ability to use our knowledge of bone biology to ensure study conditions are optimal to detect an effect will be presented. This includes study design considerations and the utility of other models to explore the impact new compounds may have on the skeleton in the development of safe and effective drugs.作者: generic 時間: 2025-3-28 03:51
Jean-Pierre Durand,Nicolas Hatzfeldst commonly used species in the study of bone metabolic disorders. Other large animals like dogs, sheep, mini-pigs, or rabbits which are being successfully used to study orthopedic conditions (implant ingrowth, fracture healing, and bone augmentation) have not been addressed in this chapter.作者: 代理人 時間: 2025-3-28 08:36 作者: 苦笑 時間: 2025-3-28 14:14
Living Longer and Healthier at Older Agesnt understanding of the central regulation of bone homeostasis. Herein, we will discuss the contribution of central peptides, and other peptides such as leptin, and semaphorins and involvement of the brain in regulation of bone metabolism.作者: BRIDE 時間: 2025-3-28 15:23
https://doi.org/10.1007/978-3-031-69773-9rine studies that investigate how probiotic supplementation can increase bone mineral density in “healthy” individuals and protect against the pathological bone loss associated with menopausal estrogen deficiency. Finally, we highlight the advances made in unearthing the mechanisms that potentially lead to these observed beneficial effects.作者: 胰臟 時間: 2025-3-28 21:31
Bone Physiology and Biologyst commonly used species in the study of bone metabolic disorders. Other large animals like dogs, sheep, mini-pigs, or rabbits which are being successfully used to study orthopedic conditions (implant ingrowth, fracture healing, and bone augmentation) have not been addressed in this chapter.作者: Orgasm 時間: 2025-3-29 01:28
Biomechanicschanical testing procedures for achieving functional outcome measures are outlined in this chapter. Test modes and measurements that will be described are related to compressive, bending, torsion, and shear properties of bone.作者: Explicate 時間: 2025-3-29 04:24
Bone and the Central Nervous Systemnt understanding of the central regulation of bone homeostasis. Herein, we will discuss the contribution of central peptides, and other peptides such as leptin, and semaphorins and involvement of the brain in regulation of bone metabolism.作者: AV-node 時間: 2025-3-29 09:30 作者: immunity 時間: 2025-3-29 13:23 作者: 易于交談 時間: 2025-3-29 16:33 作者: 敬禮 時間: 2025-3-29 20:24
Specific Considerations for Bone Evaluations for Pediatric Therapeuticsan also be incorporated in clinical trials. These techniques along with routine toxicology endpoints, growth measurements, and ex vivo techniques, such as histomorphometry and biomechanical testing, can be incorporated into juvenile toxicology studies, each of which is designed on a case-by-case bas作者: 威脅你 時間: 2025-3-30 03:25 作者: 為現(xiàn)場 時間: 2025-3-30 05:54
Biochemical Markers of Bone Turnover drug development or to monitor temporal changes in a chronic setting. When combined with additional (in vivo) end-points such as calcium and phosphorus measures, analysis of the calciotropic hormones, fibroblast growth factor 23, insulin-like growth factor-1, and bone densitometry, they provide imp作者: CULP 時間: 2025-3-30 10:23 作者: Hectic 時間: 2025-3-30 14:38 作者: Allodynia 時間: 2025-3-30 18:27
Bone and Muscleen the factors regulating both bone and muscle, including factors like myogenic regulatory factors (MRFs) and myostatin from muscle, bone-derived factors like bone morphogenetic proteins (BMPs) and prostaglandin E. (PGE.), as well as other secretory factors, are discussed to provide a better underst作者: 填料 時間: 2025-3-30 23:09
Pituitary Hormone-Driven Mechanism for Skeletal Lossand and/or receptor yields a skeletal phenotype with the primary target organ remaining unaffected. Recognition and in-depth analysis of the mechanism of action of each pituitary hormone has improved our understanding of bone pathophysiology and opens new avenues for therapy. Here we discuss the int作者: 優(yōu)雅 時間: 2025-3-31 04:31
Kidney–Bone: Interactionlites, as well as blood electrolyte status and (2) bone-derived factors including FGF23, MEPE, and osteocalcin. Dysfunction in any of these factors alone or in combination can disrupt a multitude of the mineral balance in the cross-organ communication between the kidneys, intestine, bones, and parat作者: Sigmoidoscopy 時間: 2025-3-31 07:45
Bone and the Immune System formation. Specifically, the bone anabolic actions of parathyroid hormone and the pharmaceutical costimulation inhibitor CTLA4-Ig (abatacept) are mediated though mechanisms involving T-cells. This chapter documents some of the key discoveries in the field of osteoimmunology in the context of both p作者: ARCHE 時間: 2025-3-31 12:37
Bone and Energy Metabolismdulate adipose tissue function and pancreatic islet cells production of insulin in the pancreas. The central nervous system is the final common pathway modulating these signals, both in the skeleton and in adipose tissue. Disruption in this complex regulatory circuit and its downstream tissues is ma作者: Pillory 時間: 2025-3-31 14:50 作者: Projection 時間: 2025-3-31 20:46
2168-4219 eans to develop the concepts in part three which describes bone and its interaction with other organ systems.? The unique series of chapters in part three, contributed to by key leaders in their respective fiel978-3-319-85848-7978-3-319-56192-9Series ISSN 2168-4219 Series E-ISSN 2168-4235
