作者: Ischemia 時(shí)間: 2025-3-21 22:13
Chemistry of Covalent Binding: Studies with Bromobenzene and Thiobenzamides introduced by J. A. Miller and E. C. Miller almost 40 years ago. . Since then considerable effort has been spent investigating the chemistry, biochemistry and biological consequences of reactive metabolic intermediates. Our laboratory has been interested in the metabolic activation, covalent bindi作者: mosque 時(shí)間: 2025-3-22 01:21 作者: jumble 時(shí)間: 2025-3-22 06:08
Role of Parenchymal Versus Non-Parenchymal Cells on the Control of Biologically Reactive Intermediate of their critical location along the sinusoids where they are the first cells to encounter blood borne xenobiotics. To study the possible role of the NPC in the metabolism of xenobiotics, populations of NPC and parenchymal cells (PC) were prepared from rats and various xenobiotic metabolizing enzy作者: 他姓手中拿著 時(shí)間: 2025-3-22 11:31 作者: 生來(lái) 時(shí)間: 2025-3-22 16:54
Structure and Function of Cytochrome P-450ts that can be attacked by cellular nucleophiles or solvolyzed (Guengerich and Liebler, 1985). Much has been learned about the isozymes in this family of hemoproteins from studies with microorganisms and experimental animals. Biochemical studies with humans were started shortly after the discovery o作者: linguistics 時(shí)間: 2025-3-22 18:41 作者: anaerobic 時(shí)間: 2025-3-23 00:20 作者: ethereal 時(shí)間: 2025-3-23 02:07 作者: 疏忽 時(shí)間: 2025-3-23 07:31 作者: 難管 時(shí)間: 2025-3-23 11:46 作者: incontinence 時(shí)間: 2025-3-23 17:39
Isomeric Composition of ,-Alkylated Protoporphyrins Produced by Substituted Dihydropyridines , and ,onating their intact 4-alkyl group to one of the pyrrole nitrogens of haem in hepatic cytochrome P-450 (De Matteis et al., 1981; Ortiz de Montellano et al., 1981; Tephly et al., 1981). Because of the asymmetrical arrangement of the two vinyl and propionate side chains in protoporphyrin IX, four stru作者: 排他 時(shí)間: 2025-3-23 21:48
UDP-Glucuronyltransferases and Their Toxicological Significanceraction of the more reactive electrophilic metabolites with critical cellular macromolecules plays a major role in their toxicity (Miller and Miller, 1981). Therefore much interest was given to the control of electrophilic metabolites. However the more stable and more abundant nucleophilic metabolit作者: 老人病學(xué) 時(shí)間: 2025-3-24 01:40 作者: Expand 時(shí)間: 2025-3-24 03:12
Rat Cytosolic Epoxide Hydrolaseially hydrolyzed by the microsomal form, while .-stilbene oxide is the prefered substrate for cytosolic epoxide hydrolase. Large interindividual differences in the specific activity of SpragueDawley (outbred strain) liver cytosolic epoxide hydrolase were observed, varying from 2 to 77 pmol/min x mg 作者: concentrate 時(shí)間: 2025-3-24 07:52
Multiplicity of Cytochrome P-450 in Morris Hepatomame activities in normal adult liver, from which hepatic tumor was originated (Adamson and Fouts, 1961). Conney et al. (1957) described the remarkable and now widely recognized induction of BP hydroxylase activity in rat liver by the prior administration of BP itself, or 3-methylcholanthrene (MC), or作者: 紅潤(rùn) 時(shí)間: 2025-3-24 11:21 作者: Paraplegia 時(shí)間: 2025-3-24 16:53
Comparison of the Metabolism of Benzene and Its Metabolite Phenol in Rat Liver Microsomese apparent that benzene can also be leukemogenic (Snyder, 1984). Benzene-induced bone marrow depression is caused by one or more metabolites of benzene (Snyder, et al., 1981). Cytochrane P-450 mediates the first step in benzene metabolism (Gonasun et al., 1973). The initial metabolite formed in the 作者: Spangle 時(shí)間: 2025-3-24 21:40
Age and Sex Differences in Constitutive Forms of Cytochrome P-450 of Rat Liver Microsomesdrug and chemical-treated animals respond to challenge by such agents with an increase in the hepatic microsomal content of cytochrome P-450. It wasn’t long, however, before it was realized that the cytochrome P-450 increase was the result of an induction of different forms of cytochrome P-450..作者: 得罪人 時(shí)間: 2025-3-25 02:03
Advances in Experimental Medicine and Biologyhttp://image.papertrans.cn/b/image/187440.jpg作者: 偏狂癥 時(shí)間: 2025-3-25 05:20
Biological Reactive Intermediates III978-1-4684-5134-4Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: tic-douloureux 時(shí)間: 2025-3-25 08:38 作者: SPER 時(shí)間: 2025-3-25 14:51
https://doi.org/10.1007/978-3-658-20573-7ransformation to chemically reactive species which covalently modify cellular macromolecules. Ten years ago.’. we proposed that bay-region diol epoxides are prime candidates for the ultimate carcinogenic metabolites of the carcinogenic hydrocarbons provided that these molecules contained a bay-regio作者: 上坡 時(shí)間: 2025-3-25 19:25 作者: HACK 時(shí)間: 2025-3-25 22:57
Klimazeugnisse der Erdgeschichteof chemicals are mediated by reactive products formed during their biotransformation in the organism. It is equally clear that there exist a number of protective systems which can trap, or inactivate, toxic metabolites and thereby prevent their accumulation within the tissues and subsequent toxic ef作者: 滔滔不絕地說(shuō) 時(shí)間: 2025-3-26 00:28
Wolfgang Janke,Heinz Kliewe,Horst Sterre of their critical location along the sinusoids where they are the first cells to encounter blood borne xenobiotics. To study the possible role of the NPC in the metabolism of xenobiotics, populations of NPC and parenchymal cells (PC) were prepared from rats and various xenobiotic metabolizing enzy作者: deforestation 時(shí)間: 2025-3-26 05:13 作者: 紳士 時(shí)間: 2025-3-26 08:28
Das ?Wetter“ im Meer: Nord- und Ostseets that can be attacked by cellular nucleophiles or solvolyzed (Guengerich and Liebler, 1985). Much has been learned about the isozymes in this family of hemoproteins from studies with microorganisms and experimental animals. Biochemical studies with humans were started shortly after the discovery o作者: CRAFT 時(shí)間: 2025-3-26 13:11 作者: 煉油廠 時(shí)間: 2025-3-26 17:49 作者: 占卜者 時(shí)間: 2025-3-27 00:29
Ulrich Bathmann,Victor Smetacekesis, carcinogenesis, and other cytotoxicities (Mitchell et al., 1976; Boyd, 1980; Wright, 1980; Miller and Miller, 1981, 1982; Boyd and Statham, 1983). It is also evident, however, that xenobiotics that are biotransformed into reactive metabolites usually exert relatively selective toxic effects wi作者: 惡意 時(shí)間: 2025-3-27 01:13 作者: 北極人 時(shí)間: 2025-3-27 07:38
https://doi.org/10.1007/978-3-642-57807-6 P-450 by forming stable complex with the Iron of the hemoporphyrin. Several derivatives of erythromycin having lost their cladinose moiety are stronger inducer of liver cytochrome P-450 itself. The major form of cytochrome P-450 induced by all these macrolides in rat liver electrophoretically and i作者: Projection 時(shí)間: 2025-3-27 13:29
Klima?nderungen und Klimaschwankungenonating their intact 4-alkyl group to one of the pyrrole nitrogens of haem in hepatic cytochrome P-450 (De Matteis et al., 1981; Ortiz de Montellano et al., 1981; Tephly et al., 1981). Because of the asymmetrical arrangement of the two vinyl and propionate side chains in protoporphyrin IX, four stru作者: 健忘癥 時(shí)間: 2025-3-27 15:36 作者: dry-eye 時(shí)間: 2025-3-27 20:05
,Hypothalamic–Pituitary Axis Function,rious electrophiles. In addition, the transferases bind with high affinity various exogenous hydrophobic compounds as well as potentially toxic endogenous compounds such as bilirubin and heme (1–3). The enzymes are comprised of binary combinations of at least six major subunits, Yα, Ya, Ybl, Yb2, Yc作者: 阻塞 時(shí)間: 2025-3-28 01:36
A. Barbarino,L. De Marinis,A. Manciniially hydrolyzed by the microsomal form, while .-stilbene oxide is the prefered substrate for cytosolic epoxide hydrolase. Large interindividual differences in the specific activity of SpragueDawley (outbred strain) liver cytosolic epoxide hydrolase were observed, varying from 2 to 77 pmol/min x mg 作者: 殺子女者 時(shí)間: 2025-3-28 02:29 作者: 交響樂(lè) 時(shí)間: 2025-3-28 09:52 作者: SLUMP 時(shí)間: 2025-3-28 14:28
https://doi.org/10.1007/978-3-662-36245-7e apparent that benzene can also be leukemogenic (Snyder, 1984). Benzene-induced bone marrow depression is caused by one or more metabolites of benzene (Snyder, et al., 1981). Cytochrane P-450 mediates the first step in benzene metabolism (Gonasun et al., 1973). The initial metabolite formed in the 作者: Dorsal-Kyphosis 時(shí)間: 2025-3-28 14:40 作者: 小教堂 時(shí)間: 2025-3-28 19:37
978-1-4684-5136-8The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines作者: 被告 時(shí)間: 2025-3-29 00:30
Energiewirtschaftliche Analyse,When James Watson wrote “The Double Helix” he began by remarking “I have never seen Francis Crick in a modest mood.”作者: 熔巖 時(shí)間: 2025-3-29 04:33
Years with Elizabeth and James Miller: in AppreciationWhen James Watson wrote “The Double Helix” he began by remarking “I have never seen Francis Crick in a modest mood.”作者: Intend 時(shí)間: 2025-3-29 07:25
Book 1986s. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth o作者: Neolithic 時(shí)間: 2025-3-29 14:16 作者: 才能 時(shí)間: 2025-3-29 17:52
Drug Interactions with Macrolide Antibiotics: Specificity of Pseudo-Suicide Inhibition and Inductionmmunogically indistiguishable from the major form induced by pregnenolone 16 ∝ carbonitrile (PCN). This form is particularly able to metabolize macrolide and to lead to the corresponding 456nm absorbing cytochrome P-4540 complexes . and ..作者: Hemodialysis 時(shí)間: 2025-3-29 19:59 作者: Pert敏捷 時(shí)間: 2025-3-30 01:56 作者: ENNUI 時(shí)間: 2025-3-30 04:48 作者: 哭得清醒了 時(shí)間: 2025-3-30 09:16
https://doi.org/10.1007/978-3-642-77776-9 aromatic hydrocarbons are carcinogenic, and that the cytochrome P450-dependent mixed function oxidase system preferentially catalyzes the formation of the optical isomer with the highest carcinogenic activity (3).作者: 施舍 時(shí)間: 2025-3-30 15:08
Role of Thiols in Protection Against Biological Reactive Intermediatesly serve a protective function. Hence, it is obvious that the formation of toxic metabolites cannot be attributed to any single enzyme or enzyme system, and that the balance between metabolic activation and inactivation is absolutely critical in deciding whether exposure to a potentially toxic compound will result in toxicity, or not.作者: STIT 時(shí)間: 2025-3-30 17:36
Role of Parenchymal Versus Non-Parenchymal Cells on the Control of Biologically Reactive Intermediat activities than did the PC. Furthermore, the NPC were capable of forming biologically reactive intermediates which caused cyto- and genotoxicity. From these data we conclude that the NPC provide a distinct contribution to hepatic metabolism of xenobiotics.作者: hyperuricemia 時(shí)間: 2025-3-31 00:26
Significance of Covalent Binding of Chemically Reactive Metabolites of Foreign Compounds to Proteinswever, many foreign compounds have been shown to be transformed to chemically reactive metabolites that combine with proteins and lipids. Indeed, even carcinogens that presumably evoke mutagenic changes in DNA almost invariably also become covalently bound to proteins.作者: 敘述 時(shí)間: 2025-3-31 01:11 作者: 安裝 時(shí)間: 2025-3-31 08:06 作者: JEER 時(shí)間: 2025-3-31 13:08 作者: 人類學(xué)家 時(shí)間: 2025-3-31 15:16 作者: dainty 時(shí)間: 2025-3-31 17:51 作者: 放棄 時(shí)間: 2025-3-31 21:52
Expression and Sequence Analysis of Rat Liver Glutathione S-Transferase Genesnous compounds such as bilirubin and heme (1–3). The enzymes are comprised of binary combinations of at least six major subunits, Yα, Ya, Ybl, Yb2, Yc and Yn, which can be separated by onedimensional SDS-polyacrylamide gel electrophoresis (4–6).作者: 寄生蟲 時(shí)間: 2025-4-1 02:41
Klimazeugnisse der Erdgeschichteentity of their reactive metabolites, the chemistry of their covalent binding to cellular macromolecules and the relationship of the various types of covalent binding events to the biological changes which follow. This report summarizes some of our recent efforts toward these objectives.作者: BLAZE 時(shí)間: 2025-4-1 06:04 作者: 肥料 時(shí)間: 2025-4-1 11:37 作者: Headstrong 時(shí)間: 2025-4-1 14:32
Das ?Wetter“ im Meer: Nord- und Ostseelerath et al., 1985; Guengerich et al., 1985). In the earlier efforts catalytic activity data were difficult to evaluate because most of the assays were not specific to individual P-450 isozymes (Wang et al., 1980, 1983). More recently we have focused our efforts on the biochemical characterization 作者: SEED 時(shí)間: 2025-4-1 22:03 作者: Dri727 時(shí)間: 2025-4-2 02:38
