標題: Titlebook: Bone Metastasis and Molecular Mechanisms; Pathophysiology Gurmit Singh (Director of Research, Professor of P Book 2004 Springer Science+Bus [打印本頁] 作者: fasten 時間: 2025-3-21 17:39
書目名稱Bone Metastasis and Molecular Mechanisms影響因子(影響力)
書目名稱Bone Metastasis and Molecular Mechanisms影響因子(影響力)學(xué)科排名
書目名稱Bone Metastasis and Molecular Mechanisms網(wǎng)絡(luò)公開度
書目名稱Bone Metastasis and Molecular Mechanisms網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Bone Metastasis and Molecular Mechanisms被引頻次
書目名稱Bone Metastasis and Molecular Mechanisms被引頻次學(xué)科排名
書目名稱Bone Metastasis and Molecular Mechanisms年度引用
書目名稱Bone Metastasis and Molecular Mechanisms年度引用學(xué)科排名
書目名稱Bone Metastasis and Molecular Mechanisms讀者反饋
書目名稱Bone Metastasis and Molecular Mechanisms讀者反饋學(xué)科排名
作者: debase 時間: 2025-3-21 21:33 作者: 小木槌 時間: 2025-3-22 01:52 作者: Vasoconstrictor 時間: 2025-3-22 06:25 作者: anatomical 時間: 2025-3-22 11:43
https://doi.org/10.1007/978-3-540-70766-0ew spontaneous models of bone metastasis despite the fact that rodents (rats and mice) and other animals (dogs and cats) often spontaneously develop cancer. Therefore, most experimental models of bone metastasis in rodents require injection or implantation of neoplastic cells into orthotopic locations, bones, or the left ventricle of the heart.作者: 不能仁慈 時間: 2025-3-22 13:38 作者: 不透明 時間: 2025-3-22 19:15 作者: thrombosis 時間: 2025-3-22 21:13 作者: GRACE 時間: 2025-3-23 02:34 作者: 不連貫 時間: 2025-3-23 06:47 作者: Entreaty 時間: 2025-3-23 12:05
The Role of Bisphosphonates in Bone Metastasis,igure 1). These compounds were first synthesized in Germany in 1865. Their initial use was industrial (textile, fertilizer and oil industries) and for prevention of mineral scaling (due to their ability to inhibit calcium carbonate precipitation). The biological properties of these compounds, however, were not explored until the 1960’s (1, 2).作者: 托運 時間: 2025-3-23 15:59
https://doi.org/10.1007/978-1-4020-2036-0angiogenesis; bisphosphonates; bone marrow; cancer; macrophages; metastasis; pain; pathophysiology; prostate作者: Antioxidant 時間: 2025-3-23 21:43 作者: 污點 時間: 2025-3-24 01:58
Springer Series in Materials Sciencete of metastasis of some other cancers, including prostate. Bone metastases in breast cancer are predominantly osteolytic due to the resorption of bone following excessive activation of osteoclasts. This leads to major clinical problems including severe pain, hypercalcemia, bone fractures and nerve-作者: 滴注 時間: 2025-3-24 03:42
https://doi.org/10.1007/978-3-540-70766-0ew spontaneous models of bone metastasis despite the fact that rodents (rats and mice) and other animals (dogs and cats) often spontaneously develop cancer. Therefore, most experimental models of bone metastasis in rodents require injection or implantation of neoplastic cells into orthotopic locatio作者: 態(tài)度暖昧 時間: 2025-3-24 09:40 作者: Pruritus 時間: 2025-3-24 13:28 作者: electrolyte 時間: 2025-3-24 17:57
Springer Series in Materials Scienceastasis to the bone marrow. The extensive changes induced by cancer metastasis in bone (either lytic, or more rarely, sclerotic) represent secondary changes induced to fulfill the need of cancer cells for their anti-homeostatic growth. A common biological paradigm — “the seed and the soil” — is used作者: TRUST 時間: 2025-3-24 19:09 作者: Inclement 時間: 2025-3-25 01:28 作者: 阻止 時間: 2025-3-25 03:55 作者: Ornithologist 時間: 2025-3-25 10:40
https://doi.org/10.1007/978-3-540-70766-0men and is the second leading cause of cancer mortality following lung cancer (1–3). Recently, increases in the number of men diagnosed with prostate cancer has been attributed to an increase in the awareness of the disease as well as to better improvements in screening and detection. However, despi作者: 貴族 時間: 2025-3-25 14:13
https://doi.org/10.1007/978-3-540-70766-0o spread to bone amongst which are the three most common cancers — lung, breast and prostate. Patients with lung cancer are more likely to succumb quickly to their disease than those with breast or prostate tumors in whom, relatively, bone metastases are more of a problem. Patients with advanced bre作者: obstinate 時間: 2025-3-25 17:27
Steven Specter,Gerald Lancz,Ricardo O. Bach proteins helped to resolve numerous questions regarding the exact molecular mechanisms for bone resorption. These proteins also neatly account for the long-recognized dependence of osteoclasts on the osteoblast/stromal cell population. This pathway was rapidly elucidated after the discovery of oste作者: 周興旺 時間: 2025-3-25 21:08
Lithium and Dermatological Disorders,and mortality. They cause clinical disease due to extensive, intractable bone pain, pathological fractures, and spinal cord compression and leads eventually to death. 70% of patients that die of breast cancer have noticeable disease in their bones (1, 2). Similar numbers are found for prostate cance作者: 短程旅游 時間: 2025-3-26 01:37
https://doi.org/10.1007/978-1-4613-4598-5igure 1). These compounds were first synthesized in Germany in 1865. Their initial use was industrial (textile, fertilizer and oil industries) and for prevention of mineral scaling (due to their ability to inhibit calcium carbonate precipitation). The biological properties of these compounds, howeve作者: 威脅你 時間: 2025-3-26 04:57 作者: majestic 時間: 2025-3-26 09:09
1568-2102 e cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and pr作者: 美色花錢 時間: 2025-3-26 15:55
Lithium and Dermatological Disorders,tually to death. 70% of patients that die of breast cancer have noticeable disease in their bones (1, 2). Similar numbers are found for prostate cancer patients (2). Bone disease is also a major problem in multiple myeloma patients. The manifestation of the bone involvement is distinct for the three types of cancers.作者: Vasodilation 時間: 2025-3-26 16:49
Role of Matrix Metalloproteinases in Bone Metastasis from Human Breast and Prostate Cancer,tually to death. 70% of patients that die of breast cancer have noticeable disease in their bones (1, 2). Similar numbers are found for prostate cancer patients (2). Bone disease is also a major problem in multiple myeloma patients. The manifestation of the bone involvement is distinct for the three types of cancers.作者: 空氣傳播 時間: 2025-3-26 23:59
Book 2004y of life for patients with breast and prostate cancer. ..Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies. .作者: RAGE 時間: 2025-3-27 02:16 作者: 猛擊 時間: 2025-3-27 08:10
Potential Therapeutic Targets for Bone Metastasis,ast and prostate cancers usually develop bone metastases and tend to harbour the bulk of their tumor burden in their bones at the time of death. The concepts and data reviewed in this chapter relate mainly to these malignancies although some are also relevant to bone metastases secondary to multiple myeloma.作者: 熱情贊揚 時間: 2025-3-27 09:50 作者: Foment 時間: 2025-3-27 14:15
Springer Series in Materials Scienceoenvironment suited for their proliferation. Circulating cells capable of growing in the bone marrow environment represent the seed. Characteristics of the bone marrow stroma that are conducive for the establishment of a bone metastasis provide the soil.作者: cogent 時間: 2025-3-27 18:07
Springer Series in Materials Sciencels and the (a)cellular bone marrow stoma lead to differential expression of (lymph)angiogenic factors and their inhibitors in the bone microenvironment, thus explaining -at least in part- the observed bone tropism by a limited number of carcinomas.作者: Aesthete 時間: 2025-3-27 22:11
Steven Specter,Gerald Lancz,Ricardo O. Bachfunctions by binding to its receptor RANK on the surface of osteoclasts and their precursors. RANKL is the final mediator of osteoclast activation induced by most, if not all, proresorptive cytokines.作者: Incorporate 時間: 2025-3-28 05:49 作者: 擦掉 時間: 2025-3-28 06:52 作者: 向宇宙 時間: 2025-3-28 11:06 作者: 摘要 時間: 2025-3-28 16:42
Models of Breast Cancer Metastasis to Bone: Characterization of a Clinically Relevant Model,te of metastasis of some other cancers, including prostate. Bone metastases in breast cancer are predominantly osteolytic due to the resorption of bone following excessive activation of osteoclasts. This leads to major clinical problems including severe pain, hypercalcemia, bone fractures and nerve-作者: 脆弱吧 時間: 2025-3-28 21:23 作者: 散布 時間: 2025-3-29 00:31
Comparative Morphometric Study on Bone Remodeling in Human Specimens and in Experimental Models of pathological fracture, spinal compression syndromes and hypercalcemia. Bone destruction is a marked clinical feature and the major source of morbidity associated with bone metastases. Most of these clinical features can be related to structural changes in bone that are caused by effects of the tumor作者: Canvas 時間: 2025-3-29 03:52 作者: 偉大 時間: 2025-3-29 09:11
Metastasis in the Bone Marrow Microenvironment,astasis to the bone marrow. The extensive changes induced by cancer metastasis in bone (either lytic, or more rarely, sclerotic) represent secondary changes induced to fulfill the need of cancer cells for their anti-homeostatic growth. A common biological paradigm — “the seed and the soil” — is used作者: 膠水 時間: 2025-3-29 13:28
The Role of Tumor-Associated Macrophages in Metastasis-Associated Osteolysis,umors not only have the potential for metastasis at a relatively early stage of the disease but can also produce metastases many years after adequate local treatment (1, 2). A significant macrophage infiltrate is often found in these metastatic cancers. On the basis that monocytes and macrophages ar作者: 表臉 時間: 2025-3-29 17:50
The Malignant Hierarchy in Multiple Myeloma: Relationships between Malignant Cells and Bone Disease from hematological malignancies. It is characterized by monoclonal immunoglobulin (mIg) in the blood, lytic bone lesions, and monoclonal plasma cells in the BM. These plasma cells are responsible for most symptoms of MM, but considerable work confirms that the MM clone also includes earlier stage B作者: Morose 時間: 2025-3-29 22:33
Angiogenesis and Lymphangiogenesis in Metastatic Bone Disease: A Matter of Networking, cycle). In normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. In pathologic conditions, however, this delicate balance can be disrupted and lead to initiation and stimulation of blood or lymphatic vessel formati作者: 預(yù)兆好 時間: 2025-3-30 01:03
Prostate Cancer: Models for Developing Novel Therapeutic Approaches,men and is the second leading cause of cancer mortality following lung cancer (1–3). Recently, increases in the number of men diagnosed with prostate cancer has been attributed to an increase in the awareness of the disease as well as to better improvements in screening and detection. However, despi作者: 籠子 時間: 2025-3-30 04:40
Potential Therapeutic Targets for Bone Metastasis,o spread to bone amongst which are the three most common cancers — lung, breast and prostate. Patients with lung cancer are more likely to succumb quickly to their disease than those with breast or prostate tumors in whom, relatively, bone metastases are more of a problem. Patients with advanced bre作者: BLAND 時間: 2025-3-30 09:23
OPG, RANK and RANKL in Bone Metastasis and Cancer-Associated Osteolysis, proteins helped to resolve numerous questions regarding the exact molecular mechanisms for bone resorption. These proteins also neatly account for the long-recognized dependence of osteoclasts on the osteoblast/stromal cell population. This pathway was rapidly elucidated after the discovery of oste作者: Cupping 時間: 2025-3-30 16:23
Role of Matrix Metalloproteinases in Bone Metastasis from Human Breast and Prostate Cancer,and mortality. They cause clinical disease due to extensive, intractable bone pain, pathological fractures, and spinal cord compression and leads eventually to death. 70% of patients that die of breast cancer have noticeable disease in their bones (1, 2). Similar numbers are found for prostate cance
