標(biāo)題: Titlebook: Biopharmaceutical Manufacturing; Progress, Trends and Ralf P?rtner Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusi [打印本頁] 作者: McKinley 時間: 2025-3-21 18:52
書目名稱Biopharmaceutical Manufacturing影響因子(影響力)
作者: lobster 時間: 2025-3-21 23:45 作者: Emg827 時間: 2025-3-22 01:14
Advances in Characterization of Industrial Bioreactors for Cell Culture Process of uses. This book chapter provides an overview of the main characterization methods for aerated stirred tank reactors in the context of cell culture processes. The methods described include mechanical power input, volumetric mass transfer, flow field, and mixing characterization. Examples are give作者: 可卡 時間: 2025-3-22 07:56 作者: Congeal 時間: 2025-3-22 10:24
Continuous Bioprocessing for Downstreamreasing equipment footprint and increase equipment utilization. For the interested reader this chapter provides an overview over the main developments in continuous downstream processing of biopharmaceuticals and introduces the main unit operations such as continuous chromatography, continuous filtr作者: MEAN 時間: 2025-3-22 14:38
Towards Digital Twin for Biopharmaceutical Processes: Concept and Progressopharmaceutical manufacturing field. The realization of DT could help reduce cost, improve productivity, maintain high and constant product quality, and meet Quality-by-Design (QbD) guidelines. Nonetheless, the development of DT is still at its infancy stage and an integrated DT in biopharma is rare作者: OATH 時間: 2025-3-22 21:00 作者: NAV 時間: 2025-3-22 21:19
Production of Complex Proteins in Plants: From Farming to Manufacturingl host cells cannot produce complex biopharmaceuticals that require defined oligomerization or specific glycosylation profiles, and mammalian cells are unsuitable for the production of toxic proteins. These issues are readily overcome by plant cell cultures, which have the machinery required for com作者: 慢跑鞋 時間: 2025-3-23 03:22 作者: 形狀 時間: 2025-3-23 08:59
Biopharma 4.0 for Biologics Manufacturing Under Pandemic Constraintslow doses and less side effects. Biopharma 4.0 relates to the fourth industrial revolution based on digitalization. Digitalization has reached biopharmaceutical industry along the whole development and value chain. Biologics manufacturing of such complex three-dimensional molecules in correct foldin作者: 有角 時間: 2025-3-23 11:50
Biopharma 4.0: Digital Technologies Driving Smart Manufacturingbiopharma industry has embraced this new paradigm in response to the challenges posed by the COVID-19 pandemic. The Biopharma 4.0 transformation is being driven by three categories of forces: market forces, advancements in life science technologies, and the digital technology revolution. The market 作者: nepotism 時間: 2025-3-23 15:19 作者: 吞沒 時間: 2025-3-23 18:18
Towards a Continuous Production of Human Mesenchymal Stromal Cells in a Chemically Defined Medium: Oes focus more and more on juvenile hMSCs (e.g. isolated from the umbilical cord) as these show unique therapeutic properties. For their therapeutic application, a complex manufacturing process is required to produce the high hMSC yield in the therapeutic quality as it is need for the indication. Thi作者: 死亡率 時間: 2025-3-23 23:12 作者: 消毒 時間: 2025-3-24 05:12
Manufacturing and Quality of Advanced Therapeutics: Cellular Therapies, CAR-T and Gene Therapies.Common to all facets of advanced therapies is that the active pharmaceutical ingredients are vastly more complex than those of common biologics such as antibodies and hence pose elevated challenges regarding their manufacture and quality control..We discuss prominent examples of advanced therapies 作者: 責(zé)問 時間: 2025-3-24 09:49
https://doi.org/10.1007/978-3-031-45669-5biopharmaceuticals; therapeutic antibodies; manufacturing; viral vaccines; gene and cell therapy; up- and作者: PARA 時間: 2025-3-24 14:31 作者: d-limonene 時間: 2025-3-24 15:34
Biopharmaceutical Manufacturing978-3-031-45669-5Series ISSN 1389-6946 Series E-ISSN 2542-9515 作者: SHRIK 時間: 2025-3-24 21:26
Ralf P?rtnerComprehensive review of manufacturing aspects for biopharmaceuticals, including cell and gene therapy.Brings together the knowledge and experience of leading international experts from academia and in作者: 使出神 時間: 2025-3-25 01:33
Cell Engineeringhttp://image.papertrans.cn/b/image/188317.jpg作者: 修改 時間: 2025-3-25 06:27 作者: 最有利 時間: 2025-3-25 10:51
Vascular Lesions: Port Wine Stains advancements in the development of these systems. One of the most notable developments in bioprocess monitoring systems is the use of biosensors, which can detect and measure biological molecules such as enzymes and proteins. The use of imaging technologies, such as microscopy and flow cytometry, h作者: quiet-sleep 時間: 2025-3-25 13:50
https://doi.org/10.1007/978-3-642-95780-2 of uses. This book chapter provides an overview of the main characterization methods for aerated stirred tank reactors in the context of cell culture processes. The methods described include mechanical power input, volumetric mass transfer, flow field, and mixing characterization. Examples are give作者: 輕推 時間: 2025-3-25 18:21
Entwicklung der Planungsmethode,bring is attractive and inclusion of perfusion process is nowadays often envisioned for a switch towards continuous processing including downstream, for an intensification only in the upstream production process or for the intensification at the level of the seed bioreactor only. In all cases, the i作者: 巡回 時間: 2025-3-25 21:03
Laserchirurgie der Gesichtshaut,reasing equipment footprint and increase equipment utilization. For the interested reader this chapter provides an overview over the main developments in continuous downstream processing of biopharmaceuticals and introduces the main unit operations such as continuous chromatography, continuous filtr作者: GNAW 時間: 2025-3-26 02:07
https://doi.org/10.1007/978-3-642-56734-6opharmaceutical manufacturing field. The realization of DT could help reduce cost, improve productivity, maintain high and constant product quality, and meet Quality-by-Design (QbD) guidelines. Nonetheless, the development of DT is still at its infancy stage and an integrated DT in biopharma is rare作者: 包裹 時間: 2025-3-26 05:04
Diode-Laser Sensors for In-Situ Gas Analysisg genes, cells, or tissues. Owing to their promising clinical outcomes in the treatment of rare and life-threatening diseases, ATMPs, have been gaining increasing interest from the global scientific and industrial community. The rapid growth in the demand for ATMPs is challenging manufacturers who a作者: REP 時間: 2025-3-26 08:43 作者: 謙卑 時間: 2025-3-26 14:55
F. Lewitzka,M. Niederkrüger,G. Marowskyoncept of QbD is that the development of a therapeutic protein starts with the comprehensive understanding of the target product profile in terms of identity, strength, quality, purity, and potency. The manufacturing is then designed to ensure the product produced from the designed process meet the 作者: 預(yù)示 時間: 2025-3-26 18:52 作者: Bravura 時間: 2025-3-26 23:43 作者: 翻布尋找 時間: 2025-3-27 01:37 作者: 友好關(guān)系 時間: 2025-3-27 05:16 作者: bypass 時間: 2025-3-27 12:53 作者: Arctic 時間: 2025-3-27 14:09
,Einführung: Strahlwerkzeug Laser,.Common to all facets of advanced therapies is that the active pharmaceutical ingredients are vastly more complex than those of common biologics such as antibodies and hence pose elevated challenges regarding their manufacture and quality control..We discuss prominent examples of advanced therapies 作者: 極小 時間: 2025-3-27 21:12
Single-Use Systems in Biopharmaceutical Manufacture: State of the Art and Recent Trendsiscusses the most important advantages and existing limitations of the single-use systems currently available on the market. Subsequently, the current state of development of single-use technology is presented on the basis of selected product examples. The focus is on the upstream area and single-us作者: 混亂生活 時間: 2025-3-27 22:10 作者: 賞錢 時間: 2025-3-28 05:33
Advances in Characterization of Industrial Bioreactors for Cell Culture Processrt in numerical flow simulation is discussed, using aerated stirred tank reactors as an example to illustrate the challenges and opportunities offered by numerical flow simulation. It is highlighted that the methods described are specifically focused on cell culture applications, which have lower sp作者: FAR 時間: 2025-3-28 09:11 作者: 無畏 時間: 2025-3-28 10:26 作者: 裙帶關(guān)系 時間: 2025-3-28 17:43 作者: 言外之意 時間: 2025-3-28 20:09
Biopharma 4.0 for Biologics Manufacturing Under Pandemic Constraintsnufacturing processes. Qualified operators are the rare resource bottleneck to guarantee product quality. Therefore,?continuous biomanufacturing as well as the consequent?application of the quality by design approachare key-enablers?towards biopharma 4.0.作者: CHECK 時間: 2025-3-29 01:43 作者: Oligarchy 時間: 2025-3-29 06:51
Towards a Continuous Production of Human Mesenchymal Stromal Cells in a Chemically Defined Medium: Ose of umbilical cord hMSCs and their manufacturing thereby focusing on the cell expansion, the use of chemically defined media, design-of-experiment (DoE)?approaches for process development and intensified bioreactor processes.作者: Custodian 時間: 2025-3-29 10:42 作者: 冥想后 時間: 2025-3-29 12:30
Karin Kunzi-Rapp,Rudolf Steineriscusses the most important advantages and existing limitations of the single-use systems currently available on the market. Subsequently, the current state of development of single-use technology is presented on the basis of selected product examples. The focus is on the upstream area and single-us作者: Hemiplegia 時間: 2025-3-29 17:18
Vascular Lesions: Port Wine Stains can be beneficial for optimizing bioprocesses in real-time. Overall, recent advancements in sensor technology can help in improving the efficiency and effectiveness of bioprocessing. The integration of advanced sensing technologies, and machine learning can provide valuable insights and improve the作者: Infelicity 時間: 2025-3-29 19:51
https://doi.org/10.1007/978-3-642-95780-2rt in numerical flow simulation is discussed, using aerated stirred tank reactors as an example to illustrate the challenges and opportunities offered by numerical flow simulation. It is highlighted that the methods described are specifically focused on cell culture applications, which have lower sp作者: BABY 時間: 2025-3-30 02:17
Diode-Laser Sensors for In-Situ Gas Analysis this space and discuss how those can assist systematic and proactive decision-making throughout stages of process development, design and optimization, and supply chain planning for ATMPs. We propose an integrated computational framework for process design and optimization and conclude with its dem作者: 狂亂 時間: 2025-3-30 04:13 作者: accrete 時間: 2025-3-30 10:18
F. Lewitzka,M. Niederkrüger,G. Marowskyt protein profile in the beginning of development process, (2) complexity of input and output parameters prohibiting the full design of experiments, and (3) challenges in collecting and analyzing the end-to-end product and manufacturing data. In order to overcome those challenges, many efforts are o
