作者: 戲服 時(shí)間: 2025-3-21 23:47
Mechanism of Microsomal Monooxygenases and Drug Toxicityug may cause an activation of another drug which could result in cell damage or even cancer. Therefore, the booming research in drug metabolism during the last two decades has also provided the knowledge for our understanding of drug toxicity.作者: Constitution 時(shí)間: 2025-3-22 03:18 作者: 供過(guò)于求 時(shí)間: 2025-3-22 05:53 作者: FUME 時(shí)間: 2025-3-22 09:50 作者: 斗爭(zhēng) 時(shí)間: 2025-3-22 15:39 作者: Firefly 時(shí)間: 2025-3-22 20:18
https://doi.org/10.1007/978-3-658-19515-1e intermediates. These epoxide intermediates in turn undergo enzymatic reactions mediated by epoxide hydrase or glutathione-.-epoxide transferase, or are non-enzymatically converted to various hydroxylated products. Epoxides also react irreversibly with cellular components (2).作者: alleviate 時(shí)間: 2025-3-23 01:12
Introduction to the Concept of Reactive Intermediatestes may be the cause of serious forms of toxicity including cellular necrosis, mutagenesis, carcinogenesis, teratogenesis, hypersensitivity, and blood disorders such as hemolytic anemia, blood dyscrasias, and methemoglobinemia.作者: mercenary 時(shí)間: 2025-3-23 01:34 作者: 蛤肉 時(shí)間: 2025-3-23 06:21
Discussiona fundamental component of the fetal liver. In contrast, the lack of P450 in the fetus of common laboratory animals suggests that they may not require the ability to metabolize steroids during fetal life.作者: AMOR 時(shí)間: 2025-3-23 12:35 作者: Contort 時(shí)間: 2025-3-23 17:27
Klimawirksame Kennzahlen Band Iractions used in his study, and is not recoverable. Further discussion concerned the substrate specificity of Ziegler’s amine oxidase and the capacity of cytochrome P450-dependent microsomal enzymes to oxidize amides.作者: 昏暗 時(shí)間: 2025-3-23 19:48
Klimawirksame Kennzahlen Band IIrescent conjugates are also produced from the hydroxylated intermediates in a microsomal system. Thus he agreed that great care must be exercised in interpreting all results obtained in fluorescent assays of benzpyrene hydroxylase activity.作者: 神圣不可 時(shí)間: 2025-3-23 23:17
,Weitere Daten der L?nder Afrikas,t reactive arene oxides are formed by the microsomal cytochrome P450-mediated monooxygenase systems and that these intermediates can rearrange nonenzymatically to form phenols, be hydrated to form .-dihydrodiols, and be conjugated with glutathione (4) [.. refs. 5–8 for reviews].作者: 值得尊敬 時(shí)間: 2025-3-24 02:36 作者: 玩笑 時(shí)間: 2025-3-24 09:41
Energiewirtschaftliche Analyse,duces mild, clinically covert hepatic injury in more than 15% of recipients when liver function tests are monitored (5), and thus the injury is not restricted to rare, idiosyncratic individuals. To determine if the toxicity produced by MD might be due to a reactive intermediate, [.H] MD was incubated with liver microsomes.作者: Mutter 時(shí)間: 2025-3-24 11:26
Discussionractions used in his study, and is not recoverable. Further discussion concerned the substrate specificity of Ziegler’s amine oxidase and the capacity of cytochrome P450-dependent microsomal enzymes to oxidize amides.作者: BOAST 時(shí)間: 2025-3-24 18:23
Discussionrescent conjugates are also produced from the hydroxylated intermediates in a microsomal system. Thus he agreed that great care must be exercised in interpreting all results obtained in fluorescent assays of benzpyrene hydroxylase activity.作者: 露天歷史劇 時(shí)間: 2025-3-24 19:57 作者: 平靜生活 時(shí)間: 2025-3-25 02:09 作者: 就職 時(shí)間: 2025-3-25 06:31
Metabolic Activation of Methyldopa by Cytochrome P450-Generated Superoxide Anionduces mild, clinically covert hepatic injury in more than 15% of recipients when liver function tests are monitored (5), and thus the injury is not restricted to rare, idiosyncratic individuals. To determine if the toxicity produced by MD might be due to a reactive intermediate, [.H] MD was incubated with liver microsomes.作者: ALIAS 時(shí)間: 2025-3-25 10:58 作者: 瑣碎 時(shí)間: 2025-3-25 12:11 作者: 歪曲道理 時(shí)間: 2025-3-25 15:58 作者: osteopath 時(shí)間: 2025-3-25 21:57
https://doi.org/10.1007/978-3-658-25827-6ng metabolic inhibitors, but that CN is not a good inhibitor for this purpose. The oxidation of ethanol has not been proven to be mediated by a species of P450 which ethanol induces; however, this P450 does differ from the types of P450 inhibited by metyrapone and 7,8-benzoflavone (see text).作者: 卵石 時(shí)間: 2025-3-26 01:52 作者: 鬼魂 時(shí)間: 2025-3-26 06:37 作者: EXUDE 時(shí)間: 2025-3-26 12:13 作者: anagen 時(shí)間: 2025-3-26 13:16 作者: defeatist 時(shí)間: 2025-3-26 17:01 作者: 泥沼 時(shí)間: 2025-3-26 22:21
https://doi.org/10.1007/978-3-658-30335-8cent years. It is now appreciated that reactive alkylating, arylating, or acylating derivatives may arise during the metabolism of xenobiotics and that the covalent binding of these reactive metabolites to cellular macromolecules may initiate events leading to the destruction of specific cellular co作者: Adj異類的 時(shí)間: 2025-3-27 01:21 作者: 臥虎藏龍 時(shí)間: 2025-3-27 07:39 作者: 補(bǔ)角 時(shí)間: 2025-3-27 12:53 作者: gustation 時(shí)間: 2025-3-27 15:48
Klimawirksame Kennzahlen Band II enzyme(s) responsible for the oxidation of benzpyrene to be located in the microsomal fraction of the liver. In that study it was shown that the enzyme system required both NADPH and molecular oxygen to function, and produced a number of mono- and dihydroxy products.作者: Deduct 時(shí)間: 2025-3-27 18:28
Klimawirksame Kennzahlen Band IIized that most benzpyrene hydroxylase assays monitor the appearance of a fluorescent metabolite, despite the lack of stoichiometric relationship between the fluorescent compounds produced and the disappearance of benzpyrene. It has been shown that fluorescent metabolites other than the 3-hydroxy der作者: GLADE 時(shí)間: 2025-3-28 01:57
Klimawirksame Kennzahlen Band II, the initial biogical receptors for the hydrocarbons have been identified as the microsomal mixed-function oxygenases. The polycyclic aromatic hydrocarbons are initially oxygenated by this enzyme system and the metabolites formed can be further oxygenated by the same mixed-function oxygenases. Othe作者: 饑荒 時(shí)間: 2025-3-28 03:41 作者: 托運(yùn) 時(shí)間: 2025-3-28 09:24
Energiewirtschaftliche Analyse,h DNA had been added, his group had observed the same peaks of metabolite—DNA complexes as those obtained by Nebert’s group. However, the first four peaks were not identified by Brookes’ group, as they considered these minimal in both size and importance. Peak A of Brookes, therefore, corresponds to作者: 圓錐體 時(shí)間: 2025-3-28 11:19
Klimawirksame Kennzahlen für Amerikathan by the unchanged compounds themselves. For example, bromobenzene and other halogenated hydrocarbons are converted to reactive epoxides by the action of a drug-oxidizing monooxygenase system in the liver and other tissues, with resultant liver injury (1,2). Most carcinogenic substances, e.g., ac作者: Adulterate 時(shí)間: 2025-3-28 17:02 作者: 小說(shuō) 時(shí)間: 2025-3-28 22:43
https://doi.org/10.1007/978-3-658-19515-1ion has been focused on the cytochrome P450-linked monooxygenase system which hydroxylates polycyclic aromatic hydrocarbons via highly reactive epoxide intermediates. These epoxide intermediates in turn undergo enzymatic reactions mediated by epoxide hydrase or glutathione-.-epoxide transferase, or 作者: Deduct 時(shí)間: 2025-3-28 23:05 作者: 珠寶 時(shí)間: 2025-3-29 03:35 作者: Largess 時(shí)間: 2025-3-29 11:10 作者: Exploit 時(shí)間: 2025-3-29 12:03 作者: 奇思怪想 時(shí)間: 2025-3-29 18:18 作者: instill 時(shí)間: 2025-3-29 20:46 作者: 原諒 時(shí)間: 2025-3-30 01:18
Discussionng metabolic inhibitors, but that CN is not a good inhibitor for this purpose. The oxidation of ethanol has not been proven to be mediated by a species of P450 which ethanol induces; however, this P450 does differ from the types of P450 inhibited by metyrapone and 7,8-benzoflavone (see text).作者: 壯麗的去 時(shí)間: 2025-3-30 05:26 作者: 凹槽 時(shí)間: 2025-3-30 09:55 作者: penance 時(shí)間: 2025-3-30 12:45 作者: stratum-corneum 時(shí)間: 2025-3-30 20:11
rcinogenesis, and pathways for true detoxication of these chemicals. The work of R. T. Williams, beginning in the late 1920s and early 1930s, marked the first concerted effort to understand the biotransformation of foreign chemicals in animals. He investigated the metabolic pathway of numerous compounds in a 978-1-4613-4126-0978-1-4613-4124-6作者: 藐視 時(shí)間: 2025-3-30 20:50
The Concept of Reactive Electrophilic Metabolites in Chemical Carcinogenesis: Recent Results with Arractions .. Such interactions may pose carcinogenic, mutagenic, teratogenic, allergenic, necrogenic, and possibly other hazards that must be weighed against the benefits provided by each drug in this category.作者: RAG 時(shí)間: 2025-3-31 04:23 作者: 變態(tài) 時(shí)間: 2025-3-31 07:16
https://doi.org/10.1007/978-3-658-22972-6ractions .. Such interactions may pose carcinogenic, mutagenic, teratogenic, allergenic, necrogenic, and possibly other hazards that must be weighed against the benefits provided by each drug in this category.作者: adequate-intake 時(shí)間: 2025-3-31 11:14
Klimawirksame Kennzahlen Band IIhus be an important factor in the heterogeneity of individuals to carcinogen susceptibility. Thus it is important to have methods to determine the profiles of these enzyme activities in individuals so that their relationship to carcinogenesis can be understood. In this chapter we present various met作者: 一瞥 時(shí)間: 2025-3-31 17:15
Introduction to the Concept of Reactive Intermediatesresponses has been developing since the beginning of this century. In the last 10 years or so, it has become evident that chemically reactive metabolites may be the cause of serious forms of toxicity including cellular necrosis, mutagenesis, carcinogenesis, teratogenesis, hypersensitivity, and blood作者: 厭倦嗎你 時(shí)間: 2025-3-31 21:33
The Concept of Reactive Electrophilic Metabolites in Chemical Carcinogenesis: Recent Results with Arth tissue macromolecules (1,2), and a large literature now exists on this subject and its relevance to carcinogenesis by these agents (3–5). Considering the great structural heterogeneity of chemical carcinogens (5–8) and of drugs in general, it is not surprising that at high dosage levels a few dru作者: 織物 時(shí)間: 2025-3-31 21:45
Kinetics of Reactive Metabolites and Covalent Binding , and ,t with a number of substances in tissues and thereby cause changes which result in various toxicites including cancer, mutagenesis, cellular necrosis, immunological reactions, blood dyscrasias, and fetal damage (1–11). Because of the seriousness of these toxicities, my laboratory has been engaged in作者: 發(fā)酵 時(shí)間: 2025-4-1 02:09
Biochemical Aspects of Toxic Metabolites: Formation, Detoxication, and Covalent Bindingcent years. It is now appreciated that reactive alkylating, arylating, or acylating derivatives may arise during the metabolism of xenobiotics and that the covalent binding of these reactive metabolites to cellular macromolecules may initiate events leading to the destruction of specific cellular co作者: 寬度 時(shí)間: 2025-4-1 06:29
Discussionors. Miller replied that the enzyme activity is not very inducible by 3-MC or phenobarbital. He considered the enzyme to be essentially the same as the primary and secondary amine oxidase isolated by Ziegler from pig liver. The purified flavoprotein enzyme, supplied by Ziegler, catalyzes the .-hydro作者: ANIM 時(shí)間: 2025-4-1 13:47
