作者: 顛簸下上 時(shí)間: 2025-3-21 23:01
Klinik der gyn?kologischen R?ntgentherapie 1991). The inhibitory effect of both retinoids and carotenoids towards neoplastic transformation correlates with their activity to induce gap junctional communication (Zhang et al., 1991; Bertram et al., 1991).作者: Overstate 時(shí)間: 2025-3-22 02:37 作者: Oligarchy 時(shí)間: 2025-3-22 07:19 作者: 粘連 時(shí)間: 2025-3-22 12:27
https://doi.org/10.1007/978-3-642-95977-6olabeled acetaminophen resulted in covalent binding of radiolabel to protein in the necrotic hepatocytes (5). . experiments revealed that the metabolism was by a cytochrome P-450 dependent mechanism (6). It was postulated that covalent binding of this metabolite to critical proteins was the mechanism of the hepatotoxicity.作者: inspiration 時(shí)間: 2025-3-22 14:45 作者: MENT 時(shí)間: 2025-3-22 20:50
Pathologische Anatomie der Tuberkulose,that it might be feasable to invert the topology of the mEH in the membrane of the endoplasmic reticulum without affecting the catalytic activity of this protein. With this strategy it will be possible to investigate whether the membrane topology of xenobiotic metabolizing enzymes is important for their role in chemical carcinogenesis.作者: 培養(yǎng) 時(shí)間: 2025-3-22 21:52 作者: antenna 時(shí)間: 2025-3-23 02:44
https://doi.org/10.1007/978-3-662-34539-9gid et al., 1993). There is also growing evidence that endogenous factors such as oxidative stress and DA itself may contribute to the neurodegenerative process (Cohen, 1983; Agid et al., 1993; Zigmond et al., 1992).作者: 確認(rèn) 時(shí)間: 2025-3-23 08:10 作者: ablate 時(shí)間: 2025-3-23 11:54
An Oxidant Sensor at the Plasma Membraner-specific recognition elements, the growth factors induce, through their cell surface receptors, a complex process of signal transduction to the nucleus (for reviews see Beato, 1989; Karin, 1994; Gilbert, 1994; Angel and Herrlich, 1994; McCormick, 1995; Howe and Weiss, 1995; Ullrich and Simon, 1995).作者: endocardium 時(shí)間: 2025-3-23 14:37
Reactive Dopamine Metabolites and Neurotoxicitygid et al., 1993). There is also growing evidence that endogenous factors such as oxidative stress and DA itself may contribute to the neurodegenerative process (Cohen, 1983; Agid et al., 1993; Zigmond et al., 1992).作者: 蛛絲 時(shí)間: 2025-3-23 21:14
Book 1996try is replete with exam- ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive作者: moratorium 時(shí)間: 2025-3-24 00:53 作者: 厚顏無(wú)恥 時(shí)間: 2025-3-24 05:09 作者: 阻止 時(shí)間: 2025-3-24 09:29 作者: 有其法作用 時(shí)間: 2025-3-24 14:26 作者: Oratory 時(shí)間: 2025-3-24 15:15 作者: 喃喃訴苦 時(shí)間: 2025-3-24 22:16
Development of a Mass Spectrometric Assay for 5,6,7,9-Tetrahydro-7-Hydroxy-9-Oximidazo [1,2-,]Purinear basis for the genotoxic effects of the parent compound, and site specific mutagenesis studies (Basu et al., 1993) show its mutagenicity. There is evidence that ε adducts might not only be formed by vinyl chloride metabolites but also be present at a certain level due to endogeneous sources (Misra et al., 1994).作者: 蒸發(fā) 時(shí)間: 2025-3-25 01:31
Hepatic Epoxide Concentrations during Biotransformation of 1,2- and 1,4-Dichlorobenzenet al., 1971). Both 1,2-dichlorobenzene and its 1,4-isomer are metabolized by cytochrome P450 enzymes to an epoxide intermediate. This epoxide may either rearrange to produce phenols, hydrolyse to form dihydrodiols or conjugate with glutathione.作者: Conflagration 時(shí)間: 2025-3-25 03:56
Akrodermatitis atrophicans chronica (,),ene oxides as electrophilic reactive metabolites. Much less was known until very recently about the metabolic oxidative activation of thiophene derivatives (Rance, 1989). A first report on the metabolism of thiophene itself in rats has shown the formation of thiophene-derived mercapturates in urine 作者: 就職 時(shí)間: 2025-3-25 09:27
Pathologische Anatomie der Tuberkulose,ymes are also the major ones involved in the oxidation of potential toxicants and carcinogens such as those encountered among pollutants, solvents, and pesticides, as well as many natural products. A proper understanding of the basic mechanisms by which the P450 enzymes oxidize such compounds is imp作者: adroit 時(shí)間: 2025-3-25 12:15 作者: Oafishness 時(shí)間: 2025-3-25 18:48
,Acardiacus, Acardius, herzlose Mi?geburt,iety of physiological and pathophysiological processes [22]. Despite of its function in the control of blood pressure, platelet aggregation and neurotransmission, which are mediated via the activation of the soluble guanylate cyclase, ·NO has been shown to be a potent modulator of the cytotoxic acti作者: 變量 時(shí)間: 2025-3-25 23:15
Muskelrelaxation bei alten Menschen,r, and the rearrangement product chloroacetaldehyde give rise to the etheno (ε) DNA adducts. This type of modified DNA bases appears to be the molecular basis for the genotoxic effects of the parent compound, and site specific mutagenesis studies (Basu et al., 1993) show its mutagenicity. There is e作者: 溫室 時(shí)間: 2025-3-26 02:12 作者: 使苦惱 時(shí)間: 2025-3-26 06:06 作者: Mnemonics 時(shí)間: 2025-3-26 09:58
E. Lüllwitz,U. Dybus,S. Piepenbrockryonic development of all multicellular organisms and also in the adult when various cytokines and hormones exert highly inducer-specific influences on genes. The naturally occurring regulating agents interact with specific receptors: e.g., the retinoids, vitamin D3, thyroid hormones and the steroid作者: Laconic 時(shí)間: 2025-3-26 15:11 作者: conscribe 時(shí)間: 2025-3-26 19:52
Muskelrelaxanzien und Leberinsuffizienz,DNA binding activity of Fos and Jun is regulated . by a posttranslational mechanism involving reduction-oxidation. Redox regulation is mediated through a conserved cysteine residue located in the DNA binding domain of both proteins. Oxidation or chemical modification of the cysteine has an inhibitor作者: ascend 時(shí)間: 2025-3-27 00:29
Muskelrelaxation bei alten Menschen,uction via the serum response element SRE in the c-. promoter. Their activation leads to a rapid induction of c-. gene expression. Activation of mitogen-activated protein kinases (MAPK) by signalling cascades and subsequent TCF phosphorylation are known to be essential steps in this transcriptional 作者: Introvert 時(shí)間: 2025-3-27 03:56 作者: Comprise 時(shí)間: 2025-3-27 09:12
https://doi.org/10.1007/978-3-662-34539-9d bradykinesia. Pathologically, the hallmark of Parkinson’s disease is the progressive degeneration of the dopamine (DA)-containing neurons of the nigrostriatal projection. Neurological deficits associated with the loss of DA neurons do not appear until the degeneration is extensive, presumably due 作者: Fibrillation 時(shí)間: 2025-3-27 09:55 作者: 記憶 時(shí)間: 2025-3-27 16:37 作者: breadth 時(shí)間: 2025-3-27 21:13 作者: Brocas-Area 時(shí)間: 2025-3-28 01:53
Klinik der gyn?kologischen R?ntgentherapiegnificant environmental contaminants (Hawley, 1971; US-EPA, 1985). It has been shown that biotransformation is necessary to exhibit toxicity (Brodie et al., 1971). Both 1,2-dichlorobenzene and its 1,4-isomer are metabolized by cytochrome P450 enzymes to an epoxide intermediate. This epoxide may eith作者: 揮舞 時(shí)間: 2025-3-28 03:40
,Die Anwendung der R?ntgenstrahlen am Ovar, allograft rejection. However, its metabolism by the cytochrome P450 mixed-function oxidase (MFO) system frequently results in hepatotoxicity as seen by jaundice and altered serum enzyme in hepatic transplant recipients, hyperbilirubinemia, hypoproteinemia, and albuminemia in rats (Whiting et al., 1作者: maintenance 時(shí)間: 2025-3-28 10:02
Selective Depletion of Mitochondrial Glutathione Content by Pivalic Acid and Valproic Acid in Rat Lialoyloxymethyl dopa ester (Binderup et al. 1971, Wickers et al. 1985). These pro-drugs administrated to rat and monkey undergo an hydrolysis releasing free PIV, which is excreted in urine mostly unchanged or as carnitine or glucuronic acid conjugates.作者: 違法事實(shí) 時(shí)間: 2025-3-28 12:07 作者: miracle 時(shí)間: 2025-3-28 16:50
Pathologie und Klink in EinzeldarstellungenThe quinolone antibiotic BAY y 3118 is a photochemically labile compound, and irradiation with UV-A light leads to its rapid decomposition. In vivo, following oral drug administration to guinea pigs, irradiation of the animals not only results in a severe local phototoxicity, but also leads to systemic phototoxic reactions [1].作者: FATAL 時(shí)間: 2025-3-28 19:44
Studies on the Mechanism of Phototoxicity of BAY y 3118 and Other QuinolonesThe quinolone antibiotic BAY y 3118 is a photochemically labile compound, and irradiation with UV-A light leads to its rapid decomposition. In vivo, following oral drug administration to guinea pigs, irradiation of the animals not only results in a severe local phototoxicity, but also leads to systemic phototoxic reactions [1].作者: visceral-fat 時(shí)間: 2025-3-29 02:32
Biological Reactive Intermediates V978-1-4757-9480-9Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: 遭遇 時(shí)間: 2025-3-29 03:18
https://doi.org/10.1007/978-3-662-34539-9aloyloxymethyl dopa ester (Binderup et al. 1971, Wickers et al. 1985). These pro-drugs administrated to rat and monkey undergo an hydrolysis releasing free PIV, which is excreted in urine mostly unchanged or as carnitine or glucuronic acid conjugates.作者: 確定無(wú)疑 時(shí)間: 2025-3-29 10:02
Definition, Klassifikation und Nomenklatur,r- and intracellular signal transduction. Ca./calmodulin are involved in the activation process of the ROI-generating system. A rise of intracellular Ca. is necessary, but not sufficient to trigger the release of ROIs. As a second signal, protein phosphorylation seems to be involved in the activation process.作者: 恩惠 時(shí)間: 2025-3-29 15:23
https://doi.org/10.1007/978-1-4757-9480-9Oxidation; biochemistry; cytochrome P450; dopamine; enzymes; metabolism; neurotoxicity; proteins作者: Invertebrate 時(shí)間: 2025-3-29 17:01
978-1-4757-9482-3The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines作者: GRAVE 時(shí)間: 2025-3-29 22:05 作者: 接觸 時(shí)間: 2025-3-30 03:17 作者: 亂砍 時(shí)間: 2025-3-30 04:07 作者: Orgasm 時(shí)間: 2025-3-30 10:15 作者: GEM 時(shí)間: 2025-3-30 14:15
Muskelrelaxation bei alten Menschen,able as inducer of many immediate-early inflammatory and immune reactions, the transcription factor is likely to play a fatal role in certain diseases and syndromes that involve an abberrant expression of inflammatory cytokines [22–24].作者: FLIT 時(shí)間: 2025-3-30 18:11
Muskelrelaxanzien und Leberinsuffizienz,ells. Interestingly, Ref-1 is a bifunctional protein; it also possesses an apurinic/apyrimidinic (A/P) endonuclease DNA repair activity. However, the redox and DNA repair activities of Ref-1 are physically and biochemically distinguishable. Ref-1 may represent a novel component of the signal transdu作者: 柱廊 時(shí)間: 2025-3-30 23:09
Muskelrelaxation bei alten Menschen,PK Ser/Thr kinase activity by both oxidant and antioxidant stimuli, which temporally correlates with the appearance of hyperphosphorylated TCF/Elk-1. Thus antagonistic intracellular redox changes can lead to the same functional modulation of the nuclear transcription factor TCF/Elk-1 that was previo作者: Choreography 時(shí)間: 2025-3-31 04:35 作者: 卷發(fā) 時(shí)間: 2025-3-31 06:16 作者: profligate 時(shí)間: 2025-3-31 10:31
0065-2598 d below, as well as the book for which this serves as the Preface. ? Jollow, DJ., Kocsis, J.J., Snyder, R. and Vainio, H. (eds), Biological Reactive Intermediat978-1-4757-9482-3978-1-4757-9480-9Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: 吼叫 時(shí)間: 2025-3-31 15:21 作者: NUL 時(shí)間: 2025-3-31 19:25
Reactions of Reactive Metabolites with Hemoproteins—Toxicological Implicationsctive metabolites. It is known that at least three pathways exist for the covalent alteration of the cytochrome P450, one that involves alteration of the heme, a second that involves alteration of the protein, and a third that involves the crosslinking of heme to the protein (Scheme I) (Osawa & Pohl作者: concert 時(shí)間: 2025-3-31 22:25
Identification of Hydrogen Peroxide as the Relevant Messenger in the Activation Pathway of Transcripable as inducer of many immediate-early inflammatory and immune reactions, the transcription factor is likely to play a fatal role in certain diseases and syndromes that involve an abberrant expression of inflammatory cytokines [22–24].作者: ostracize 時(shí)間: 2025-4-1 05:06
Redox Regulation of Ap-1ells. Interestingly, Ref-1 is a bifunctional protein; it also possesses an apurinic/apyrimidinic (A/P) endonuclease DNA repair activity. However, the redox and DNA repair activities of Ref-1 are physically and biochemically distinguishable. Ref-1 may represent a novel component of the signal transdu作者: 陶醉 時(shí)間: 2025-4-1 09:01
The Transcription Factor TCF/Elk-1PK Ser/Thr kinase activity by both oxidant and antioxidant stimuli, which temporally correlates with the appearance of hyperphosphorylated TCF/Elk-1. Thus antagonistic intracellular redox changes can lead to the same functional modulation of the nuclear transcription factor TCF/Elk-1 that was previo作者: oxidant 時(shí)間: 2025-4-1 10:41
Some Activities of the Oxidant Chromatethe nucleus, as only Cr(III) is detected bound to DNA. Thus it may be that only the Cr(III) formed . is toxic. Cr(VI) compounds are not mutagenic without metabolic reduction, (Petrilli and De Flora, 1978). The intermediates, Cr(V) and Cr(IV), are being investigated as putative toxins/carcinogens of 作者: 幼稚 時(shí)間: 2025-4-1 15:20 作者: 誓言 時(shí)間: 2025-4-1 19:26
New Biological Reactive Intermediatesene oxides as electrophilic reactive metabolites. Much less was known until very recently about the metabolic oxidative activation of thiophene derivatives (Rance, 1989). A first report on the metabolism of thiophene itself in rats has shown the formation of thiophene-derived mercapturates in urine
