作者: Encoding 時(shí)間: 2025-3-21 21:09 作者: BURSA 時(shí)間: 2025-3-22 00:41
Molecular Mechanisms of B Cell Antigen Gathering and Endocytosis,lper T cells. B cell antigen internalization is initiated by antigen capture, either from solution or from immune synapses formed on the surface of antigen-presenting cells, and proceeds via clathrin-dependent endocytosis and intracellular routing to late endosomes. Although the components of this p作者: Externalize 時(shí)間: 2025-3-22 08:04
BTK Signaling in B Cell Differentiation and Autoimmunity,(XLA) in 1993, our knowledge on the physiological function of BTK has expanded impressively. In this review, we focus on the role of BTK during B cell differentiation in vivo, both in the regulation of expansion and in the developmental progression of pre-B cells in the bone marrow and as a crucial 作者: 合乎習(xí)俗 時(shí)間: 2025-3-22 11:49
The Memory Function of the B Cell Antigen Receptor, of memory B cells (MBCs). The former population constantly produces serum immunoglobulins with sufficient specificity and affinity to thwart infections with recurrent pathogens. By contrast, memory B cell populations retain their antigen receptors on the cell surface and hence need pathogen-induced作者: 消極詞匯 時(shí)間: 2025-3-22 14:19
PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL),igens. The B cell receptor (BCR) is a transmembrane antibody, which facilitates the clonal selection of B cells producing secreted antibodies of the same specificity. The diverse antibody repertoire is generated by V(D)J recombination of heavy and light chain genes, whereas affinity maturation is me作者: 嚙齒動(dòng)物 時(shí)間: 2025-3-22 17:39
Role of Calcium Signaling in B Cell Activation and Biology, diverse Ca. signals finely controlled by multiple factors participate in the regulation of gene expression, B cell development, and effector functions. B cell receptor (BCR)-initiated Ca. mobilization is sourced from two pathways: one is the release of Ca. from the intracellular stores, endoplasmic作者: 內(nèi)部 時(shí)間: 2025-3-23 00:35
,Roles of the NF-κB Pathway in B-Lymphocyte Biology,ction in the regulation of immunoglobulin κ light-chain gene remains unclear, NF-κB plays critical roles in development, survival, and activation of B lymphocytes. In B cells, many receptors, including B-cell antigen receptor (BCR), activate NF-κB pathway, and the molecular mechanism of receptor-med作者: Instinctive 時(shí)間: 2025-3-23 04:58 作者: 宏偉 時(shí)間: 2025-3-23 05:44 作者: 衰老 時(shí)間: 2025-3-23 10:38
Current Topics in Microbiology and Immunologyhttp://image.papertrans.cn/b/image/180011.jpg作者: deciduous 時(shí)間: 2025-3-23 16:48
B Cell Receptor Signaling978-3-319-26133-1Series ISSN 0070-217X Series E-ISSN 2196-9965 作者: 索賠 時(shí)間: 2025-3-23 20:34
https://doi.org/10.1007/978-3-319-26133-1B cell development; Calcium signaling; MAP kinase; PI3K signaling; Autoimmunity; Lymphoma; B cell antigen 作者: inspiration 時(shí)間: 2025-3-24 00:07 作者: 評(píng)論性 時(shí)間: 2025-3-24 04:04 作者: Breach 時(shí)間: 2025-3-24 08:44 作者: Decrepit 時(shí)間: 2025-3-24 12:20 作者: 單片眼鏡 時(shí)間: 2025-3-24 15:51
Handbook of Floating-Point Arithmetic(XLA) in 1993, our knowledge on the physiological function of BTK has expanded impressively. In this review, we focus on the role of BTK during B cell differentiation in vivo, both in the regulation of expansion and in the developmental progression of pre-B cells in the bone marrow and as a crucial 作者: Firefly 時(shí)間: 2025-3-24 19:53 作者: 防銹 時(shí)間: 2025-3-24 23:21
Nutritional Disorders of Florists’ Cropsigens. The B cell receptor (BCR) is a transmembrane antibody, which facilitates the clonal selection of B cells producing secreted antibodies of the same specificity. The diverse antibody repertoire is generated by V(D)J recombination of heavy and light chain genes, whereas affinity maturation is me作者: aqueduct 時(shí)間: 2025-3-25 05:13 作者: 嬉耍 時(shí)間: 2025-3-25 09:22 作者: 演講 時(shí)間: 2025-3-25 15:23
Stilbenes and Its Derivatives and Glycosidesular responses, thereby directing cells to proliferation, differentiation, survival, apoptosis, and migration. Studies of genetically engineered mice or chemical inhibitors specific to each MAPK signaling pathway revealed that MAPKs have various, but non-redundant physiologically important roles amo作者: 浸軟 時(shí)間: 2025-3-25 16:43 作者: 五行打油詩 時(shí)間: 2025-3-25 23:44
The Fused Multiply-Add Instructionh reside within membrane confinements. This finding is more in line with the dissociation activation model (DAM), wherein B-cell activation is accompanied by an opening of the auto-inhibited BCR oligomers instead of a cross-linking of the BCR monomers. In this review, we discuss in detail the new findings and their implications for BCR signaling.作者: 陶器 時(shí)間: 2025-3-26 01:34 作者: eardrum 時(shí)間: 2025-3-26 07:02
Handbook of Floating-Point Arithmetic very recently shown impressive anti-tumor activity in clinical studies in patients with various B cell malignancies. Since promising effects of BTK inhibition were also seen in experimental animal models for lupus and rheumatoid arthritis, BTK may be a good target for controlling autoreactive B cells in patients with systemic autoimmune disease.作者: aplomb 時(shí)間: 2025-3-26 09:33 作者: MAIZE 時(shí)間: 2025-3-26 16:18 作者: Resign 時(shí)間: 2025-3-26 19:39
Molecular Mechanisms of B Cell Antigen Gathering and Endocytosis,ibute to enhanced B cell activation in models of autoimmune diseases and in B cell lymphomas. In this review, we discuss how BCR signaling complexes regulate each of the steps of this endocytic process and why defects along this pathway manifest as hyperactive B cell responses in vivo.作者: 邊緣 時(shí)間: 2025-3-26 23:09 作者: 喚醒 時(shí)間: 2025-3-27 02:36
Role of Calcium Signaling in B Cell Activation and Biology,nit of the CRAC channel pore, has now provided the tools to understand the mode of Ca. influx regulation and physiological relevance. Herein, we discuss our current understanding of the molecular mechanisms underlying BCR-triggered Ca. signaling as well as its contribution to the B cell biological processes and diseases.作者: 裝入膠囊 時(shí)間: 2025-3-27 08:19 作者: 事物的方面 時(shí)間: 2025-3-27 09:47
0070-217X ignaling pathways.Describes modulation of B cell activation .Thisvolume details our current understanding of the architecture and signalingcapabilities of the B cell antigen receptor (BCR) in health and disease. Thefirst chapters review new insights into the assembly of BCR components andtheir organ作者: 預(yù)防注射 時(shí)間: 2025-3-27 14:40 作者: 沒有希望 時(shí)間: 2025-3-27 19:04 作者: notion 時(shí)間: 2025-3-27 23:14 作者: seduce 時(shí)間: 2025-3-28 02:50
https://doi.org/10.1007/978-0-8176-4705-6ation. Nonetheless, the pre-BCR downstream signaling cascade is largely similar to that of the BCR suggesting that the characteristic LC of the pre-BCR mediates important receptor interactions thereby providing distinctive, germ line-encoded features to the pre-BCR. In fact, the SLC enables the pre-作者: conceal 時(shí)間: 2025-3-28 10:16 作者: 果核 時(shí)間: 2025-3-28 11:07
Nutritional Disorders of Florists’ Cropstoire, but also support the growth and survival of neoplastic B cells, focusing on chronic lymphocytic leukemia (CLL) B cells. Perhaps because of the central role played by PI3K in BCR signaling, B cell leukemia and lymphomas are the first diseases for which a PI3K inhibitor has been approved for cl作者: 感情脆弱 時(shí)間: 2025-3-28 16:01
Robert J. McGovern,Wade H. Elmeranding the molecular mechanism of receptor-mediated activation of the IKK complex, focusing on the roles of the ubiquitin system. In the last section, we describe oncogenic mutations that induce NF-κB activation in B-cell lymphoma.作者: Armada 時(shí)間: 2025-3-28 19:19 作者: inspired 時(shí)間: 2025-3-29 00:44
Assembly and Function of the Precursor B-Cell Receptor,ation. Nonetheless, the pre-BCR downstream signaling cascade is largely similar to that of the BCR suggesting that the characteristic LC of the pre-BCR mediates important receptor interactions thereby providing distinctive, germ line-encoded features to the pre-BCR. In fact, the SLC enables the pre-作者: 作嘔 時(shí)間: 2025-3-29 05:56
The Memory Function of the B Cell Antigen Receptor,al principles of B cell memory were enigmatic for decades. Only recently, we have begun to understand the underlying mechanisms. This review summarizes our current understanding of how different subpopulations of MBCs are generated during primary immune responses and how their functional heterogenei作者: 可卡 時(shí)間: 2025-3-29 10:48
PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL),toire, but also support the growth and survival of neoplastic B cells, focusing on chronic lymphocytic leukemia (CLL) B cells. Perhaps because of the central role played by PI3K in BCR signaling, B cell leukemia and lymphomas are the first diseases for which a PI3K inhibitor has been approved for cl作者: Galactogogue 時(shí)間: 2025-3-29 14:16 作者: Respond 時(shí)間: 2025-3-29 15:40 作者: Musket 時(shí)間: 2025-3-29 23:21
