標(biāo)題: Titlebook: Biologically Based Methods for Cancer Risk Assessment; Curtis C. Travis Book 1989 Springer Science+Business Media New York 1989 assessment [打印本頁] 作者: Carter 時間: 2025-3-21 16:36
書目名稱Biologically Based Methods for Cancer Risk Assessment影響因子(影響力)
書目名稱Biologically Based Methods for Cancer Risk Assessment影響因子(影響力)學(xué)科排名
書目名稱Biologically Based Methods for Cancer Risk Assessment網(wǎng)絡(luò)公開度
書目名稱Biologically Based Methods for Cancer Risk Assessment網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Biologically Based Methods for Cancer Risk Assessment被引頻次
書目名稱Biologically Based Methods for Cancer Risk Assessment被引頻次學(xué)科排名
書目名稱Biologically Based Methods for Cancer Risk Assessment年度引用
書目名稱Biologically Based Methods for Cancer Risk Assessment年度引用學(xué)科排名
書目名稱Biologically Based Methods for Cancer Risk Assessment讀者反饋
書目名稱Biologically Based Methods for Cancer Risk Assessment讀者反饋學(xué)科排名
作者: Surgeon 時間: 2025-3-21 20:53 作者: Champion 時間: 2025-3-22 03:34 作者: Vital-Signs 時間: 2025-3-22 04:52 作者: anthesis 時間: 2025-3-22 10:34
Interspecies Extrapolationlation procedures will be exactly correct for all compounds and that when species-specific data are available, they should be used in risk assessment. In their absence, body weight or surface area extrapolations are used with the explicit knowledge that they are only approximately correct.作者: Impugn 時間: 2025-3-22 14:13
Comparative Carcinogenesis : Is There a Theoretical Approach to Inter-Species Similarity ?biological applications. By comparing the enunciation of the empirical problem with the suggested dimensional-analytical one,it appears that a scientific solution cannot be envisaged without a deep and novel study of the process of carcinogenesis get rid of current beliefs.作者: conspicuous 時間: 2025-3-22 20:00
The Role of Inhibited Intercellular Communication in Carcinogenesis: Implications for Risk Assessmennancial, technical) to perform the toxicological tests; and (d) imprecise ability due to species, genetic, developmental stage, sex and nutritional/occupational/environmental background, to extrapolate from short-term test or animal bioassay results to the unique individual human situation, put great uncertainties in any risk assessment process.作者: 爭吵 時間: 2025-3-23 00:54 作者: entreat 時間: 2025-3-23 04:02
ation (NATO) was held in Corfu, Greece in June, 1989. The intent of the workshop was to survey available pharmacokinetic and pharmacodynamic methods in cancer risk assessment and identify methodological gaps and research needs for biologically based methods in cancer risk assessment. Incorporation o作者: Generic-Drug 時間: 2025-3-23 08:05
From Alternating to Quasi-Alternating Links,the necessity to extrapolate experimental results (1) across species from mice or rats to humans, (2) from the high-dose regions to which animals are exposed in the laboratory to the low-dose regions to which humans are exposed in the environment, and (3) across routes of administration.作者: beta-cells 時間: 2025-3-23 13:30 作者: Awning 時間: 2025-3-23 17:20
https://doi.org/10.1007/978-1-4302-4786-9sis (Hennings and Yuspa [1985]) indicate that a similar stochastic process operates in the development of the tumor from initiated cell clones and intermediate neoplastic cell populations (promotion).作者: 樂意 時間: 2025-3-23 20:33
https://doi.org/10.1007/978-3-030-79349-4ls significantly below those typically used in experimental toxicology studies. To quantitatively estimate risk at low exposure levels, mathematical modeling and extrapolation procedures are necessary.作者: chastise 時間: 2025-3-24 01:12
Book 1989O) was held in Corfu, Greece in June, 1989. The intent of the workshop was to survey available pharmacokinetic and pharmacodynamic methods in cancer risk assessment and identify methodological gaps and research needs for biologically based methods in cancer risk assessment. Incorporation of such met作者: DAUNT 時間: 2025-3-24 02:47 作者: 善于騙人 時間: 2025-3-24 06:56 作者: Bravado 時間: 2025-3-24 12:14
State Epistemic Environmentalismtain carcinogenic polycyclic aromatic hydrocarbons (P.A.Hs) in all rat strains tested (Marselos and Hanninen, 1974; Deitrich et al., 1978; Marselos et al., 1979). This isozyme is induced also in cultures of human hepatocytes, after in vitro exposure to 3-methylcholanthrene (Marselos et al., 1987).作者: Regurgitation 時間: 2025-3-24 17:07 作者: creditor 時間: 2025-3-24 22:55
https://doi.org/10.1007/978-1-4684-5625-7assessment; cancer; carcinogenesis; carcinoma; cell; cell culture; development; liver; methodology; mutagen; o作者: CESS 時間: 2025-3-24 23:33
978-1-4684-5627-1Springer Science+Business Media New York 1989作者: Explicate 時間: 2025-3-25 06:57 作者: Spirometry 時間: 2025-3-25 11:30
From Knot Invariants to Knot Dynamics,uch a model should have clear interpretation in biological terms and, if their dependence on dose of environmental agent can be measured or inferred, then the model can be used for low-dose and inter-species extrapolation of cancer risk.作者: 仔細閱讀 時間: 2025-3-25 13:01 作者: 痛苦一下 時間: 2025-3-25 17:38 作者: 協(xié)定 時間: 2025-3-25 22:31 作者: Synchronism 時間: 2025-3-26 02:25 作者: 我邪惡 時間: 2025-3-26 07:26
https://doi.org/10.1007/978-1-4302-4786-9n. Lacking detailed information on interspecies differences, it is frequently assumed that experimental results can be extrapolated between species when administered dosage is standardized as either mg/kg body weight per day (body weight scaling) or mg/m. per day (surface area scaling). Several inve作者: 安撫 時間: 2025-3-26 10:40
Know and Grow the Value of Your Businessnd similarities between experimental and observed carcinogenesis (‘the mouse-to-man problem’) In this area, two extreme positions can be made out: (1) the ‘optimistic’ one (frequent among regulatory authorities), which accepts a direct “extrapolation” of all kinds of xenobiotic effects from strains 作者: malign 時間: 2025-3-26 15:51
The Hardest Step: Succession Planningthe use of pharmacokinetic models considering relevant metabolic routes may considerably improve risk assessment procedures (Bolt, 1987; Travis, 1987). The biological basis for an appropriate interspecies extrapolation is knowledge of the biochemical mode of action and of the toxicologically relevan作者: mediocrity 時間: 2025-3-26 19:07 作者: Latency 時間: 2025-3-26 21:52 作者: Affection 時間: 2025-3-27 04:45 作者: BLINK 時間: 2025-3-27 05:40 作者: Volatile-Oils 時間: 2025-3-27 10:57 作者: Anal-Canal 時間: 2025-3-27 14:25
The Epistemology of Mengzian Extensionflection of the presence or absence of exogenous, causal factors (Wynder and Gori, 1977; Doll, 1978). The investigation of possible nutritional and other environmentally derived influences in animal experiments has further established that a vast array of compounds are capable of playing a role in t作者: 討人喜歡 時間: 2025-3-27 18:18
State Epistemic Environmentalismion of the rat liver (Deitrich, 1966; Tottmar et al., 1973). Previous studies have described the induction of two cytosolic aldehyde dehydrogenases by a variety of xenobiotics (Deitrich, 1971; Deitrich et al., 1977). Phenobarbital induces a specific ALDH (PB-ALDH) in certain genetically defined rat 作者: 煩擾 時間: 2025-3-28 01:28
Matthew Kieran,Dominic McIver Lopesocess through successive stages which are determined by different biochemical mechanisms. This concept initially elaborated on the basis of the observation of experimental skin carcinogenesis has been confirmed to apply to all kinds of living tissues..作者: MOCK 時間: 2025-3-28 04:29 作者: 防御 時間: 2025-3-28 09:29 作者: 期滿 時間: 2025-3-28 12:32 作者: 空氣傳播 時間: 2025-3-28 18:27
https://doi.org/10.1007/978-3-642-28515-82-Nitropropane (2-NP), methyl ethyl ketone (MEK), and n-hexane (HEX) are used in large quantities for industrial processes. They are components of solvent mixtures and are present as thinners in commercial products like glues, paints, and laquers. Because of their high volatility persons are mainly exposed via inhalation of the vapors.作者: Malaise 時間: 2025-3-28 20:59 作者: BOOST 時間: 2025-3-29 02:57 作者: Macronutrients 時間: 2025-3-29 05:36
Multistage Models for Cancer Risk Assessmentuch a model should have clear interpretation in biological terms and, if their dependence on dose of environmental agent can be measured or inferred, then the model can be used for low-dose and inter-species extrapolation of cancer risk.作者: GLUE 時間: 2025-3-29 08:25 作者: CLIFF 時間: 2025-3-29 15:20 作者: irreducible 時間: 2025-3-29 15:49 作者: Altitude 時間: 2025-3-29 21:45 作者: glisten 時間: 2025-3-30 01:00
,The acute abdomen—case histories A to Z,en the total volume of enzyme-altered tissue in liver and the subsequent development of liver tumors have been established (Emmelot and Scherer, 1980; Kunz et al., 1983, 1985). Enzyme-altered foci are monoclonal in origin (Rabes et al., 1982; Williams et al., 1983) and show a growth advantage over t作者: 犬儒主義者 時間: 2025-3-30 05:40
The Hardest Step: Succession PlanningIARC, 1986). The diagnosis of foci implies that the altered cell populations are perfectly integrated into the normal architecture of the respective tissue and do not show any expansive growth. At the histological level, preneoplasia may be defined as a phenotypically altered cell population which h作者: acheon 時間: 2025-3-30 10:18
The Hardest Step: Succession Planningdose), and no positive carcinogenicity data have hitherto been obtained. However, the closely related compounds 1,1,2-trichloroethane and 1,1,2,2-tetrachloroethane which are extensively metabolized have produced liver tumors in mice (Baseman et al., 1984).作者: Commentary 時間: 2025-3-30 14:48 作者: V洗浴 時間: 2025-3-30 17:49
https://doi.org/10.1007/978-3-322-85198-7xpression of gene programs in initiated/preneoplastic cells in the liver; inhibition of death of preneoplastic cells by promoters seems to cause rapid growth of preneoplastic lesions. Possible implications for risk assessment are discussed.作者: Delude 時間: 2025-3-30 22:50
The Epistemology of Mengzian Extension rats, mice or hamsters has been considered to be the most reliable method for the prediction of carcinogenic potential in man (NCI, 1976; IARC, 1980). However, to be internationally accepted these long-term tests must satisfy costly regulatory guidelines for appropriate facilities, long duration (2作者: Demonstrate 時間: 2025-3-31 01:13
https://doi.org/10.1007/978-1-4020-5265-1ll cultures, 12-0-tetradecanoylphorbol-13-acetate (TPA) enhanced colony formation of rat cells, while it was inhibitory to hamster and human cells (Beeman et al., 1987). We should, therefore, recognize such species-dependent variations and try to understand the mechanisms underlying their occurrence作者: 繁榮中國 時間: 2025-3-31 07:12 作者: 桉樹 時間: 2025-3-31 09:55 作者: Anecdote 時間: 2025-3-31 14:54 作者: 交響樂 時間: 2025-3-31 21:28
The Use of Enzyme-Altered Foci for Risk Assessment of Hepatocarcinogensen the total volume of enzyme-altered tissue in liver and the subsequent development of liver tumors have been established (Emmelot and Scherer, 1980; Kunz et al., 1983, 1985). Enzyme-altered foci are monoclonal in origin (Rabes et al., 1982; Williams et al., 1983) and show a growth advantage over t作者: hurricane 時間: 2025-4-1 00:42
Phenotypic Cellular Changes in Multistage CarcinogenesisIARC, 1986). The diagnosis of foci implies that the altered cell populations are perfectly integrated into the normal architecture of the respective tissue and do not show any expansive growth. At the histological level, preneoplasia may be defined as a phenotypically altered cell population which h作者: 極深 時間: 2025-4-1 03:01 作者: 圍巾 時間: 2025-4-1 06:34 作者: MIRTH 時間: 2025-4-1 13:31 作者: 信徒 時間: 2025-4-1 14:40 作者: Temporal-Lobe 時間: 2025-4-1 19:32
An in Vitro Approach for Interspecies Extrapolation Using Animal and Human Airway Epithelial Cell Cull cultures, 12-0-tetradecanoylphorbol-13-acetate (TPA) enhanced colony formation of rat cells, while it was inhibitory to hamster and human cells (Beeman et al., 1987). We should, therefore, recognize such species-dependent variations and try to understand the mechanisms underlying their occurrence
