作者: 灌溉 時(shí)間: 2025-3-21 23:29
1078-0491 r genetic manipulation. The reasons for this include the fact that a very large number of inherited disorders (including some of the most common disorders, such as the hemoglobinopathies) are disorders of the hemopoietic system, and the large amount of experience in hematopoietic transplantation bio作者: LEVY 時(shí)間: 2025-3-22 00:36 作者: 不怕任性 時(shí)間: 2025-3-22 04:37 作者: 察覺(jué) 時(shí)間: 2025-3-22 12:14
https://doi.org/10.1057/9781137441836 of either DNA or mRNA. However, in practice there are very few RNA vaccines (., .; .), probably because expression is too shortlived to be effective. Thus, most models of nucleic acid-based immunization described to date have used DNA, most often in the form of double-stranded, closed, circular plasmid DNA.作者: 抗體 時(shí)間: 2025-3-22 16:00 作者: amenity 時(shí)間: 2025-3-22 19:17 作者: Abbreviate 時(shí)間: 2025-3-22 23:33 作者: flaunt 時(shí)間: 2025-3-23 03:24 作者: GROWL 時(shí)間: 2025-3-23 07:42 作者: Bumptious 時(shí)間: 2025-3-23 12:11
Hemopoietic Stem Cells as Targets for Genetic Manipulation,ne marrow of one mouse repopulates about 2000 potentially lethally irradiated mice. In turn, each of these mice provides cells for a similar number of second generation recipients. In turn under certain conditions these may repopulate a third generation of mice (.). In recent experiments, as few as 作者: 內(nèi)行 時(shí)間: 2025-3-23 14:15 作者: 刺耳的聲音 時(shí)間: 2025-3-23 22:01
Retroviral Vectors,elivery to mammalian cells are based on murine C-type retroviruses, which have a small, simple, and well-characterized genome. This allows extensive vector manipulation, for example, to achieve tissue-specific expression. Complementary sequences between vector and packaging constructs can essentiall作者: insecticide 時(shí)間: 2025-3-24 01:16
Parvoviral Vectors for Human Hematopoietic Gene Therapy,mber of physical and chemical methods for gene transfer have been developed, viruses have generally proven much more efficient in transferring genetic material into cells. Indeed, viral vectors based on retroviruses and adenoviruses have already been employed in a number of clinical trials (.; .; .)作者: Mystic 時(shí)間: 2025-3-24 05:51
Nonviral Methods for Gene Transfer,oduced into cells to synthesize therapeutically active products which may in turn influence the clinical progression of the disease. Successful gene therapy requires identifying an appropriate therapeutic gene and also developing delivery systems through which genes are efficiently transferred to th作者: blackout 時(shí)間: 2025-3-24 10:13
Prospects for Gene Therapy of Inherited Immunodeficiency, we are probably closer to its realization in the realm of the inherited immunodeficiencies than with any other group of disorders. Moreover, much of the groundbreaking development work on gene therapy (safety aspects, testing of vector systems etc.) has been in immunodeficiency, culminating with th作者: armistice 時(shí)間: 2025-3-24 12:29 作者: 歪曲道理 時(shí)間: 2025-3-24 17:26 作者: 變白 時(shí)間: 2025-3-24 20:49
Gene Marking and the Biology of Hematopoietic Cell Transfer in Human Clinical Trials,.). By 1996, gene marking or gene therapy protocols were underway worldwide (.). Unexpectedly, a high percentage of early protocols were designed for cancer patients rather than, as had originally been anticipated, inherited single gene defects (.; .; .). This shift in emphasis reflects early uncert作者: 親密 時(shí)間: 2025-3-25 01:58
Antisense Strategies to Leukemia,sease has developed at a remarkable rate. However, the potential of exploiting this knowledge in disrupting molecular genetic processes for experimental or therapeutic purposes has been disappointing. Antisense technology offers this possibility and the hope of highly specific anti-leukemia/lymphoma作者: Type-1-Diabetes 時(shí)間: 2025-3-25 03:51 作者: delusion 時(shí)間: 2025-3-25 08:04 作者: Habituate 時(shí)間: 2025-3-25 14:58
DNA-Based Immunization,mmune response to an antigenic protein expressed . after introducing its encoding polynucleotide. In theory, the encoding sequences can be in the form of either DNA or mRNA. However, in practice there are very few RNA vaccines (., .; .), probably because expression is too shortlived to be effective.作者: arthrodesis 時(shí)間: 2025-3-25 16:22
Blood Cell Biochemistry978-1-4615-4889-8Series ISSN 1078-0491 作者: 怒目而視 時(shí)間: 2025-3-25 22:30 作者: agitate 時(shí)間: 2025-3-26 00:12 作者: 竊喜 時(shí)間: 2025-3-26 06:40 作者: 錯(cuò)誤 時(shí)間: 2025-3-26 09:55 作者: 歸功于 時(shí)間: 2025-3-26 12:52
Theoretical Approaches and Recent Research,mber of physical and chemical methods for gene transfer have been developed, viruses have generally proven much more efficient in transferring genetic material into cells. Indeed, viral vectors based on retroviruses and adenoviruses have already been employed in a number of clinical trials (.; .; .)作者: 慢跑 時(shí)間: 2025-3-26 18:48 作者: 緯線 時(shí)間: 2025-3-27 00:56 作者: podiatrist 時(shí)間: 2025-3-27 01:07 作者: 殺蟲(chóng)劑 時(shí)間: 2025-3-27 05:53 作者: 無(wú)孔 時(shí)間: 2025-3-27 10:31 作者: Amnesty 時(shí)間: 2025-3-27 15:05
https://doi.org/10.1007/978-3-531-91123-6sease has developed at a remarkable rate. However, the potential of exploiting this knowledge in disrupting molecular genetic processes for experimental or therapeutic purposes has been disappointing. Antisense technology offers this possibility and the hope of highly specific anti-leukemia/lymphoma作者: 都相信我的話 時(shí)間: 2025-3-27 19:53 作者: 天真 時(shí)間: 2025-3-27 21:57
Lifelong Learning and adult education,ctures have been isolated from such diverse sources as tetrahymena, tobacco ringspot virus, plant viroids, virusoids, and satellite viruses; and hepatitis delta virus (.; .). According to their molecular structures, the natural ribozymes are classified into at least six different groups: Group I int作者: tympanometry 時(shí)間: 2025-3-28 02:26
https://doi.org/10.1057/9781137441836mmune response to an antigenic protein expressed . after introducing its encoding polynucleotide. In theory, the encoding sequences can be in the form of either DNA or mRNA. However, in practice there are very few RNA vaccines (., .; .), probably because expression is too shortlived to be effective.作者: engender 時(shí)間: 2025-3-28 10:17 作者: 同時(shí)發(fā)生 時(shí)間: 2025-3-28 10:38 作者: overreach 時(shí)間: 2025-3-28 15:29
Blood Cell Biochemistryhttp://image.papertrans.cn/b/image/189299.jpg作者: CEDE 時(shí)間: 2025-3-28 22:48 作者: 吞沒(méi) 時(shí)間: 2025-3-29 02:13
https://doi.org/10.1057/9781137441836An attractive approach to cancer gene therapy is to deliver genes that enhance the immunogenicity of tumor cells, thereby augmenting the immune response against them (Nabel ., 1992, Rosenberg ., 1993, Tepper and Mule, 1994. 作者: paleolithic 時(shí)間: 2025-3-29 05:17
Molecular Immunotherapy by Gene Transfer,An attractive approach to cancer gene therapy is to deliver genes that enhance the immunogenicity of tumor cells, thereby augmenting the immune response against them (Nabel ., 1992, Rosenberg ., 1993, Tepper and Mule, 1994. 作者: Expiration 時(shí)間: 2025-3-29 08:55 作者: contradict 時(shí)間: 2025-3-29 13:19
https://doi.org/10.1007/978-94-6209-389-8 an irradiated mouse (.). Again, the proportion of mice reconstituted after injection with a single cell agrees with the expected proportion of cells that seed in the bone marrow. Transplantation studies with marked murine cells have demonstrated that monoclonal or oligoclonal hematopoiesis occurs f作者: tympanometry 時(shí)間: 2025-3-29 17:55
https://doi.org/10.1007/978-94-011-0087-8eny carrying the vector sequence, a property which is desirable if a stem cell is to be infected. Recent research has partly solved some of the well-known drawbacks of recombinant retroviruses, for example, the low titers, the sensitivity to human serum, the requirement for target cell division to a作者: 疲憊的老馬 時(shí)間: 2025-3-29 20:57
Theoretical Approaches and Recent Research,iruses, which are among the smallest of the DNA-containing viruses that infect a wide variety of vertebrates (.), remain the only group of viruses that have thus far not been associated with malignant disease (.; .). In fact, parvoviruses possess antitumor properties (.; .; .). One of the members of作者: 抒情短詩(shī) 時(shí)間: 2025-3-30 00:48 作者: 我不怕?tīng)奚?nbsp; 時(shí)間: 2025-3-30 07:46
Lifelong Learning and school education,ngled out for praise by recent review committees which have generally criticized the early introduction of gene therapy clinical trials (.; .). The biological outcomes of such marking studies have been surprisingly rewarding, albeit at times disappointing. The purpose of this chapter is to reiterate作者: 國(guó)家明智 時(shí)間: 2025-3-30 12:14
https://doi.org/10.1007/978-3-531-91123-6h groups to investigate antisense as an experimental and therapeutic tool. In the early 1980s little further work was conducted mainly because of the difficulties in reliably synthesizing adequate quantities of DNA oligonucleotides. However, innovative biotechnology companies developed DNA synthesis作者: diathermy 時(shí)間: 2025-3-30 15:56 作者: 圓錐 時(shí)間: 2025-3-30 19:04
Genetic Approaches to Therapy for the Hemoglobinopathies,lypeptide ratio (thalassaemia) of hemoglobin (Hb) or abnormalities in the function of the β-globin chain (sickle cell disease) (see .; .). It is estimated that approximately 250 million people carry hemoglobinopathies worldwide. This gives rise to more than 300,000 births each year that are homozygous for either thalassaemia or sickle cell disease.作者: single 時(shí)間: 2025-3-31 00:16
Hemopoietic Stem Cells as Targets for Genetic Manipulation, an irradiated mouse (.). Again, the proportion of mice reconstituted after injection with a single cell agrees with the expected proportion of cells that seed in the bone marrow. Transplantation studies with marked murine cells have demonstrated that monoclonal or oligoclonal hematopoiesis occurs f
