標(biāo)題: Titlebook: Biomarkers for Huntington‘s Disease; Improving Clinical O Elizabeth A. Thomas,Georgia M. Parkin Book 2023 The Editor(s) (if applicable) and [打印本頁] 作者: retort 時間: 2025-3-21 17:50
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書目名稱Biomarkers for Huntington‘s Disease網(wǎng)絡(luò)公開度學(xué)科排名
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書目名稱Biomarkers for Huntington‘s Disease讀者反饋
書目名稱Biomarkers for Huntington‘s Disease讀者反饋學(xué)科排名
作者: 北極熊 時間: 2025-3-21 22:45 作者: 諂媚于性 時間: 2025-3-22 00:23
,Konflikte in der Wirtschaftsprüfung,with the diagnosis and management of this disorder. This chapter then reviews the different classes of CSF biomarkers that have been studied in HD, including neurotransmitters, amino acids, proteins, metabolites, metals, and microRNAs. CSF levels of mutant huntingtin and neurofilament light chain ar作者: climax 時間: 2025-3-22 06:18
,Konflikte in der Wirtschaftsprüfung,apter will review findings from the literature that have explored saliva as a non-invasive biofluid for biomarker research in Huntington’s disease and have identified factors, such as huntingtin, cortisol, uric acid and cytokines, in saliva that track with features of the disease. These studies offe作者: farewell 時間: 2025-3-22 09:33 作者: EWE 時間: 2025-3-22 13:19
Wolfgang H. C. Junge,Martina Jungedetecting early HD pathophysiology before clinical onset. This chapter will provide an overview of the functional and physiological MRI studies conducted in the premanifest and early-stage HD patients, as well as in preclinical HD models, focusing on discussing the potential of different MRI measure作者: 亞當(dāng)心理陰影 時間: 2025-3-22 19:42 作者: 發(fā)微光 時間: 2025-3-22 23:05 作者: Nonflammable 時間: 2025-3-23 03:35
Konflikte um die Aneignung von Landmutant huntingtin within inflammatory cells have been demonstrated. As circulating markers of inflammation has been shown to mirror brain inflammatory changes in HD, this has raised the possibility that these markers could be useful as markers of disease features. This chapter aims to summarize curr作者: 草率男 時間: 2025-3-23 07:11
Beitr?ge zum Diversity ManagementHowever, several case reports of individuals with the HTT mutation and ALS-like syndrome suggest potential interactions and involvement of TDP-43 in the pathophysiology and phenotype of some individuals with HD. Investigations into other PolyQ diseases, such as Spinocerebellar Ataxias, have provided作者: Dna262 時間: 2025-3-23 10:27 作者: 嚙齒動物 時間: 2025-3-23 15:37 作者: inchoate 時間: 2025-3-23 19:49 作者: Expiration 時間: 2025-3-23 23:06
Positron Emission Tomography (PET) Imaging Biomarkers in Huntington’s Diseases in pwHD have been performed, most of which have claimed subclinical biomarker (e.g. phosphodiesterase 10a, dopaminergic receptors) impairment before the appearance of overt HD symptoms. This finding stresses the importance of early detection and potential intervention, decades before age of onset.作者: 確定無疑 時間: 2025-3-24 04:09 作者: 光亮 時間: 2025-3-24 08:07
Proteomics in Huntington’s Disease Biomarker Discovery tissues and models, several known and novel candidates emerged as consistently affected in HD. Based on MS-based HD studies, we propose the monitoring of existing markers mutant Huntingtin (mHTT) and neurofilament light polypeptide (NfL), together with novel candidate markers, such as proenkephalin作者: cumulative 時間: 2025-3-24 12:21
Microbiome and Metabolomic Biomarkers for Huntington’s Diseaseate biomarkers, including components of the gut microbiome and circulating metabolites. Changes to gut microbiome composition can be quantified using a variety of sequencing methods. This includes polymerase chain reaction, 16S rRNA sequencing, and metagenomic analysis. Metabolomic techniques can be作者: Opponent 時間: 2025-3-24 16:05 作者: 古代 時間: 2025-3-24 21:13
TAR DNA-Binding Protein 43 as a Potential Biomarker for Huntington’s DiseaseHowever, several case reports of individuals with the HTT mutation and ALS-like syndrome suggest potential interactions and involvement of TDP-43 in the pathophysiology and phenotype of some individuals with HD. Investigations into other PolyQ diseases, such as Spinocerebellar Ataxias, have provided作者: 懶鬼才會衰弱 時間: 2025-3-25 02:10 作者: orient 時間: 2025-3-25 06:13
https://doi.org/10.1007/978-3-8350-9626-4ons and cognitive decline. The specific mutation responsible for HD is an expanded CAG repeat in exon 1 of the Huntington gene. This mutation can now be easily detected through genetic testing, allowing for confirmation of the genetic status in individuals at risk of developing HD, which occurs at a作者: Servile 時間: 2025-3-25 07:34 作者: 抑制 時間: 2025-3-25 13:22 作者: hedonic 時間: 2025-3-25 19:00 作者: 進(jìn)入 時間: 2025-3-25 22:26
https://doi.org/10.1007/978-3-322-95093-2e only portion of the central nervous system that is optically accessible for high-resolution imaging. Over the last several decades there has been significant interest in leveraging the optical accessibility of the retina to understand, diagnose and monitor neurological diseases such as Huntington’作者: condone 時間: 2025-3-26 01:54 作者: myalgia 時間: 2025-3-26 06:11
Wolfgang H. C. Junge,Martina Jungegenesis of HD is progressive with a long premanifest phase in which subtle changes in the brain occur up to two decades before the onset of clinical symptoms. Early biomarkers reflecting the subtle changes in the HD brain for better understanding disease progression and evaluating treatment efficacy作者: maudtin 時間: 2025-3-26 08:51 作者: troponins 時間: 2025-3-26 13:05 作者: CONE 時間: 2025-3-26 20:31 作者: medieval 時間: 2025-3-26 21:48 作者: Adj異類的 時間: 2025-3-27 04:21 作者: SUE 時間: 2025-3-27 05:57
https://doi.org/10.1007/978-3-658-20524-9his results in a widespread dysregulation of cellular pathways and death of medium spiny neurons of the striatum. Due to the high metabolic demand of brain tissue, mitochondrial dysfunction and resulting oxidative stress are common pathological features contributing to many neurodegenerative disease作者: KIN 時間: 2025-3-27 12:24
Beitr?ge zum Diversity Managementscovery of aggregated TDP-43 as a pathological hallmark in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis (ALS) in 2006, this protein has been predominantly linked to neurodegenerative diseases. The pathophysiological role of aggregated TDP-43 in these diseases is not completely作者: 殺子女者 時間: 2025-3-27 16:19 作者: flimsy 時間: 2025-3-27 21:50
https://doi.org/10.1007/978-3-031-32815-2neurodegeneration; chorea; movement disorders; Huntington‘s disease; biofluids; biomarkers; imaging bioma作者: Admonish 時間: 2025-3-27 22:29 作者: 壓艙物 時間: 2025-3-28 03:52 作者: 新鮮 時間: 2025-3-28 08:14
Contemporary Clinical Neurosciencehttp://image.papertrans.cn/b/image/187798.jpg作者: 能夠支付 時間: 2025-3-28 11:41
The Utility of Biomarkers for Huntington’s Diseaseons and cognitive decline. The specific mutation responsible for HD is an expanded CAG repeat in exon 1 of the Huntington gene. This mutation can now be easily detected through genetic testing, allowing for confirmation of the genetic status in individuals at risk of developing HD, which occurs at a作者: Obligatory 時間: 2025-3-28 18:01 作者: 項(xiàng)目 時間: 2025-3-28 21:50
Extracellular Vesicles as Possible Sources of Huntington’s Disease Biomarkersnthesis, lipids, proteins, nucleic acids, metabolites and other molecules of the EV producing cell are incorporated into EVs. EVs are able to transfer such molecular cargo to recipient cells and thus participate in intercellular communication. In this chapter, we review the current knowledge about E作者: instate 時間: 2025-3-29 00:37
Saliva as a Relevant Biofluid for Huntington’s Disease Biomarker Researchritical advances in biomarker discovery for neurodegenerative diseases, such as Huntington’s disease, a progressive, inherited disease associated with disrupted motor abilities and cognitive decline. Nonetheless, there remains a need for biomarkers that can be reliably measured in more easily-access作者: FATAL 時間: 2025-3-29 05:32
Retinal Imaging and Functional Biomarkers of Huntington’s Diseasee only portion of the central nervous system that is optically accessible for high-resolution imaging. Over the last several decades there has been significant interest in leveraging the optical accessibility of the retina to understand, diagnose and monitor neurological diseases such as Huntington’作者: pancreas 時間: 2025-3-29 10:53
Positron Emission Tomography (PET) Imaging Biomarkers in Huntington’s Diseaseprotein (mHTT). People with HD (pwHD) suffer from progressive neuronal cell loss in the striatum and cortex, causing progressive motor impairments, psychiatric symptoms, and cognitive impairment. HD symptoms can partially be explained by the disruption of a wide variety of molecular processes. Monit作者: MAG 時間: 2025-3-29 12:20
Functional and Physiological MRI Measures as Early Biomarkers for Huntington’s Diseasegenesis of HD is progressive with a long premanifest phase in which subtle changes in the brain occur up to two decades before the onset of clinical symptoms. Early biomarkers reflecting the subtle changes in the HD brain for better understanding disease progression and evaluating treatment efficacy作者: 轉(zhuǎn)折點(diǎn) 時間: 2025-3-29 18:18
Metabolomics in Huntington’s DiseaseThe present chapter contains an introduction to the field of metabolomics as well as a comprehensive summary of the literature describing metabolomics and lipidomics in HD to date, divided in two sections covering animal and cell model studies and human studies with more than 30?studies?discussed in作者: 有幫助 時間: 2025-3-29 21:55 作者: 必死 時間: 2025-3-30 01:20 作者: Ingenuity 時間: 2025-3-30 07:17
Inflammation Biomarkers in Huntington’s Diseaseand treatment of neurodegenerative diseases, and inflammatory markers are suggested important tools to identify disease risk, diagnose disease, monitor disease progression or treatment response, as well as predict clinical outcomes. In Huntington’s disease (HD) inflammatory processes, both centrally作者: 珊瑚 時間: 2025-3-30 09:24
