標(biāo)題: Titlebook: Biomedical Translational Research; Drug Design and Disc R.C. Sobti,Naranjan S. Dhalla Book 2022 The Editor(s) (if applicable) and The Autho [打印本頁] 作者: ambulance 時(shí)間: 2025-3-21 18:19
書目名稱Biomedical Translational Research影響因子(影響力)
作者: Notify 時(shí)間: 2025-3-21 23:23
Polypharmacology: New Paradigms in Drug Development of drugs. The advent of various in silico computational approaches would help to identify multi-target activates and anticipate potential selectivity issues early in the iterative drug design process. This would not only prevent costly failures but also offer the possibility of identification of no作者: 陶瓷 時(shí)間: 2025-3-22 01:48 作者: 錯(cuò)誤 時(shí)間: 2025-3-22 04:35 作者: Pedagogy 時(shí)間: 2025-3-22 11:12
Genomic Approaches for Drug Repositioningrch. Drug repositioning (DR) is an alternative approach to usurp already available drugs or drug candidates with FDA approval, which have been initially developed for specific diseases and re-establish their use for other diseases. Modern genomic methods for drug repositioning involve the usage of c作者: 有權(quán)威 時(shí)間: 2025-3-22 14:37 作者: Awning 時(shí)間: 2025-3-22 18:53
Precision Radiomolecular Oncology: Challenging the Classical Statistical Evidence-Based Medicineer cells, evolving from the “normal cells” of . are thus governed by the same rules. This is one of the reasons why, despite the advances in modern oncology, cure is not achievable in several cancers. Driven by the challenges posed by cancerous tissue, several new multipronged strategies have been e作者: infantile 時(shí)間: 2025-3-22 23:27
Drug Repositioning of the Phenylpiperazine Derivative Naftopidil in Prostate Cancer Treatmentin elderly men. In drug repositioning studies conducted from our laboratory, we demonstrated that naftopidil has growth inhibitory effects by inducing G. cell cycle arrest in cancer cells, fibroblasts, and vascular endothelial cells. Moreover, naftopidil has been shown to bind directly to and inhibi作者: Kinetic 時(shí)間: 2025-3-23 03:50 作者: Inclement 時(shí)間: 2025-3-23 06:19
Nanotechnology in Dentistryefined dental practice to be able to efficiently and effectively achieve the goal of positive oral health. The nanomaterials’ enhanced mechanical properties, increased durability in the oral environment, biocompatibility, better aesthetics and, above all, atraumatic experience to the patients make t作者: 偏狂癥 時(shí)間: 2025-3-23 13:22 作者: CLEAR 時(shí)間: 2025-3-23 16:09 作者: Microgram 時(shí)間: 2025-3-23 20:36
Nanodrugs: A Futuristic Approach for Treating Nephrolithiasislth and economic status globally. Although they vary widely in their composition, calcium oxalate stones form the predominant kidney stones. The degradation of calcium oxalate stones using enzymes such as oxalate decarboxylase and oxalate oxidase has been a potential therapeutic approach for treatme作者: Extemporize 時(shí)間: 2025-3-24 01:55
Lipodermaceuticals: Technological Transformationsle. Several skin disorders like dermatitis, psoriasis, scabies, acne vulgaris, alopecia areata, urticaria, and keratinocyte carcinoma have created a challenging task the drugs to penetrate and reach to the target sites. Lipid-based delivery systems are preferred more over conventional methods (chemi作者: 使更活躍 時(shí)間: 2025-3-24 06:09 作者: 離開就切除 時(shí)間: 2025-3-24 07:40
Role of Microfluidics and Nanofluidics in Managing CAD diseases paving way to develop methods of their treatment. Qualitative methods alone are not sufficient enough unless and until they are supplemented by quantification of various involved parameters and consequently cultivate various techniques to treat the diseases. Coronary artery diseases (CAD) 作者: single 時(shí)間: 2025-3-24 13:34 作者: 過分 時(shí)間: 2025-3-24 18:40
https://doi.org/10.1007/978-981-16-9232-1Drug discovery; Clinical genomics; Psychopharmacology; Drug repurposing; Microfluidic mass spectrometry作者: 自戀 時(shí)間: 2025-3-24 23:00
978-981-16-9234-5The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapor作者: Abrade 時(shí)間: 2025-3-25 02:18
R.C. Sobti,Naranjan S. DhallaPresents genomic computational integrative approaches for drug re-positioning.Examines biomarker-based drug discovery with a reverse translational approach.Provides a brief overview of microdosing for作者: 打擊 時(shí)間: 2025-3-25 06:12 作者: instill 時(shí)間: 2025-3-25 11:32 作者: 鋪?zhàn)?nbsp; 時(shí)間: 2025-3-25 13:56 作者: onlooker 時(shí)間: 2025-3-25 19:26 作者: Lipoma 時(shí)間: 2025-3-25 22:28
Kimberley J Dripps,Martin Blumllly efficient pipeline to identify new indications for existing drugs. The candidates for repurposing are essentially marketed drugs or drugs that have been discontinued in clinical trials for reasons other than safety concerns. To date, repurposed drugs have been the consequence of serendipitous ob作者: Sleep-Paralysis 時(shí)間: 2025-3-26 02:27 作者: 天賦 時(shí)間: 2025-3-26 06:56 作者: 舊病復(fù)發(fā) 時(shí)間: 2025-3-26 10:24
Landscape Analysis and Visualisationer cells, evolving from the “normal cells” of . are thus governed by the same rules. This is one of the reasons why, despite the advances in modern oncology, cure is not achievable in several cancers. Driven by the challenges posed by cancerous tissue, several new multipronged strategies have been e作者: AVANT 時(shí)間: 2025-3-26 12:52
https://doi.org/10.5822/978-1-61091-751-3in elderly men. In drug repositioning studies conducted from our laboratory, we demonstrated that naftopidil has growth inhibitory effects by inducing G. cell cycle arrest in cancer cells, fibroblasts, and vascular endothelial cells. Moreover, naftopidil has been shown to bind directly to and inhibi作者: Nebulous 時(shí)間: 2025-3-26 20:16 作者: Conduit 時(shí)間: 2025-3-27 01:02
https://doi.org/10.5822/978-1-61091-751-3efined dental practice to be able to efficiently and effectively achieve the goal of positive oral health. The nanomaterials’ enhanced mechanical properties, increased durability in the oral environment, biocompatibility, better aesthetics and, above all, atraumatic experience to the patients make t作者: BAIL 時(shí)間: 2025-3-27 01:43 作者: SEVER 時(shí)間: 2025-3-27 07:52 作者: 摻假 時(shí)間: 2025-3-27 12:56
Rudolf Kr?nert,Martin Volk,Uta Steinhardtlth and economic status globally. Although they vary widely in their composition, calcium oxalate stones form the predominant kidney stones. The degradation of calcium oxalate stones using enzymes such as oxalate decarboxylase and oxalate oxidase has been a potential therapeutic approach for treatme作者: 殘忍 時(shí)間: 2025-3-27 13:47
Diagnostic Evaluation of the Landscape,le. Several skin disorders like dermatitis, psoriasis, scabies, acne vulgaris, alopecia areata, urticaria, and keratinocyte carcinoma have created a challenging task the drugs to penetrate and reach to the target sites. Lipid-based delivery systems are preferred more over conventional methods (chemi作者: 織布機(jī) 時(shí)間: 2025-3-27 20:46
Historical Evaluation of the Landscape,ndingly increasing worldwide. In clinical trials and under doctor’s office settings, the drug dosages are generally computed on mg/kg body wt. basis in young adults and middle-aged men and women (<40?years). It is well recognized that in comparison with the younger age counterparts, the geriatric su作者: organism 時(shí)間: 2025-3-27 22:19
Paul A. Delcourt,Hazel R. Delcourt diseases paving way to develop methods of their treatment. Qualitative methods alone are not sufficient enough unless and until they are supplemented by quantification of various involved parameters and consequently cultivate various techniques to treat the diseases. Coronary artery diseases (CAD) 作者: 委托 時(shí)間: 2025-3-28 04:28
Andrew Hansen,Dean L. Urban,Barbara Marksundamental challenges, magnetofection has emerged as a cutting-edge technology. The scientific premise is that DNA, RNA, biomolecules, or simply the drugs are either linked to, or encapsulated within, magnetic nanoparticle. The whole therapeutic agent—magnetic nanoparticle (magnetofectin) complex—is作者: Gingivitis 時(shí)間: 2025-3-28 06:42
https://doi.org/10.5822/978-1-61091-751-3t the polymerization of tubulins; thus, naftopidil may exhibit general cytotoxicity in many types of cells. Recent evidence has supported that additive naftopidil treatment in combination with chemotherapy could be a new clinical application for the treatment of prostate cancer.作者: Explosive 時(shí)間: 2025-3-28 11:47
Book 2022edicinal products. It emphasizes the importance of understanding biological and pathophysiological mechanisms underlying the disease to discover and develop new biological agents. The book uniquely explores the genomic computational integrative approach for drug repositioning. Further, it discusses 作者: BUOY 時(shí)間: 2025-3-28 18:40 作者: 熱烈的歡迎 時(shí)間: 2025-3-28 20:26
David H Duncan,Brendan A Wintleudy polypharmacology in the drug development process. Polypharmacology has emerged as a new paradigm in drug discovery as it promises to provide novel avenues to rationally design the next generation of more effective but less toxic therapeutic agents.作者: Fsh238 時(shí)間: 2025-3-29 01:24
Polypharmacology: New Paradigms in Drug Developmentudy polypharmacology in the drug development process. Polypharmacology has emerged as a new paradigm in drug discovery as it promises to provide novel avenues to rationally design the next generation of more effective but less toxic therapeutic agents.作者: stress-test 時(shí)間: 2025-3-29 03:16
Drug Repositioning of the Phenylpiperazine Derivative Naftopidil in Prostate Cancer Treatmentt the polymerization of tubulins; thus, naftopidil may exhibit general cytotoxicity in many types of cells. Recent evidence has supported that additive naftopidil treatment in combination with chemotherapy could be a new clinical application for the treatment of prostate cancer.作者: BAIT 時(shí)間: 2025-3-29 10:59
tional approach.Provides a brief overview of microdosing for.This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. It emphasizes the importance of understanding biological and pathophysi作者: FILLY 時(shí)間: 2025-3-29 13:37
David H Duncan,Brendan A Wintle existing experimental, approved, discontinued, or shelved drugs for several diseases. This article provides a brief synopsis about repurposing and particularly evokes its most recent scientific basis used to render it more efficient.作者: overweight 時(shí)間: 2025-3-29 16:34
Drug Repurposing in Biomedical Research: Benefits and Challenges existing experimental, approved, discontinued, or shelved drugs for several diseases. This article provides a brief synopsis about repurposing and particularly evokes its most recent scientific basis used to render it more efficient.作者: FICE 時(shí)間: 2025-3-29 23:17 作者: gerontocracy 時(shí)間: 2025-3-30 02:22
Nanotechnology in Dentistryts for early diagnosis and prompt treatment of oral cancer has the potential to redefine the dental practice enormously. Future research needs to be focussed on addressing the production and social and biological challenges for adopting nanodentistry in clinical practice.作者: avenge 時(shí)間: 2025-3-30 05:42
Emerging Technologies: Gateway to Understand Molecular Insight of Diseases, Newer Drugs, Their Desigl methods. New data can be converted into usable knowledge to allow for faster diagnosis and treatment choices using these advanced technologies, such as artificial intelligence, machine learning algorithms, computational biology, and digital BMs. As a result, it is expected that such advancements w作者: AVOID 時(shí)間: 2025-3-30 10:21
Computational Methods for Drug Repurposingproved drugs to treat the disease and several other drugs which are not toxic to humans but failed to treat the diseases. In silico approaches for analyzing and integrating large-scale genomic datasets have been incorporated in the drug repurposing methodologies. Here, we focus on describing existin作者: Corporeal 時(shí)間: 2025-3-30 14:30
Genomic Approaches for Drug Repositioningolecular docking, genome-wide association studies, and network-based approaches aided by artificial intelligence will be described in this chapter along with research examples that have used these methods. Drug repositioning for certain diseases, such as Alzheimer’s disease, cystic fibrosis, and SAR作者: obstruct 時(shí)間: 2025-3-30 18:36
Organ-on-a-Chip: Novel In Vitro Model for Drug Discoveryimensional (3D) in vitro model is 3D bioprinting, which makes realistic in vitro disease models and mimics the actual cellular arrangement of any human tissue or organ. Organ-on-a-chip as 3D in vitro model has shown its potential to understand the disease mechanism along with evaluation of new thera作者: 假裝是我 時(shí)間: 2025-3-30 21:12 作者: Graphite 時(shí)間: 2025-3-31 03:03
Biomarker-Based Drug Discovery with Reverse Translational Approachedside to bench/clinics to laboratories’ instead of ‘bench to bedside/laboratories to clinics’. It is a science of integrating and understanding the mechanism of action ‘man to mice to molecule’ through multiple levels of safety, efficacy and acceptability based on relevant science. The concept of r作者: 陳腐的人 時(shí)間: 2025-3-31 05:02
Nanoparticles: A Potential Breakthrough in Counteracting Multidrug-Resistant Bacterial Infections—A the public health. Apart from this, biofilm-associated infections have also significantly reduced the efficacy of currently imparted antibacterial remedial therapy, thus leaving no viable therapeutic option available. This alarming situation thus calls for the development of and designing novel alt作者: Cholagogue 時(shí)間: 2025-3-31 10:01 作者: 急急忙忙 時(shí)間: 2025-3-31 15:15
Nanodrugs: A Futuristic Approach for Treating Nephrolithiasisveral nanoparticles such as those made up of metals or metal oxides besides lipid and polymer encapsulated nanoparticles have been reported lately for targeting kidney stones. The present article discusses the current challenges and futuristic approaches for the development of nanoparticles of oxala作者: Alveolar-Bone 時(shí)間: 2025-3-31 20:02
Lipodermaceuticals: Technological Transformationschnologies could be promising for the delivery of the drug into the deeper tissues. The present book chapter deals with various aspects which are pertinent for the development and translation of such carrier systems.作者: Meditative 時(shí)間: 2025-4-1 01:19
The Importance of Drug Dose Adjustment in Elderly Patients with Special Considerations for Patients st of the physiological functions, including drug metabolizing and excretory capacity declines in the elderly, consequently cause significant alterations in the metabolic disposition as well as changes in the pharmacokinetic (PK) and pharmacodynamic (PD) parameters of administered drugs in elderly s作者: frugal 時(shí)間: 2025-4-1 03:41
