標題: Titlebook: Biochemical Modulation of Anticancer Agents: Experimental and Clinical Approaches; Proceedings of the 1 Frederick A. Valeriote,Laurence H. [打印本頁] 作者: Buren 時間: 2025-3-21 17:23
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書目名稱Biochemical Modulation of Anticancer Agents: Experimental and Clinical Approaches讀者反饋
書目名稱Biochemical Modulation of Anticancer Agents: Experimental and Clinical Approaches讀者反饋學科排名
作者: Devastate 時間: 2025-3-21 23:09 作者: Constitution 時間: 2025-3-22 02:31 作者: 避開 時間: 2025-3-22 06:59
https://doi.org/10.1007/978-1-4613-2331-0Purine; Pyrimidine; cell; clinical trial; metabolism; tumor作者: Wallow 時間: 2025-3-22 12:42
978-1-4612-9432-0Martinus Nijhoff Publishing, Boston 1986作者: malapropism 時間: 2025-3-22 14:15
https://doi.org/10.1007/978-3-030-79489-7tivity against a given normal or tumor cell population are employed to . of an .anticancer agent. The modulation can be either to increase the cytotoxicity of the anticancer agent against clonogenic tumor cells or to decrease the cytotoxicity of the anticancer agent against cells of the dose-limitin作者: 暗指 時間: 2025-3-22 18:12 作者: 表主動 時間: 2025-3-22 23:12 作者: 表狀態(tài) 時間: 2025-3-23 03:25 作者: Modicum 時間: 2025-3-23 07:10
Journeys in Argentine and Brazilian Cinemaism and the consequence of these perturbations on a second drug is the foundation of the principles of biochemical modulation. Our research laboratories have been investigating the modulating effects of drugs that either increase or decrease intracellular levels of 5-phosphoribosyl-1-pyrophosphate (作者: Obscure 時間: 2025-3-23 12:39
,Social Education – Sacrality in Education,covorin rescue phenomenon as an approach to the enhancement of the chemotherapeutic efficacy of 4-amino antifolates in murine tumor systems (1). This modality was introduced in the clinics in the following decade and remains an important component of many chemotherapeutic regimens (2, 3). Despite it作者: 饒舌的人 時間: 2025-3-23 14:55
Journeys in Social Education: A Primerciting experimental findings, clinical trials employing biochemical modulation have not clearly demonstrated improvement in the therapeutic indices of the effector agents” (1). This paper will address the problem of the translation of preclinical models of the modulation of FUra metabolism into the 作者: ASSAY 時間: 2025-3-23 20:39 作者: 關心 時間: 2025-3-24 01:42 作者: 讓空氣進入 時間: 2025-3-24 02:55
Migration and Living in the UK,vidual alkylating agents usually are not cross resistant, since the mechanisms and sites of alkylation of each agent may differ considerably. Alkylating agents can produce cures in clinical treatment programs in patients with pediatric tumors, Hodgkins disease and malignant lymphomas, as well as epi作者: 伙伴 時間: 2025-3-24 07:09
https://doi.org/10.1007/978-1-137-45665-6t of “radical repair” (1–3). The model states that radiation-induced radicals produced in critical molecules (like DNA) undergo competitive reactions either with oxidizing species, such as oxygen or other electron affinic agents (e.g. misonidazole) leading to damage “fixation” followed by cell death作者: 我還要背著他 時間: 2025-3-24 11:37
Anh Bourcet Nguyen,Indira Umareddycreasing glutathione levels, and studies on the effects of modulation of cellular glutathione levels. Readers interested in earlier work on the enzymology, metabolism, transport, and functions of glutathione should consult several recent reviews (1–5).作者: GLIB 時間: 2025-3-24 18:24
Making the Equations at Par: Women in STEM, cancer, non-small lung cancer and malignant melanoma are inherently resistant to chemotherapy and response rates in these patients are low. In contrast, patients with tumors such as ovarian cancer and small cell lung cancer usually respond to the initial drug regimen but acquired drug resistance of作者: puzzle 時間: 2025-3-24 21:57 作者: Inertia 時間: 2025-3-25 02:24
Fonvizin: letters from foreign journeys, cross resistance to other structurally unrelated anticancer agents. In order to elucidate the etiology of drug resistance, many possible mechanisms have been proposed and examined, including the development of a membrane barrier (1, 2, 3, 4), gene amplification (5, 6, 7), enhanced drug degradation 作者: Prosaic 時間: 2025-3-25 04:37 作者: fabricate 時間: 2025-3-25 11:16 作者: 混合 時間: 2025-3-25 12:41 作者: CHIP 時間: 2025-3-25 17:43 作者: 熄滅 時間: 2025-3-25 20:57 作者: 里程碑 時間: 2025-3-26 03:30 作者: 較早 時間: 2025-3-26 06:42
odulated (usually by a noncytotoxic agent or a cytotoxic agent at sufficiently low dosage to make it non- cytotoxic) in order to either increase the effectiveness of the particular agent against tumor cells or decrease its cytotox- icity against normal cells. The major focus of modulation has been t作者: Gourmet 時間: 2025-3-26 08:41 作者: 壯觀的游行 時間: 2025-3-26 14:56 作者: compel 時間: 2025-3-26 19:23 作者: Favorable 時間: 2025-3-26 23:39 作者: vibrant 時間: 2025-3-27 04:12 作者: 朋黨派系 時間: 2025-3-27 07:08
Problems in the Clinical Evaluation of Biochemical Modulation Therapy,r restore health) are based on the same scientific rationale as an in vitro study, for example, and are regarded as the same we will always have difficulty in successfully transferring ideas into useful medical practice. Such has often been the case with biochemical modulation.作者: 違抗 時間: 2025-3-27 13:23 作者: 繼而發(fā)生 時間: 2025-3-27 14:42
https://doi.org/10.1007/978-3-030-79489-7 would allow dose escalation with, presumably, increased antitumor activity. Obviously, for either case, the goal of biochemical modulation is to increase the selective cytotoxicity of an anticancer agent for tumor versus normal cells.作者: indenture 時間: 2025-3-27 20:41 作者: clarify 時間: 2025-3-28 00:08
https://doi.org/10.1007/978-3-031-29735-9the role of anemia and pretreatment blood transfusion on the cure rate of carcinoma of the cervix, and from studies of the influence of hyperbaric oxygen on local control for carcinoma of the cervix (3), and carcinoma of the head and neck (4).作者: GRAZE 時間: 2025-3-28 05:21
Biochemical Modulation of Anticancer Agents: An Overview, would allow dose escalation with, presumably, increased antitumor activity. Obviously, for either case, the goal of biochemical modulation is to increase the selective cytotoxicity of an anticancer agent for tumor versus normal cells.作者: 你敢命令 時間: 2025-3-28 07:58
Biochemical Loci for Modulation of 5-Fluorouracil Activity,problems in biochemistry and cell biology. As might be expected, a vast literature on fluoropyrimidines has been generated describing studies on their metabolism, mechanism of action, biochemical pharmacology, synthesis of new derivatives, and clinical antitumor activity.作者: 妨礙議事 時間: 2025-3-28 12:40 作者: FUSC 時間: 2025-3-28 14:46 作者: 注視 時間: 2025-3-28 21:08 作者: agonist 時間: 2025-3-29 01:20 作者: 流動性 時間: 2025-3-29 06:49
Modification of Cell Sensitivity to Anticancer Agents by Polyenes,ical modulation, one attempts to expand upon these differences. Since most of the current approaches to cancer chemotherapy are directed primarily at modifying the synthesis or function of DNA or RNA, consequently biochemical modulators have mainly been applied at these loci. However, other potential loci exist, one of which is the cell membrane.作者: 妨礙議事 時間: 2025-3-29 07:35 作者: Prognosis 時間: 2025-3-29 13:57
Conference proceedings 1986 researchers, application of biochemical modulatory schemes to clinical protocols necessitate a dramatic break with the past procedures. As shown in the laboratory- clinical loop below, close collaboration between the laboratory and clinical investigator is essential. While the laboratory REDEFINE T作者: defenses 時間: 2025-3-29 18:04
laboratory researchers, application of biochemical modulatory schemes to clinical protocols necessitate a dramatic break with the past procedures. As shown in the laboratory- clinical loop below, close collaboration between the laboratory and clinical investigator is essential. While the laboratory REDEFINE T978-1-4612-9432-0978-1-4613-2331-0作者: 束以馬具 時間: 2025-3-29 19:57
https://doi.org/10.1007/978-981-19-0991-7ta concerning the mechanism of action of FUra have revitalized the field. I will outline in this review the most important contributions to this area, focusing on the use of pyrimidines, purines and their nucleosides, as well as the need for future studies.作者: 輕而薄 時間: 2025-3-30 01:23
,Social Education – Sacrality in Education,6). This nucleoside circumvents the need for tetrahydrofolate cofactors by providing the end-product of tetrahydrofolate-dependent thymidylate synthesis. However, no clear biochemical rationale has been defined that could provide a basis for an inherent selectivity in the use of thymidine with metho作者: intoxicate 時間: 2025-3-30 06:10 作者: CODE 時間: 2025-3-30 12:05 作者: FLIRT 時間: 2025-3-30 13:17 作者: organism 時間: 2025-3-30 16:42
Biochemical Rationale for Selectivity in the Modulation of Methotrexate Activity During Leucovorin 6). This nucleoside circumvents the need for tetrahydrofolate cofactors by providing the end-product of tetrahydrofolate-dependent thymidylate synthesis. However, no clear biochemical rationale has been defined that could provide a basis for an inherent selectivity in the use of thymidine with metho作者: 小鹿 時間: 2025-3-30 22:09 作者: 陰郁 時間: 2025-3-31 04:43 作者: 新字 時間: 2025-3-31 07:17
Biochemical Modulation of Anticancer Agents: Experimental and Clinical ApproachesProceedings of the 1作者: Cursory 時間: 2025-3-31 09:24 作者: 富饒 時間: 2025-3-31 16:18
Biochemical Modulation of Anticancer Agents: An Overview,tivity against a given normal or tumor cell population are employed to . of an .anticancer agent. The modulation can be either to increase the cytotoxicity of the anticancer agent against clonogenic tumor cells or to decrease the cytotoxicity of the anticancer agent against cells of the dose-limitin作者: Mri485 時間: 2025-3-31 17:44
Biochemical Loci for Modulation of 5-Fluorouracil Activity,orouracil (FU) (1). This compound was soon found to possess significant antitumor activity in both mice (2) and men (3) and today FU and some of its derivatives, notably the deoxyribonucleoside 5-fluoro-2′-deoxyuridine (FdUrd), are extensively used in the treatment of metastatic cancers, singly or i
