標題: Titlebook: Biological Reactive Intermediates—II; Chemical Mechanisms Robert Snyder,David J. Jollow,Stephen L. Longacre Book 1982 The Editor(s) (if ap [打印本頁] 作者: AMUSE 時間: 2025-3-21 19:44
書目名稱Biological Reactive Intermediates—II影響因子(影響力)
作者: CRAB 時間: 2025-3-21 22:36 作者: exquisite 時間: 2025-3-22 01:09 作者: 罐里有戒指 時間: 2025-3-22 05:49
Manfred Wick,Wulf Pinggera,Paul Lehmannide in cultured human blood cells..Although also an arene oxide, styrene-3,4-oxide, has been suggested in the biotransformation of styrene, the evidence so far supports the view that the vinyl group oxidation and oxirane formation plays a predominant role in the genotoxicity of styrene.作者: Deceit 時間: 2025-3-22 09:16 作者: Antioxidant 時間: 2025-3-22 16:16
Relationship between Benzene Metabolism and Toxicity: A Proposed Mechanism for the Formation of Reacave demonstrated that benzene exposure in rats or rabbits result in bone marrow hypoplasia accompanied by a dose-related lymphocytopenia which precedes a decrease in the number of other circulating cells (Selling, 1916; Weiskotten et al, 1920; Svirbely et al, 1944; Nau et al, 1966; Irons et al, 1979作者: 圣歌 時間: 2025-3-22 20:55 作者: musicologist 時間: 2025-3-22 22:16 作者: 中子 時間: 2025-3-23 04:10 作者: obligation 時間: 2025-3-23 09:01 作者: meritorious 時間: 2025-3-23 12:31 作者: 中止 時間: 2025-3-23 14:49 作者: SHOCK 時間: 2025-3-23 20:33
Mitgliederversammlung (Zweiter Teil)The characterization and quantitation of cytochrome P-450 as it is known to much of the scientific community, depends not on its enzymic activity, but on the interaction of the heme iron with a ligand (Omura and Sato 1964).作者: expeditious 時間: 2025-3-24 01:46
Zur Diagnostik der Herzerkrankungen,Benzene is a ubiquitous component of our chemical age. Due to its very special chemical and physical properties, benzene is widely used in the chemical industry and in the manufacture of rubber and plastics. In addition, benzene is used in motor fuel as an anti-knocking agent (Berlin et al., 1974).作者: Catheter 時間: 2025-3-24 03:00
Ligand Complexes Generated during Cytochrome P-450 Dependent MetabolismThe characterization and quantitation of cytochrome P-450 as it is known to much of the scientific community, depends not on its enzymic activity, but on the interaction of the heme iron with a ligand (Omura and Sato 1964).作者: CRUC 時間: 2025-3-24 09:49 作者: 天空 時間: 2025-3-24 14:37
Alkylation and Peroxidation Injury from Chemically Reactive Metabolitesompeting adversaries for our love and affection, our hearts and souls. They are neither mutually exclusive nor competing hypotheses. In fact for some chemicals converted to radical metabolites, they might even be additive.作者: diskitis 時間: 2025-3-24 16:42
https://doi.org/10.1007/978-1-4757-0674-1DNA; NADP; NADPH; Nucleotide; Oxidation; alcohol; biochemistry; enzymes; metabolism; mutation; pharmacology; pr作者: 疏遠天際 時間: 2025-3-24 20:27
978-1-4757-0676-5The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines作者: 烤架 時間: 2025-3-25 01:45 作者: 我要沮喪 時間: 2025-3-25 05:07
F. Loew,K. A. Jochheim,R. Kivelitz enzyme system, which comprises cytochromes P-450 and cytochrome P-450 reductase, is a ubiquitous system found in every living organism which has been investigated, including bacteria, yeasts and flowering plants. The system varies with the type of living organism, with its stage of development, and作者: 強制性 時間: 2025-3-25 09:53 作者: ARENA 時間: 2025-3-25 15:11 作者: 發(fā)起 時間: 2025-3-25 19:45
https://doi.org/10.1007/978-3-642-60881-0dicated by the recent review of Chasseaud, 1979. Neither the intermediary fate of these glutathione-Sconjugates nor the extent of extrahepatic sites for the initial hydrolytic reaction catalyzed by γ-glutamyl transpeptidase (EC 2.3. 2.2) is well understood. Biliary excretion of glutathione-Sconjugat作者: 偽證 時間: 2025-3-25 22:48 作者: Indolent 時間: 2025-3-26 03:43
Mitgliederversammlung (Erster Teil)ompounds with tissue receptors; the extent and duration of the effects being proportional to the concentration-time profile of the compound in the target tissue. If, as is often the case, there is a rapid equilibrium between compound in tissues and in plasma, determination of the plasma concentratio作者: 聯(lián)合 時間: 2025-3-26 05:43 作者: forager 時間: 2025-3-26 12:32
Deutsche Gesellschaft für Chirurgiee an intermediate in the NADH-supported electron transfer pathway (Sasame et al., 1973; Hrycay and Prough, 1974; Hrycay and Estabrook, 1974; Lu et al., 1974; Jansson and Schenkman 1975, 1977). Less clear is the role of cytochrome .. in the NADPH-supported and NADH-synergized reactions. This synergis作者: Demonstrate 時間: 2025-3-26 15:27 作者: xanthelasma 時間: 2025-3-26 16:50 作者: Tinea-Capitis 時間: 2025-3-26 23:23 作者: Interlocking 時間: 2025-3-27 04:31
Manfred Wick,Wulf Pinggera,Paul Lehmann chemicals is seen only after metabolic activation of the original chemical to a more toxic form. Several lines of evidence indicate that benzene also must be metabolically activated in order to exert its characteristic toxicity on bone marrow. Most of the hydroxylated benzene metabolites known toda作者: Vulnerable 時間: 2025-3-27 05:18 作者: 廣告 時間: 2025-3-27 10:57 作者: deactivate 時間: 2025-3-27 15:59
,Bestimmungsmethoden für Elektrolyte,(Koch-Weser et al., 1953; Reid et al., 1971). Metabolic activation of bromobenzene to reactive intermediate(s) by the cytochrome P-450-linked monooxygenase system is required for this agent to produce liver damage which, in turn, is preceded by depletion of hepatic glutathione (GSH) (Jollow et al., 作者: 陪審團 時間: 2025-3-27 21:40 作者: 高貴領(lǐng)導 時間: 2025-3-27 23:11 作者: 專心 時間: 2025-3-28 03:48 作者: 凌辱 時間: 2025-3-28 08:32
Fate of Epdxidesbe the primary lesion ultimately leading to initiation of cancer (Miller and Miller, 1974; Oesch, 1973; Jerina and Daly, 1974; Sims and Grover, 1974; Heidelberger, 1975; Gelboin et al., 1972). This review first describes structure-activity relationships for the mutagenicity of some epoxides and then作者: OFF 時間: 2025-3-28 10:25 作者: endocardium 時間: 2025-3-28 15:35 作者: 傳授知識 時間: 2025-3-28 21:38 作者: START 時間: 2025-3-29 00:10 作者: 紳士 時間: 2025-3-29 06:45
The Heme Protein P-450 in Oxygen Activation: Carbon Monoxide Inhibition and Photochemical Action Speminantly in the inner membranes of the mitochondria of endocrine organs catalyze a variety of oxygenating processes which operate on many different endogenous (e.g. steroids, bile acids) as well as foreign compounds (e.g. drugs, pesticides, toxic chemicals, chemical carcinogens, and other xenobiotic作者: catagen 時間: 2025-3-29 09:36
Possible Mechanism of Coupled NADPH Oxidase and P-450 Monooxygenase Actione an intermediate in the NADH-supported electron transfer pathway (Sasame et al., 1973; Hrycay and Prough, 1974; Hrycay and Estabrook, 1974; Lu et al., 1974; Jansson and Schenkman 1975, 1977). Less clear is the role of cytochrome .. in the NADPH-supported and NADH-synergized reactions. This synergis作者: 無政府主義者 時間: 2025-3-29 12:14
Studies on the Mechanism of Stimulation of Microsomal H2O2 Formation and Benzo(a)pyrene Hydroxylatonflavone of microsomal hydroxylation of benzo(a)pyrene and its inhibition by catalase and methanol suggests but does not prove a necessary interaction of microsomal H.O. production with benzo(a)pyrene hydroxylation..Hexobarbital and flavone-stimulated H.O. formation is optimal at a stoichiometric rel作者: 使增至最大 時間: 2025-3-29 18:26 作者: Entirety 時間: 2025-3-29 21:16
Relationship between Benzene Metabolism and Toxicity: A Proposed Mechanism for the Formation of Reacing leukopenia, pancytopenia, bone marrow hypoplasia or aplasia, thrombocytopenia, granulocytopenia and lymphocytopenia (Aksoy et al, 1971; 1972 Goldwater, 1941; for review see Laskin & Goldstein, 1977). Among these abnormalities one of the most frequently cited is lymphocytopenia. In one of the few作者: Microaneurysm 時間: 2025-3-30 01:10 作者: Introduction 時間: 2025-3-30 06:50 作者: 壁畫 時間: 2025-3-30 08:57
Development of a Novel Method for Measuring Covalent Binding and Its Application to Investigations ot interactions have been suggested to be involved in hepatic, renal, pulmonary and bone marrow toxicity as well as carcinogenicity (Mitchell et al., 1976; Mitchell et al., 1977; Hinson, 1980; Gillette et al., 1974; Boyd, 1980; Irons et al., 1980; Miller, 1970). More recently it has become apparent t作者: Salivary-Gland 時間: 2025-3-30 15:16
Biotransformation of Bromobenzene to Reactive Metabolites by Isolated Hepatocytes(Koch-Weser et al., 1953; Reid et al., 1971). Metabolic activation of bromobenzene to reactive intermediate(s) by the cytochrome P-450-linked monooxygenase system is required for this agent to produce liver damage which, in turn, is preceded by depletion of hepatic glutathione (GSH) (Jollow et al., 作者: Diatribe 時間: 2025-3-30 17:58
Urinary Metabolites of Benzene in the Mousecaused by a metabolite of benzene. Our understanding of the metabolism of benzene derives largely from the reports of R.T. Williams and his co-workers (Porteus and Williams, 1949a, 1949b; Parke and Williams, 1952, 1953a, 1953b), who were the first to systematically identify benzene metabolites in ra作者: Forehead-Lift 時間: 2025-3-30 21:23 作者: 束縛 時間: 2025-3-31 03:08 作者: 命令變成大炮 時間: 2025-3-31 05:25
Fortschritte der Urologie und Nephrologie of conjugated phenolic metabolites of benzene. Upon acid hydrolysis of the conjugates, phenol was found to account for 24% of the dose while other metabolites included catechol (2.2%), hydroquinone (4.8%), and hydroxyhydroquinone (0.3%). 1-Phenylmercapturic acid (0.5%) and trans-trans-muconic (1.3%) acid were also recovered in the urine.作者: 物質(zhì) 時間: 2025-3-31 12:20 作者: 強行引入 時間: 2025-3-31 16:20 作者: ESO 時間: 2025-3-31 21:32 作者: 混雜人 時間: 2025-3-31 23:01 作者: Between 時間: 2025-4-1 03:43
The Heme Protein P-450 in Oxygen Activation: Carbon Monoxide Inhibition and Photochemical Action Spes). Atmospheric oxygen, O., and reducing equivalents, provided by reduced pyridine nucleotides, are co-substrates in these reactions in which, in a formal sense, one or both of the atoms of the oxygen molecule are inserted into the reaction products (monooxygenation and dioxygenation, respectively).作者: AVERT 時間: 2025-4-1 09:58 作者: 透明 時間: 2025-4-1 12:32 作者: 全面 時間: 2025-4-1 14:41
Deutsche Gesellschaft für Chirurgie, 1974; Jansson and Schenkman 1975, 1977). Less clear is the role of cytochrome .. in the NADPH-supported and NADH-synergized reactions. This synergism has been shown to require cytochrome .. by the use of antibodies (Sasame et al., 1973, Mannering et al., 1974, Jansson and Schenkman, 1977), but the mechanism has remained to be elucidated.作者: Libido 時間: 2025-4-1 20:49
Fate of EpdxidesHeidelberger, 1975; Gelboin et al., 1972). This review first describes structure-activity relationships for the mutagenicity of some epoxides and then outlines some findings on the metabolic control of the concentration of such epoxides by a number of enzymes.
