標題: Titlebook: BetaSys; Systems Biology of R Bernhelm Boo?-Bavnbek,Beate Kl?sgen,Erik Renstr?m Book 2011 Springer Science+Business Media, LLC 2011 diabete [打印本頁] 作者: purulent 時間: 2025-3-21 17:23
書目名稱BetaSys影響因子(影響力)
書目名稱BetaSys影響因子(影響力)學(xué)科排名
書目名稱BetaSys網(wǎng)絡(luò)公開度
書目名稱BetaSys網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱BetaSys被引頻次
書目名稱BetaSys被引頻次學(xué)科排名
書目名稱BetaSys年度引用
書目名稱BetaSys年度引用學(xué)科排名
書目名稱BetaSys讀者反饋
書目名稱BetaSys讀者反饋學(xué)科排名
作者: Aspiration 時間: 2025-3-21 23:28
Mitochondria and Metabolic Signals in β-Cellsexocytosis. In response to a glucose rise, nucleotides and metabolites are generated by mitochondria and participate, together with cytosolic calcium, in the stimulation of insulin release. This chapter describes the mitochondrion-dependent systems of regulated insulin secretion.作者: employor 時間: 2025-3-22 03:17
β-Cell Ontogenesis and the Insulin Production Apparatusas demonstrated that most of these genes are expressed in the pancreatic β-cell and are involved in not only transcriptional functions but also the insulin secretory apparatus. This chapter provides a short overview of these subjects.作者: 標準 時間: 2025-3-22 07:37 作者: Emmenagogue 時間: 2025-3-22 12:03
Institutioneller Wandel durch Lernprozesseom human and animal studies show that amyloid develops before β-cell deficiency, and the occurrence of oligomers and amyloid intracellular induces β-cell death. Prevention of islet amyloid most likely will save β-cells and extend hormone secretion.作者: 溫和女人 時間: 2025-3-22 13:33 作者: hair-bulb 時間: 2025-3-22 18:34
Evaluation/Empfehlungen und Ausblick as well as recent advances in the understanding of the pathogenesis of type 2 diabetes. This disease represents one of major health problems associated in economically developing countries, but recently a much improved understanding of the genetic risk for the disease has opened up the prospect of personalized treatment.作者: 引起 時間: 2025-3-22 23:59
https://doi.org/10.1007/978-3-658-35097-0 viable transplanted islets. β-cells labelled in vivo with Mn. ions can be measured as signal hyperintensity on MR images, since Mn. ions enter β-cells through voltage-gated Ca. channels. Compartmental models that describe Mn. distribution in the pancreas may provide quantitative measurements of β-cell mass and function.作者: resuscitation 時間: 2025-3-23 05:17 作者: COLON 時間: 2025-3-23 05:44 作者: 剝皮 時間: 2025-3-23 12:38 作者: canonical 時間: 2025-3-23 17:46 作者: backdrop 時間: 2025-3-23 21:58
https://doi.org/10.1007/978-3-322-90544-4n Va accomplishes their transfer along short F-actin filaments to the docking sites at the plasma membrane, where the granules are tethered by the formation of a ternary complex of Rab27a and granuphilin residing on the granular membrane and syntaxin 1a on the plasma membrane, leading to membrane fusion and insulin secretion.作者: 強有力 時間: 2025-3-23 22:49
Institutioneller Wandel durch Lernprozesseriants increasing susceptibility for the disease but also rare variants with stronger effects. For the first time we can with some confidence anticipate that the genetics of a complex disease like T2D really can be dissected.作者: ALT 時間: 2025-3-24 05:58 作者: 美學(xué) 時間: 2025-3-24 09:24
DNA Variations, Impaired Insulin Secretion and Type 2 Diabetesriants increasing susceptibility for the disease but also rare variants with stronger effects. For the first time we can with some confidence anticipate that the genetics of a complex disease like T2D really can be dissected.作者: CAGE 時間: 2025-3-24 12:15
Aufbau des Institutionenatlassescal models and numerical simulations that aim to explain major aspects of the β-cell function (see other chapters). These models, though answering many questions about the β-cell function, remain to be only isolated attempts and have not yet been integrated into a single more unified model. Thus, there is a need to apply a holistic approach.作者: GUMP 時間: 2025-3-24 17:12 作者: Calibrate 時間: 2025-3-24 20:15 作者: Inculcate 時間: 2025-3-24 23:34
Genetically Programmed Defects in β-Cell Functiongenes that encode the various components. Identifying these mutations has been important not only for tailoring treatment towards the specific subtype of diabetes associated, but also for highlighting the importance and pivotal role of a number of elements along the pathway of glucose-stimulated insulin secretion within the pancreatic β-cell.作者: FORGO 時間: 2025-3-25 07:15
2191-222X f systems biology, its methods and applications In using a f.BetaSys. uses the example of regulated exocytosis in pancreatic β-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications..978-1-4614-2815-2978-1-4419-6956-9Series ISSN 2191-222X Series E-ISSN 2191-2238 作者: yohimbine 時間: 2025-3-25 08:01 作者: 額外的事 時間: 2025-3-25 14:19 作者: HAIRY 時間: 2025-3-25 16:39 作者: 預(yù)示 時間: 2025-3-25 23:25
Institutioneller Wandel durch Lernen,genes that encode the various components. Identifying these mutations has been important not only for tailoring treatment towards the specific subtype of diabetes associated, but also for highlighting the importance and pivotal role of a number of elements along the pathway of glucose-stimulated insulin secretion within the pancreatic β-cell.作者: Licentious 時間: 2025-3-26 00:21
Aufbau des Institutionenatlassesose homeostasis. It has been a focus of intensive research for several decades, which has culminated in the characterization of processes involved in synthesis and secretion of the hormone in considerable details. The stage of knowledge of this cell is reflected in a substantial variety of mathemati作者: 昏迷狀態(tài) 時間: 2025-3-26 05:15
Evaluation/Empfehlungen und Ausblick of the main molecular events involved in that process and follows the chain of events in insulin secretion from synthesis of insulin and its storage in dense core granules and their transport to the cell surface, as well as the molecular reactions that control their fusion with the cell membrane an作者: Abduct 時間: 2025-3-26 09:15 作者: angina-pectoris 時間: 2025-3-26 16:41
Aufbau des Institutionenatlasseshe pancreas from the primitive gut endoderm. A large number of specific transcription factors have been demonstrated to be crucial to the development and function of this highly specialized cell. Recently, genome-wide association scans as well as study of maturity onset diabetes of the young genes h作者: 圓木可阻礙 時間: 2025-3-26 17:34 作者: tympanometry 時間: 2025-3-26 21:45 作者: Simulate 時間: 2025-3-27 01:32
https://doi.org/10.1007/978-3-658-35097-0odality, may play an important role in assessing transplanted islets as well as β-cell mass and function. In addition to conventional MRI of anatomical structure and function, recent advances have led to the development and application of MRI for targeted molecular and cellular imaging. Pancreatic i作者: Lice692 時間: 2025-3-27 07:32 作者: commune 時間: 2025-3-27 12:51
https://doi.org/10.1007/978-3-658-35097-0a pre-requisite for any in vivo application, and nanotoxicity. We introduce the two main fields of in vivo applications of nanoparticles: bioimaging and therapy. In the field of imaging, magnetic resonance imaging and optical imaging are distinguished, and the latter is further subdivided into group作者: 外貌 時間: 2025-3-27 14:44
Institutioneller Wandel durch Lernprozessearameters will determine the biological relevance and quality of the results. There are numerous biochemical and cellular assays available to test the vitality, i.e. the metabolic and functional activities, of cells in culture. Most of these assays, however, are end-point measurements and give infor作者: PTCA635 時間: 2025-3-27 21:27
Institutioneller Wandel durch Lernen,d during nerve signalling (Andersen et al. Prog Neurobiol 88(2):104–113, 2009; Sakmann and Neher Annu Rev Physiol 46:455–472, 1984). However, there are more electrical phenomena that play a significant role in biological systems, namely those arising from polarization effects (Grimnes Bioimpedance a作者: 表否定 時間: 2025-3-27 23:19 作者: debble 時間: 2025-3-28 06:00 作者: 艦旗 時間: 2025-3-28 07:12 作者: 易受刺激 時間: 2025-3-28 11:22 作者: 粗糙 時間: 2025-3-28 17:14
Book 2011.BetaSys. uses the example of regulated exocytosis in pancreatic β-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications..作者: 高度贊揚 時間: 2025-3-28 22:00 作者: STYX 時間: 2025-3-29 00:59
978-1-4614-2815-2Springer Science+Business Media, LLC 2011作者: 作繭自縛 時間: 2025-3-29 06:59 作者: 錯事 時間: 2025-3-29 08:27
Elke Schierer,Annette Rabe,Birgit Gronertill remain unanswered regarding how structure–function relationships change in the β-cell under different physiological conditions and how such changes contribute to the onset/progression of β-cell dysfunction and/or death. To address these key questions, we have pioneered a number of novel approac作者: allergy 時間: 2025-3-29 15:16 作者: 放逐某人 時間: 2025-3-29 15:38 作者: DEAF 時間: 2025-3-29 22:47
Institutioneller Wandel durch Lernprozessebegun to unravel the granule proteome in ever-increasing detail. Emerging data complement the results from the other approaches that have been applied to understand the granule. This chapter will explore the current state of knowledge in the field and the implications of emerging proteomic data for 作者: DOLT 時間: 2025-3-30 03:40
The Mathematical Microscope – Making the Inaccessible Accessibleical modelling is discussed for type 1 and type 2 diabetes, depression, cardiovascular diseases and the interactions between the combinations of these, the so-called grey triangle in the metabolic syndrome.作者: Decimate 時間: 2025-3-30 05:50
Mapping the β-Cell in 3D at the Nanoscale Using Novel Cellular Electron Tomography and Computationaltill remain unanswered regarding how structure–function relationships change in the β-cell under different physiological conditions and how such changes contribute to the onset/progression of β-cell dysfunction and/or death. To address these key questions, we have pioneered a number of novel approac作者: nocturnal 時間: 2025-3-30 08:46 作者: DAMN 時間: 2025-3-30 13:59 作者: resuscitation 時間: 2025-3-30 18:01
