標(biāo)題: Titlebook: Biological Barriers to Protein Delivery; Kenneth L. Audus,Thomas J. Raub Book 1993 Springer Science+Business Media New York 1993 biochemis [打印本頁] 作者: melancholy 時間: 2025-3-21 17:59
書目名稱Biological Barriers to Protein Delivery影響因子(影響力)
書目名稱Biological Barriers to Protein Delivery影響因子(影響力)學(xué)科排名
書目名稱Biological Barriers to Protein Delivery網(wǎng)絡(luò)公開度
書目名稱Biological Barriers to Protein Delivery網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Biological Barriers to Protein Delivery被引頻次
書目名稱Biological Barriers to Protein Delivery被引頻次學(xué)科排名
書目名稱Biological Barriers to Protein Delivery年度引用
書目名稱Biological Barriers to Protein Delivery年度引用學(xué)科排名
書目名稱Biological Barriers to Protein Delivery讀者反饋
書目名稱Biological Barriers to Protein Delivery讀者反饋學(xué)科排名
作者: Adulterate 時間: 2025-3-21 23:18
Ectopeptidasesly active peptides. These ectopeptidases are integral proteins of the plasma membrane, asymmetrically oriented, with the catalytic site exposed at the extracytoplasmic surface (see Fig. 1). For the majority of those ectopeptidases thus far characterized, the protein is anchored in the membrane by a 作者: Directed 時間: 2025-3-22 03:10 作者: Condyle 時間: 2025-3-22 07:22
Protein Uptake and Cytoplasmic Access in Animal Cells ways of delivering drugs into cells—for instance, with the purpose of irreversibly inhibiting the protein synthesis machinery of cancer cells—mechanisms by which various protein ligands are internalized by cells and subsequently translocated across the membrane of intracellular compartments are com作者: 一回合 時間: 2025-3-22 11:10
Transepithelial Transport of Proteins by Intestinal Epithelial Cellsn effective barrier to proteins and peptides. Epithelial cells play important roles in nutrition and mucosal immune defense apart from their simple function as a barrier, however, and some of these functions require transepithelial vesicular transport of intact macromolecules (Neutra and Kraehenbuhl作者: 點燃 時間: 2025-3-22 14:07
Intraoral Peptide Absorptionte of its apparent disadvantages such as limited absorptive surface and moderate mucosal permeability, this route of administration might be of benefit especially for small- or medium-size peptide drugs. Potential advantages for intraoral delivery are the avoidance of gastrointestinal or liver first作者: B-cell 時間: 2025-3-22 21:03 作者: 疲憊的老馬 時間: 2025-3-23 00:03
Dermal Absorption of Peptides and Proteinsd as a port for continuous systemic administration of drugs. The first transdermal drug delivery system which has used this new concept is a scopolamine-releasing transdermal therapeutic system (Transderm-Scop? by Ciba) for motion sickness. This was followed by the marketing of several nitroglycerin作者: deciduous 時間: 2025-3-23 03:06 作者: 無王時期, 時間: 2025-3-23 05:50 作者: 巨大沒有 時間: 2025-3-23 10:34
Transcytosis of Macromolecules through the Blood—Brain Fluid Barriers ,romolecule, transport of that molecule through the cell, and secretion or exocytosis of the molecule from the cell opposite the side of entry. The process has been described for a variety of molecules and a host of cell types; however, no cell type in which transcytosis has been proposed is more con作者: 漸變 時間: 2025-3-23 17:56
Renal Uptake and Disposal of Proteins and Peptidesor the elimination of most small proteins (Maack ., 1985; Rabkin and Kitaji, 1983). In health the glomerular capillary wall almost completely restricts the passage of molecules of molecular radius greater than ~ 42 ? (~ 50 kDa) while increasingly favoring the passage of proteins as their size decrea作者: cinder 時間: 2025-3-23 19:56
The Immune System as a Barrier to Delivery of Protein Therapeuticser, a protein therapeutic may also be seen as foreign. The result of being perceived as foreign can be benign, neutralize the activity of the therapeutic, or generate an adverse physiological response that may even be lethal. The protein may be intrinsically foreign because it has been obtained from作者: Surgeon 時間: 2025-3-24 00:47 作者: 戲服 時間: 2025-3-24 04:37
978-1-4613-6256-2Springer Science+Business Media New York 1993作者: 一大塊 時間: 2025-3-24 09:47 作者: Latency 時間: 2025-3-24 13:02 作者: Carcinoma 時間: 2025-3-24 16:25
Alltagsgestaltung und Erwerbsverhalten,ly active peptides. These ectopeptidases are integral proteins of the plasma membrane, asymmetrically oriented, with the catalytic site exposed at the extracytoplasmic surface (see Fig. 1). For the majority of those ectopeptidases thus far characterized, the protein is anchored in the membrane by a 作者: LARK 時間: 2025-3-24 19:43 作者: BUDGE 時間: 2025-3-25 03:08 作者: Ballad 時間: 2025-3-25 05:21 作者: Longitude 時間: 2025-3-25 09:23
Psychoanalytische Heilerziehungte of its apparent disadvantages such as limited absorptive surface and moderate mucosal permeability, this route of administration might be of benefit especially for small- or medium-size peptide drugs. Potential advantages for intraoral delivery are the avoidance of gastrointestinal or liver first作者: 浮雕寶石 時間: 2025-3-25 14:36 作者: CRAFT 時間: 2025-3-25 15:54 作者: phytochemicals 時間: 2025-3-25 20:12 作者: 富饒 時間: 2025-3-26 03:07
https://doi.org/10.1007/978-3-658-16680-9he exchange of substances between blood and tissues is of prime importance. Capillary permeability to plasma proteins is a critical factor in regulating tissue-fluid balance. The endothelial cell monolayer lining the vessel wall is a porous (semipermeable) membrane through which fluid and solutes ar作者: Facet-Joints 時間: 2025-3-26 06:22
https://doi.org/10.1007/978-3-658-16680-9romolecule, transport of that molecule through the cell, and secretion or exocytosis of the molecule from the cell opposite the side of entry. The process has been described for a variety of molecules and a host of cell types; however, no cell type in which transcytosis has been proposed is more con作者: 生氣地 時間: 2025-3-26 11:04
https://doi.org/10.1007/978-3-531-92894-4or the elimination of most small proteins (Maack ., 1985; Rabkin and Kitaji, 1983). In health the glomerular capillary wall almost completely restricts the passage of molecules of molecular radius greater than ~ 42 ? (~ 50 kDa) while increasingly favoring the passage of proteins as their size decrea作者: 留戀 時間: 2025-3-26 16:02
Karl Friedrich Bohler,Tobias Franzheld M.A.er, a protein therapeutic may also be seen as foreign. The result of being perceived as foreign can be benign, neutralize the activity of the therapeutic, or generate an adverse physiological response that may even be lethal. The protein may be intrinsically foreign because it has been obtained from作者: 確定方向 時間: 2025-3-26 17:19
Protein Uptake and Cytoplasmic Access in Animal Cells ways of delivering drugs into cells—for instance, with the purpose of irreversibly inhibiting the protein synthesis machinery of cancer cells—mechanisms by which various protein ligands are internalized by cells and subsequently translocated across the membrane of intracellular compartments are coming into focus.作者: 鈍劍 時間: 2025-3-26 21:47
Book 1993relating to the delivery of endogenous andrecombinant proteins to mammalian organs, tissues, and cells. It willpromote fruitful collaboration among academic and industrialscientists in the fields of pharmacology, cell biology, biochemistry,physiology, and immunology.作者: macabre 時間: 2025-3-27 05:04 作者: podiatrist 時間: 2025-3-27 06:12
Biological Barriers to Protein Delivery978-1-4615-2898-2Series ISSN 1078-0467 作者: Estrogen 時間: 2025-3-27 13:09
https://doi.org/10.1007/978-3-322-92267-0 ways of delivering drugs into cells—for instance, with the purpose of irreversibly inhibiting the protein synthesis machinery of cancer cells—mechanisms by which various protein ligands are internalized by cells and subsequently translocated across the membrane of intracellular compartments are coming into focus.作者: 現(xiàn)存 時間: 2025-3-27 16:36
Der frühe A. S. Neill in Gro?britannien play significant roles in fluid homeostasis, particularly in the alveolar region. Yet the knowledge of the mechanisms responsible for the maintenance of protein gradients across respiratory epithelia is primitive in relation to similar knowledge regarding ion gradients.作者: PON 時間: 2025-3-27 21:20 作者: 機(jī)密 時間: 2025-3-27 23:40 作者: 諄諄教誨 時間: 2025-3-28 03:31
Karl Friedrich Bohler,Tobias Franzheld M.A. another species and has a different amino acid sequence, or it may be perceived as foreign due to a more subtle difference, such as being denatured or aggregated. Low-molecular-weight drugs generally do not initiate an immune reaction unless they become conjugated to protein, as occasionally occurs with penicillin.作者: nostrum 時間: 2025-3-28 06:50 作者: Offset 時間: 2025-3-28 11:41
Psychoanalytische Heilerziehungt especially for small- or medium-size peptide drugs. Potential advantages for intraoral delivery are the avoidance of gastrointestinal or liver first-pass effect, the feasibility of locally controlled absorption enhancement, the ease of administration and removal of an administered device, and the sustainment of drug action.作者: 無法破譯 時間: 2025-3-28 17:59
https://doi.org/10.1007/978-3-662-32847-7ne-releasing transdermal therapeutic system (Transderm-Scop? by Ciba) for motion sickness. This was followed by the marketing of several nitroglycerin-releasing systems. Currently, about ten drugs have been either successfully marketed or are under clinical evaluation for transdermal delivery.作者: Tracheotomy 時間: 2025-3-28 22:01
Intraoral Peptide Absorptiont especially for small- or medium-size peptide drugs. Potential advantages for intraoral delivery are the avoidance of gastrointestinal or liver first-pass effect, the feasibility of locally controlled absorption enhancement, the ease of administration and removal of an administered device, and the sustainment of drug action.作者: 文字 時間: 2025-3-28 23:19
Dermal Absorption of Peptides and Proteinsne-releasing transdermal therapeutic system (Transderm-Scop? by Ciba) for motion sickness. This was followed by the marketing of several nitroglycerin-releasing systems. Currently, about ten drugs have been either successfully marketed or are under clinical evaluation for transdermal delivery.作者: deviate 時間: 2025-3-29 03:50
The Immune System as a Barrier to Delivery of Protein Therapeutics another species and has a different amino acid sequence, or it may be perceived as foreign due to a more subtle difference, such as being denatured or aggregated. Low-molecular-weight drugs generally do not initiate an immune reaction unless they become conjugated to protein, as occasionally occurs with penicillin.作者: 易改變 時間: 2025-3-29 10:09
Historische und moderne Rahmenbedingungen,ons (e.g., the frog skin, the colon mucosa, the kidney collecting tubule), the TJ is in fact very restrictive and the amount of substances flowing through the paracellular pathway is almost negligible. On the contrary, in epithelia separating two compartments with similar ionic composition, and that作者: 謊言 時間: 2025-3-29 14:55 作者: 相互影響 時間: 2025-3-29 19:16
Entwicklungstrends von Familien,nfeld and Mellman, 1989). The pH optima of many of these enzymes are less than 5 (for reviews see Barrett and McDonald, 1980; McDonald and Barrett, 1986) consistent with their acting in lysosomes, whose pH is in this vicinity (Ohkuma and Poole, 1978). However, some enzymes have a higher pH optimum, 作者: 蔑視 時間: 2025-3-29 20:49
Der frühe A. S. Neill in Gro?britannienintestine to function as a gatekeeper. In addition to controlling transepithelial transport of proteins from the lumen to the interstitial tissue of the mucosa, the intestinal epithelium fulfills other roles such as digestion and absorption of nutrients and maintenance of a functional barrier.作者: 殘暴 時間: 2025-3-30 02:32
https://doi.org/10.1007/978-3-662-32847-7., 1988) are being investigated for peptide and protein delivery. Among these routes, rectal and vaginal are potentially important routes for peptide administration, although they are poorly accepted in several countries. In contrast to the oral route, the rectal delivery of peptide/protein drugs pr作者: 濃縮 時間: 2025-3-30 04:39 作者: 懲罰 時間: 2025-3-30 11:25 作者: 1分開 時間: 2025-3-30 14:06
https://doi.org/10.1007/978-3-531-92894-4and, to a variable though usually minor extent, through the peritubular capillaries (Baylis, 1982). The contribution of the kidney to the metabolism of small proteins has been particularly well studied and, depending on the contribution of extrarenal sites, the kidney may account for up to 80% of th作者: 壓倒 時間: 2025-3-30 19:51
Mechanisms for the Hepatic Clearance of Oligopeptides and Proteins
