作者: Harness 時間: 2025-3-22 00:01
Structure Activity Relationships for the Chemical Behaviour and Toxicity of Electrophilic Quinones/s. This includes the quinones/quinone methides of catechol-type metabolites from estrogens and polycyclic aromatic hydrocarbons.. Metabolic activation of estrogens to redox active and/or electrophilic metabolites has been proposed as one of the mechanisms responsible for the link between estrogen ex作者: 辭職 時間: 2025-3-22 02:42 作者: 冰雹 時間: 2025-3-22 06:28
Structure Toxicity Relationships - How Useful Are They in Predicting Toxicities of New Drugs?, of severe toxic effects. Although in some cases the parent drug structure may be responsible for the observed toxicities, in most cases reactive metabolites are formed that interact with cellular macromolecules to stress cells directly, and/or more commonly, yield immunogenic products. Since it is 作者: Dorsal-Kyphosis 時間: 2025-3-22 11:53 作者: ANN 時間: 2025-3-22 15:30 作者: 無法破譯 時間: 2025-3-22 20:05
New Aspects of DNA Adduct Formation by the Carcinogens Crotonaldehyde and Acetaldehyde,uces altered liver cell foci, neoplastic nodules, and hepatocellular carcinoma upon oral administration to F344 rats (Chung et al, 1986; IARC, 1995). Acetaldehyde causes tumors of the respiratory tract in rats and hamsters upon exposure by inhalation (IARC, 1985; 1999). Crotonaldehyde and acetaldehy作者: 四目在模仿 時間: 2025-3-22 21:49
Mechanisms of Ovotoxicity Induced by Environmental Chemicals: 4-Vinylcyclohexene Diepoxide as a Modcan produce premature ovarian failure (early menopause in women) because once destroyed, they cannot be replaced. Menopause is known to be associated with an increased incidence of a variety of health problems such as osteoporosis, cardiovascular disease, and ovarian cancer. Exposure of women to che作者: left-ventricle 時間: 2025-3-23 02:44 作者: 無法取消 時間: 2025-3-23 08:37 作者: 纖細 時間: 2025-3-23 11:34 作者: 愛好 時間: 2025-3-23 17:47
,Formation and Fate of Reactive Intermediates of Haloalkanes, Haloalkenes, and α-Haloacids,bromo-3-chloropropane were formerly used as fumigants and nematocides, trichloroethylene is a common environmental contaminant, and dichloroacetate (DCA), which is produced during the chlorination of drinking water, is present in finished drinking water supplies in the U.S. Many haloalkanes, haloalk作者: 門窗的側(cè)柱 時間: 2025-3-23 22:06
Human Epoxide Hydrolase is the Target of Germander Autoantibodies on the Surface of Human Hepatocytgermander (.) was traditionally used as a folk medicine for its for and antiseptic properties. In 1991, germander consumed to treat obesity, caused an epidemic of cytolytic hepatitis. Thirty cases of hepatotoxicity were first reported including cases with positive rechallengge. For these patients, a作者: Chauvinistic 時間: 2025-3-24 02:10
Structural Characterisation Of the Main Epichlorohydringuanosine Adducts,, pharmaceuticals, paper, textiles and coatings. ECH has been shown to induce mutagenic and clastogenic effects in various test systems. It has been shown to be carcinogenic in animals and classified as probably carcinogenic to humans. Recently, ECH was shown to induce formation of DNA adducts in hu作者: 皺痕 時間: 2025-3-24 05:48 作者: enormous 時間: 2025-3-24 08:57 作者: 忙碌 時間: 2025-3-24 13:43 作者: Ordnance 時間: 2025-3-24 17:55 作者: faction 時間: 2025-3-24 20:26 作者: 夾死提手勢 時間: 2025-3-25 02:44
Advances in Experimental Medicine and Biologyhttp://image.papertrans.cn/b/image/187443.jpg作者: 不規(guī)則的跳動 時間: 2025-3-25 04:52
https://doi.org/10.1007/978-3-211-76633-0by cell shrinkage, nuclear and cytoplasmic condensation, chromatin fragmentation and phagocytosis. In contrast, necrosis is a passive form of cell death associated with inflammation resulting from cellular and organelle swelling, rupture of the plasma membrane and spilling of cellular contents into 作者: 意外的成功 時間: 2025-3-25 10:47 作者: fetter 時間: 2025-3-25 12:43 作者: amnesia 時間: 2025-3-25 19:13
Optische — Entopische Ph?nomene of severe toxic effects. Although in some cases the parent drug structure may be responsible for the observed toxicities, in most cases reactive metabolites are formed that interact with cellular macromolecules to stress cells directly, and/or more commonly, yield immunogenic products. Since it is 作者: 暫時別動 時間: 2025-3-25 21:41 作者: 搏斗 時間: 2025-3-26 00:27 作者: 提升 時間: 2025-3-26 08:07 作者: 兵團 時間: 2025-3-26 08:32 作者: 王得到 時間: 2025-3-26 14:44
Klinik der rheumatischen Erkrankungenturing of food antioxidants. HQ is also an important metabolite of benzene (12). HQ has been identified in relatively high concentrations in the smoke of unfiltered cigarettes (up to 155 .g per cigarette) (3) and was chosen for study by the National Cancer Institute because it is produced in large q作者: STALE 時間: 2025-3-26 18:38 作者: 一致性 時間: 2025-3-26 22:44 作者: 暴行 時間: 2025-3-27 03:29
Athyreosis, Hypophysistumor und Akromegaliebromo-3-chloropropane were formerly used as fumigants and nematocides, trichloroethylene is a common environmental contaminant, and dichloroacetate (DCA), which is produced during the chlorination of drinking water, is present in finished drinking water supplies in the U.S. Many haloalkanes, haloalk作者: Offset 時間: 2025-3-27 06:48 作者: 反抗者 時間: 2025-3-27 10:51
P. Brandt,J. Gerlach,W. Volland, pharmaceuticals, paper, textiles and coatings. ECH has been shown to induce mutagenic and clastogenic effects in various test systems. It has been shown to be carcinogenic in animals and classified as probably carcinogenic to humans. Recently, ECH was shown to induce formation of DNA adducts in hu作者: 心胸狹窄 時間: 2025-3-27 14:14 作者: 天真 時間: 2025-3-27 18:58 作者: delusion 時間: 2025-3-27 22:54
H. Lange-Cosack,G. Norlén,W. Waltern France in 1992. Early batches of tienilic acid also contained 0.1–0.5% tienilic acid isomer. Tienilic acid isomer (TAI), has been shown to be metabolised by Cytochrome P450 into a reactive thiophene 1-oxide which either binds to proteins, or can be trapped by sulfur nucleophiles (Valadon et al. 19作者: receptors 時間: 2025-3-28 05:50 作者: vitrectomy 時間: 2025-3-28 07:20
https://doi.org/10.1007/978-3-642-87179-5rphyrin IX covalently bound through thioether links to two cysteine side chains and a histidine is axially coordinated to the heme iron, and acts as its fifth ligand. MP8 has an open active site, which leads to broad substrate specificity in the two types of catalytic activities it shows: a peroxida作者: 財主 時間: 2025-3-28 11:26
https://doi.org/10.1007/978-1-4615-0667-6Carcinom; DNA; Oxidation; amphetamine; dopamine; metabolism; neurotoxicity; transcription作者: Fester 時間: 2025-3-28 17:46
978-1-4613-5185-6The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines作者: heterogeneous 時間: 2025-3-28 21:33 作者: 不可比擬 時間: 2025-3-29 02:58
0065-2598 Overview: 978-1-4613-5185-6978-1-4615-0667-6Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: Mhc-Molecule 時間: 2025-3-29 03:07
Erfahrungen mit Cochlea-Implantaten of estrogens to redox active and/or electrophilic metabolites has been proposed as one of the mechanisms responsible for the link between estrogen exposure and the risk of developing cancer..Especially catechol (ortho-diol)-type of metabolites resulting from cytochrome P450 catalysed hydroxylation of estrogens(Figure.1) may be involved.作者: browbeat 時間: 2025-3-29 08:34
P. Brandt,J. Gerlach,W. Vollandhown to be carcinogenic in animals and classified as probably carcinogenic to humans. Recently, ECH was shown to induce formation of DNA adducts in humans exposed to ECH (Plna et al., 2000). A review article concerning the toxicology of ECH has been written by Giri (1997)作者: Immortal 時間: 2025-3-29 14:46 作者: 指派 時間: 2025-3-29 17:00 作者: 提煉 時間: 2025-3-29 20:37
Structure Activity Relationships for the Chemical Behaviour and Toxicity of Electrophilic Quinones/ of estrogens to redox active and/or electrophilic metabolites has been proposed as one of the mechanisms responsible for the link between estrogen exposure and the risk of developing cancer..Especially catechol (ortho-diol)-type of metabolites resulting from cytochrome P450 catalysed hydroxylation of estrogens(Figure.1) may be involved.作者: ABIDE 時間: 2025-3-30 03:00 作者: 爵士樂 時間: 2025-3-30 05:28 作者: Hippocampus 時間: 2025-3-30 09:35
Microperoxidase 8 (MP8) as a Convenient Model for Hemoproteins: Formation and Characterisation of Nts fifth ligand. MP8 has an open active site, which leads to broad substrate specificity in the two types of catalytic activities it shows: a peroxidase-like activity (Baldwin . 1987) and a cytochrome P450-like activity (Osman . 1996).作者: 甜瓜 時間: 2025-3-30 12:26 作者: hegemony 時間: 2025-3-30 16:59 作者: 輕信 時間: 2025-3-30 23:07 作者: 兇殘 時間: 2025-3-31 01:05 作者: GLOSS 時間: 2025-3-31 05:51
Inhibition by Ticlopidine and Its Derivatives of Human Liver Cytochrome P450. Mechanism-Based Inactism (.) an indication of inhibition . of CYP 2C19 activity by ticlopidine. . such inhibitory effects on bufuralol hydroxylation(.)and on S-mephenytoin 4-hydroxylation (.) have been shown on recombinant CYP 2C19.作者: Frequency 時間: 2025-3-31 12:15
Optische — Entopische Ph?nomenethe structures of drugs and their metabolites that dictate reactivity, and not the metabolic pathways themselves, this chapter will focus on what can be empirically learned from comparisons of structures associated with toxic effects and similar structures that are less toxic.作者: 帶子 時間: 2025-3-31 13:30 作者: V洗浴 時間: 2025-3-31 17:48 作者: 摻假 時間: 2025-4-1 00:51 作者: Deduct 時間: 2025-4-1 03:21 作者: 薄荷醇 時間: 2025-4-1 08:36
