標(biāo)題: Titlebook: Biology of Cellular Transducing Signals; Jack Y. Vanderhoek Book 1990 Plenum Press, New York 1990 Calcium.Colon.DNA.Nucleotide.cyclin.enzy [打印本頁] 作者: 不足木 時間: 2025-3-21 17:02
書目名稱Biology of Cellular Transducing Signals影響因子(影響力)
書目名稱Biology of Cellular Transducing Signals影響因子(影響力)學(xué)科排名
書目名稱Biology of Cellular Transducing Signals網(wǎng)絡(luò)公開度
書目名稱Biology of Cellular Transducing Signals網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Biology of Cellular Transducing Signals被引頻次
書目名稱Biology of Cellular Transducing Signals被引頻次學(xué)科排名
書目名稱Biology of Cellular Transducing Signals年度引用
書目名稱Biology of Cellular Transducing Signals年度引用學(xué)科排名
書目名稱Biology of Cellular Transducing Signals讀者反饋
書目名稱Biology of Cellular Transducing Signals讀者反饋學(xué)科排名
作者: 使腐爛 時間: 2025-3-21 21:42
Identification of Residues Essential for the Active Conformation of the ?-Adrenergic Receptor by Sitide binding regulatory proteins (G-proteins). Activation of the G-protein by the agonist-occupied form of the receptor causes the release of GDP from the G-protein, allowing GTP to bind. The GTP-bound form of the G-protein is the active form, which dissociates from the receptor, leading to the activ作者: ALLEY 時間: 2025-3-22 03:53 作者: 腫塊 時間: 2025-3-22 07:17
The Role of Covalent and Non-Covalent Mechanisms in Insulin Receptor Actionommonly in insulin and non-insulin dependent diabetes mellitus, but also in obesity, uremia, glucocorticoid and growth hormone excess, and in certain rare syndromes such as lipoatrophic diabetes and leprechaunism (Kahn, 1985; Reaven, 1988). Although insulin action has been intensively investigated a作者: Metamorphosis 時間: 2025-3-22 10:52
EGF Triggers a Similar Signalling Cascade in Different Cell Types Overexpressing the EGF Receptorintracellular second messengers. EGF. is regarded as a classical example of a growth factor which acts on a receptor harboring tyrosine kinase activity (Berridge, 1987 a,b; Carpenter, 1987). Recently, several reports have indicated that in certain cell types, EGF stimulates inositol lipid turnover w作者: 施舍 時間: 2025-3-22 14:50
Second Messenger Receptors in the Phosphoinositide Cycleterm changes in humoral transmission, the PI cycle may regulate long term alterations evoked by growth factors, hormones and in learning and memory, as is exemplified by long term potentiation. The PI cycle influences cellular function through the generation of diacylglycerol (DAG) and inositol tris作者: colloquial 時間: 2025-3-22 18:31 作者: 靦腆 時間: 2025-3-22 22:25 作者: Gullible 時間: 2025-3-23 04:37
The Family of G Proteinsar effectors, are a family of heterotrimeric proteins composed of α, ? and γ subunits (reviewed by Gilman, 1987; Lochrie and Simon, 1988; Neer and Clapham, 1988). Each of these subunits consists of a super gene family with many members. The α subunits bind guanine nucleotides and all have an intrins作者: 金盤是高原 時間: 2025-3-23 07:50 作者: Nefarious 時間: 2025-3-23 13:47 作者: Abutment 時間: 2025-3-23 15:54
Antibodies as Probes of G-Protein Structure and Function tubulin, soluble proteins (initiation and elongation factors involved in protein synthesis), and low molecular weight GTP-binding proteins such as the . p21 protooncogenes and .-related proteins (Spiegel, 1987; Gilman, 1987; Iyengar & Birnbaumer, 1987). Members of the G-protein subset of the GTP-bi作者: 詞匯 時間: 2025-3-23 18:10 作者: 護(hù)身符 時間: 2025-3-23 22:35 作者: 謊言 時間: 2025-3-24 04:19
‘Cross-Talk’ and the Regulation of Repatocyte Adenylate Cyclase Activity: Desensitization, G1 and Cyacellular concentrations of cyclic AMP. In hepatocytes, glucagon achieves just this (fig.1). We show that such an event is determined by the initial rapid activation of adenylate cyclase which is then followed by the activation of a specific cyclic AMP phosphodiesterase and desensitization of adenyl作者: seduce 時間: 2025-3-24 09:38 作者: 縮減了 時間: 2025-3-24 13:28
Cytoskeletal Participation in the Signal Transduction Process: Tubulin G Protein Interactions in the discovered as proteins which conferred stimulation [Gs] or inhibition [Gi] upon adenylate cyclase. Since their initial discovery, these proteins have been assigned new roles at an alarming rate. Further, molecular genetic techniques have demonstrated that the signal transducing G proteins [for this作者: 嗎啡 時間: 2025-3-24 15:04
Initiation and Modulation of Signal Output from the T cell Antigen Receptorx molecules. The T cell receptor for antigen is a multimeric structure consisting of a polymorphic, antigen-binding heterodimer (T.) noncovalently associated with a series of at least 5 invariant polypeptides termed CD3 (Samelson et al., 1985; Baniyash et al., 1988). The highly polymorphic nature of作者: Abbreviate 時間: 2025-3-24 19:02 作者: 品嘗你的人 時間: 2025-3-25 01:21 作者: ectropion 時間: 2025-3-25 06:51 作者: 陶器 時間: 2025-3-25 11:14
‘Cross-Talk’ and the Regulation of Repatocyte Adenylate Cyclase Activity: Desensitization, G1 and Cyapid activation of adenylate cyclase which is then followed by the activation of a specific cyclic AMP phosphodiesterase and desensitization of adenylate cyclase. These events identify ‘interplay’ or ‘cross-talk’ occurring between two distinct cellular signalling systems.作者: 廣大 時間: 2025-3-25 15:43
Georg Herzwurm,Werner Mellis,Dirk Stelzercauses dissociation of the heterotrimer into ? and ?γ subunits. Although the molecule is heterotrimeric, it is functionally a heterodimer because the ? and γ subunits do not dissociate in the native state. The ? and γ peptides can only be separated under strongly denaturing conditions (Neer, unpublished).作者: 開始發(fā)作 時間: 2025-3-25 16:25
https://doi.org/10.1007/978-3-642-58167-0 neutrophil activation as well as the activation of phospholipase C and A2. Further, some G proteins may act as second messengers, via direct effects on ion channels. The purpose of this chapter is to provide a scheme whereby components of the cell thought to be primarily structural, might participate in the signal transduction process.作者: GLADE 時間: 2025-3-25 23:44 作者: 思想靈活 時間: 2025-3-26 01:07 作者: Sarcoma 時間: 2025-3-26 05:41
Book 1990rs include hormones, peptide growth factors, neurotransmitters as well as some lipid-soluble mediators. Once signalling molecules are bound to their cell surface receptors, one or more intracellular signals are generated which alter the Qehavior of the target cell. The IXth International Washington 作者: 敬禮 時間: 2025-3-26 11:24
Die Grundlagen des Beziehungsmanagementst the physiological and biochemical level for close to half a century, we are only beginning to obtain an in-depth understanding of the molecular mechanism of insulin signal transduction. A complete molecular analysis of this process will be necessary for a rational therapeutic approach to insulin-resistant disease states.作者: 植物茂盛 時間: 2025-3-26 16:16
https://doi.org/10.1007/978-3-322-89813-5urther interest in that the action of norepinephrine was found to result not from a direct action of the transmitter on the channel but rather from a receptor-mediated activation of adenylate cyclase (Sperelakis, 1985).作者: ADJ 時間: 2025-3-26 20:12
Kommunikation - Erfolgsfaktor in der Medizinbstrate, PIP2; and finally, calcium elevation following the release of inositol trisphosphate from the substrate. Since calcium release is detected within two seconds, the macromolecular asembly and dissasembly within the sequence occurs on a subsecond time scale.作者: 山間窄路 時間: 2025-3-26 22:24
https://doi.org/10.1007/978-3-322-89813-5ins bind guanine nucleotides with high affinity and specificity, and possess intrinsic GTPase activity that modulates interactions between the GTP-binding protein and other elements; 2) GTP-binding proteins serve as substrates for ADP-ribosylation by bacterial toxins; this covalent modification disrupts normal function.作者: legitimate 時間: 2025-3-27 02:21 作者: pester 時間: 2025-3-27 05:27
Antibodies as Probes of G-Protein Structure and Functionins bind guanine nucleotides with high affinity and specificity, and possess intrinsic GTPase activity that modulates interactions between the GTP-binding protein and other elements; 2) GTP-binding proteins serve as substrates for ADP-ribosylation by bacterial toxins; this covalent modification disrupts normal function.作者: CHAFE 時間: 2025-3-27 10:47
The Role of Covalent and Non-Covalent Mechanisms in Insulin Receptor Actiont the physiological and biochemical level for close to half a century, we are only beginning to obtain an in-depth understanding of the molecular mechanism of insulin signal transduction. A complete molecular analysis of this process will be necessary for a rational therapeutic approach to insulin-resistant disease states.作者: Aura231 時間: 2025-3-27 14:40 作者: enlist 時間: 2025-3-27 20:27 作者: artless 時間: 2025-3-28 00:02
https://doi.org/10.1007/978-1-4613-0559-0Calcium; Colon; DNA; Nucleotide; cyclin; enzymes; metabolism; proteins作者: Heretical 時間: 2025-3-28 05:25 作者: genesis 時間: 2025-3-28 08:34 作者: GRIEF 時間: 2025-3-28 10:24
https://doi.org/10.1007/978-3-540-48592-6ide binding regulatory proteins (G-proteins). Activation of the G-protein by the agonist-occupied form of the receptor causes the release of GDP from the G-protein, allowing GTP to bind. The GTP-bound form of the G-protein is the active form, which dissociates from the receptor, leading to the activ作者: Dawdle 時間: 2025-3-28 14:52
Durch Menschenkenntnis besser kommunizierencally potent mediators of physiological, as well as pathological events (Samuelsson, 1983; Goetzl & Scott, 1984). The leukotrienes (LTs) are products of the 5-lipoxygenase pathway found in mast cells, polymorphonuclear (PMN) leukocytes and macrophages (Samuelsson, 1983), and exhibit two classes of a作者: flimsy 時間: 2025-3-28 19:36 作者: 分開 時間: 2025-3-29 01:41 作者: 任意 時間: 2025-3-29 05:50 作者: anthesis 時間: 2025-3-29 11:00 作者: AWRY 時間: 2025-3-29 13:55 作者: SOB 時間: 2025-3-29 15:48 作者: Abominate 時間: 2025-3-29 20:13
https://doi.org/10.1007/978-3-322-89813-5y the activated forms of G proteins are also increasing, most notably through the discovery in 1986-1987 that ionic channels form part of the family of molecules regulated by G proteins. Using cell free systems such as provided by excision of membrane patches from cells and incorporation of plasma m作者: 遺傳 時間: 2025-3-30 01:35
https://doi.org/10.1007/978-3-322-89813-5cardiac muscle (Reuter. 1983; Tsien, 1987). The transmitter-induced increase in calcium channel current observed following application of norepinephrine likely explains the increase in the force of contraction that is produced upon sympathetic nerve stimulation to the heart. These findings were of f作者: Additive 時間: 2025-3-30 07:56 作者: Ballerina 時間: 2025-3-30 11:21
Rudolf Volkart,Teodoro Cocca,Gabriele Mollresponses range from chemotaxis, cell differentiation and proliferation, sporulation and germination, to changes inside the cell, such as the modulation of enzyme activities, activation of protein kinases, and expression of new gene products. The network of cellular coupling processes is too complic作者: fatuity 時間: 2025-3-30 13:20
Rudolf Volkart,Teodoro Cocca,Gabriele Moll., the family of G proteins has expanded in both number and scope of action. Arrangements of G proteins within the plasma membrane and among subcellular structures, however, remain largely uncharacterized. Compartmentation within the plasma membrane may indeed provide the means by which agonists can作者: uncertain 時間: 2025-3-30 19:38
Schlussbetrachtung und Ausblick,acellular concentrations of cyclic AMP. In hepatocytes, glucagon achieves just this (fig.1). We show that such an event is determined by the initial rapid activation of adenylate cyclase which is then followed by the activation of a specific cyclic AMP phosphodiesterase and desensitization of adenyl作者: 欲望 時間: 2025-3-30 21:57
Budgetierung des Kommunikations-Mix,, is an important stimulus for the proliferation of erythroid and myelomonocytic stem cells .. (Golde and Gasson, 1988). GM-CSF is also an important . regulator of granulopoiesis and neutrophil function. It induces significant leukocytosis and shortens the period of neutropenia following bone marrow作者: 智力高 時間: 2025-3-31 01:02
https://doi.org/10.1007/978-3-642-58167-0 discovered as proteins which conferred stimulation [Gs] or inhibition [Gi] upon adenylate cyclase. Since their initial discovery, these proteins have been assigned new roles at an alarming rate. Further, molecular genetic techniques have demonstrated that the signal transducing G proteins [for this作者: 高深莫測 時間: 2025-3-31 06:23
Kommunikations-Strategien im Pharma-Marktx molecules. The T cell receptor for antigen is a multimeric structure consisting of a polymorphic, antigen-binding heterodimer (T.) noncovalently associated with a series of at least 5 invariant polypeptides termed CD3 (Samelson et al., 1985; Baniyash et al., 1988). The highly polymorphic nature of作者: tendinitis 時間: 2025-3-31 11:41 作者: 你正派 時間: 2025-3-31 14:02 作者: Senescent 時間: 2025-3-31 20:08
egulation of receptors such as ,B-pdr.‘nergic receptors and receptors for EGF, insulin, leukotrienes, phosphoinositides and prostaglandins. Section two focuses on the family of guanine nucleotide regulatory proteins (G proteins). These G proteins are known to mediate the coupling of receptor-mediated signals 978-1-4612-7866-5978-1-4613-0559-0作者: 爵士樂 時間: 2025-4-1 00:51 作者: 印第安人 時間: 2025-4-1 04:32
Mechanisms for Diversification of Responses of Human Polymorphonuclear Leukocytes to Leukotrienes; Goetzl, 1980; Lewis & Austen, 1984; Dahlen et al., 1980; Pologe et al., 1984; Johnson & Torres, 1984; Pek & Walsh, 1984). The specific di-hydroxy-LT or LTB., on the other hand, elicits PMN leukocyte and eosinophil chemotaxis, initiates PMN leukocyte lysosomal enzyme secretion, and stimulates the r作者: 鉗子 時間: 2025-4-1 09:47
EGF Triggers a Similar Signalling Cascade in Different Cell Types Overexpressing the EGF Receptorl., 1986; Pandiella et al, 1987). Therefore, EGFinduced inositol lipid turnover might be considered lineagespecific, or at least cell type-specific (Earp et al., 1988), and the role of phosphoinositide metabolism in EGF-induced mitogenesis remains to be established.作者: 陳腐的人 時間: 2025-4-1 12:55 作者: corn732 時間: 2025-4-1 16:19
Mechanisms of Receptor Regulation for the Phosphoinositide Signalling Systemoluble inositol phosphates. These may also be involved in the regulation of intracellular calcium or may have other intracellular functions. Diacylglycerol activates protein kinase C (Nishizuka, 1984), resulting in the cell specific phosphorylation of intracellular proteins.
