標(biāo)題: Titlebook: Autoimmunity and the Pathogenesis of Diabetes; Fredda Ginsberg-Fellner (Professor of Pediatrics, Book 1990 Springer-Verlag New York Inc. [打印本頁] 作者: 貶損 時間: 2025-3-21 19:32
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作者: CRUE 時間: 2025-3-21 22:58 作者: 閑逛 時間: 2025-3-22 04:21 作者: maintenance 時間: 2025-3-22 04:40 作者: Engulf 時間: 2025-3-22 11:42 作者: 哄騙 時間: 2025-3-22 15:17
The Humoral Anti-Islet Immune Response: Immunochemical Studies of Glycoconjugate Antigens,-cell autoantibodies were detected by indirect immunofluorescence on a substrate of unfixed, fresh frozen, human pancreas sections. Since this initial demonstration, it has been shown that type I diabetes has a prodromal phase during which islet-cell autoantibodies can be demonstrated in the circula作者: indoctrinate 時間: 2025-3-22 19:51 作者: 能量守恒 時間: 2025-3-23 00:58 作者: electrolyte 時間: 2025-3-23 01:44
The Pathogenesis of Immunologically Mediated Diabetes,y over the last 60 years, and it is probably fair to say that we still do not understand the physiologic trigger for the process that leads to insulin-dependent (type I) diabetes nor the detailed mechanisms of beta-cell destruction. This lack of detailed knowledge is no reason to shy away from the s作者: cinder 時間: 2025-3-23 07:35
Viral Pathogenesis of Insulin-Dependent Diabetes Mellitus,anisms governing transmission of the diabetes trait still is not well understood. Concordance for insulin-dependent diabetes mellitus (IDDM) between identical twins approaches 50%, suggesting that nongenetic influences, such as environmental factors, contribute to the clinical expression of a geneti作者: incubus 時間: 2025-3-23 12:45
Immune Intervention in Diabetes: State of the Art and Future Directions,s depends on three main lines of evidence. First the association of IDDM with markers of the major histocompatibility complex (MHC) indicates not only that genetic factors are important in determining susceptibility to the disease but also that this may be related to immune system functions.. Second作者: 槍支 時間: 2025-3-23 17:56
,Diskursanalyse literarischer Gest?ndnisse,c susceptibility. Triggering factors that might induce diabetes include diabetogenic viruses, chemicals, diet, and toxins. Such likely candidates act either as primary injurious agents to pancreatic beta-cells or as triggers of autoimmunity in man and animals (Fig. 10.1)..作者: AGGER 時間: 2025-3-23 21:39 作者: anachronistic 時間: 2025-3-24 01:44 作者: 五行打油詩 時間: 2025-3-24 02:32
Damian M. Lyons,Daniel L. Pelletierted. Do autoantibodies appear after presentation of islet antigens as the primary event? Do they appear following an undefined injury to beta-cells? The latter may include attacks by virus, bacteria, environmental antigens, or possible cytotoxic lymphocytes that have been activated to detect beta-cell antigens.作者: Ganglion 時間: 2025-3-24 07:29
Michael Blatz,Karl-J. Kraus,Sascha Haghani transplantation in discordant identical twins, during which the histology of the pancreatitis that occurs in the recipient in the absence of immunosuppression has been studied.. Investigations concerning each of these lines of evidence continue, as discussed elsewhere in this volume.作者: Anticoagulant 時間: 2025-3-24 13:46 作者: neutral-posture 時間: 2025-3-24 15:32
The Humoral Anti-Islet Immune Response: Cytoplasmic Islet-Cell Antibodies: Technical Aspects and Clogressive destruction of the insulin-producing beta-cells of the islets of Langerhans; unequivocal proof for a direct autoimmune attack against beta-cells has yet to be demonstrated, however, despite the finding of a constellation of immune abnormalities around and inside injured islets at the time of diagnosis..作者: 亞當(dāng)心理陰影 時間: 2025-3-24 19:59 作者: 跑過 時間: 2025-3-25 02:13
Immune Intervention in Diabetes: State of the Art and Future Directions, transplantation in discordant identical twins, during which the histology of the pancreatitis that occurs in the recipient in the absence of immunosuppression has been studied.. Investigations concerning each of these lines of evidence continue, as discussed elsewhere in this volume.作者: 取消 時間: 2025-3-25 04:19 作者: orthodox 時間: 2025-3-25 10:49 作者: Spinous-Process 時間: 2025-3-25 15:41 作者: 和諧 時間: 2025-3-25 19:43
The Pathogenesis of Immunologically Mediated Diabetes,ideas and theories are hotly debated in the light of experimental data. In this chapter, we approach our subject as immunologists rather than endocrinologists; it is now clear that type I diabetes, both in man and in animal models, is a pathologic process with an immunologic etiology..作者: Arable 時間: 2025-3-25 21:15 作者: 單片眼鏡 時間: 2025-3-26 02:30
Christian Brockmann,Heinrich Müller demonstration, it has been shown that type I diabetes has a prodromal phase during which islet-cell autoantibodies can be demonstrated in the circulation. and that islet-cell antibodies are an important predictive hallmark of type I diabetes mellitus.作者: 詩集 時間: 2025-3-26 05:27
The Humoral Anti-Islet Immune Response: Immunochemical Studies of Glycoconjugate Antigens, demonstration, it has been shown that type I diabetes has a prodromal phase during which islet-cell autoantibodies can be demonstrated in the circulation. and that islet-cell antibodies are an important predictive hallmark of type I diabetes mellitus.作者: Chameleon 時間: 2025-3-26 08:49
https://doi.org/10.1007/978-3-642-34182-3,. and from the finding of genetic linkage between susceptibility to type I diabetes and the HLA loci.. In addition it was discovered almost simultaneously that many type I patients have autoantibodies reactive with the islets of Langerhans,. whereas patients with type II disease were essentially al作者: clarify 時間: 2025-3-26 15:52
Gesture Modelling for Linguistic Purposesdly destroyed by the diabetogenic process when transplanted into the diabetic twin, and the ability of such immunosuppressive drugs as azothioprine. and cyclosporin A. to preserve beta-cell function and increase remission rates in newly diagnosed, insulin-dependent diabetics, provide the strongest e作者: Affirm 時間: 2025-3-26 20:11 作者: arthroplasty 時間: 2025-3-26 23:29 作者: 就職 時間: 2025-3-27 02:36 作者: Coeval 時間: 2025-3-27 05:48 作者: aphasia 時間: 2025-3-27 11:00
Insulin Autoantibodies,dly destroyed by the diabetogenic process when transplanted into the diabetic twin, and the ability of such immunosuppressive drugs as azothioprine. and cyclosporin A. to preserve beta-cell function and increase remission rates in newly diagnosed, insulin-dependent diabetics, provide the strongest e作者: FER 時間: 2025-3-27 14:53
,Cell-Mediated Anti-Islet—Cell Immune Response: Clinical Experience and Lessons from Animal Models,essor cells, CD8.) or class II (helper/inducer cells CD4.). This issue of MHC-restriction in the immune system has been reviewed recently.. Although MHC-restriction is not now considered to be an absolute requirement for cell-mediated cytolysis, further research in the description and analysis of th作者: Corral 時間: 2025-3-27 20:14
Book 1990hogenesis of human type I diabetes, to place this information in historical perspective, to include relevant information from animal models of type I diabetes in which more invasive experimentation is ethical, and, finally, to update the reader on the current status of attempts to intervene in the p作者: Truculent 時間: 2025-3-28 01:54
Caroline Hummels,Gerda Smets,Kees Overbeekenot arbitrary. In his 1965 paper,. Willy Gepts cautiously interpreted histopathologic findings in pancreases of recent-onset juvenile diabetic patients as supportive of the view pointing “to a possible immunologic derangement…of the greatest interest in view of the high frequency with which we have 作者: Visual-Acuity 時間: 2025-3-28 02:51 作者: 喊叫 時間: 2025-3-28 08:30
Towards a Gesture-Sound Cross-Modal Analysishas been known for many years . even though, to date, a total understanding of these related phenomena is lacking. The endocrine diseases include goitrous and non-goitrous forms of Hashimoto’s thyroiditis, pernicious anemia, Grave’s disease, Addison’s disease, and less common diseases of other endoc作者: Torrid 時間: 2025-3-28 13:38 作者: agenda 時間: 2025-3-28 16:40 作者: palpitate 時間: 2025-3-28 19:59
Christian Brockmann,Heinrich Müller-cell autoantibodies were detected by indirect immunofluorescence on a substrate of unfixed, fresh frozen, human pancreas sections. Since this initial demonstration, it has been shown that type I diabetes has a prodromal phase during which islet-cell autoantibodies can be demonstrated in the circula作者: 模仿 時間: 2025-3-29 02:58
Gesture Modelling for Linguistic Purposesbetes (IDDM) in man is an autoimmune disease. The immunologic attack on beta-cells usually begins several years before the patient presents with clinical IDDM and occurs during an asymptomatic “prediabetic” period. Antibodies directed against islet antigens and evidence of cell-mediated immunity aga作者: 外露 時間: 2025-3-29 05:16
https://doi.org/10.1057/9780230376960ells has been discussed in several reviews,. as well as in other chapters in this volume. Relatively early in the analysis of autoimmunity and diabetes, a small number of papers presented evidence of a direct anti-beta—cell (or pancreatic islet-cell) cellular immune response in individuals with diab作者: Coronary-Spasm 時間: 2025-3-29 07:45 作者: chiropractor 時間: 2025-3-29 14:45 作者: 幼稚 時間: 2025-3-29 19:30 作者: 吹氣 時間: 2025-3-29 20:12
