標(biāo)題: Titlebook: Bleomycin: Chemical, Biochemical, and Biological Aspects; Proceedings of a joi Sidney M. Hect Conference proceedings 1979 Springer-Verlag N [打印本頁(yè)] 作者: 評(píng)估 時(shí)間: 2025-3-21 18:34
書目名稱Bleomycin: Chemical, Biochemical, and Biological Aspects影響因子(影響力)
書目名稱Bleomycin: Chemical, Biochemical, and Biological Aspects影響因子(影響力)學(xué)科排名
書目名稱Bleomycin: Chemical, Biochemical, and Biological Aspects網(wǎng)絡(luò)公開(kāi)度
書目名稱Bleomycin: Chemical, Biochemical, and Biological Aspects網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書目名稱Bleomycin: Chemical, Biochemical, and Biological Aspects被引頻次
書目名稱Bleomycin: Chemical, Biochemical, and Biological Aspects被引頻次學(xué)科排名
書目名稱Bleomycin: Chemical, Biochemical, and Biological Aspects年度引用
書目名稱Bleomycin: Chemical, Biochemical, and Biological Aspects年度引用學(xué)科排名
書目名稱Bleomycin: Chemical, Biochemical, and Biological Aspects讀者反饋
書目名稱Bleomycin: Chemical, Biochemical, and Biological Aspects讀者反饋學(xué)科排名
作者: 要塞 時(shí)間: 2025-3-22 00:15
Advances in Bleomycin Studiesh bleomycin treatment and even cases of complete cure have been reported. Among the tumors belonging to this group, the well-differentiated type responds to bleomycin treatment with a very high frequency. There are patients who have lived more than 10 years after several courses of treatment with bl作者: Accomplish 時(shí)間: 2025-3-22 01:39
Review of the Structural Studies on Bleomycind as a mixture of more than 10 components from the culture filtrate of .. These were separated by CM-Sephadex column chromatography. and found to be different from one another in their terminal amine moieties.. BLMs thus isolated were blue-colored equimolar copper complexes. BLM has not yet been cry作者: REP 時(shí)間: 2025-3-22 07:12 作者: 責(zé)難 時(shí)間: 2025-3-22 11:52
A Synthetic Approach to the Pyrimidine Moiety of Bleomycinrolysis, proton and .C-NMR, infrared spectra and p..′ values (1)(.). A revised structure (2) containing an open chain β-aminopropionamide group instead of the β-lactam ring has been proposed at this symposium by Dr. Takita. It should be pointed out that the new structure (2) was considered to be one作者: faddish 時(shí)間: 2025-3-22 14:41
Biogenetic Aspects of Bleomycin-Phleomycin Group Antibioticsophisticated natural products containing unusual amino acids as their building blocks .; they also have interesting glycosidic moieties . and are efficient chelating agents. In addition, new members of this family have recently been isolated . . The production of various bleomycins . and phleomycins作者: Original 時(shí)間: 2025-3-22 20:30
Liquid Chromatography of Bleomycinmical study of bleomycin (BLM) for the following reasons: (i) BLMs are produced as a mixture by fermentation together with their biosynthetic intermediates. To facilitate their chemical study, they have been separated into individual species by LC, (ii) BLM has many susceptible functional groups. Th作者: 生命層 時(shí)間: 2025-3-22 23:47 作者: gangrene 時(shí)間: 2025-3-23 01:58
The Metallobleomycins Of these, bleomycin A. (BLM A.) , 1., is the most abundant, accounting for 55-70% (w/w) of the mixture. Bleomycin is of value in the treatment of squamous cell carcinomas, lymphomas, and testicular carcinomas (.). The mechanism of action of bleomycin is not understood. Most of the early efforts as 作者: resuscitation 時(shí)間: 2025-3-23 08:31
Metal Complex of Bleomycin and Its Implication for the Mechanism of Bleomycin Action salt added to the fermentation medium; without addition of the copper, the fermentation yield of BLM is significantly reduced. The chelated copper can be removed from BLM by precipitation with hydrogen sulfide in methanol solution. Treatment of metal-free BLM with an excess of an inorganic cupric s作者: Gum-Disease 時(shí)間: 2025-3-23 12:37 作者: 脆弱帶來(lái) 時(shí)間: 2025-3-23 16:53
A Role for Iron in the Degradation of DNA by BleomycinrsS. as a copper chelate, it is used clinically as a metal-free preparation. Studies with bleomycin have suggested that its cytotoxic properties are related to effects of the compound on the physical integrity of DNA in cells. In cultures of bacterial or eukaryotic cells, a major effect of bleomycin作者: Recess 時(shí)間: 2025-3-23 21:47
Contribution of the Superoxide Anion-Hydroxyl Radical Pathway to the Cleavage of DNA by Bleomycinre effective against squamous cell carcinoma, Hodgkin’s disease, and malignant lymphoma and are particularly valuable since they show no immunosuppression.. The mode of action has attracted a great deal of attention but the molecular mechanism of action is by no means clear. BLM shows interference w作者: 省略 時(shí)間: 2025-3-23 22:49
Interaction of Bleomycin with DNAbited by simultaneous addition of DNA from other species (protection by competitive binding) but not by the addition of RNA. Based on the protective effect of the added DNA, the preferred DNA structure for interaction with bleomycin was determined. The results indicate that bleomycin binds preferent作者: 搖曳 時(shí)間: 2025-3-24 04:06 作者: 愛(ài)國(guó)者 時(shí)間: 2025-3-24 08:18
Molecular Aspects of Bleomycin-Promoted Damage of Covalently Closed Circular DNAezawa ... It has been established that the drug causes the release of free bases, ruptures the phosphodiester backbone, and damages the deoxyribose moiety of DNA. There are no detectable damaging effects on RNA, nor does the drug alter the ability of mRNA to direct cell-free protein synthesis. For a作者: Nonthreatening 時(shí)間: 2025-3-24 13:19 作者: 含糊 時(shí)間: 2025-3-24 16:39
http://image.papertrans.cn/b/image/189132.jpg作者: Detoxification 時(shí)間: 2025-3-24 20:02
https://doi.org/10.1007/978-1-4612-6191-9Bleomycin; Pyrimidine; biochemistry; biology; cancer; cell; chemistry; synthesis作者: 高腳酒杯 時(shí)間: 2025-3-25 02:12
978-1-4612-6193-3Springer-Verlag New York Inc. 1979作者: hegemony 時(shí)間: 2025-3-25 06:11
Jan Glaubitz,Daniel Rademacher,Thomas SonarDuring chemical studies of bleomycin (BLM), many fragments and derivatives have been isolated and characterized. The NMR spectra of these compounds were taken and analyzed for structural information.作者: 人類學(xué)家 時(shí)間: 2025-3-25 09:02
Verfahren für einfache Zusammenh?ngeFirst, this chapter summarizes our experimental results on the lesions produced by the antitumor drug, bleomycin, on DNA in solution. These results are compared critically with those reported in the literature in an attempt to assess the state of current knowledge in this area.作者: 碳水化合物 時(shí)間: 2025-3-25 11:48
NMR Study of BleomycinDuring chemical studies of bleomycin (BLM), many fragments and derivatives have been isolated and characterized. The NMR spectra of these compounds were taken and analyzed for structural information.作者: 支柱 時(shí)間: 2025-3-25 16:22
The Action of Bleomycin on DNAFirst, this chapter summarizes our experimental results on the lesions produced by the antitumor drug, bleomycin, on DNA in solution. These results are compared critically with those reported in the literature in an attempt to assess the state of current knowledge in this area.作者: 依法逮捕 時(shí)間: 2025-3-25 22:15 作者: 圣歌 時(shí)間: 2025-3-26 02:05
Leistung in der Entwicklung des Kindes,h bleomycin treatment and even cases of complete cure have been reported. Among the tumors belonging to this group, the well-differentiated type responds to bleomycin treatment with a very high frequency. There are patients who have lived more than 10 years after several courses of treatment with bl作者: 溫和女孩 時(shí)間: 2025-3-26 08:02 作者: 冷淡周邊 時(shí)間: 2025-3-26 10:42
Intrinsische und extrinsische Motivation,ect verification of the proposed structure (which has been revised during this meeting by Dr. Umezawa and his co-workers) and hopefully extending the repertoire of available synthetic techniques, bleomycins of modified structure should facilitate the study of the mechanism of action of the drug and 作者: 有害 時(shí)間: 2025-3-26 13:28
Unternehmenspolitische Schlu?folgerungenrolysis, proton and .C-NMR, infrared spectra and p..′ values (1)(.). A revised structure (2) containing an open chain β-aminopropionamide group instead of the β-lactam ring has been proposed at this symposium by Dr. Takita. It should be pointed out that the new structure (2) was considered to be one作者: 捐助 時(shí)間: 2025-3-26 19:20
,Ausgangspunkte und Reflexionsanl?sse,ophisticated natural products containing unusual amino acids as their building blocks .; they also have interesting glycosidic moieties . and are efficient chelating agents. In addition, new members of this family have recently been isolated . . The production of various bleomycins . and phleomycins作者: 壁畫 時(shí)間: 2025-3-26 22:02 作者: 剝皮 時(shí)間: 2025-3-27 04:31
Jan Glaubitz,Daniel Rademacher,Thomas Sonar.) and the ferrous complex has been implicated as the possible active species causing bleomycin-catalyzed DNAstrand scission (.). Both cupic and ferrous ions are paramagnetic, hence proton nuclear magnetic resonance (NMR) is of limited value for the study of any of their complexes with bleomycin bec作者: BILK 時(shí)間: 2025-3-27 08:58 作者: theta-waves 時(shí)間: 2025-3-27 11:43
,Vektorr?ume und lineare Abbildungen, salt added to the fermentation medium; without addition of the copper, the fermentation yield of BLM is significantly reduced. The chelated copper can be removed from BLM by precipitation with hydrogen sulfide in methanol solution. Treatment of metal-free BLM with an excess of an inorganic cupric s作者: 蘆筍 時(shí)間: 2025-3-27 13:39
https://doi.org/10.1007/978-3-8348-9858-6ity to coordinate a variety of metals. Recently, bleomycin-metal complexes have attracted particular attention because of their interesting behavior: (i) the copper(II) complex is a metabolic form of bleomycin (2), (ii) γ-emitting metal complexes such as .CO, .Tc, and .In have been investigated as a作者: 不在灌木叢中 時(shí)間: 2025-3-27 18:01 作者: Debility 時(shí)間: 2025-3-27 22:27
https://doi.org/10.1007/978-3-658-18191-8re effective against squamous cell carcinoma, Hodgkin’s disease, and malignant lymphoma and are particularly valuable since they show no immunosuppression.. The mode of action has attracted a great deal of attention but the molecular mechanism of action is by no means clear. BLM shows interference w作者: 討厭 時(shí)間: 2025-3-28 05:49
,Vektorr?ume und lineare Abbildungen,bited by simultaneous addition of DNA from other species (protection by competitive binding) but not by the addition of RNA. Based on the protective effect of the added DNA, the preferred DNA structure for interaction with bleomycin was determined. The results indicate that bleomycin binds preferent作者: Analogy 時(shí)間: 2025-3-28 06:33
Bilineare Algebra und Geometrie,Nuclear magnetic resonance studies. suggest that the bithiazole and terminal amine moieties of the bleomycins bind to DNA; certain other functional groups of the antibiotic serve as ligands for the metal ion.. Some of the structural requirements for biological activity of bleomycin have been establi作者: licence 時(shí)間: 2025-3-28 14:26
,Vektorr?ume und lineare Abbildungen,ezawa ... It has been established that the drug causes the release of free bases, ruptures the phosphodiester backbone, and damages the deoxyribose moiety of DNA. There are no detectable damaging effects on RNA, nor does the drug alter the ability of mRNA to direct cell-free protein synthesis. For a作者: OTTER 時(shí)間: 2025-3-28 18:02 作者: AND 時(shí)間: 2025-3-28 21:35 作者: extrovert 時(shí)間: 2025-3-29 01:08
Biogenetic Aspects of Bleomycin-Phleomycin Group Antibioticsidine, and (v) the mechanism of glycoside formation. The first problem has already been solved and reported (9). As an approach to solution of the other problems, we chose to isolate intermediate peptide fragments from the culture medium. The exciting results obtained, which exceeded our expectation作者: Visual-Acuity 時(shí)間: 2025-3-29 03:29
Liquid Chromatography of Bleomycinlar products. Moreover, the retention time of a given compound on LC is sometimes useful for predicting what modification has occurred, (iv) The purity of BLM and its modification products can be verified by high-performance liquid chromatography (HPLC).作者: 尖牙 時(shí)間: 2025-3-29 09:48
The Metallobleomycinsn and in so doing apparently inactivate the drug. The addition of Pe(II)salts to the reaction mixture, on the other hand, under conditions which lead to.the formation of the Fe(II)-BLM complex, greatly enhances the DNA degradingability of bleomycin..作者: 細(xì)節(jié) 時(shí)間: 2025-3-29 13:38 作者: 脫離 時(shí)間: 2025-3-29 18:01 作者: Substance 時(shí)間: 2025-3-29 23:00 作者: MAZE 時(shí)間: 2025-3-30 01:28
The Use of Covalently Closed Circular DNA to Investigate Properties of Bleomycin and Its Analogs fluorescenceresults upon alkaline denaturation of broken eee DNA. This provides the basis for a fluorescent assay of DNAbreakage (Fig. I). Bleomycin-induced DNAfragmentation can also be detected using electrophoresis of eeeDNA. This is because the products of broken superhelicaleee DNA(form I), rel作者: VERT 時(shí)間: 2025-3-30 04:35 作者: 有權(quán)威 時(shí)間: 2025-3-30 10:41 作者: inclusive 時(shí)間: 2025-3-30 16:07
Leistung in der Entwicklung des Kindes, mg exhibits a therapeutic effect on Hodgkin’s lymphoma. Recently, treatment by a combination of bleomycin and a . alkaloid or a platinum compound was found to have a therapeutic effect on testis tumors. Bleomycin treatment does not suppress immune function and does not damage bone marrow; however, 作者: Certainty 時(shí)間: 2025-3-30 20:02 作者: cardiopulmonary 時(shí)間: 2025-3-30 23:08
https://doi.org/10.1007/978-3-658-19776-6lar products. Moreover, the retention time of a given compound on LC is sometimes useful for predicting what modification has occurred, (iv) The purity of BLM and its modification products can be verified by high-performance liquid chromatography (HPLC).作者: 平躺 時(shí)間: 2025-3-31 02:43
,Vektorr?ume und lineare Abbildungen,n and in so doing apparently inactivate the drug. The addition of Pe(II)salts to the reaction mixture, on the other hand, under conditions which lead to.the formation of the Fe(II)-BLM complex, greatly enhances the DNA degradingability of bleomycin..作者: bleach 時(shí)間: 2025-3-31 05:48 作者: 加強(qiáng)防衛(wèi) 時(shí)間: 2025-3-31 11:51
https://doi.org/10.1007/978-3-658-18191-8 the principal cell target is DNA which is degraded by BLM both . and ... DNA cleavage is enhanced in the presence of reducing agents such as 2-mercaptoethanol, dithiothreitol, or ascorbate and by the addition of Fe(II) and requires oxygen.. The DNA cleavage is inhibited by Cu, Zn, Co, Mg, and EDTA.作者: ELUDE 時(shí)間: 2025-3-31 16:14
,Vektorr?ume und lineare Abbildungen,the reaction. The use of linear DNA in conjunction with velocity sedimentation analyses requires the introduction of many single- or double-strand breaks into the DNA before an appreciable (and measurable) decrease in the sedimentation velocity occurs. The use of such a limited technology precludes 作者: Flat-Feet 時(shí)間: 2025-3-31 18:05 作者: refraction 時(shí)間: 2025-3-31 22:24 作者: prolate 時(shí)間: 2025-4-1 03:25
Bleomycin: Chemical, Biochemical, and Biological Aspects978-1-4612-6191-9作者: Agronomy 時(shí)間: 2025-4-1 09:21
Conference proceedings 1979shown to be effective therapeutically against, eg, squamous cell carcinomas, Hodgkin‘s lymphoma, and testicular tumors. Several important and previously unreported observations were presented and the status of experimental work in the United States and Japan was reviewed; a summary and interpretatio作者: Hippocampus 時(shí)間: 2025-4-1 13:41
,Spa? am Lernen — Zwang zum Lernen?,e included some unusual structural features, verification by total synthesis or X-ray crystallography has not been possible as yet due to the complexity of the molecule and the lack of any crystalline derivative (Fig. 1).作者: 中止 時(shí)間: 2025-4-1 15:13
Leistungsmotivation und Kausalattribution,stallized, so that we could not utilize X-ray crystallographic analysis. In the initial stages of our structural studies, we used exclusively metal-free BLM A., the main component of the natural BLMs. Metal-free BLM was prepared by treatment of the copper complex with hydrogen sulfide in methanolic solution.作者: 生銹 時(shí)間: 2025-4-1 21:53 作者: 激怒某人 時(shí)間: 2025-4-2 01:21 作者: bypass 時(shí)間: 2025-4-2 04:47 作者: 低三下四之人 時(shí)間: 2025-4-2 07:28
