作者: Definitive 時間: 2025-3-21 23:33 作者: optional 時間: 2025-3-22 00:25 作者: dapper 時間: 2025-3-22 07:49 作者: 編輯才信任 時間: 2025-3-22 10:39
,NMR Analysis of Bioprotective Sugars: Sucrose and Oligomeric (1→2)-α-,-glucopyranosyl-(1→2)-β-,-fru.-fructofuranoside. Their smallest representative is sucrose for which conflictingmodels try to explain its cryoprotective properties. Starting from sucrose, we characterize the influenceof the growing chain of oligo(1?→?2)-α-.-glucopyranoses.An analytical approach will be presented that can identif作者: exigent 時間: 2025-3-22 16:52 作者: 撫育 時間: 2025-3-22 20:40 作者: candle 時間: 2025-3-23 00:45
Exploiting Ligand and Receptor Adaptability in Rational Drug Design Using Dynamics and Structure-Bastructure and dynamics factors. The ligand andreceptor must mutually fit and adapt to each other to form a?strong complex, and detailed knowledgeof these factors would certainly aid drug design efforts. This work describes our experience in the characterizationand exploitation of these properties wi作者: myriad 時間: 2025-3-23 02:06
https://doi.org/10.1007/3-540-34583-3→?2)-α-.-glucopyranose oligomers is theirwell-defined solution structure with a?stand-alone sugar helix. The unfolding barrier of this helixis large enough to become observable as line-broadening in the .H NMR.作者: 極大的痛苦 時間: 2025-3-23 08:24
,NMR Analysis of Bioprotective Sugars: Sucrose and Oligomeric (1→2)-α-,-glucopyranosyl-(1→2)-β-,-fru→?2)-α-.-glucopyranose oligomers is theirwell-defined solution structure with a?stand-alone sugar helix. The unfolding barrier of this helixis large enough to become observable as line-broadening in the .H NMR.作者: 人類的發(fā)源 時間: 2025-3-23 09:59
,Dynamics and Thermodynamics of Ligand–Protein Interactions,osition of interacting groups (loosely, enthalpy), but also by thedynamics of these groups (loosely, entropy) including solvent effects. In this work I will review currentmethodology for unravelling this complex problem, including X-ray crystallography, NMR, isothermal titrationcalorimetry and theoretical free energy perturbation methods.作者: Hypopnea 時間: 2025-3-23 17:24 作者: municipality 時間: 2025-3-23 19:09
Domino-Objekt- und Speichermodellosition of interacting groups (loosely, enthalpy), but also by thedynamics of these groups (loosely, entropy) including solvent effects. In this work I will review currentmethodology for unravelling this complex problem, including X-ray crystallography, NMR, isothermal titrationcalorimetry and theoretical free energy perturbation methods.作者: 侵略 時間: 2025-3-24 01:04
Domino-Objekt- und Speichermodellon-state NMR spectroscopy can provide insight into the interactionsbetween the misfolding protein and the chaperone at atomic resolution. In particular, experimental resultsfor Sup35, a?yeast prion protein, and β-amyloid, which is responsible for Alzheimer‘s disease,and their interactions with Hsp104 and αB-crystallin, respectively, are discussed.作者: 種子 時間: 2025-3-24 03:51
Thomas PetersThis series presents critical reviews of the present position and future trends in modern chemical research.Short and concise reports on chemistry, each written by the world renowned experts.Still val作者: bacteria 時間: 2025-3-24 09:10 作者: Melatonin 時間: 2025-3-24 12:15 作者: 容易做 時間: 2025-3-24 18:01
978-3-642-08035-7Springer-Verlag Berlin Heidelberg 2007作者: 文字 時間: 2025-3-24 19:14
Domino-Objekt- und Speichermodellenges in medicinal chemistry. In the absence of a?crystalstructure of the receptor, success in mimicking natural peptide ligands with potent non-peptides has beenelusive. A?systematic stepwise strategy has been developed to accomplish these goals. These includedetermining the primary amino acid side作者: floaters 時間: 2025-3-24 23:29 作者: shrill 時間: 2025-3-25 06:51
https://doi.org/10.1007/3-540-34583-3ritis. The need to understand the mechanismsof these diseases, and the potential for the development of novel therapeutics, has driven the characterizationof complexes of the FGFs, FGFRs, and the co-receptor heparin. These efforts have led to the proposal oftwo models, based on crystal structures, f作者: 諷刺滑稽戲劇 時間: 2025-3-25 09:11
Domino-Objekt- und Speichermodellby maintaining polypeptides in conformations competentfor folding and subunit assembly. On the other hand, specific chaperones are considered to be involvedin the mechanism of prion propagation and others are found to colocalize in plaques of patients sufferingfrom neurodegenerative diseases. Soluti作者: 仇恨 時間: 2025-3-25 15:44 作者: 南極 時間: 2025-3-25 19:23 作者: capillaries 時間: 2025-3-25 22:02 作者: 強壯 時間: 2025-3-26 02:50 作者: CURT 時間: 2025-3-26 04:27
Bioactive Conformation I978-3-540-49078-4Series ISSN 0340-1022 Series E-ISSN 1436-5049 作者: Commentary 時間: 2025-3-26 08:36 作者: Arctic 時間: 2025-3-26 14:55 作者: Yag-Capsulotomy 時間: 2025-3-26 19:48
https://doi.org/10.1007/3-540-34583-3lution, and has suggested that botharchitectures bind only one molecule of heparin. New methods for sequencing heparin and preparing heparinderivatives have allowed the affinity of FGFs for heparins to be determined. Finally, evidence has accumulatedfor complexes involving more than two FGFRs, and t作者: 友好關(guān)系 時間: 2025-3-26 23:11
https://doi.org/10.1007/3-540-34583-3odel membranes. Further, transient bindingof small carbohydrates to soluble proteins was characterized using RDCs. A?brief literature reviewis followed by a?detailed discussion of the RDC-based structure determination of a?rhodopsin-boundtransducin peptide.作者: 陳舊 時間: 2025-3-27 04:51
Domino-Objekt- und Speichermodellilies have memberswith known structure. This is in sharp contrast with glycosylhydrolases, which to date have published structuresfor 70 of the so far described 102 classes. The paucity of structural data for glycosyltransferases hasbeen attributed to their membrane-associated character and low expr作者: forager 時間: 2025-3-27 08:29
https://doi.org/10.1007/3-540-34583-3y relationships, NMR spectroscopy,computational chemistry, and X-ray crystallography. An important emphasis was made to monitor the relationshipbetween inhibitor activity and ligand flexibility using .C?NMR . . relaxation data, within the context of promoting thebioactive conformation as a?drug desi作者: 搜集 時間: 2025-3-27 12:08 作者: 農(nóng)學(xué) 時間: 2025-3-27 17:33
,The Fibroblast Growth Factor (FGF) – FGF Receptor Complex: Progress Towards the Physiological Statelution, and has suggested that botharchitectures bind only one molecule of heparin. New methods for sequencing heparin and preparing heparinderivatives have allowed the affinity of FGFs for heparins to be determined. Finally, evidence has accumulatedfor complexes involving more than two FGFRs, and t作者: 高腳酒杯 時間: 2025-3-27 21:48 作者: 獨特性 時間: 2025-3-28 00:46
Glycosyltransferase Structure and Function,ilies have memberswith known structure. This is in sharp contrast with glycosylhydrolases, which to date have published structuresfor 70 of the so far described 102 classes. The paucity of structural data for glycosyltransferases hasbeen attributed to their membrane-associated character and low expr作者: 瑣碎 時間: 2025-3-28 03:16
Exploiting Ligand and Receptor Adaptability in Rational Drug Design Using Dynamics and Structure-Bay relationships, NMR spectroscopy,computational chemistry, and X-ray crystallography. An important emphasis was made to monitor the relationshipbetween inhibitor activity and ligand flexibility using .C?NMR . . relaxation data, within the context of promoting thebioactive conformation as a?drug desi作者: 使人入神 時間: 2025-3-28 06:50 作者: CURL 時間: 2025-3-28 12:20
