標(biāo)題: Titlebook: Bioinformatics and Drug Discovery; Richard S. Larson Book 2012Latest edition Springer Science+Business Media New York 2012 cheminformatics [打印本頁(yè)] 作者: Fuctionary 時(shí)間: 2025-3-21 18:50
書(shū)目名稱(chēng)Bioinformatics and Drug Discovery影響因子(影響力)
書(shū)目名稱(chēng)Bioinformatics and Drug Discovery影響因子(影響力)學(xué)科排名
書(shū)目名稱(chēng)Bioinformatics and Drug Discovery網(wǎng)絡(luò)公開(kāi)度
書(shū)目名稱(chēng)Bioinformatics and Drug Discovery網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱(chēng)Bioinformatics and Drug Discovery被引頻次
書(shū)目名稱(chēng)Bioinformatics and Drug Discovery被引頻次學(xué)科排名
書(shū)目名稱(chēng)Bioinformatics and Drug Discovery年度引用
書(shū)目名稱(chēng)Bioinformatics and Drug Discovery年度引用學(xué)科排名
書(shū)目名稱(chēng)Bioinformatics and Drug Discovery讀者反饋
書(shū)目名稱(chēng)Bioinformatics and Drug Discovery讀者反饋學(xué)科排名
作者: Guaff豪情痛飲 時(shí)間: 2025-3-21 21:45 作者: GLIB 時(shí)間: 2025-3-22 00:31
Functional Characterization of Human Genes from Exon Expression and RNA Interference Results,involved genes and proteins are crucial for modeling and understanding such systems. To interrogate the various cellular processes, high-throughput techniques such as the Affymetrix Exon Array or RNA interference (RNAi) screens are powerful experimental approaches for functional genomics. However, t作者: 干旱 時(shí)間: 2025-3-22 05:19
,Barcode Sequencing for Understanding Drug–Gene Interactions, describe in detail a protocol for Barcode analysis by sequencing (Bar-seq) to assess pooled competitive growth of individually barcoded yeast deletion mutants. This protocol has been optimized on two sequencing platforms: Illumina’s Genome Analyzer IIx/HiSeq2000 and Life Technologies SOLiD3/5500. I作者: 我正派 時(shí)間: 2025-3-22 12:06
High-Throughput Sequencing of the Methylome Using Two-Base Encoding,ells. Changes in the methylation patterns have been shown to be associated with the development of cancer, growth, neurodevelopmental, and endocrine disorders (Laird PW, Nat Rev Genet 11:191–203, 2010; Tost J, Mol Biotechnol 44:71–81, 2010; Zuo T et al., Epigenomics 1:331–345, 2009). Thus, studying 作者: AWE 時(shí)間: 2025-3-22 15:07 作者: 虛度 時(shí)間: 2025-3-22 17:56 作者: exquisite 時(shí)間: 2025-3-23 00:23
Mapping Between Databases of Compounds and Protein Targets,They join the expanding universes of cheminformatics via chemical structures on the one hand and bioinformatics via sequences on the other. However, it is difficult to assess the relative utility of databases without the explicit comparison of content. We have exemplified an approach to this by comp作者: 偽善 時(shí)間: 2025-3-23 03:00 作者: 小歌劇 時(shí)間: 2025-3-23 06:34 作者: 癡呆 時(shí)間: 2025-3-23 11:27
Human ABC Transporter ABCG2 in Cancer Chemotherapy: Drug Molecular Design to Circumvent Multidrug Road substrate specificity toward structurally diverse compounds, as do other ABC transporters, such as ABCB1 (P-glycoprotein/MDR1), ABCC1 (MRP1/GS-X pump), and ABCC2 (MRP2/cMOAT). To gain insight into the relationship between the molecular structure of compounds and the ABCG2-mediated transport acti作者: COLIC 時(shí)間: 2025-3-23 17:16 作者: Encoding 時(shí)間: 2025-3-23 19:44 作者: 大溝 時(shí)間: 2025-3-24 00:51 作者: 卜聞 時(shí)間: 2025-3-24 05:42 作者: 法官 時(shí)間: 2025-3-24 09:27
Book 2012Latest editionde topics that range from new technologies in target identification, genomic analysis, cheminformatics, protein analysis, and network or pathway analysis. Each chapter provides an extended introduction that describes the theory and application of the technology. In the second part of each chapter,? 作者: happiness 時(shí)間: 2025-3-24 13:26 作者: locus-ceruleus 時(shí)間: 2025-3-24 15:19 作者: 獨(dú)行者 時(shí)間: 2025-3-24 20:35
Applications and Limitations of In Silico Models in Drug Discovery,e and annotate the data from a target perspective, and chemoinformatics methods to integrate chemistry methods into lead design process. This chapter highlights the applications of some of these methods and their limitations. We hope this serves as an introduction to in silico drug discovery.作者: Esophagus 時(shí)間: 2025-3-25 02:47 作者: Interstellar 時(shí)間: 2025-3-25 06:05
High-Throughput Sequencing of the Methylome Using Two-Base Encoding,the methylation pattern can give important insights to the underlying causes of disease and development. A method for studying the methylome on a single base resolution is described, using bisulfite sequencing in combination with the high-throughput SOLiD. sequencing technology.作者: 最后一個(gè) 時(shí)間: 2025-3-25 08:37
Human ABC Transporter ABCG2 in Cancer Chemotherapy: Drug Molecular Design to Circumvent Multidrug Rvity, we have developed a high-speed screening method to analyze the substrate specificity of ABCG2. In addition, we have developed an algorithm that analyzes QSAR to evaluate ABCG2–drug interactions. This chapter presents our strategy of transport mechanism-based molecular design to circumvent multidrug resistance of cancer.作者: 接觸 時(shí)間: 2025-3-25 14:09
Book 2012Latest editionar Biology.? series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. .Thorough and intuitive,. Bioinformatics and Drug Discovery, Second Edition .?seeks to aid scientists in the further study of the rapidly expanding field of drug discovery..作者: 圖表證明 時(shí)間: 2025-3-25 19:48
Wichtige Systeme der Radiochemie,h defined-target approaches in the past, cell-based screens depend on a successful establishment of robust phenotypic assays, the ability to quantitatively measure phenotypic changes and bioinformatics methods for data analysis, integration, and interpretation.作者: cancellous-bone 時(shí)間: 2025-3-25 22:30
Pieternel Dijkstra,Remco Coppoolsend model interpretation. This chapter seeks to review these considerations in light of the current state of the art in statistical modeling and to summarize the best practices in predictive cheminformatics.作者: WAG 時(shí)間: 2025-3-26 03:21 作者: 整潔 時(shí)間: 2025-3-26 06:39
Predictive Cheminformatics in Drug Discovery: Statistical Modeling for Analysis of Micro-array and nd model interpretation. This chapter seeks to review these considerations in light of the current state of the art in statistical modeling and to summarize the best practices in predictive cheminformatics.作者: 混亂生活 時(shí)間: 2025-3-26 11:02
1064-3745 .Contains key notes and implementation advice from experts.Recent advances in drug discovery have been rapid. ?The second edition of .?Bioinformatics and Drug Discovery .has. .been completely updated to include topics that range from new technologies in target identification, genomic analysis, chemi作者: aggrieve 時(shí)間: 2025-3-26 14:20
,Jugend – interdisziplin?r betrachtet,n mutants. This protocol has been optimized on two sequencing platforms: Illumina’s Genome Analyzer IIx/HiSeq2000 and Life Technologies SOLiD3/5500. In addition, we provide guidelines for assessment of human knockdown cells using short-hairpin RNAs (shRNA) and an Illumina sequencing readout.作者: 男學(xué)院 時(shí)間: 2025-3-26 17:31 作者: FEAT 時(shí)間: 2025-3-26 23:32
,Barcode Sequencing for Understanding Drug–Gene Interactions,n mutants. This protocol has been optimized on two sequencing platforms: Illumina’s Genome Analyzer IIx/HiSeq2000 and Life Technologies SOLiD3/5500. In addition, we provide guidelines for assessment of human knockdown cells using short-hairpin RNAs (shRNA) and an Illumina sequencing readout.作者: CURL 時(shí)間: 2025-3-27 03:09
Linking Variants from Genome-Wide Association Analysis to Function via Transcriptional Network Analetwork to expand the regulatory context of the candidate genes, functional analysis to determine putative functional roles, and subsequent analysis of regulatory elements. We describe these sub-strategies and variations, along with guidelines for alternatives in the overall analysis.作者: STING 時(shí)間: 2025-3-27 08:14
Kernaufgaben der Offenen Jugendarbeitthe methylation pattern can give important insights to the underlying causes of disease and development. A method for studying the methylome on a single base resolution is described, using bisulfite sequencing in combination with the high-throughput SOLiD. sequencing technology.作者: garrulous 時(shí)間: 2025-3-27 12:52 作者: opinionated 時(shí)間: 2025-3-27 15:28 作者: membrane 時(shí)間: 2025-3-27 21:05
Kernanalysen der Financial Due Diligencen more commonly investigated ailments. Current findings characterize DD as a disease with complex molecular pathology, with changes in expression of multiple genes and proteins as well as many contributing risk factors. Some of the observed changes include genes and proteins that have been identifie作者: Munificent 時(shí)間: 2025-3-28 01:51
Kernanalysen der Financial Due Diligenceinvolved genes and proteins are crucial for modeling and understanding such systems. To interrogate the various cellular processes, high-throughput techniques such as the Affymetrix Exon Array or RNA interference (RNAi) screens are powerful experimental approaches for functional genomics. However, t作者: STIT 時(shí)間: 2025-3-28 05:36
,Jugend – interdisziplin?r betrachtet, describe in detail a protocol for Barcode analysis by sequencing (Bar-seq) to assess pooled competitive growth of individually barcoded yeast deletion mutants. This protocol has been optimized on two sequencing platforms: Illumina’s Genome Analyzer IIx/HiSeq2000 and Life Technologies SOLiD3/5500. I作者: 露天歷史劇 時(shí)間: 2025-3-28 09:11
Kernaufgaben der Offenen Jugendarbeitells. Changes in the methylation patterns have been shown to be associated with the development of cancer, growth, neurodevelopmental, and endocrine disorders (Laird PW, Nat Rev Genet 11:191–203, 2010; Tost J, Mol Biotechnol 44:71–81, 2010; Zuo T et al., Epigenomics 1:331–345, 2009). Thus, studying 作者: 腐敗 時(shí)間: 2025-3-28 12:48
Kernaufgaben der Offenen Jugendarbeitis likely to be successful, or conversely enable identification of molecules with liabilities as early as possible. These changes include integration of in silico strategies for lead design and optimization that perform complementary roles to that of the traditional in vitro and in vivo approaches. 作者: OATH 時(shí)間: 2025-3-28 14:36 作者: 配置 時(shí)間: 2025-3-28 20:37 作者: 易碎 時(shí)間: 2025-3-29 02:36 作者: 骨 時(shí)間: 2025-3-29 04:25 作者: Irrepressible 時(shí)間: 2025-3-29 07:33 作者: 容易懂得 時(shí)間: 2025-3-29 14:16
Gliederung nach der typischen Skala,ms do not act alone, but rather team up into macromolecular structures enclosing intricate physicochemical dynamic connections to undertake biological functions. A critical step towards unraveling the complex molecular relationships in living systems is the mapping of protein-to-protein physical “in作者: 不可接觸 時(shí)間: 2025-3-29 18:11 作者: 分貝 時(shí)間: 2025-3-29 20:41
,Einführung in die Hadronenphysik,curs at multiple levels from the whole heart, to single myocytes and down to the sarcomere. A central process that links electrical excitation to contraction is calcium mobilization. Computational models that are well grounded in experimental data have been an effective tool to understand the comple作者: 逗留 時(shí)間: 2025-3-30 03:04
,Einführung in die Physik der Higgs-Bosonen, regulation, as a target for degradation to the proteasome or as a signal that controls protein function in a complex manner. Even though many aspects of the ubiquitin system remain unexplored, the contributions on the field uncover that ubiquitin represents one of the most sophisticated codes in ce作者: maculated 時(shí)間: 2025-3-30 05:19 作者: offense 時(shí)間: 2025-3-30 10:49
978-1-4939-5929-7Springer Science+Business Media New York 2012
