標(biāo)題: Titlebook: Behavioral Neurobiology of Bipolar Disorder and its Treatment; Husseini K. Manji,Carlos A. Zarate Jr. Book 2011 Springer-Verlag Berlin Hei [打印本頁(yè)] 作者: Destruct 時(shí)間: 2025-3-21 19:39
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書目名稱Behavioral Neurobiology of Bipolar Disorder and its Treatment網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Behavioral Neurobiology of Bipolar Disorder and its Treatment被引頻次
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書目名稱Behavioral Neurobiology of Bipolar Disorder and its Treatment讀者反饋
書目名稱Behavioral Neurobiology of Bipolar Disorder and its Treatment讀者反饋學(xué)科排名
作者: 錯(cuò)誤 時(shí)間: 2025-3-21 22:01
https://doi.org/10.37307/b.978-3-503-19992-1 chromatin structure. In this chapter, we revisit the epidemiological, clinical, and molecular findings in BPD and reanalyze them from the perspective of inherited and acquired epigenetic misregulation. Epigenetic research has great potential to enhance our understanding of the molecular basis of BPD.作者: 犬儒主義者 時(shí)間: 2025-3-22 03:13 作者: Water-Brash 時(shí)間: 2025-3-22 07:43
https://doi.org/10.1007/978-3-322-93436-9on to many neurodegenerative disorders. It would be reasonable to assume that neurons regulating mood are progressively impaired during the course of BPD. Further studies are needed to clarify which neural systems are impaired by mitochondrial dysfunction in BPD.作者: 過濾 時(shí)間: 2025-3-22 08:43 作者: faction 時(shí)間: 2025-3-22 13:04 作者: interference 時(shí)間: 2025-3-22 18:34
The Role of the Aminergic Systems in the Pathophysiology of Bipolar Disorder,the permissive hypothesis. Evidence from select studies of cerebrospinal fluid, postmortem subjects, neuroimaging, genetic factors, and pharmacological agents will be used to reconcile these hypotheses. Possible explanations for discrepancies in these hypotheses are given, and directions for future studies are suggested.作者: 跳脫衣舞的人 時(shí)間: 2025-3-23 00:28 作者: conceal 時(shí)間: 2025-3-23 04:17
Bipolar Disorder: A Neurobiological Synthesis,al impairment, psychosocial disability, and diminished well-being. Furthermore, the disorder is frequently unrecognized, misdiagnosed, and mismanaged, and much still remains unknown about its pathophysiology.作者: 掙扎 時(shí)間: 2025-3-23 08:56 作者: 婚姻生活 時(shí)間: 2025-3-23 10:21 作者: 心痛 時(shí)間: 2025-3-23 15:39
Implementierung von Controllinginstrumentenonsidered. Finally, new research approaches that have begun to reveal the contribution of specific genetic mechanisms to regional dysfunction in the disorder, potential salutary effects of medications, and structure–function relationships will be discussed.作者: hair-bulb 時(shí)間: 2025-3-23 20:30 作者: 口訣法 時(shí)間: 2025-3-24 00:29
Course and Outcome of Bipolar Disorder,, we will limit discussion to those studies that have used the conservative historical definitions of BPD (as used in DSM-IIIR, DSM-IV, and ICD-10), eschewing the recent controversial concepts of “pediatric” BPD and “soft BPD spectrum.”作者: 別名 時(shí)間: 2025-3-24 04:56
Functional Neuroimaging Research in Bipolar Disorder,onsidered. Finally, new research approaches that have begun to reveal the contribution of specific genetic mechanisms to regional dysfunction in the disorder, potential salutary effects of medications, and structure–function relationships will be discussed.作者: 不要不誠(chéng)實(shí) 時(shí)間: 2025-3-24 07:04 作者: 為寵愛 時(shí)間: 2025-3-24 12:34
https://doi.org/10.1007/978-3-322-91362-3ent points along a circuit like the trisynaptic pathway. Our ability to understand the functional implications in terms of complex molecular changes will ultimately influence our ability to develop novel treatments for BPD.作者: MINT 時(shí)間: 2025-3-24 18:14 作者: 移植 時(shí)間: 2025-3-24 19:28
https://doi.org/10.1007/978-3-8350-9038-5thm abnormalities and review the evidence supporting their role in bipolar episodes. Last, we discuss a number of pharmacologic and psychosocial treatments for bipolar disorder that target sleep and biological rhythm abnormalities, and we examine their effect on bipolar episodes and symptoms.作者: Notorious 時(shí)間: 2025-3-25 03:09
Implementierung von Controllinginstrumentend protein kinase C) are also reviewed, as are agents that affect multiple targets (e.g., modafinil, Uridine RG2417). Further study of these and similar agents may improve our understanding of relevant drug targets and their clinical utility as potential therapeutics for this devastating disorder.作者: Slit-Lamp 時(shí)間: 2025-3-25 07:18
The Neurobiology of Bipolar Disorder: From Circuits to Cells to Molecular Regulation,ent points along a circuit like the trisynaptic pathway. Our ability to understand the functional implications in terms of complex molecular changes will ultimately influence our ability to develop novel treatments for BPD.作者: Trigger-Point 時(shí)間: 2025-3-25 08:01
Synaptic Plasticity in the Pathophysiology and Treatment of Bipolar Disorder,h in the hippocampus and also correlate with antidepressant-like behaviors. In contrast, inhibiting monoaminergic signaling, long-term stress, and pathophysiological concentrations of cytokines weakens glutamatergic synaptic strength in the hippocampus and is associated with depressive-like symptoms.作者: 使出神 時(shí)間: 2025-3-25 15:11 作者: 松軟 時(shí)間: 2025-3-25 16:26 作者: Processes 時(shí)間: 2025-3-25 20:54
Book 2011he development of animal models. Finally, the book covers treatment strategies for bipolar disorder, including both traditional and novel therapeutics, as well as non-pharmacological treatments. It offers both researchers and clinicians key insights into this devastating disorder.作者: Ferritin 時(shí)間: 2025-3-26 03:17
Husseini K. Manji,Carlos A. Zarate Jr.Covers a wide range of methodologies including neuroimaging, genetics and epigenetics, animal models, translational research and psychopharmacology.Describes the most effective currently available tre作者: 生存環(huán)境 時(shí)間: 2025-3-26 04:51 作者: 樂意 時(shí)間: 2025-3-26 09:33
Behavioral Neurobiology of Bipolar Disorder and its Treatment978-3-642-15757-8Series ISSN 1866-3370 Series E-ISSN 1866-3389 作者: Amplify 時(shí)間: 2025-3-26 15:41 作者: notion 時(shí)間: 2025-3-26 20:05 作者: 美學(xué) 時(shí)間: 2025-3-26 21:16
Schlussbetrachtung und Ausblick,dominate; for others, depression is the major key. For a minority, the condition is predictably cyclical; for most, it is unpredictably chaotic. This chapter examines those studies that have attempted to draw coherence from this enigmatic disorder. Where possible, we will focus on data derived from 作者: CHOP 時(shí)間: 2025-3-27 03:53 作者: Concomitant 時(shí)間: 2025-3-27 06:55
,Projektgeschichte und überblick,llness remains elusive. Given evidence that genes predisposing to BPD may be transmitted without expression of the clinical phenotype, interest has arisen in developing endophenotypes – indicators of processes mediating between genotype and phenotype. Patients with BPD have subtle neuropsychological作者: cavity 時(shí)間: 2025-3-27 12:03
,Projektgeschichte und überblick,physiology of the disorder and the development of truly novel treatments. Recent advances in our understanding of the biological basis of bipolar disorder can be used to identify and develop better models. One possibility that is discussed in a separate chapter of this book is the use of molecular b作者: Ventricle 時(shí)間: 2025-3-27 17:23 作者: 澄清 時(shí)間: 2025-3-27 19:32 作者: entreat 時(shí)間: 2025-3-28 01:01
https://doi.org/10.1007/978-3-322-91362-3ities affecting the gamma aminobutyric acid (GABA)ergic system. Although some of the changes are similar to those seen in individuals with schizophrenia, there are pronounced differences in the regulation of complex networks of genes involved in the expression of GAD., a key marker for functionally 作者: 柳樹；枯黃 時(shí)間: 2025-3-28 03:41 作者: 粗野 時(shí)間: 2025-3-28 07:46 作者: Accessible 時(shí)間: 2025-3-28 11:42 作者: 偏狂癥 時(shí)間: 2025-3-28 18:06 作者: 平項(xiàng)山 時(shí)間: 2025-3-28 20:24
Implementierung von Controllinginstrumentenal brain functioning that reflect the mental state at the time of scanning and have helped to elucidate both state and trait features of BPD. This chapter will review converging functional neuroimaging evidence implicating state and trait dysfunction in a ventral prefrontal cortex–amygdala neural sy作者: Nonconformist 時(shí)間: 2025-3-29 00:00 作者: 洞察力 時(shí)間: 2025-3-29 05:07
Implementierung von Controllinginstrumenteny is to have good working knowledge of up-to-date practice guidelines. The World Federation of Societies of Biological Psychiatry Guidelines has the reasoned advantage of weighing safety/tolerability as high as efficacy. Most successful treatments for BPD start to separate from placebo within 1 week作者: 不幸的人 時(shí)間: 2025-3-29 08:57
Implementierung von Controllinginstrumenten therapy (ECT) is an effective treatment for acute mania, bipolar depression, and mixed affective states. Furthermore, it is an important second-line treatment option, as most pharmacotherapy-resistant patients respond to ECT. Specific challenges for patients with BPD receiving ECT include the risk 作者: 音樂戲劇 時(shí)間: 2025-3-29 14:01
Implementierung von Controllinginstrumentente adequate doses and treatment duration, many individuals with this disease continue to experience mood episode relapses, residual symptoms, and functional impairment. This chapter reviews a number of targets/compounds that could result in putative novel treatments for BPD, including the dynorphin 作者: boisterous 時(shí)間: 2025-3-29 18:28
Implementierung von Controllinginstrumenten is one of the most debilitating medical illnesses, and a growing number of recent studies indicate that outcome is quite poor for many individuals with BPD. Afflicted patients generally experience high rates of relapse, a chronic recurrent course, lingering residual symptoms, cognitive and function作者: cutlery 時(shí)間: 2025-3-29 21:20 作者: HERE 時(shí)間: 2025-3-30 00:47
978-3-642-26599-0Springer-Verlag Berlin Heidelberg 2011作者: Allege 時(shí)間: 2025-3-30 07:10 作者: acrobat 時(shí)間: 2025-3-30 08:27
Understanding Bipolar Disorder: The Epigenetic Perspective,s made BPD an appealing target for genetic studies yet, despite numerous attempts, the genetic basis of this disease remains elusive. Recently, it has come to light that epigenetic factors may also influence the development of BPD. These factors act via stable but reversible modifications of DNA and作者: institute 時(shí)間: 2025-3-30 12:56
Clinical Endophenotypes for Bipolar Disorder,llness remains elusive. Given evidence that genes predisposing to BPD may be transmitted without expression of the clinical phenotype, interest has arisen in developing endophenotypes – indicators of processes mediating between genotype and phenotype. Patients with BPD have subtle neuropsychological作者: Indigence 時(shí)間: 2025-3-30 20:24 作者: 動(dòng)作謎 時(shí)間: 2025-3-31 00:01
Partial Rodent Genetic Models for Bipolar Disorder,bility to mood swings in euthymic BPD patients, and spontaneous cyclicity in at least some BPD patients. Currently, there is no rodent genetic model capable of encompassing the whole phenotype of BPD exists; however, recent genetic-behavioral studies have delineated partial models for some component作者: integral 時(shí)間: 2025-3-31 04:49
The Role of the Aminergic Systems in the Pathophysiology of Bipolar Disorder, the aminergic system include serotonin (5-HT), norepinephrine (NE), dopamine (DA), and acetylcholine (ACh). By analyzing these neurotransmitters, this chapter highlights three hypotheses in the pathophysiology of BPD: the biogenic amine hypothesis, the cholinergic–aminergic balance hypothesis, and 作者: 禮節(jié) 時(shí)間: 2025-3-31 09:06 作者: 我不重要 時(shí)間: 2025-3-31 11:14 作者: CRASS 時(shí)間: 2025-3-31 17:07 作者: OATH 時(shí)間: 2025-3-31 19:06
Mitochondrial Dysfunction and Bipolar Disorder,e roles of maternal inheritance, comorbidity with mitochondrial diseases, the mechanism of action of mood stabilizers, magnetic resonance spectroscopy, mitochondrial DNA mutations, gene expression analysis, and phenotypes of animal models. Mitochondrial dysfunction is not specific to BPD but is comm作者: Pantry 時(shí)間: 2025-3-31 21:48 作者: 努力趕上 時(shí)間: 2025-4-1 03:45 作者: 新手 時(shí)間: 2025-4-1 08:16
