標(biāo)題: Titlebook: Blood-Brain Barrier; Tatiana Barichello Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Neuronal progenitor c [打印本頁] 作者: TUMOR 時(shí)間: 2025-3-21 18:58
書目名稱Blood-Brain Barrier影響因子(影響力)
書目名稱Blood-Brain Barrier影響因子(影響力)學(xué)科排名
書目名稱Blood-Brain Barrier網(wǎng)絡(luò)公開度
書目名稱Blood-Brain Barrier網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Blood-Brain Barrier被引頻次
書目名稱Blood-Brain Barrier被引頻次學(xué)科排名
書目名稱Blood-Brain Barrier年度引用
書目名稱Blood-Brain Barrier年度引用學(xué)科排名
書目名稱Blood-Brain Barrier讀者反饋
書目名稱Blood-Brain Barrier讀者反饋學(xué)科排名
作者: Confirm 時(shí)間: 2025-3-21 23:52 作者: hysterectomy 時(shí)間: 2025-3-22 02:29 作者: 食道 時(shí)間: 2025-3-22 05:10 作者: Hectic 時(shí)間: 2025-3-22 11:33 作者: 沒有貧窮 時(shí)間: 2025-3-22 14:38
Approximate Inference Via the EM Algorithmthe difficulty in delivering diagnostic and therapeutic molecules across the blood-brain barrier (BBB) and into the brain. This chapter describes these and other challenges and the progress that has been made in transporting molecules into the brain. The pathways that molecules can take to cross the作者: 誘騙 時(shí)間: 2025-3-22 17:27
An Introduction to Bayesian Inferencetive function, BBB regulates entry of nutrients into the central nervous system by selective transport and metabolism of blood- and brain-borne substances. Successful modeling of BBB in vitro is established since 1970s and has been used to study mechanisms of transport, cellular interaction, and gen作者: 真繁榮 時(shí)間: 2025-3-23 00:47
https://doi.org/10.1007/978-3-319-72425-6e performed in vivo. However, major limitations of this approach, including limited translational significance to human patients, high cost, time, and labor to develop the appropriate model (e.g., transgenic or inbred models), have greatly favored the parallel development of in vitro models. These a作者: hedonic 時(shí)間: 2025-3-23 04:05
https://doi.org/10.1007/978-3-319-72425-6ly mimic the physiological complexity of the in vivo BBB continues to be a challenge, however. To meet this challenge, in vitro BBB models have evolved significantly over the last three decades, from static monocultures to dynamic multicellular flow-based systems. In this chapter, we initially focus作者: FLINT 時(shí)間: 2025-3-23 07:38
Beyond First-Order Truthlikeness, in vitro cellular barriers for transport studies. TEER measurement has advantages over traditional permeability measurements as a quick, label-free, and non-invasive method. TEER measurement has an added advantage that it can be performed in real -time if the measurement electrodes are integrated i作者: 鉆孔 時(shí)間: 2025-3-23 12:20
https://doi.org/10.1007/978-94-009-4658-3bstances. This dynamic barrier, which is primarily comprised of precisely arranged, specialized endothelial cells, astrocytes, and pericytes, not only prevents the brain interstitial fluid from mixing with the components of blood but also maintains a delicate balance between central nervous system (作者: 密切關(guān)系 時(shí)間: 2025-3-23 16:31
The prosthetic service in the UK,lieu intérieur of the central nervous system. To elucidate the function of CPECs, in vitro primary culture is an ideal system as the choroid plexus (CP) is situated deep in the brain ventricular system in situ. This location makes detailed analysis of these cells difficult. Moreover, its highly undu作者: insightful 時(shí)間: 2025-3-23 21:20
Haim Shtarker,Mikhail Samchukovailable for this organism, . is uniquely suited to study bbb physiology and function, with high relevance for mammalian function. In this chapter we discuss targeting strategies to specifically mark and manipulate BBB cells, how to test BBB integrity, and methods to isolate single-BBB cells.作者: 付出 時(shí)間: 2025-3-24 02:10
https://doi.org/10.1007/978-3-319-18023-6the BBB is a major obstacle for drug delivery into the brain. Under pathological conditions, the integrity of the BBB is susceptible to disruption and can be broken down in severe brain diseases. Therefore, the understanding of intrinsic complexity as well as modulation of the BBB is critical to dis作者: 自負(fù)的人 時(shí)間: 2025-3-24 02:52
Growth Plate Injuries: An Introductionquires appropriate models and markers to demonstrate the integrity of the interface between the blood and the brain. Historically, dyes have been used to analyze the blood-brain barrier (BBB) mechanisms and for measurements of plasma volume. Despite some limitations, Evans blue is still the most com作者: 群島 時(shí)間: 2025-3-24 08:30
Pablo Wagner,John E. Herzenbergh neurologic diseases, in newborns, young adults, and the elderly, like kernicterus, multiple sclerosis, and Alzheimer’s disease. Yet, the CP still remains an overlooked organ requiring further investigation..The minute size of the CP, particularly in rodent models, increases the difficulties associ作者: 招募 時(shí)間: 2025-3-24 14:10 作者: 割讓 時(shí)間: 2025-3-24 17:09
Jason H. Calhoun,Anne C. Sullivanng specific transport of drugs and nutrients is essential to improve our understanding of the pharmacological and physiological roles of the BRB. This will contribute to the development of novel systemic drug delivery system that will help with safer and more efficient therapy of severe retinal dise作者: 蝕刻 時(shí)間: 2025-3-24 20:09
S. Robert Rozbruch,Reggie C. Hamdy(CNS) diseases. The use of focused ultrasound (FUS), in conjunction with circulating microbubbles, is a unique approach whereby the transcranial application of acoustic energy, focused within targeted brain areas, can be used to induce a noninvasive, transient, and targeted increase in BBB permeabil作者: 同時(shí)發(fā)生 時(shí)間: 2025-3-25 01:07 作者: 含鐵 時(shí)間: 2025-3-25 05:20
Pablo Wagner,John E. Herzenbergevelopment of inflammatory response in the brain. The use of intravital microscopy technique allows direct in vivo assessment of leukocyte rolling and adhesion on cortical meningeal vessels. The current review highlights the use of intravital microscopy and its association with neuroinflammatory par作者: 觀點(diǎn) 時(shí)間: 2025-3-25 09:35
S. Robert Rozbruch,Reggie C. Hamdy such as infections. The integrity of BBB is preserved by multi-structural and functional components. Increasing evidence indicates that BBB is used as an important marker measured in variety of pathological condition with large permeability leaks, such as?brain tumors and multiple sclerosis, to mor作者: DUST 時(shí)間: 2025-3-25 14:43 作者: 可忽略 時(shí)間: 2025-3-25 17:02
https://doi.org/10.1007/978-1-4939-8946-1Neuronal progenitor cell; TEER; Sodium fluorescein; choroid plexuses; drug transport作者: STENT 時(shí)間: 2025-3-26 00:02
Springer Science+Business Media, LLC, part of Springer Nature 2019作者: 松果 時(shí)間: 2025-3-26 02:30
0893-2336 n your laboratory.?.Cutting-edge and thorough, .Blood-Brain Barrier. is a valuable resource to aid both novice and experienced investigators with performing experiments using new and classic translational approaches..978-1-4939-8946-1Series ISSN 0893-2336 Series E-ISSN 1940-6045 作者: 擦掉 時(shí)間: 2025-3-26 08:13 作者: 煤渣 時(shí)間: 2025-3-26 09:55
An Overview of the Blood-Brain Barrier,neuroimmune response to maintain CNS homeostasis. Thus, the NVU facilitates the cross talk between the CNS and the periphery through the BBB. The BBB is organized to prevent undesirable substances from entering the brain while allowing access to necessary compounds. In consequence of its structure, 作者: 手術(shù)刀 時(shí)間: 2025-3-26 13:13
In Vitro BBB Models: Working with Static Platforms and Microfluidic Systems,e of potentially harmful xenobiotics, the study of the BBB in vitro is gaining momentum. As new cell culture techniques and improved in vitro technologies and biomaterials become available, in vitro modeling of the BBB is progressing rapidly. In this book chapter, we provide a detailed view and anal作者: Flavouring 時(shí)間: 2025-3-26 18:33 作者: accessory 時(shí)間: 2025-3-27 00:27
Transepithelial/Transendothelial Electrical Resistance (TEER) to Measure the Integrity of Blood-Brad consensus between TEER reported from various BBBs-on-chips, it is important to understand various factors that affect TEER. The aim of this chapter is to introduce TEER and its significance, explore the different TEER measurement protocols along with their strengths and weaknesses, and review nume作者: 珍奇 時(shí)間: 2025-3-27 04:03
Cell-Penetrating Peptides as Theranostics Against Impaired Blood-Brain Barrier Permeability: Implicstic traits of various BBB-permeable cell-penetrating peptides (CPPs), which have emerged as a potential drug delivery tool in CNS therapeutics. In this chapter, we would like to review the benefits of employing nuclear magnetic resonance (NMR) techniques toward understanding the structural, functio作者: 貧困 時(shí)間: 2025-3-27 05:55 作者: BILE 時(shí)間: 2025-3-27 12:21
Experimental Tools to Study the Regulation and Function of the Choroid Plexus,-cerebrospinal fluid barrier (BCSFB) in vitro models. This chapter describes these protocols aiming to attract more researchers willing to enhance the current knowledge on CP functions and the relevance of its malfunction to the central nervous system pathophysiology.作者: MOAT 時(shí)間: 2025-3-27 14:46 作者: 熱烈的歡迎 時(shí)間: 2025-3-27 18:45
Increasing BBB Permeability via Focused Ultrasound: Current Methods in Preclinical Research,, there is a need for improved?monitoring strategies that can precisely predict resulting bio-effects. This will allow the continued?development of control algorithms that can?further increase the safety profile of FUS. Here we will describe two approaches to study FUS-mediated increases in BBB perm作者: 不理會(huì) 時(shí)間: 2025-3-27 23:06
,Evaluation of Blood–Brain Barrier Permeability and Integrity in Juvenile Rodents: Dynamic Contrast-ssociated with reflow through ischemic tissue. We are particularly interested in the reperfusion-induced injury to the blood–brain barrier (BBB) that follows after blood flow to the ischemic brain is restored..Our goal is to provide the reader with guidelines on how to execute the tMCAo surgical pro作者: Accrue 時(shí)間: 2025-3-28 02:33 作者: 驚呼 時(shí)間: 2025-3-28 07:57
https://doi.org/10.1007/978-3-319-72425-6e of potentially harmful xenobiotics, the study of the BBB in vitro is gaining momentum. As new cell culture techniques and improved in vitro technologies and biomaterials become available, in vitro modeling of the BBB is progressing rapidly. In this book chapter, we provide a detailed view and anal作者: 本能 時(shí)間: 2025-3-28 13:13
https://doi.org/10.1007/978-3-319-72425-6rived human brain microvascular endothelial cells (HBMvECs), and showing how BBB phenotype is improved in response to flow by using immunocytochemical localization of tight-junction zonula occludens-1 (ZO-1) as a reporter index. The ability of applied shear to attenuate the pro-oxidant effects of in作者: Lipoprotein(A) 時(shí)間: 2025-3-28 17:08
Beyond First-Order Truthlikeness,d consensus between TEER reported from various BBBs-on-chips, it is important to understand various factors that affect TEER. The aim of this chapter is to introduce TEER and its significance, explore the different TEER measurement protocols along with their strengths and weaknesses, and review nume作者: 四牛在彎曲 時(shí)間: 2025-3-28 22:22
https://doi.org/10.1007/978-94-009-4658-3stic traits of various BBB-permeable cell-penetrating peptides (CPPs), which have emerged as a potential drug delivery tool in CNS therapeutics. In this chapter, we would like to review the benefits of employing nuclear magnetic resonance (NMR) techniques toward understanding the structural, functio作者: rectocele 時(shí)間: 2025-3-29 01:12 作者: 文藝 時(shí)間: 2025-3-29 06:08 作者: 哥哥噴涌而出 時(shí)間: 2025-3-29 08:18
Jason H. Calhoun,Anne C. Sullivand plexus prepared from rat cerebroventricles and a conditionally immortalized rat choroid plexus epithelial cell line, TR-CSFB3 cells, are described in detail. The information obtained from these studies will help us to understand the molecular mechanisms of compound efflux transport across the BCSF作者: 許可 時(shí)間: 2025-3-29 13:59 作者: 呼吸 時(shí)間: 2025-3-29 18:41 作者: Serenity 時(shí)間: 2025-3-29 21:58 作者: RENAL 時(shí)間: 2025-3-30 02:59
Methods of Delivering Molecules Through the Blood-Brain Barrier for Brain Diagnostics and Therapeutthe difficulty in delivering diagnostic and therapeutic molecules across the blood-brain barrier (BBB) and into the brain. This chapter describes these and other challenges and the progress that has been made in transporting molecules into the brain. The pathways that molecules can take to cross the作者: 女歌星 時(shí)間: 2025-3-30 05:19
Culturing of Rodent Brain Microvascular Endothelial Cells for In Vitro Modeling of the Blood-Brain tive function, BBB regulates entry of nutrients into the central nervous system by selective transport and metabolism of blood- and brain-borne substances. Successful modeling of BBB in vitro is established since 1970s and has been used to study mechanisms of transport, cellular interaction, and gen作者: 殘忍 時(shí)間: 2025-3-30 09:55
In Vitro BBB Models: Working with Static Platforms and Microfluidic Systems,e performed in vivo. However, major limitations of this approach, including limited translational significance to human patients, high cost, time, and labor to develop the appropriate model (e.g., transgenic or inbred models), have greatly favored the parallel development of in vitro models. These a作者: 最小 時(shí)間: 2025-3-30 14:58 作者: STING 時(shí)間: 2025-3-30 19:51
Transepithelial/Transendothelial Electrical Resistance (TEER) to Measure the Integrity of Blood-Bra in vitro cellular barriers for transport studies. TEER measurement has advantages over traditional permeability measurements as a quick, label-free, and non-invasive method. TEER measurement has an added advantage that it can be performed in real -time if the measurement electrodes are integrated i作者: 軍火 時(shí)間: 2025-3-30 20:57
Cell-Penetrating Peptides as Theranostics Against Impaired Blood-Brain Barrier Permeability: Implicbstances. This dynamic barrier, which is primarily comprised of precisely arranged, specialized endothelial cells, astrocytes, and pericytes, not only prevents the brain interstitial fluid from mixing with the components of blood but also maintains a delicate balance between central nervous system (作者: Pelvic-Floor 時(shí)間: 2025-3-31 04:42 作者: 責(zé)怪 時(shí)間: 2025-3-31 05:04 作者: GRAIN 時(shí)間: 2025-3-31 11:25
Zebrafish (,) as a Viable Model to Study the Blood-Brain Barrier,the BBB is a major obstacle for drug delivery into the brain. Under pathological conditions, the integrity of the BBB is susceptible to disruption and can be broken down in severe brain diseases. Therefore, the understanding of intrinsic complexity as well as modulation of the BBB is critical to dis作者: cyanosis 時(shí)間: 2025-3-31 13:58
Evans Blue-Albumin as a Marker to Evaluate Blood-Brain Barrier Integrity in Neonatal and Adult Rodequires appropriate models and markers to demonstrate the integrity of the interface between the blood and the brain. Historically, dyes have been used to analyze the blood-brain barrier (BBB) mechanisms and for measurements of plasma volume. Despite some limitations, Evans blue is still the most com作者: 盡忠 時(shí)間: 2025-3-31 21:36
Experimental Tools to Study the Regulation and Function of the Choroid Plexus,h neurologic diseases, in newborns, young adults, and the elderly, like kernicterus, multiple sclerosis, and Alzheimer’s disease. Yet, the CP still remains an overlooked organ requiring further investigation..The minute size of the CP, particularly in rodent models, increases the difficulties associ作者: curriculum 時(shí)間: 2025-4-1 00:07 作者: 懦夫 時(shí)間: 2025-4-1 04:26 作者: Instrumental 時(shí)間: 2025-4-1 10:05
Increasing BBB Permeability via Focused Ultrasound: Current Methods in Preclinical Research,(CNS) diseases. The use of focused ultrasound (FUS), in conjunction with circulating microbubbles, is a unique approach whereby the transcranial application of acoustic energy, focused within targeted brain areas, can be used to induce a noninvasive, transient, and targeted increase in BBB permeabil作者: TERRA 時(shí)間: 2025-4-1 12:08 作者: 使習(xí)慣于 時(shí)間: 2025-4-1 16:21
Recording Leukocyte Rolling and Adhesion on Meningeal Vessels by Intravital Microscopy,evelopment of inflammatory response in the brain. The use of intravital microscopy technique allows direct in vivo assessment of leukocyte rolling and adhesion on cortical meningeal vessels. The current review highlights the use of intravital microscopy and its association with neuroinflammatory par作者: Commodious 時(shí)間: 2025-4-1 20:08
,Molecular Imaging of Blood–Brain Barrier Permeability in Preclinical Models Using PET and SPECT, such as infections. The integrity of BBB is preserved by multi-structural and functional components. Increasing evidence indicates that BBB is used as an important marker measured in variety of pathological condition with large permeability leaks, such as?brain tumors and multiple sclerosis, to mor作者: amyloid 時(shí)間: 2025-4-2 00:12 作者: Licentious 時(shí)間: 2025-4-2 03:50
In Vivo Analysis to Study Transport Across the Blood-Retinal Barrier,microdialysis, a protocol for analyzing efflux transport across the BRB, provides the apparent first-order rate constant during the terminal phase. Furthermore, in vivo inhibition analyses using RUI and microdialysis provide the data which will help in investigating the involvement of carrier-mediated transport process.作者: FECT 時(shí)間: 2025-4-2 07:01
