標(biāo)題: Titlebook: Biological Reactive Intermediates IV; Molecular and Cellul Charlotte M. Witmer,Robert R. Snyder,I. Glenn Sipe Book 1991 The Editor(s) (if a [打印本頁] 作者: Flange 時(shí)間: 2025-3-21 19:54
書目名稱Biological Reactive Intermediates IV影響因子(影響力)
作者: 厭煩 時(shí)間: 2025-3-21 23:37 作者: locus-ceruleus 時(shí)間: 2025-3-22 00:35 作者: 饑荒 時(shí)間: 2025-3-22 08:31
https://doi.org/10.1007/978-3-642-47411-8ich would permit careful investigation of their mechanism. It is probable that if enough different types of animals were tried, an animal model could be developed, but it might take many thousands of different species before one was found that would have a reaction similar to the rare individual hum作者: Ovulation 時(shí)間: 2025-3-22 11:08 作者: BIBLE 時(shí)間: 2025-3-22 16:29
Allgemeine Di?tetik der Darmkrankheitenelectrophoretic technique capable of detecting DNA single-strand breaks and alkali labile sites in individual cells was developed (Singh et al., 1988). Eukaryote cells are embedded in an agarose gel on a microscope slide, lysed by detergents and high salt at pH 10, and then electrophoresed for a sho作者: 歸功于 時(shí)間: 2025-3-22 19:36
https://doi.org/10.1007/978-3-662-41617-4ividuals with a specific phenotype (e.g. poor metabolizers of debrisoquin or lacking specific glutathione transferase activity) among cancer cases than controls (Ayesh et al. 1984, Seidegard et al. 1986).作者: 個(gè)人長篇演說 時(shí)間: 2025-3-23 00:51
Formation of Biological Reactive Intermediates by Peroxidases: Halide Mediated Acetaminophen Oxidati作者: Hypopnea 時(shí)間: 2025-3-23 04:33 作者: exclamation 時(shí)間: 2025-3-23 08:53 作者: muffler 時(shí)間: 2025-3-23 11:22
Bioactivation of Xenobiotics by Flavin-Containing Monooxygenasese prosthetic group. The enzyme is apparently present within the cell in this form and any soft nucleophile that can gain access to the enzyme-bound oxygenating intermediate will be oxidized. Precise fit of substrate to enzyme is not necessary, and FMO catalyzes at the same maximum velocity the oxida作者: 溫和女孩 時(shí)間: 2025-3-23 17:55
S-Thiolation of Protein Sulfhydrylstabolically labile and the rapid “dethiolation” of these proteins by several reductive processes (Park and Thomas, 1989) prevents lasting damage to the protein. Thus, the dynamic modification of proteins by S-thiolation/dethiolation processes represents one of the more important cellular mechanisms 作者: 開玩笑 時(shí)間: 2025-3-23 19:17 作者: FLAT 時(shí)間: 2025-3-23 23:59 作者: 6Applepolish 時(shí)間: 2025-3-24 05:53 作者: 不安 時(shí)間: 2025-3-24 07:55
Monitoring Human Exposure to Environmental Carcinogensividuals with a specific phenotype (e.g. poor metabolizers of debrisoquin or lacking specific glutathione transferase activity) among cancer cases than controls (Ayesh et al. 1984, Seidegard et al. 1986).作者: 胰臟 時(shí)間: 2025-3-24 11:50 作者: 植物學(xué) 時(shí)間: 2025-3-24 18:37
,Lagerung von Spiralkegelr?dern,The toxic effects of many xenobiotics are very often not due to the parent compound itself but to reactive intermediates or metabolites formed . inside the cell. These reactive species may bind covalently to cell proteins leading to various cell disorders and eventually to toxic effects.作者: 繁殖 時(shí)間: 2025-3-24 21:15
Formation of Reactive Metabolites and Appearance of Antiorganelle Antibodies in ManThe toxic effects of many xenobiotics are very often not due to the parent compound itself but to reactive intermediates or metabolites formed . inside the cell. These reactive species may bind covalently to cell proteins leading to various cell disorders and eventually to toxic effects.作者: magnanimity 時(shí)間: 2025-3-25 00:32 作者: 夾死提手勢 時(shí)間: 2025-3-25 03:49 作者: Palpable 時(shí)間: 2025-3-25 11:02
Biological Significance of Active Oxygen Species: In Vitro Studies on Singlet Oxygen-Induced DNA Damve Intermediates III (Wefers and Sies, 1986), work from our laboratory has been presented comprehensively (Sies, 1986, 1988; Ishikawa and Sies, 1989). Further, the biochemistry of oxygen toxicity has been presented (Cadenas, 1989).作者: Congestion 時(shí)間: 2025-3-25 13:41
Advances in Experimental Medicine and Biologyhttp://image.papertrans.cn/b/image/187441.jpg作者: Anecdote 時(shí)間: 2025-3-25 16:55 作者: 諄諄教誨 時(shí)間: 2025-3-25 20:46
978-1-4684-5879-4The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines作者: asthma 時(shí)間: 2025-3-26 00:45
Technische Hilfswissenschaften,e has been accrued over the years to support the view that the majority of chemical carcinogens require bioactivation in order to elicit tumor initiation, and many toxic chemicals other than carcinogens also require bioactivation. The P-450 enzymes are probably involved to a greater extent than any 作者: nostrum 時(shí)間: 2025-3-26 06:01
Klingelnberg Technisches Hilfsbuchechanism for the termination of drug action. Metabolism may quantitatively alter drug action and may also convert pharmacologically inactive prodrugs to their pharmacologically active metabolites. In addition, metabolism of xenobiotics to polar, readily excretable metabolites is a major detoxication作者: HOWL 時(shí)間: 2025-3-26 09:35 作者: Bravado 時(shí)間: 2025-3-26 13:28 作者: Indurate 時(shí)間: 2025-3-26 17:12 作者: 掙扎 時(shí)間: 2025-3-26 22:08 作者: Complement 時(shí)間: 2025-3-27 05:01 作者: 公共汽車 時(shí)間: 2025-3-27 05:49
Klingelnberg-Palloid-Spiralkegelr?derave provided valuable information on the mechanisms of enzymes. Most of the theories that permit interpretation of these measurements are based on the following assumptions: 1) Deuterium is substituted on only one position. 2) The isotope effect is on only one rate constant, namely the one which is 作者: myopia 時(shí)間: 2025-3-27 11:08
,Spiralkegelr?der in Fahrzeugen,“reactive” sulfhydryl are prevelant in cytoplasm, membranes, and nuclei, and the concentration of these reactive sites is impressive, reaching or exceeding the concentration of glutathione in many cells. Most proteins contain a single reactive sulfhydryl and are unlikely to form protein-protein disu作者: Nonporous 時(shí)間: 2025-3-27 17:03
https://doi.org/10.1007/978-3-642-91854-4, 1987; Weis and Engelhardt, 1989) is important since halothane is still widely used in adults in the United Kingdom and Europe (Neuberger and Kenna, 1987; Weis and Engelhardt, 1989) and is often an agent of choice for children (Hals et al., 1986; Whitburn and Sumner, 1986; Kenna et al., 1987a). Als作者: 會(huì)犯錯(cuò)誤 時(shí)間: 2025-3-27 19:01 作者: cluster 時(shí)間: 2025-3-28 00:06 作者: 通知 時(shí)間: 2025-3-28 03:28 作者: 出生 時(shí)間: 2025-3-28 06:43 作者: legitimate 時(shí)間: 2025-3-28 11:32 作者: CURT 時(shí)間: 2025-3-28 15:54
https://doi.org/10.1007/978-3-662-41617-4tations and gene rearrangements are involved in causing one or more of the required changes. However, the molecular mechanisms by which carcinogens induce such changes in mammalian cells are not well understood. One reason for this has been the difficulty involved in sequencing the newly mutated gen作者: 先驅(qū) 時(shí)間: 2025-3-28 19:28
Cytochrome P-450 Oxidations and the Generation of Biologically Reactive Intermediatese has been accrued over the years to support the view that the majority of chemical carcinogens require bioactivation in order to elicit tumor initiation, and many toxic chemicals other than carcinogens also require bioactivation. The P-450 enzymes are probably involved to a greater extent than any 作者: Omniscient 時(shí)間: 2025-3-29 02:13
Formation of Reactive Intermediates by Phase II Enzymes: Glutathione-Dependent Bioactivation Reactioechanism for the termination of drug action. Metabolism may quantitatively alter drug action and may also convert pharmacologically inactive prodrugs to their pharmacologically active metabolites. In addition, metabolism of xenobiotics to polar, readily excretable metabolites is a major detoxication作者: fledged 時(shí)間: 2025-3-29 04:49
Role of the Well-Known Basic and Recently Discovered Acidic Glutathione S-Transferases in the Contro initially believed to serve as intracellular transport proteins for endogenous compounds with limited solubility in water, thereby acting as an intracellular equivalent to albumin. In this assumed capacity of reversible binding and transport of various ligands, the corresponding protein was named l作者: 戰(zhàn)役 時(shí)間: 2025-3-29 08:43 作者: Osteoporosis 時(shí)間: 2025-3-29 11:26 作者: 觀點(diǎn) 時(shí)間: 2025-3-29 18:52
Biological Significance of Active Oxygen Species: In Vitro Studies on Singlet Oxygen-Induced DNA Damve Intermediates III (Wefers and Sies, 1986), work from our laboratory has been presented comprehensively (Sies, 1986, 1988; Ishikawa and Sies, 1989). Further, the biochemistry of oxygen toxicity has been presented (Cadenas, 1989).作者: In-Situ 時(shí)間: 2025-3-29 21:59 作者: 弄污 時(shí)間: 2025-3-30 01:47 作者: cogitate 時(shí)間: 2025-3-30 07:48
S-Thiolation of Protein Sulfhydryls“reactive” sulfhydryl are prevelant in cytoplasm, membranes, and nuclei, and the concentration of these reactive sites is impressive, reaching or exceeding the concentration of glutathione in many cells. Most proteins contain a single reactive sulfhydryl and are unlikely to form protein-protein disu作者: extemporaneous 時(shí)間: 2025-3-30 08:26 作者: 個(gè)人長篇演說 時(shí)間: 2025-3-30 12:45
Metabolism of Drugs by Activated Leukocytes: Implications for Drug-Induced Lupus and Other Drug Hype which makes them difficult to prevent, and because they are associated with a relatively high mortality rate. General agreement on the definition of an idiosyncratic reaction is lacking, but the term will be used to mean a reaction that does not occur in most patients given the drug even at a high 作者: Heterodoxy 時(shí)間: 2025-3-30 19:08
Formation of a Protein-Acetaldehyde Adduct in Liver during Chronic Alcohol Exposured by two alcohol metabolizing systems: alcohol dehydrogenase (ADH) (Li, 1977) and the microsomal ethanol oxidizing system (MEOS or cytP450IIE1) (Lieber et al., 1970). In individuals who do not abuse alcohol, ADH is the most important enzyme responsible for the conversion of ethanol to acetaldehyde. 作者: LEVER 時(shí)間: 2025-3-30 22:36
Dose-Response Relationships in Chemical Carcinogenesis: From DNA Adducts to Tumor Incidencend saturation of enzymatic activation and detoxification processes and of DNA repair affect the relationship between dose and steady-state DNA adduct level; (ii) The fixation of DNA adducts in the form of mutations is accelerated by stimulation of the cell division, for instance due to regenerative 作者: 問到了燒瓶 時(shí)間: 2025-3-31 04:16
The Single Cell Gel (SCG) Assay: An Electrophoretic Technique for the Detection of DNA Damage in Indince the effects of many reactive intermediates are tissue and cell-type specific, it is important to utilize techniques which can directly detect DNA damage in individual cells. Cytogenetic techniques, while providing information at the level of the individual cell, are largely limited to prolifera作者: 令人不快 時(shí)間: 2025-3-31 05:28
