標題: Titlebook: Bone Regulators and Osteoporosis Therapy; Paula H. Stern Book 2020 Springer Nature Switzerland AG 2020 Bone.Bone cell regulators.Osteoporo [打印本頁] 作者: malcontented 時間: 2025-3-21 18:47
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書目名稱Bone Regulators and Osteoporosis Therapy被引頻次
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書目名稱Bone Regulators and Osteoporosis Therapy讀者反饋學(xué)科排名
作者: 召集 時間: 2025-3-21 22:31 作者: 沙發(fā) 時間: 2025-3-22 04:05 作者: 發(fā)微光 時間: 2025-3-22 07:50 作者: V切開 時間: 2025-3-22 11:21
Viral Hepatitis: Hepatitis B (& D)esis revealed that, in vivo, the adipocyte-derived hormone leptin is a powerful inhibitor of bone mass accrual following its signaling in the brain. This chapter details the molecular bases and biological relevance of this regulation of bone mass accrual by leptin.作者: Offbeat 時間: 2025-3-22 13:54
Liver Stiffness and Its Measurementdetailed clinical assessment of the wide variety of symptoms and signs associated with these diseases. Thus, clinicians should undertake a systematic approach commencing with careful history taking and physical examination, followed by appropriate laboratory and skeletal imaging investigations. Fina作者: 凹槽 時間: 2025-3-22 18:58
Liver Stiffness and Its Measurementenesis also contributes to bone deterioration with aging and osteoporosis; hence the factors and signaling pathways mediating osteoblast formation and function will be examined. Osteocytes are mature osteoblasts embedded in bone matrix and act as endocrine cells; their role in bone health and pathol作者: 包裹 時間: 2025-3-22 23:34
Liver Stiffness in Autoimmune Hepatitise by histology as well as micro-computed tomography and infra-red spectroscopy or backscattered electron microscopy. Force can be directly applied to bone samples to measure the bones strength. Impact microindentation is a new minimally invasive technique that measures bone hardness. Metabolic asses作者: panorama 時間: 2025-3-23 03:24 作者: Manifest 時間: 2025-3-23 07:59 作者: glomeruli 時間: 2025-3-23 11:18
William E. Russell,Robert S. Carverre risk. However, glucocorticoids may also interfere with the unmineralized matrix leading to an increase in fracture risk, not mirrored in BMD changes. Some drugs such as selective serotonin reuptake inhibitors (SSRI), paracetamol, and non-steroidal anti-inflammatory drugs (NSAIDs) may not per se b作者: podiatrist 時間: 2025-3-23 16:06 作者: 打谷工具 時間: 2025-3-23 18:23
Vitamin D and Bone,increase the availability of calcium for bone mineralization. Specific actions of 1,25(OH).D. on the intestine, kidney, and bone needed to maintain calcium homeostasis are summarized, and the impact of vitamin D status on bone health is discussed.作者: Servile 時間: 2025-3-24 01:31 作者: Substance 時間: 2025-3-24 02:23
Prostaglandins and Bone,, as expected for such a widespread local factor, hard to study. Some of the complexity of PGE. actions on bone can be explained by the fact that there are four receptors for PGE. (EP1–4). Some of the major actions of PGE. in vitro occur via EP2 and EP4, both of which can stimulate cAMP signaling, b作者: 思想 時間: 2025-3-24 10:31
Calcium and Bone,als which demonstrate anti-fracture efficacy of estrogens and bisphosphonates in the absence of such supplementation. Thus, calcium supplements have only a minor place in contemporary medical practice.作者: 集中營 時間: 2025-3-24 13:48
The Central Regulation of Bone Mass: Genetic Evidence and Molecular Bases,esis revealed that, in vivo, the adipocyte-derived hormone leptin is a powerful inhibitor of bone mass accrual following its signaling in the brain. This chapter details the molecular bases and biological relevance of this regulation of bone mass accrual by leptin.作者: Gratulate 時間: 2025-3-24 18:01
Genetics of Skeletal Disorders,detailed clinical assessment of the wide variety of symptoms and signs associated with these diseases. Thus, clinicians should undertake a systematic approach commencing with careful history taking and physical examination, followed by appropriate laboratory and skeletal imaging investigations. Fina作者: fallible 時間: 2025-3-24 21:40
Pathogenesis of Osteoporosis,enesis also contributes to bone deterioration with aging and osteoporosis; hence the factors and signaling pathways mediating osteoblast formation and function will be examined. Osteocytes are mature osteoblasts embedded in bone matrix and act as endocrine cells; their role in bone health and pathol作者: cortex 時間: 2025-3-25 02:57
Structural and Metabolic Assessment of Bone,e by histology as well as micro-computed tomography and infra-red spectroscopy or backscattered electron microscopy. Force can be directly applied to bone samples to measure the bones strength. Impact microindentation is a new minimally invasive technique that measures bone hardness. Metabolic asses作者: 帶子 時間: 2025-3-25 06:06
Osteoporosis Therapeutics 2020,we focus on the management of different forms of osteoporosis and give a review of the respective current guidelines for treatment. Adverse effects of treatment such as atypical femoral fractures, osteonecrosis of the jaw or influence of fracture healing are considered also in this context.作者: 售穴 時間: 2025-3-25 09:13
Reduced Bone Modeling and Unbalanced Bone Remodeling: Targets for Antiresorptive and Anabolic Therato complete the slow process of secondary mineralization which reduces the heterogeneity of matrix mineralization and allows it to become glycosylated, changes that may make the smaller and microstructurally deteriorated bone volume more brittle. Neither class of antiresorptive restores bone volume 作者: 吹牛需要藝術(shù) 時間: 2025-3-25 13:04 作者: 配偶 時間: 2025-3-25 18:55
New Targets and Emergent Therapies for Osteoporosis,tinues, potential novel targets for future drug development are identified. This review takes a wide perspective to describe potentially rewarding topics to explore, including knowledge of genes and pathways involved in bone cell metabolism, the utility of animal models, targeting drugs to bone, and ongoing advances in drug design and delivery.作者: Palliation 時間: 2025-3-25 23:36
Zaid H. Tafesh,Nikolaos Pyrsopoulostinues, potential novel targets for future drug development are identified. This review takes a wide perspective to describe potentially rewarding topics to explore, including knowledge of genes and pathways involved in bone cell metabolism, the utility of animal models, targeting drugs to bone, and ongoing advances in drug design and delivery.作者: Cytology 時間: 2025-3-26 01:59 作者: etidronate 時間: 2025-3-26 05:09 作者: 懶惰人民 時間: 2025-3-26 09:23 作者: tenosynovitis 時間: 2025-3-26 12:37 作者: 蛙鳴聲 時間: 2025-3-26 20:51
Growth Factors, Carrier Materials, and Bone Repair,air (including bone grafts) are summarized, and carrier systems (scaffolds) for bone tissue engineering via localized growth factor delivery are reviewed. The chapter concludes with a consideration of how bone repair might be improved in the future.作者: 直覺沒有 時間: 2025-3-27 00:00
Cytokines and Bone: Osteoimmunology, the diverse effects that cytokines and inflammation have on osteoblasts, osteoclasts, and bone mass. This chapter provides a broad overview of this topic with extensive references so that, if desired, readers can access specific references to delve into individual topics in greater detail.作者: 館長 時間: 2025-3-27 03:09
0171-2004 of bone disorders and discusses the pathophysiology of osteo.This volume is designed to provide an understanding of current and potential therapies for osteoporosis. The opening chapter introduces the? cells of bone and their interactions. ?Several following chapters describe factors affecting bone 作者: 啞巴 時間: 2025-3-27 06:05 作者: Calculus 時間: 2025-3-27 12:49
Thyroid Hormones, Glucocorticoids, Insulin, and Bone,eral pathways. Their endogenous or exogenous excess will induce pathological processes that might elevate the risk of fractures. Insulin and the carbohydrate metabolism elicit a physiological effect on bone; however, the lack of insulin (type 1 diabetes) or insulin resistance (type 2 diabetes) have deleterious influence on bone tissue.作者: 無法破譯 時間: 2025-3-27 17:07 作者: patriarch 時間: 2025-3-27 18:03 作者: 同義聯(lián)想法 時間: 2025-3-27 23:20
Vascular Disorders of the?Liverary aspects of how PTH and PTHrP behave and as a call to encourage further investigation that will yield more comprehensive understanding of the physiological and pathological steps at play, with a goal toward novel therapeutic interventions.作者: 相同 時間: 2025-3-28 02:26
https://doi.org/10.1007/978-3-030-79132-2chemokines in altering the bone microenvironment through effects on angiogenesis and tumor invasion is discussed. Very few therapeutic agents that influence bone formation by targeting chemokines or chemokine receptors are available, although a few are currently being evaluated.作者: 窩轉(zhuǎn)脊椎動物 時間: 2025-3-28 08:22
Nonalcoholic Fatty Liver Disease matrix. In contrast, deficient actions of FGF23 result in hyperphosphatemic tumoral calcinosis with high 1,25-dihydroxyvitamin D levels. These results indicate that FGF23 is a physiological regulator of phosphate and vitamin D metabolism and indispensable for the maintenance of serum phosphate levels.作者: CAND 時間: 2025-3-28 11:33
PTH and PTHrP Actions on Bone,ary aspects of how PTH and PTHrP behave and as a call to encourage further investigation that will yield more comprehensive understanding of the physiological and pathological steps at play, with a goal toward novel therapeutic interventions.作者: 美麗的寫 時間: 2025-3-28 16:44 作者: 沙草紙 時間: 2025-3-28 19:57 作者: Blemish 時間: 2025-3-29 00:58
Liver Ischaemia-Reperfusion Injurycts the amount and structure of bone, as well as its quality. These qualities are determined and maintained by osteoblasts (bone-forming cells) and osteoclasts (bone-resorbing cells) on the surface of the bone and osteocytes embedded within the bone matrix. Bone development and growth also involves 作者: 寄生蟲 時間: 2025-3-29 03:46
Vascular Disorders of the?Livertracellular calcium and phosphate metabolism and in controlling skeletal growth and repair. Acting through complex signaling mechanisms that in many instances proceed in a tissue-specific manner, precise control of these processes is achieved. A variety of direct and indirect disease processes, alon作者: 邊緣帶來墨水 時間: 2025-3-29 09:35 作者: hallow 時間: 2025-3-29 14:22 作者: 精致 時間: 2025-3-29 15:42 作者: Arctic 時間: 2025-3-29 23:02 作者: 跳脫衣舞的人 時間: 2025-3-30 02:38
Bile Acid Sulfation and Cholestasis,ing (osteoblast) lineage and the bone-resorbing (osteoclast) lineage. The inducible cyclooxygenase, COX-2, is largely responsible for most PGE. production in bone, and once released, PGE. is rapidly degraded in vivo. COX-2 is induced by multiple agonists – hormones, growth factors, and proinflammato作者: 搖擺 時間: 2025-3-30 04:36
Laurence Tabone,Pierre Teira,Annie Lavoie However, an ever-expanding number of these factors have been discovered to have major effects on bone cells and the development of the skeleton in health and disease (Table .). In addition, several cytokines have been directly linked to the development of osteoporosis in both animal models and in p作者: MOTTO 時間: 2025-3-30 12:13
https://doi.org/10.1007/978-3-030-79132-2eir cognate G-protein-coupled receptors to elicit downstream signals that result in cell migration, proliferation, and survival. This review presents evidence for how the various CXC and CC subfamily chemokines influence bone hemostasis by acting on osteoclasts, osteoblasts, and progenitor cells. Al作者: RENIN 時間: 2025-3-30 13:47 作者: 小步走路 時間: 2025-3-30 19:21 作者: 高貴領(lǐng)導(dǎo) 時間: 2025-3-30 22:04
Viral Hepatitis: Hepatitis B (& D)childhood and bone remodeling during adulthood. A central question raised by this physiological process that is fundamental to longitudinal growth during childhood and adolescence and that is attacked at the other end of life in the context of osteoporosis is to know how it is regulated. This questi作者: 關(guān)節(jié)炎 時間: 2025-3-31 03:38 作者: profligate 時間: 2025-3-31 05:06
Liver Stiffness and Its Measurementosis is on the rise. Although advances in the field have made progress in targeting the mechanisms of the disease, the efficacy of current treatments remains limited and is complicated by unexpected side effects. Therefore, to overcome this treatment gap, new approaches are needed to identify and el作者: 僵硬 時間: 2025-3-31 11:39 作者: Terminal 時間: 2025-3-31 17:10 作者: refraction 時間: 2025-3-31 21:23
Liver Stiffness in Alcoholic Liver Diseaseng by basic multicellular units (BMUs) upon the three (intracortical, endocortical, and trabecular) components of the inner (endosteal) bone envelope. Each BMU deposits less bone than resorbed, reducing total bone volume and deteriorating the microstructure of the diminished residual bone volume..An作者: graphy 時間: 2025-3-31 22:27
