作者: 黑豹 時(shí)間: 2025-3-21 21:06
Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water,alysis is the breakdown of the Debye . that postulates the alignment of water polarization with the protein electrostatic field. The complexities of biological interfaces are shown to be in good measure due to this departure from the standard dielectric picture that has been historically extrapolate作者: 冥想后 時(shí)間: 2025-3-22 00:58
Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistaches to the problem. The structural approach focuses on the molecular basis of cooperativity. We explore the concept of protein wrapping, its intimate relation to cooperativity, and its bearing on the expediency of the folding process for single-domain?natural proteins. As previously described, wra作者: Platelet 時(shí)間: 2025-3-22 08:34 作者: NAUT 時(shí)間: 2025-3-22 10:22 作者: 高談闊論 時(shí)間: 2025-3-22 16:06 作者: hyperuricemia 時(shí)間: 2025-3-22 18:47 作者: MUMP 時(shí)間: 2025-3-22 23:45 作者: Little 時(shí)間: 2025-3-23 02:38
Wrapping-Based Re-engineering of an Anticancer Drug to Make it Safer,ell fate or proliferation. These strategies target kinases, the signal transducers in the cell. This approach remains challenging because kinases are evolutionarily and therefore structurally related and thus kinase inhibitors (KIs) often lack the required specificity, which may lead to toxic side e作者: 承認(rèn) 時(shí)間: 2025-3-23 09:32
Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine,ersal selectivity filter, applicable to the entire human kinome—even to kinases with unreported structure——and to idiosyncratic variations of the kinome would be truly useful for the drug designer. This chapter thematically belongs to the bioinformatics realm and addresses this issue at the broadest作者: 采納 時(shí)間: 2025-3-23 13:10 作者: 鞭子 時(shí)間: 2025-3-23 15:21
Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping om the highly diverse cellular contexts wherein a protein may constitute a desirable or undesirable target. While dehydron wrapping enables the control of specificity, it may not be able to exclude every single toxicity-related target, especially if the latter shares with the therapeutically relevan作者: conflate 時(shí)間: 2025-3-23 18:47 作者: DEI 時(shí)間: 2025-3-24 02:02 作者: 說明 時(shí)間: 2025-3-24 03:29
High-Level Quantum Chemistry Empowers the Wrapping Technology for Drug Design,her empower the paradigmatic concept of “dehydron-wrapping drug.” This type of analysis provides the required guidance for the incorporation of halogens as wrapping groups in the drug?chemical scaffold. The chapter explores the possibility that the group that wraps exogenously a dehydron upon drug b作者: cathartic 時(shí)間: 2025-3-24 09:06
Textbook 2015peutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering..作者: 不成比例 時(shí)間: 2025-3-24 13:40 作者: Madrigal 時(shí)間: 2025-3-24 16:40
Textbook 2015ully understood at the molecular level without considering interfacial behavior..The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, .epistructural biology., centered on the interactions of water and bio molecular structures across the interfac作者: AGATE 時(shí)間: 2025-3-24 19:06 作者: 豐富 時(shí)間: 2025-3-25 00:47
Dennis S. Bernstein,David C. Hylandse and natural killer cell cytotoxicity compromised by the original drug treatment. The redesign strategy enables us to create synergies that may empower drug-based anticancer therapy, aligning the immune response with the molecularly targeted treatment?while retaining the anticancer efficacy of the parental compound.作者: 看法等 時(shí)間: 2025-3-25 06:08 作者: ARCH 時(shí)間: 2025-3-25 09:04
http://image.papertrans.cn/b/image/188258.jpg作者: FOVEA 時(shí)間: 2025-3-25 13:57 作者: 在駕駛 時(shí)間: 2025-3-25 17:54
The stability theory of comparison systems,alysis is the breakdown of the Debye . that postulates the alignment of water polarization with the protein electrostatic field. The complexities of biological interfaces are shown to be in good measure due to this departure from the standard dielectric picture that has been historically extrapolate作者: 充滿裝飾 時(shí)間: 2025-3-25 20:02 作者: Breach 時(shí)間: 2025-3-26 01:52 作者: fructose 時(shí)間: 2025-3-26 05:02 作者: VOC 時(shí)間: 2025-3-26 08:52
https://doi.org/10.1007/BFb0043807herapeutic imperative in drug treatment is the control of specificity. As shown in this chapter, while the folding topology of the native structure is highly similar across homologs, the wrapping and expression regulation patterns tend to be different, offering an opportunity to funnel the impact of作者: Arthritis 時(shí)間: 2025-3-26 12:51 作者: Occlusion 時(shí)間: 2025-3-26 20:40 作者: ADORE 時(shí)間: 2025-3-26 22:01
Characterization of fixed modes,ell fate or proliferation. These strategies target kinases, the signal transducers in the cell. This approach remains challenging because kinases are evolutionarily and therefore structurally related and thus kinase inhibitors (KIs) often lack the required specificity, which may lead to toxic side e作者: 很是迷惑 時(shí)間: 2025-3-27 02:57 作者: inhibit 時(shí)間: 2025-3-27 07:11 作者: 越自我 時(shí)間: 2025-3-27 10:46
https://doi.org/10.1007/BFb0043807om the highly diverse cellular contexts wherein a protein may constitute a desirable or undesirable target. While dehydron wrapping enables the control of specificity, it may not be able to exclude every single toxicity-related target, especially if the latter shares with the therapeutically relevan作者: 確定無疑 時(shí)間: 2025-3-27 17:27 作者: placebo-effect 時(shí)間: 2025-3-27 17:55
Dennis S. Bernstein,David C. Hylandenic activity. We focus on reengineering immunosuppressive anticancer drugs where the impact on the immune system is an undesirable outcome, betraying their own .. The goal is to remove the immunosuppressive effects through molecular redesign, more specifically, to restore the adaptive immune respon作者: 陰險(xiǎn) 時(shí)間: 2025-3-28 00:44 作者: RLS898 時(shí)間: 2025-3-28 04:09 作者: Arthropathy 時(shí)間: 2025-3-28 06:44 作者: ACE-inhibitor 時(shí)間: 2025-3-28 13:14 作者: 杠桿 時(shí)間: 2025-3-28 17:11
The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology,gment of how exquisitely the structure of proteins and their aqueous environment are dynamically entangled attests to the overdue recognition that the biomolecular phenomena cannot be effectively understood without dealing with interfacial behavior. There is an urge to grasp how biological behavior 作者: Flavouring 時(shí)間: 2025-3-28 19:02 作者: sparse 時(shí)間: 2025-3-29 00:43 作者: Osteoporosis 時(shí)間: 2025-3-29 05:52
Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface,family may be exploited to enhance drug specificity. This finding is noteworthy since homologous proteins are known to share a common structure topology and therefore, telling them apart through molecular recognition becomes a particularly arduous problem.作者: Minuet 時(shí)間: 2025-3-29 10:23 作者: Lymphocyte 時(shí)間: 2025-3-29 13:38
Evolution of Protein Structure Degradation and Lessons for the Drug Designer,d malignancy. In assessing the evolutionary forces that promote differences in the dehydron patterns across orthologous proteins (homologs from different species), we came across the surprising finding that random genetic drift plays a central role in causing dehydron enrichment. This type of struct作者: ABYSS 時(shí)間: 2025-3-29 16:50
Chemical Functionality of the Aqueous Interface in Soluble Proteins,splacement coordinate, we show that nucleophilic groups are functionally enabled by nearby dehydrons. The computations are validated against experimentally evidence on specific . decreases at functional sites and on degenerative deregulation of catalytic activity arising from dehydron-generating mut作者: thalamus 時(shí)間: 2025-3-29 20:49 作者: committed 時(shí)間: 2025-3-30 00:43 作者: 分期付款 時(shí)間: 2025-3-30 05:50 作者: 大酒杯 時(shí)間: 2025-3-30 11:46
Controlling Induced Folding Through Wrapping Drug Design,loop (or even the nucleotide-binding loop). Yet, the activation loop is the structural region that presents the largest amino acid variability within the superfamily and thus constitutes an attractive target to control specificity. In this chapter we advocate for a strategy to target flexible region作者: 種子 時(shí)間: 2025-3-30 12:56 作者: Harness 時(shí)間: 2025-3-30 19:57
