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標(biāo)題: Titlebook: Behavioral Pharmacology of the Cholinergic System; Mohammed Shoaib,Tanya L. Wallace Book 2020 Springer Nature Switzerland AG 2020 Nicotini [打印本頁]

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作者: 無瑕疵    時(shí)間: 2025-3-21 21:09
Endogenous Acetylcholine and Its Modulation of Cortical Microcircuits to Enhance Cognition,ions of in vivo manipulations of endogenous acetylcholine. We find broader similarities than we expected between the cholinergic regulation of sensory and prefrontal cortex, but there are some differences and some gaps in knowledge. In visual, auditory, and somatosensory cortex, the cell and circuit
作者: arcane    時(shí)間: 2025-3-22 02:59
Nicotinic Receptors Underlying Nicotine Dependence: Evidence from Transgenic Mouse Models, function are considered. Taken together, these discoveries have provided a foundational understanding of various genetic, neurobiological, and behavioral factors underlying the motivation to use nicotine and related dependence processes, which are thereby advancing drug discovery efforts to promote
作者: Comedienne    時(shí)間: 2025-3-22 07:15

作者: Neuropeptides    時(shí)間: 2025-3-22 11:02
,An Evolving Therapeutic Rationale for Targeting the α7 Nicotinic Acetylcholine Receptor in Autism St. Synchronous oscillatory output is an electrophysiological substrate for higher executive functions, such as working memory, and functional connectivity between discrete anatomic areas of the brain. The α. nAChR regulates PV expression and works cooperatively with the co-expressed NMDA receptor in
作者: JIBE    時(shí)間: 2025-3-22 16:17
Dortmunder Beitr?ge zur Sozialforschunglcholine receptors (nAChRs). These receptor systems are described in detail within this chapter along with discussion on the successes and failures of synthetic ligands designed to selectively target receptor subtypes for treating brain disorders. New molecular approaches and advances in our underst
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Import Levels of the Developing Countries,hways of the brain. We also discuss the unique roles of homomeric α7 nAChR in behavioral responses to nicotine and how our knowledge of nAChR functional diversity may help guide pharmacotherapeutic approaches for treating nicotine addiction. While nicotine addiction is a truly global problem, the us
作者: aesthetician    時(shí)間: 2025-3-23 09:02

作者: 邪惡的你    時(shí)間: 2025-3-23 11:23
Book 2020esis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable imp
作者: 混合    時(shí)間: 2025-3-23 16:07

作者: EVADE    時(shí)間: 2025-3-23 19:59
Introduction: Imports and Protection,t, including inflammatory and neuropathic pain. More recently, alternative nAChRs ligands such as positive allosteric modulators and silent agonists have shown potential to develop into new treatments for chronic pain.
作者: Virtues    時(shí)間: 2025-3-24 00:00

作者: 絕緣    時(shí)間: 2025-3-24 03:02
,Activators of α7 nAChR as Potential Therapeutics for Cognitive Impairment,nd academia, none of the α7 nAChR ligands has been approved for clinical use. This chapter will focus on the α7 nAChR ligands that have advanced to clinical studies and explore the reasons why these agents have not met with unequivocal clinical success.
作者: 入會    時(shí)間: 2025-3-24 08:02
1866-3370 ht into the diverse array of disease states affected by dysfThe molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacol
作者: 中子    時(shí)間: 2025-3-24 14:21
Implizites Wissen in Organisationentylcholine in memory, and episodic memory in particular. We propose that patterns of impairment can best be understood in terms of a role for hippocampal acetylcholine in resolving spatial interference and we discuss the benefits of new tasks of episodic memory in animals allowing clearer translation of findings to the clinic.
作者: 自制    時(shí)間: 2025-3-24 16:44
Rekonstruktive Bildungsforschung sensory input. Emerging evidence supports a prominent and permissive role for acetylcholine in these excitatory circuits, through actions at cholinergic nicotinic receptors. Here we review the involvement of acetylcholine in working memory via actions at nicotinic receptors.
作者: HUSH    時(shí)間: 2025-3-24 20:08
Acetylcholine and Spontaneous Recognition Memory in Rodents and Primates,tylcholine in memory, and episodic memory in particular. We propose that patterns of impairment can best be understood in terms of a role for hippocampal acetylcholine in resolving spatial interference and we discuss the benefits of new tasks of episodic memory in animals allowing clearer translation of findings to the clinic.
作者: 花束    時(shí)間: 2025-3-25 01:09

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Mohammed Shoaib,Tanya L. WallaceMaximises readers insight into the translational perspective on targeting nicotinic and muscarinic acetylcholine receptors.Provides an insight into the diverse array of disease states affected by dysf
作者: FEAT    時(shí)間: 2025-3-26 01:51

作者: Antioxidant    時(shí)間: 2025-3-26 06:45
Behavioral Pharmacology of the Cholinergic System978-3-030-56013-3Series ISSN 1866-3370 Series E-ISSN 1866-3389
作者: SPECT    時(shí)間: 2025-3-26 10:33

作者: 合適    時(shí)間: 2025-3-26 15:01
Implizites Wissen in Organisationeninergic manipulations in primates and rodents has often been at odds. Here, we review the work in primates and rodents on the specific function of acetylcholine in memory, and episodic memory in particular. We propose that patterns of impairment can best be understood in terms of a role for hippocam
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作者: capsule    時(shí)間: 2025-3-27 02:23

作者: accomplishment    時(shí)間: 2025-3-27 08:48
https://doi.org/10.1007/978-3-658-13909-4inic acetylcholine receptor (nAChR) subtypes localized on the pre- and postsynaptic membranes of cells, which subsequently leads to the modulation of cellular function and neurotransmitter signaling. In this chapter, we begin by briefly reviewing the current understanding of nicotine’s actions on nA
作者: Counteract    時(shí)間: 2025-3-27 11:25
Import Levels of the Developing Countries,ety is the use of tobacco products which contain nicotine. This addiction can be associated with specific receptors in the brain that respond to the natural neurotransmitter acetylcholine. These nicotinic acetylcholine receptors (nAChR) are ligand-gated ion channels formed by the assembly of one or
作者: intricacy    時(shí)間: 2025-3-27 14:14
Introduction: Imports and Protection, and α9α10 nAChR subtypes have been investigated as potential targets to treat pain. The nAChRs are distributed on the pain transmission pathways, including central and peripheral nervous systems and immune cells as well. Several agonists for α4β2? nAChR subtypes have been investigated in multiple a
作者: Demulcent    時(shí)間: 2025-3-27 18:06

作者: Postulate    時(shí)間: 2025-3-28 01:34

作者: confide    時(shí)間: 2025-3-28 03:46
https://doi.org/10.1007/978-3-030-56013-3Nicotinic receptor systems biology; Muscarinic receptors; Cholinesterase; Physiology; Behavior; Disease
作者: dermatomyositis    時(shí)間: 2025-3-28 07:37

作者: 發(fā)酵    時(shí)間: 2025-3-28 11:39
A Review of the Cholinergic System and Therapeutic Approaches to Treat Brain Disorders,verse functions. Some well-characterized functions include: chemical transmission at the neuromuscular junction; autonomic function in the peripheral nervous system; and, sustained attention, sleep/wake regulation, and learning and memory within the central nervous system. Within the brain, major ch
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作者: 民間傳說    時(shí)間: 2025-3-29 03:32
Involvement of Nicotinic Receptors in Working Memory Function, prefrontal cortex is particularly critical for rule representation and working memory, or the ability to hold information “in mind” in the absence of sensory input. Emerging evidence supports a prominent and permissive role for acetylcholine in these excitatory circuits, through actions at choliner
作者: Amylase    時(shí)間: 2025-3-29 10:07

作者: 玷污    時(shí)間: 2025-3-29 11:55
Cholinergic Receptors and Addiction,ety is the use of tobacco products which contain nicotine. This addiction can be associated with specific receptors in the brain that respond to the natural neurotransmitter acetylcholine. These nicotinic acetylcholine receptors (nAChR) are ligand-gated ion channels formed by the assembly of one or
作者: 可耕種    時(shí)間: 2025-3-29 17:06
Behavioral and Molecular Basis of Cholinergic Modulation of Pain: Focus on Nicotinic Acetylcholine and α9α10 nAChR subtypes have been investigated as potential targets to treat pain. The nAChRs are distributed on the pain transmission pathways, including central and peripheral nervous systems and immune cells as well. Several agonists for α4β2? nAChR subtypes have been investigated in multiple a
作者: 謊言    時(shí)間: 2025-3-29 20:12
,An Evolving Therapeutic Rationale for Targeting the α7 Nicotinic Acetylcholine Receptor in Autism Sturation and maintenance of cholinergic neurons, have been described in postmortem brains of persons with autism spectrum disorder (ASD). Further, microdeletions of the 15q13.3 locus that encompasses ., the gene coding the α. nicotinic acetylcholine receptor (α. nAChR), are associated with a spectru




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